Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FMN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed, PubMed). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed, PubMed). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport . Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis . Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FMN2_HUMAN
GO:0043168 anion binding 56.6667 4 no
GO:0000166 nucleotide binding 53.3333 4 no
GO:0017076 purine nucleotide binding 53.3333 5 no
GO:0032555 purine ribonucleotide binding 53.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 53.3333 4 no
GO:0003924 GTPase activity 40.0000 7 no
GO:0005525 GTP binding 40.0000 5 no
GO:0016462 pyrophosphatase activity 40.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 40.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 40.0000 6 no
GO:0019001 guanyl nucleotide binding 40.0000 6 no
GO:0032561 guanyl ribonucleotide binding 40.0000 5 no
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0003779 actin binding 23.3333 4 yes
GO:0019003 GDP binding 23.3333 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in FMN2_HUMAN
GO:0048522 positive regulation of cellular process 86.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 70.0000 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 no
GO:0008104 protein localization 63.3333 4 yes
GO:0006996 organelle organization 60.0000 4 yes
GO:0080090 regulation of primary metabolic process 60.0000 4 yes
GO:0009893 positive regulation of metabolic process 56.6667 4 yes
GO:0048523 negative regulation of cellular process 56.6667 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 53.3333 5 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 yes
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0007010 cytoskeleton organization 46.6667 5 yes
GO:0022607 cellular component assembly 46.6667 4 yes
GO:0031323 regulation of cellular metabolic process 46.6667 4 no
GO:0071702 organic substance transport 43.3333 4 yes
GO:0071705 nitrogen compound transport 43.3333 4 yes
GO:0009889 regulation of biosynthetic process 43.3333 4 no
GO:0009966 regulation of signal transduction 43.3333 4 no
GO:0010468 regulation of gene expression 43.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 43.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 43.3333 5 no
GO:0051049 regulation of transport 43.3333 4 no
GO:0033043 regulation of organelle organization 43.3333 5 no
GO:0051246 regulation of protein metabolic process 40.0000 5 yes
GO:0007015 actin filament organization 36.6667 5 yes
GO:0015031 protein transport 36.6667 4 yes
GO:0042981 regulation of apoptotic process 36.6667 5 yes
GO:0043067 regulation of programmed cell death 36.6667 4 yes
GO:0097435 supramolecular fiber organization 36.6667 4 yes
GO:0031325 positive regulation of cellular metabolic process 36.6667 5 no
GO:1902531 regulation of intracellular signal transduction 36.6667 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 yes
GO:0030030 cell projection organization 33.3333 4 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0060627 regulation of vesicle-mediated transport 33.3333 4 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0051493 regulation of cytoskeleton organization 33.3333 6 no
GO:0009967 positive regulation of signal transduction 30.0000 5 no
GO:0010647 positive regulation of cell communication 30.0000 5 no
GO:0019220 regulation of phosphate metabolic process 30.0000 6 no
GO:0023056 positive regulation of signaling 30.0000 4 no
GO:0030155 regulation of cell adhesion 30.0000 4 no
GO:0030334 regulation of cell migration 30.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 30.0000 5 no
GO:2000145 regulation of cell motility 30.0000 4 no
GO:0032956 regulation of actin cytoskeleton organization 30.0000 5 no
GO:0032970 regulation of actin filament-based process 30.0000 4 no
GO:0007264 small GTPase-mediated signal transduction 30.0000 5 no
GO:0141124 intracellular signaling cassette 30.0000 4 no
GO:0080134 regulation of response to stress 26.6667 4 yes
GO:0001932 regulation of protein phosphorylation 26.6667 7 no
GO:0030335 positive regulation of cell migration 26.6667 6 no
GO:0031344 regulation of cell projection organization 26.6667 5 no
GO:0031399 regulation of protein modification process 26.6667 6 no
GO:0040017 positive regulation of locomotion 26.6667 4 no
GO:0042127 regulation of cell population proliferation 26.6667 4 no
GO:0042325 regulation of phosphorylation 26.6667 7 no
GO:0045595 regulation of cell differentiation 26.6667 4 no
GO:0045785 positive regulation of cell adhesion 26.6667 5 no
GO:0051240 positive regulation of multicellular organismal process 26.6667 4 no
GO:0071310 cellular response to organic substance 26.6667 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.6667 6 no
GO:1902533 positive regulation of intracellular signal transduction 26.6667 6 no
GO:2000147 positive regulation of cell motility 26.6667 5 no
GO:0044089 positive regulation of cellular component biogenesis 26.6667 5 no
GO:0061024 membrane organization 26.6667 4 no
GO:0009891 positive regulation of biosynthetic process 26.6667 5 no
GO:0031328 positive regulation of cellular biosynthetic process 26.6667 6 no
GO:0009892 negative regulation of metabolic process 23.3333 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.3333 5 yes
GO:0002684 positive regulation of immune system process 23.3333 4 no
GO:0051247 positive regulation of protein metabolic process 23.3333 6 no
GO:0120036 plasma membrane bounded cell projection organization 23.3333 5 no
GO:2000026 regulation of multicellular organismal development 23.3333 4 no
GO:0010638 positive regulation of organelle organization 23.3333 6 no
GO:0110053 regulation of actin filament organization 23.3333 6 no
GO:1902903 regulation of supramolecular fiber organization 23.3333 5 no
GO:0022603 regulation of anatomical structure morphogenesis 23.3333 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.3333 6 no
GO:0051050 positive regulation of transport 23.3333 4 no
GO:0060341 regulation of cellular localization 23.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 20.0000 5 yes
GO:0043066 negative regulation of apoptotic process 16.6667 6 yes
GO:0043069 negative regulation of programmed cell death 16.6667 5 yes
GO:0051052 regulation of DNA metabolic process 16.6667 5 yes
GO:0051054 positive regulation of DNA metabolic process 16.6667 6 yes
GO:0051248 negative regulation of protein metabolic process 16.6667 6 yes
GO:0061640 cytoskeleton-dependent cytokinesis 16.6667 4 yes
GO:0080135 regulation of cellular response to stress 16.6667 4 yes
GO:0006282 regulation of DNA repair 13.3333 5 yes
GO:0006974 DNA damage response 13.3333 4 yes
GO:0045739 positive regulation of DNA repair 13.3333 5 yes
GO:0051017 actin filament bundle assembly 13.3333 5 yes
GO:0061572 actin filament bundle organization 13.3333 6 yes
GO:2000779 regulation of double-strand break repair 13.3333 6 yes
GO:2000781 positive regulation of double-strand break repair 13.3333 6 yes
GO:0009894 regulation of catabolic process 10.0000 4 yes
GO:0030046 parallel actin filament bundle assembly 10.0000 6 yes
GO:0036293 response to decreased oxygen levels 10.0000 4 yes
GO:0040038 polar body extrusion after meiotic divisions 10.0000 4 yes
GO:0042176 regulation of protein catabolic process 10.0000 5 yes
GO:0051293 establishment of spindle localization 10.0000 4 yes
GO:0070649 formin-nucleated actin cable assembly 10.0000 7 yes
GO:0110009 formin-nucleated actin cable organization 10.0000 7 yes
GO:0007292 female gamete generation 6.6667 4 yes
GO:0009895 negative regulation of catabolic process 6.6667 5 yes
GO:0036294 cellular response to decreased oxygen levels 6.6667 5 yes
GO:0042177 negative regulation of protein catabolic process 6.6667 6 yes
GO:0048477 oogenesis 6.6667 4 yes
GO:0051758 homologous chromosome movement towards spindle pole in meiosis I anaphase 6.6667 4 yes
GO:0071453 cellular response to oxygen levels 6.6667 4 yes
GO:0071456 cellular response to hypoxia 6.6667 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SMUF1_HUMAN [view interactions] Low throughput no yes
SMUF2_HUMAN [view interactions] Low throughput no yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
FMN2_HUMAN [view entry] [view interactions] Low throughput yes no
SPIR1_HUMAN [view entry] [view interactions] Low throughput yes yes
AL3B1_HUMAN [view interactions] High throughput no yes
RAB2B_HUMAN [view interactions] High throughput no no
BT2A1_HUMAN [view interactions] High throughput no yes
KPTN_HUMAN [view entry] [view interactions] High throughput yes yes
TGFR2_HUMAN [view interactions] High throughput no no
TP4A2_HUMAN [view interactions] High throughput no yes
BOD1_HUMAN [view interactions] High throughput no yes
MANF_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
CF298_HUMAN [view interactions] High throughput no yes
CTDSL_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
APBB2_HUMAN [view interactions] High throughput no yes
CASP1_HUMAN [view interactions] High throughput no yes
AFG2B_HUMAN [view interactions] High throughput no yes
GALD1_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
TIF1A_HUMAN [view interactions] High throughput no yes
NRBP_HUMAN [view interactions] High throughput no yes
COPT1_HUMAN [view interactions] High throughput no no
BD1L2_HUMAN [view interactions] High throughput no no
V1BR_HUMAN [view interactions] High throughput no no
IMP3_HUMAN [view interactions] High throughput no no
CAN2_HUMAN [view entry] [view interactions] High throughput yes no
AVR2B_HUMAN [view interactions] High throughput no no
CEP19_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP3_HUMAN [view interactions] High throughput no no
FMN1_HUMAN [view interactions] High throughput no no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
DIRA3_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
VASP_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes