RUSC1_HUMAN
Evidence for PS localization
Functions
Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RUSC1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 38.8889 | 4 | no |
| GO:0043169 | cation binding | 27.7778 | 4 | no |
| GO:0046872 | metal ion binding | 27.7778 | 5 | no |
| GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
| GO:0003779 | actin binding | 11.1111 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RUSC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.1111 | 4 | no |
| GO:0036211 | protein modification process | 50.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 44.4444 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 44.4444 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.4444 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.4444 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.8889 | 4 | no |
| GO:0022607 | cellular component assembly | 38.8889 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 38.8889 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.8889 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.8889 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.8889 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 38.8889 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 33.3333 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0043687 | post-translational protein modification | 33.3333 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 33.3333 | 6 | yes |
| GO:0032880 | regulation of protein localization | 33.3333 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 33.3333 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 33.3333 | 4 | no |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 27.7778 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 27.7778 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.7778 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.7778 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 27.7778 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 27.7778 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.7778 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.7778 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 27.7778 | 6 | no |
| GO:0031399 | regulation of protein modification process | 27.7778 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 27.7778 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | no |
| GO:0071310 | cellular response to organic substance | 27.7778 | 4 | no |
| GO:0080134 | regulation of response to stress | 27.7778 | 4 | no |
| GO:0008104 | protein localization | 27.7778 | 4 | no |
| GO:0034330 | cell junction organization | 27.7778 | 4 | no |
| GO:0043933 | protein-containing complex organization | 27.7778 | 4 | no |
| GO:0032446 | protein modification by small protein conjugation | 27.7778 | 7 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.7778 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.7778 | 5 | no |
| GO:0030030 | cell projection organization | 27.7778 | 4 | no |
| GO:0051049 | regulation of transport | 27.7778 | 4 | no |
| GO:0060284 | regulation of cell development | 27.7778 | 5 | no |
| GO:0001817 | regulation of cytokine production | 22.2222 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.2222 | 7 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.2222 | 7 | no |
| GO:0010720 | positive regulation of cell development | 22.2222 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.2222 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 22.2222 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 22.2222 | 7 | no |
| GO:0032101 | regulation of response to external stimulus | 22.2222 | 4 | no |
| GO:0034097 | response to cytokine | 22.2222 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
| GO:0045597 | positive regulation of cell differentiation | 22.2222 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 22.2222 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.2222 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.2222 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.2222 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.2222 | 5 | no |
| GO:0022411 | cellular component disassembly | 22.2222 | 4 | no |
| GO:0034329 | cell junction assembly | 22.2222 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.2222 | 5 | no |
| GO:0050806 | positive regulation of synaptic transmission | 22.2222 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.2222 | 4 | no |
| GO:0010629 | negative regulation of gene expression | 22.2222 | 7 | no |
| GO:0000209 | protein polyubiquitination | 22.2222 | 9 | yes |
| GO:0016567 | protein ubiquitination | 22.2222 | 8 | yes |
| GO:0007010 | cytoskeleton organization | 22.2222 | 5 | no |
| GO:0031175 | neuron projection development | 22.2222 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.2222 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 22.2222 | 5 | no |
| GO:0033043 | regulation of organelle organization | 22.2222 | 5 | no |
| GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.2222 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MTAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RUSC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KLC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TBB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ZN620_HUMAN | [view interactions] | High throughput | no | no |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOZ3_HUMAN | [view interactions] | High throughput | no | no |
| PRD14_HUMAN | [view interactions] | High throughput | no | no |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| NC2B_HUMAN | [view interactions] | High throughput | no | yes |
| TF2B_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TPC6A_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1A_HUMAN | [view interactions] | High throughput | no | yes |
| FND3B_HUMAN | [view interactions] | High throughput | no | no |
| CREM_HUMAN | [view interactions] | High throughput | no | no |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| TLE5_HUMAN | [view interactions] | High throughput | no | no |
| ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
| MEIS2_HUMAN | [view interactions] | High throughput | no | yes |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG8_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD57_HUMAN | [view interactions] | High throughput | no | yes |
| TRI73_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF34_HUMAN | [view interactions] | High throughput | no | no |
| ZN765_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| VGLL3_HUMAN | [view interactions] | High throughput | no | no |
| LIMS3_HUMAN | [view interactions] | High throughput | no | no |
| HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBD2_HUMAN | [view interactions] | High throughput | no | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| FA83H_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2S_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| FAM9B_HUMAN | [view interactions] | High throughput | no | no |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| CTG1B_HUMAN | [view interactions] | High throughput | no | no |
| EXOS8_HUMAN | [view interactions] | High throughput | no | yes |
| MOAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PRR35_HUMAN | [view interactions] | High throughput | no | no |
| INSC_HUMAN | [view interactions] | High throughput | no | yes |
| AIRIM_HUMAN | [view interactions] | High throughput | no | yes |
| LIMS4_HUMAN | [view interactions] | High throughput | no | no |
| DMRT3_HUMAN | [view interactions] | High throughput | no | no |
| ZIC1_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA3_HUMAN | [view interactions] | High throughput | no | no |
| CDN2B_HUMAN | [view interactions] | High throughput | no | no |
| TCHP_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD9_HUMAN | [view interactions] | High throughput | no | no |
| NUD22_HUMAN | [view interactions] | High throughput | no | yes |
| TTC19_HUMAN | [view interactions] | High throughput | no | yes |
| UFSP1_HUMAN | [view interactions] | High throughput | no | yes |
| TEKT4_HUMAN | [view interactions] | High throughput | no | no |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| KRA62_HUMAN | [view interactions] | High throughput | no | no |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| P20D2_HUMAN | [view interactions] | High throughput | no | yes |
| N4BP3_HUMAN | [view interactions] | High throughput | no | yes |
| SUOX_HUMAN | [view interactions] | High throughput | no | no |
| ZNF77_HUMAN | [view interactions] | High throughput | no | no |
| ZMY12_HUMAN | [view interactions] | High throughput | no | no |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNC_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| CRBA2_HUMAN | [view interactions] | High throughput | no | no |
| SMYD1_HUMAN | [view interactions] | High throughput | no | no |
| PLPL9_HUMAN | [view interactions] | High throughput | no | yes |
| MORN3_HUMAN | [view interactions] | High throughput | no | no |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| GCM2_HUMAN | [view interactions] | High throughput | no | no |
| MED25_HUMAN | [view interactions] | High throughput | no | yes |
| SOLH1_HUMAN | [view interactions] | High throughput | no | no |
| RPAC1_HUMAN | [view interactions] | High throughput | no | no |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| TET5B_HUMAN | [view interactions] | High throughput | no | no |
| TTC7B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BPIA1_HUMAN | [view interactions] | High throughput | no | no |
| KRA81_HUMAN | [view interactions] | High throughput | no | no |
| KR191_HUMAN | [view interactions] | High throughput | no | no |
| DOK6_HUMAN | [view interactions] | High throughput | no | yes |
| TSSK3_HUMAN | [view interactions] | High throughput | no | no |
| AKP8L_HUMAN | [view interactions] | High throughput | no | yes |
| ABHD5_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D2_HUMAN | [view interactions] | High throughput | no | no |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| KR195_HUMAN | [view interactions] | High throughput | no | no |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| NICN1_HUMAN | [view interactions] | High throughput | no | no |
| CKLF6_HUMAN | [view interactions] | High throughput | no | yes |