RUSC1_HUMAN
Evidence for PS localization
Functions
Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RUSC1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 36.8421 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.0526 | 4 | no |
| GO:0019901 | protein kinase binding | 21.0526 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.0526 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.0526 | 4 | no |
| GO:0003779 | actin binding | 10.5263 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RUSC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.8947 | 4 | no |
| GO:0036211 | protein modification process | 52.6316 | 4 | yes |
| GO:0043412 | macromolecule modification | 52.6316 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 52.6316 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.3684 | 4 | no |
| GO:0060341 | regulation of cellular localization | 47.3684 | 4 | no |
| GO:0006996 | organelle organization | 42.1053 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.1053 | 4 | no |
| GO:0032880 | regulation of protein localization | 42.1053 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.1053 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.1053 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.1053 | 4 | no |
| GO:0022607 | cellular component assembly | 36.8421 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.8421 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.8421 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 36.8421 | 4 | no |
| GO:0008104 | protein localization | 31.5789 | 4 | no |
| GO:0030030 | cell projection organization | 31.5789 | 4 | no |
| GO:0051049 | regulation of transport | 31.5789 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 31.5789 | 5 | no |
| GO:0023056 | positive regulation of signaling | 31.5789 | 4 | no |
| GO:0043933 | protein-containing complex organization | 31.5789 | 4 | no |
| GO:0010468 | regulation of gene expression | 31.5789 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 31.5789 | 5 | no |
| GO:0033043 | regulation of organelle organization | 31.5789 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.5789 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 31.5789 | 6 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 26.3158 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 26.3158 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 26.3158 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.3158 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.3158 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.3158 | 6 | no |
| GO:0034330 | cell junction organization | 26.3158 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.3158 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.3158 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.3158 | 5 | no |
| GO:0031175 | neuron projection development | 26.3158 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.3158 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 26.3158 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.3158 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.3158 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 26.3158 | 5 | no |
| GO:0032446 | protein modification by small protein conjugation | 21.0526 | 6 | yes |
| GO:0001932 | regulation of protein phosphorylation | 21.0526 | 7 | no |
| GO:0006897 | endocytosis | 21.0526 | 5 | no |
| GO:0007010 | cytoskeleton organization | 21.0526 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.0526 | 6 | no |
| GO:0034329 | cell junction assembly | 21.0526 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 21.0526 | 7 | no |
| GO:0043269 | regulation of ion transport | 21.0526 | 5 | no |
| GO:0043393 | regulation of protein binding | 21.0526 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.0526 | 5 | no |
| GO:0051338 | regulation of transferase activity | 21.0526 | 4 | no |
| GO:0051726 | regulation of cell cycle | 21.0526 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.0526 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.0526 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 21.0526 | 4 | no |
| GO:1904375 | regulation of protein localization to cell periphery | 21.0526 | 6 | no |
| GO:1905475 | regulation of protein localization to membrane | 21.0526 | 6 | no |
| GO:0015031 | protein transport | 21.0526 | 4 | no |
| GO:0022411 | cellular component disassembly | 21.0526 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.0526 | 5 | no |
| GO:0050806 | positive regulation of synaptic transmission | 21.0526 | 5 | no |
| GO:0071702 | organic substance transport | 21.0526 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.0526 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.0526 | 4 | no |
| GO:0006468 | protein phosphorylation | 21.0526 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 21.0526 | 6 | no |
| GO:0016310 | phosphorylation | 21.0526 | 5 | no |
| GO:0032101 | regulation of response to external stimulus | 21.0526 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 21.0526 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.0526 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 21.0526 | 7 | no |
| GO:0045595 | regulation of cell differentiation | 21.0526 | 4 | no |
| GO:0051241 | negative regulation of multicellular organismal process | 21.0526 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 21.0526 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 21.0526 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.0526 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 21.0526 | 7 | no |
| GO:0043408 | regulation of MAPK cascade | 21.0526 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.0526 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.0526 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.0526 | 5 | no |
| GO:0000209 | protein polyubiquitination | 15.7895 | 8 | yes |
| GO:0016567 | protein ubiquitination | 15.7895 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
| RUSC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KLC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG8_HUMAN | [view interactions] | High throughput | no | no |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD57_HUMAN | [view interactions] | High throughput | no | yes |
| TRI73_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF34_HUMAN | [view interactions] | High throughput | no | no |
| ZN765_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| VGLL3_HUMAN | [view interactions] | High throughput | no | no |
| LIMS3_HUMAN | [view interactions] | High throughput | no | no |
| HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MBD2_HUMAN | [view interactions] | High throughput | no | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| FA83H_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2S_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| FAM9B_HUMAN | [view interactions] | High throughput | no | no |
| PNMA1_HUMAN | [view interactions] | High throughput | no | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |
| MAGA3_HUMAN | [view interactions] | High throughput | no | no |
| MAGA6_HUMAN | [view interactions] | High throughput | no | no |
| CTG1B_HUMAN | [view interactions] | High throughput | no | no |
| EXOS8_HUMAN | [view interactions] | High throughput | no | yes |
| MOAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PRR35_HUMAN | [view interactions] | High throughput | no | no |
| INSC_HUMAN | [view interactions] | High throughput | no | yes |
| CA109_HUMAN | [view interactions] | High throughput | no | yes |
| LIMS4_HUMAN | [view interactions] | High throughput | no | no |
| DMRT3_HUMAN | [view interactions] | High throughput | no | no |
| ZIC1_HUMAN | [view interactions] | High throughput | no | yes |
| P4HA3_HUMAN | [view interactions] | High throughput | no | no |
| CDN2B_HUMAN | [view interactions] | High throughput | no | no |
| TCHP_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD9_HUMAN | [view interactions] | High throughput | no | no |
| NUD22_HUMAN | [view interactions] | High throughput | no | yes |
| TTC19_HUMAN | [view interactions] | High throughput | no | yes |
| UFSP1_HUMAN | [view interactions] | High throughput | no | yes |
| TEKT4_HUMAN | [view interactions] | High throughput | no | no |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| KRA62_HUMAN | [view interactions] | High throughput | no | no |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| P20D2_HUMAN | [view interactions] | High throughput | no | yes |
| N4BP3_HUMAN | [view interactions] | High throughput | no | yes |
| SUOX_HUMAN | [view interactions] | High throughput | no | no |
| ZNF77_HUMAN | [view interactions] | High throughput | no | no |
| ZMY12_HUMAN | [view interactions] | High throughput | no | no |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNC_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| CRBA2_HUMAN | [view interactions] | High throughput | no | no |
| SMYD1_HUMAN | [view interactions] | High throughput | no | no |
| PLPL9_HUMAN | [view interactions] | High throughput | no | yes |
| MORN3_HUMAN | [view interactions] | High throughput | no | no |
| DTX2_HUMAN | [view interactions] | High throughput | no | yes |
| GCM2_HUMAN | [view interactions] | High throughput | no | no |
| MED25_HUMAN | [view interactions] | High throughput | no | yes |
| SOLH1_HUMAN | [view interactions] | High throughput | no | no |
| RPAC1_HUMAN | [view interactions] | High throughput | no | no |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| TET5B_HUMAN | [view interactions] | High throughput | no | no |
| TTC7B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BPIA1_HUMAN | [view interactions] | High throughput | no | no |
| KRA81_HUMAN | [view interactions] | High throughput | no | no |
| KR191_HUMAN | [view interactions] | High throughput | no | no |
| DOK6_HUMAN | [view interactions] | High throughput | no | yes |
| TSSK3_HUMAN | [view interactions] | High throughput | no | no |
| AKP8L_HUMAN | [view interactions] | High throughput | no | yes |
| ABHD5_HUMAN | [view interactions] | High throughput | no | yes |
| VA0D2_HUMAN | [view interactions] | High throughput | no | no |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| KR195_HUMAN | [view interactions] | High throughput | no | no |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| NICN1_HUMAN | [view interactions] | High throughput | no | no |
| CKLF6_HUMAN | [view interactions] | High throughput | no | yes |
| ZN620_HUMAN | [view interactions] | High throughput | no | no |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOZ3_HUMAN | [view interactions] | High throughput | no | no |
| PRD14_HUMAN | [view interactions] | High throughput | no | no |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| NC2B_HUMAN | [view interactions] | High throughput | no | yes |
| TF2B_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C3_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TPC6A_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1A_HUMAN | [view interactions] | High throughput | no | yes |
| FND3B_HUMAN | [view interactions] | High throughput | no | no |
| CREM_HUMAN | [view interactions] | High throughput | no | no |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| TLE5_HUMAN | [view interactions] | High throughput | no | no |
| ABHDB_HUMAN | [view interactions] | High throughput | no | yes |
| MEIS2_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RUN3A_HUMAN | [view interactions] | Computational | no | yes |