KPTN_HUMAN
Evidence for PS localization
Functions
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KPTN_HUMAN |
|---|---|---|---|---|
| GO:0015399 | primary active transmembrane transporter activity | 41.6667 | 4 | no |
| GO:0008324 | cation transmembrane transporter activity | 37.5000 | 4 | no |
| GO:0009678 | pyrophosphate hydrolysis-driven proton transmembrane transporter activity | 37.5000 | 5 | no |
| GO:0015078 | proton transmembrane transporter activity | 37.5000 | 5 | no |
| GO:0022853 | active ion transmembrane transporter activity | 37.5000 | 4 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 37.5000 | 4 | no |
| GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism | 37.5000 | 4 | no |
| GO:0046961 | proton-transporting ATPase activity, rotational mechanism | 37.5000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.1667 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.1667 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 29.1667 | 4 | no |
| GO:0005524 | ATP binding | 20.8333 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 20.8333 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.8333 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.8333 | 6 | no |
| GO:0030554 | adenyl nucleotide binding | 20.8333 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.8333 | 5 | no |
| GO:0003779 | actin binding | 8.3333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KPTN_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 66.6667 | 4 | no |
| GO:0009894 | regulation of catabolic process | 58.3333 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 54.1667 | 5 | no |
| GO:0010506 | regulation of autophagy | 50.0000 | 6 | no |
| GO:0016241 | regulation of macroautophagy | 50.0000 | 7 | no |
| GO:0006996 | organelle organization | 37.5000 | 4 | no |
| GO:0030030 | cell projection organization | 29.1667 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 29.1667 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 29.1667 | 5 | no |
| GO:0006811 | ion transport | 29.1667 | 4 | no |
| GO:0006812 | cation transport | 29.1667 | 5 | no |
| GO:0098655 | cation transmembrane transport | 29.1667 | 4 | no |
| GO:0098660 | inorganic ion transmembrane transport | 29.1667 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 29.1667 | 5 | no |
| GO:1902600 | proton transmembrane transport | 29.1667 | 6 | no |
| GO:0008104 | protein localization | 29.1667 | 4 | yes |
| GO:0010646 | regulation of cell communication | 29.1667 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | yes |
| GO:0048878 | chemical homeostasis | 25.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 20.8333 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 20.8333 | 4 | no |
| GO:0006873 | cellular ion homeostasis | 20.8333 | 4 | no |
| GO:0030003 | cellular cation homeostasis | 20.8333 | 5 | no |
| GO:0050801 | ion homeostasis | 20.8333 | 5 | no |
| GO:0055080 | cation homeostasis | 20.8333 | 6 | no |
| GO:0098771 | inorganic ion homeostasis | 20.8333 | 6 | no |
| GO:0022607 | cellular component assembly | 20.8333 | 4 | no |
| GO:0071453 | cellular response to oxygen levels | 20.8333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.8333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 20.8333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 20.8333 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 12.5000 | 4 | yes |
| GO:0097435 | supramolecular fiber organization | 12.5000 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 12.5000 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 12.5000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 12.5000 | 4 | yes |
| GO:0032006 | regulation of TOR signaling | 12.5000 | 6 | yes |
| GO:0033365 | protein localization to organelle | 8.3333 | 5 | yes |
| GO:0034198 | cellular response to amino acid starvation | 8.3333 | 5 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 8.3333 | 6 | yes |
| GO:1990928 | response to amino acid starvation | 8.3333 | 4 | yes |
| GO:0007015 | actin filament organization | 8.3333 | 5 | yes |
| GO:0009267 | cellular response to starvation | 8.3333 | 4 | yes |
| GO:0031667 | response to nutrient levels | 8.3333 | 4 | yes |
| GO:0031669 | cellular response to nutrient levels | 8.3333 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PRSR2_HUMAN | [view interactions] | High throughput | no | yes |
| BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
| VWCE_HUMAN | [view interactions] | High throughput | no | no |
| SAMTR_HUMAN | [view interactions] | High throughput | no | yes |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| FMN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| KLC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPH1_HUMAN | [view interactions] | High throughput | no | yes |
| KICS2_HUMAN | [view interactions] | High throughput | no | no |
| KLH15_HUMAN | [view interactions] | High throughput | no | yes |
| ITFG2_HUMAN | [view interactions] | High throughput | no | yes |
| TMCO4_HUMAN | [view interactions] | High throughput | no | no |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCAM_HUMAN | [view interactions] | High throughput | no | yes |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| RNH2A_HUMAN | [view interactions] | High throughput | no | no |
| HSPB9_HUMAN | [view interactions] | High throughput | no | no |
| DEPD5_HUMAN | [view interactions] | High throughput | no | yes |
| IPKG_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| TSN7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AUP1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM33_HUMAN | [view interactions] | High throughput | no | yes |
| SNX24_HUMAN | [view interactions] | High throughput | no | yes |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| NFRKB_HUMAN | [view interactions] | High throughput | no | yes |
| ELP2_HUMAN | [view interactions] | High throughput | no | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S14L1_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| UBP19_HUMAN | [view interactions] | High throughput | no | no |
| SZT2_HUMAN | [view interactions] | High throughput | no | yes |
| ELP3_HUMAN | [view interactions] | High throughput | no | no |
| COX16_HUMAN | [view interactions] | High throughput | no | no |
| WDR59_HUMAN | [view interactions] | High throughput | no | yes |
| NPRL3_HUMAN | [view interactions] | High throughput | no | yes |
| NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
| MIO_HUMAN | [view interactions] | High throughput | no | yes |
| WDR24_HUMAN | [view interactions] | High throughput | no | yes |
| SEH1_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| ADA19_HUMAN | [view interactions] | High throughput | no | no |
| RAP2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAP40_HUMAN | [view interactions] | High throughput | no | no |
| OTUD3_HUMAN | [view interactions] | High throughput | no | yes |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHSP1_HUMAN | [view interactions] | High throughput | no | yes |
| AL1A2_HUMAN | [view interactions] | High throughput | no | yes |
| GMPPB_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VATC2_HUMAN | [view interactions] | Computational | no | yes |
| VATB1_HUMAN | [view interactions] | Computational | no | no |
| VATH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RRAGA_HUMAN | [view interactions] | Computational | no | yes |
| VA0E2_HUMAN | [view interactions] | Computational | no | no |
| MTOR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VATF_HUMAN | [view interactions] | Computational | no | yes |
| VATL_HUMAN | [view interactions] | Computational | no | no |
| LTOR4_HUMAN | [view interactions] | Computational | no | yes |
| VA0D1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RHEB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VATG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VATG3_HUMAN | [view interactions] | Computational | no | no |
| LTOR2_HUMAN | [view interactions] | Computational | no | yes |
| LTOR3_HUMAN | [view interactions] | Computational | no | yes |
| VA0D2_HUMAN | [view interactions] | Computational | no | no |
| RPTOR_HUMAN | [view interactions] | Computational | no | yes |
| VATD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RRAGB_HUMAN | [view interactions] | Computational | no | yes |
| VATE2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAST1_HUMAN | [view interactions] | Computational | no | yes |
| VATC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VATE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VATB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VATG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VA0E1_HUMAN | [view interactions] | Computational | no | no |
| RRAGD_HUMAN | [view interactions] | Computational | no | yes |
| RRAGC_HUMAN | [view interactions] | Computational | no | yes |
| LST8_HUMAN | [view interactions] | Computational | no | yes |
| VPP3_HUMAN | [view interactions] | Computational | no | no |