EXOC8_HUMAN
Evidence for PS localization
Functions
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EXOC8_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 33.3333 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
| GO:0005525 | GTP binding | 25.6410 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 25.6410 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 25.6410 | 5 | no |
| GO:0045296 | cadherin binding | 23.0769 | 4 | no |
| GO:0003924 | GTPase activity | 20.5128 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 20.5128 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.5128 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.5128 | 6 | no |
| GO:0031267 | small GTPase binding | 17.9487 | 5 | yes |
| GO:0051020 | GTPase binding | 17.9487 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 7.6923 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EXOC8_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 74.3590 | 4 | yes |
| GO:0015031 | protein transport | 69.2308 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 69.2308 | 4 | yes |
| GO:0071702 | organic substance transport | 69.2308 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 69.2308 | 4 | yes |
| GO:0006996 | organelle organization | 58.9744 | 4 | yes |
| GO:0046903 | secretion | 46.1538 | 4 | yes |
| GO:0022607 | cellular component assembly | 46.1538 | 4 | no |
| GO:0006887 | exocytosis | 41.0256 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 38.4615 | 4 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 38.4615 | 4 | yes |
| GO:0006886 | intracellular protein transport | 35.8974 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 35.8974 | 4 | no |
| GO:0051049 | regulation of transport | 35.8974 | 4 | no |
| GO:0048193 | Golgi vesicle transport | 30.7692 | 5 | yes |
| GO:0030030 | cell projection organization | 30.7692 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.7692 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 30.7692 | 4 | no |
| GO:0006892 | post-Golgi vesicle-mediated transport | 28.2051 | 6 | yes |
| GO:0072657 | protein localization to membrane | 28.2051 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 28.2051 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 28.2051 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.6410 | 4 | yes |
| GO:0033365 | protein localization to organelle | 25.6410 | 5 | no |
| GO:1990778 | protein localization to cell periphery | 25.6410 | 5 | no |
| GO:0016197 | endosomal transport | 25.6410 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.6410 | 4 | no |
| GO:0051046 | regulation of secretion | 25.6410 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 25.6410 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 23.0769 | 5 | yes |
| GO:0070925 | organelle assembly | 23.0769 | 5 | no |
| GO:0007010 | cytoskeleton organization | 23.0769 | 5 | no |
| GO:0043933 | protein-containing complex organization | 23.0769 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 23.0769 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 23.0769 | 4 | no |
| GO:0010646 | regulation of cell communication | 23.0769 | 4 | no |
| GO:0071310 | cellular response to organic substance | 23.0769 | 4 | no |
| GO:0006893 | Golgi to plasma membrane transport | 20.5128 | 5 | yes |
| GO:0010506 | regulation of autophagy | 20.5128 | 6 | yes |
| GO:0016050 | vesicle organization | 20.5128 | 5 | yes |
| GO:0030031 | cell projection assembly | 20.5128 | 5 | no |
| GO:0120031 | plasma membrane bounded cell projection assembly | 20.5128 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 20.5128 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 20.5128 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 20.5128 | 5 | no |
| GO:0072659 | protein localization to plasma membrane | 20.5128 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.5128 | 4 | no |
| GO:0010468 | regulation of gene expression | 20.5128 | 5 | no |
| GO:0061024 | membrane organization | 20.5128 | 4 | no |
| GO:0016241 | regulation of macroautophagy | 12.8205 | 7 | yes |
| GO:0007032 | endosome organization | 7.6923 | 6 | yes |
| GO:0022411 | cellular component disassembly | 7.6923 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RALA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ULK1_HUMAN | [view interactions] | Low throughput | no | no |
| BECN1_HUMAN | [view interactions] | Low throughput | no | yes |
| EXOC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RALB_HUMAN | [view interactions] | Low throughput | no | no |
| WASH1_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| STMN3_HUMAN | [view interactions] | High throughput | no | yes |
| SNPC1_HUMAN | [view interactions] | High throughput | no | no |
| MYOZ3_HUMAN | [view interactions] | High throughput | no | no |
| DMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZSCA4_HUMAN | [view interactions] | High throughput | no | no |
| ZNF35_HUMAN | [view interactions] | High throughput | no | no |
| ESS2_HUMAN | [view interactions] | High throughput | no | yes |
| ISY1_HUMAN | [view interactions] | High throughput | no | yes |
| BL1S2_HUMAN | [view interactions] | High throughput | no | yes |
| SYT17_HUMAN | [view interactions] | High throughput | no | no |
| K1C20_HUMAN | [view interactions] | High throughput | no | no |
| TAD2A_HUMAN | [view interactions] | High throughput | no | no |
| K1C15_HUMAN | [view interactions] | High throughput | no | no |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C18_HUMAN | [view interactions] | High throughput | no | no |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| CC85B_HUMAN | [view interactions] | High throughput | no | yes |
| EXC6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIM2_HUMAN | [view interactions] | High throughput | no | no |
| ASC_HUMAN | [view interactions] | High throughput | no | no |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| CE57L_HUMAN | [view interactions] | High throughput | no | yes |
| SASH1_HUMAN | [view interactions] | High throughput | no | yes |
| RPGF3_HUMAN | [view interactions] | High throughput | no | yes |
| CAN3_HUMAN | [view interactions] | High throughput | no | no |
| SKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRT36_HUMAN | [view interactions] | High throughput | no | no |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| HTF4_HUMAN | [view interactions] | High throughput | no | yes |
| CCD33_HUMAN | [view interactions] | High throughput | no | no |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| SCAR5_HUMAN | [view interactions] | High throughput | no | yes |
| ZN177_HUMAN | [view interactions] | High throughput | no | no |
| ITF2_HUMAN | [view interactions] | High throughput | no | yes |
| AN36B_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| CDSN_HUMAN | [view interactions] | High throughput | no | no |
| VPS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3C3_HUMAN | [view interactions] | High throughput | no | yes |
| CEA21_HUMAN | [view interactions] | High throughput | no | yes |
| CAH14_HUMAN | [view interactions] | High throughput | no | yes |
| SCN2B_HUMAN | [view interactions] | High throughput | no | no |
| OLFM4_HUMAN | [view interactions] | High throughput | no | no |
| TARG1_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC41_HUMAN | [view interactions] | High throughput | no | no |
| LIPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| NPY2R_HUMAN | [view interactions] | High throughput | no | no |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| HCST_HUMAN | [view interactions] | High throughput | no | no |
| ARSF_HUMAN | [view interactions] | High throughput | no | no |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| DERL2_HUMAN | [view interactions] | High throughput | no | yes |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| TMM43_HUMAN | [view interactions] | High throughput | no | no |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX34_HUMAN | [view interactions] | High throughput | no | no |
| CHIO_HUMAN | [view interactions] | High throughput | no | yes |
| PRIC1_HUMAN | [view interactions] | High throughput | no | yes |
| STXB2_HUMAN | [view interactions] | High throughput | no | no |
| LPXN_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| STRP2_HUMAN | [view interactions] | High throughput | no | yes |
| BRCC3_HUMAN | [view interactions] | High throughput | no | no |
| BAKOR_HUMAN | [view interactions] | High throughput | no | yes |
| RUBIC_HUMAN | [view interactions] | High throughput | no | no |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIGL1_HUMAN | [view interactions] | High throughput | no | no |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| 3BP1_HUMAN | [view interactions] | High throughput | no | no |
| EXOC7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| EHD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SEC20_HUMAN | [view interactions] | High throughput | no | yes |
| S27A2_HUMAN | [view interactions] | High throughput | no | no |
| EXOC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNE3_HUMAN | [view interactions] | High throughput | no | yes |
| RT15_HUMAN | [view interactions] | High throughput | no | yes |
| RS9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USBP1_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| R3GEF_HUMAN | [view interactions] | High throughput | no | yes |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| EFHC2_HUMAN | [view interactions] | High throughput | no | no |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| IKZF3_HUMAN | [view interactions] | High throughput | no | no |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| LZTS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| VP37B_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| IHO1_HUMAN | [view interactions] | High throughput | no | no |
| PRR35_HUMAN | [view interactions] | High throughput | no | no |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| K22O_HUMAN | [view interactions] | High throughput | no | no |
| BL1S6_HUMAN | [view interactions] | High throughput | no | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| MIPO1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| RINT1_HUMAN | [view interactions] | High throughput | no | yes |
| NAB2_HUMAN | [view interactions] | High throughput | no | yes |
| GO45_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| RO52_HUMAN | [view interactions] | High throughput | no | yes |
| BICRL_HUMAN | [view interactions] | High throughput | no | yes |
| MARH7_HUMAN | [view interactions] | High throughput | no | yes |
| ATP23_HUMAN | [view interactions] | High throughput | no | yes |
| GRAM4_HUMAN | [view interactions] | High throughput | no | no |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| ZC21A_HUMAN | [view interactions] | High throughput | no | yes |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| PBX4_HUMAN | [view interactions] | High throughput | no | no |
| BEX2_HUMAN | [view interactions] | High throughput | no | yes |
| MB3L1_HUMAN | [view interactions] | High throughput | no | no |
| ZN628_HUMAN | [view interactions] | High throughput | no | no |
| ELL2_HUMAN | [view interactions] | High throughput | no | no |
| UQCC2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN566_HUMAN | [view interactions] | High throughput | no | no |
| F217B_HUMAN | [view interactions] | High throughput | no | yes |
| RUSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOQ_HUMAN | [view interactions] | Computational | no | no |
| STX4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MYH9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| EX3L4_HUMAN | [view interactions] | Computational | no | no |
| SNP23_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAB10_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CIP4_HUMAN | [view interactions] | Computational | no | no |
| TNAP2_HUMAN | [view interactions] | Computational | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| EX3L1_HUMAN | [view interactions] | Computational | no | yes |
| RAB13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| STXB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| C2CD5_HUMAN | [view interactions] | Computational | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |