KLC1_HUMAN
Evidence for PS localization
Functions
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KLC1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.9091 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.9091 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.9091 | 4 | no |
| GO:0005524 | ATP binding | 23.6364 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 23.6364 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.6364 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KLC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.8182 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 54.5455 | 4 | no |
| GO:0010646 | regulation of cell communication | 52.7273 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.9091 | 4 | no |
| GO:0008104 | protein localization | 49.0909 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 49.0909 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.2727 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.2727 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.2727 | 4 | no |
| GO:0071702 | organic substance transport | 45.4545 | 4 | no |
| GO:0071705 | nitrogen compound transport | 45.4545 | 4 | no |
| GO:0009966 | regulation of signal transduction | 43.6364 | 4 | no |
| GO:0006996 | organelle organization | 41.8182 | 4 | yes |
| GO:0015031 | protein transport | 40.0000 | 4 | no |
| GO:0051049 | regulation of transport | 40.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 38.1818 | 5 | no |
| GO:0030030 | cell projection organization | 36.3636 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 36.3636 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.3636 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 36.3636 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 36.3636 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 36.3636 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 34.5455 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.5455 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.5455 | 5 | no |
| GO:0031399 | regulation of protein modification process | 34.5455 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 34.5455 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 32.7273 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.7273 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.9091 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.9091 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 30.9091 | 7 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.9091 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.9091 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 29.0909 | 5 | no |
| GO:0071310 | cellular response to organic substance | 29.0909 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 29.0909 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 29.0909 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.0909 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.0909 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 29.0909 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.0909 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.0909 | 5 | no |
| GO:0006886 | intracellular protein transport | 27.2727 | 4 | no |
| GO:0051050 | positive regulation of transport | 27.2727 | 4 | no |
| GO:0060341 | regulation of cellular localization | 27.2727 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 27.2727 | 4 | no |
| GO:0010941 | regulation of cell death | 25.4545 | 4 | no |
| GO:0022607 | cellular component assembly | 25.4545 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.4545 | 4 | no |
| GO:0051338 | regulation of transferase activity | 25.4545 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.4545 | 7 | no |
| GO:0031344 | regulation of cell projection organization | 23.6364 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.6364 | 5 | no |
| GO:0036211 | protein modification process | 23.6364 | 4 | no |
| GO:0043412 | macromolecule modification | 23.6364 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.6364 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.6364 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.6364 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.6364 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.6364 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 23.6364 | 4 | no |
| GO:0008088 | axo-dendritic transport | 21.8182 | 5 | no |
| GO:0010970 | transport along microtubule | 21.8182 | 4 | no |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 21.8182 | 4 | no |
| GO:0031175 | neuron projection development | 21.8182 | 6 | no |
| GO:0032880 | regulation of protein localization | 21.8182 | 5 | no |
| GO:0099111 | microtubule-based transport | 21.8182 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.8182 | 5 | no |
| GO:0009894 | regulation of catabolic process | 21.8182 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.8182 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 21.8182 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.8182 | 8 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.8182 | 4 | no |
| GO:0043549 | regulation of kinase activity | 21.8182 | 5 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 21.8182 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.8182 | 7 | no |
| GO:0080134 | regulation of response to stress | 21.8182 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.8182 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 21.8182 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.8182 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.8182 | 4 | no |
| GO:0060548 | negative regulation of cell death | 21.8182 | 5 | no |
| GO:0043933 | protein-containing complex organization | 20.0000 | 4 | yes |
| GO:0022411 | cellular component disassembly | 9.0909 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 9.0909 | 5 | yes |
| GO:0032988 | ribonucleoprotein complex disassembly | 3.6364 | 6 | yes |
| GO:0035617 | stress granule disassembly | 3.6364 | 6 | yes |
| GO:0071826 | ribonucleoprotein complex subunit organization | 3.6364 | 5 | yes |
| GO:1903008 | organelle disassembly | 3.6364 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KLC1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 7.2727 | 3 | no |
| DOID:2476 | hereditary spastic paraplegia | 3.6364 | 5 | no |
| DOID:607 | paraplegia | 3.6364 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KIF5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SKP1_HUMAN | [view interactions] | Low throughput | no | yes |
| MINY2_HUMAN | [view interactions] | Low throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYNE4_HUMAN | [view interactions] | Low throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KLC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| JIP4_HUMAN | [view interactions] | Low throughput | no | yes |
| FAT1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARH_HUMAN | [view interactions] | Low throughput | no | yes |
| RASF8_HUMAN | [view interactions] | Low throughput | no | yes |
| AAKG3_HUMAN | [view interactions] | Low throughput | no | no |
| BSDC1_HUMAN | [view interactions] | Low throughput | no | no |
| RIC3_HUMAN | [view interactions] | Low throughput | no | yes |
| RUSC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HAP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK08_HUMAN | [view interactions] | Low throughput | no | yes |
| KCRB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| CBY1_HUMAN | [view interactions] | High throughput | no | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1AR_HUMAN | [view interactions] | High throughput | no | yes |
| ATCAY_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| TRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AZIN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| KLC3_HUMAN | [view interactions] | High throughput | no | no |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| ORC3_HUMAN | [view interactions] | High throughput | no | yes |
| RFOX1_HUMAN | [view interactions] | High throughput | no | yes |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| KIF2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCL_HUMAN | [view interactions] | High throughput | no | no |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TP4AP_HUMAN | [view interactions] | High throughput | no | yes |
| RABE2_HUMAN | [view interactions] | High throughput | no | yes |
| USF1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD83_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| ARNT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC16_HUMAN | [view interactions] | High throughput | no | no |
| DJC18_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| SPSB4_HUMAN | [view interactions] | High throughput | no | no |
| PSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| COPZ1_HUMAN | [view interactions] | High throughput | no | no |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TLE3_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P4R3B_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK1_HUMAN | [view interactions] | High throughput | no | no |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN784_HUMAN | [view interactions] | High throughput | no | no |
| RGPD5_HUMAN | [view interactions] | High throughput | no | no |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| RGPD2_HUMAN | [view interactions] | High throughput | no | no |
| RGPD1_HUMAN | [view interactions] | High throughput | no | no |
| F1891_HUMAN | [view interactions] | High throughput | no | no |
| P73_HUMAN | [view interactions] | High throughput | no | no |
| RGPD8_HUMAN | [view interactions] | High throughput | no | no |
| RGPD3_HUMAN | [view interactions] | High throughput | no | no |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| RFIP1_HUMAN | [view interactions] | High throughput | no | yes |
| RFIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AVL9_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| DPY30_HUMAN | [view interactions] | High throughput | no | yes |
| CEP44_HUMAN | [view interactions] | High throughput | no | yes |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| PIAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN503_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL9_HUMAN | [view interactions] | High throughput | no | no |
| ICOS_HUMAN | [view interactions] | High throughput | no | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| BNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| ODAD1_HUMAN | [view interactions] | High throughput | no | no |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PE2R4_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CEP43_HUMAN | [view interactions] | High throughput | no | no |
| NFM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NFL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KIF1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NFH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |