Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

FMN2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed, PubMed). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed, PubMed). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport . Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis . Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed). Protects cells against apoptosis by protecting CDKN1A against degradation (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in FMN2_HUMAN
GO:0017076 purine nucleotide binding 75.0000 4 no
GO:0032555 purine ribonucleotide binding 70.8333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 70.8333 4 no
GO:0003924 GTPase activity 50.0000 7 no
GO:0005525 GTP binding 50.0000 5 no
GO:0016462 pyrophosphatase activity 50.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 50.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 50.0000 6 no
GO:0019001 guanyl nucleotide binding 50.0000 5 no
GO:0032561 guanyl ribonucleotide binding 50.0000 5 no
GO:0019003 GDP binding 33.3333 4 no
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0003779 actin binding 20.8333 4 yes
GO:0005524 ATP binding 20.8333 5 no
GO:0032559 adenyl ribonucleotide binding 20.8333 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in FMN2_HUMAN
GO:0048522 positive regulation of cellular process 87.5000 4 yes
GO:0006996 organelle organization 70.8333 4 yes
GO:0060255 regulation of macromolecule metabolic process 70.8333 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0009893 positive regulation of metabolic process 62.5000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 62.5000 5 yes
GO:0051171 regulation of nitrogen compound metabolic process 62.5000 4 yes
GO:0007010 cytoskeleton organization 58.3333 5 yes
GO:0008104 protein localization 58.3333 4 yes
GO:0031323 regulation of cellular metabolic process 58.3333 4 yes
GO:0048584 positive regulation of response to stimulus 58.3333 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 58.3333 5 yes
GO:0051128 regulation of cellular component organization 58.3333 4 no
GO:0016192 vesicle-mediated transport 54.1667 4 yes
GO:0022607 cellular component assembly 54.1667 4 yes
GO:0048523 negative regulation of cellular process 54.1667 4 yes
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 yes
GO:0051246 regulation of protein metabolic process 45.8333 5 yes
GO:0033043 regulation of organelle organization 45.8333 5 no
GO:0009966 regulation of signal transduction 45.8333 4 no
GO:0010646 regulation of cell communication 45.8333 4 no
GO:0051049 regulation of transport 45.8333 4 no
GO:0007015 actin filament organization 41.6667 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.6667 5 yes
GO:0071702 organic substance transport 41.6667 4 yes
GO:0071705 nitrogen compound transport 41.6667 4 yes
GO:0097435 supramolecular fiber organization 41.6667 4 yes
GO:0030030 cell projection organization 41.6667 4 no
GO:0071310 cellular response to organic substance 41.6667 4 no
GO:1902531 regulation of intracellular signal transduction 41.6667 5 no
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0032956 regulation of actin cytoskeleton organization 37.5000 5 no
GO:0032970 regulation of actin filament-based process 37.5000 4 no
GO:0044087 regulation of cellular component biogenesis 37.5000 4 no
GO:0051493 regulation of cytoskeleton organization 37.5000 6 no
GO:0007264 small GTPase mediated signal transduction 37.5000 4 no
GO:0030155 regulation of cell adhesion 37.5000 4 no
GO:0010941 regulation of cell death 33.3333 4 yes
GO:0015031 protein transport 33.3333 4 yes
GO:0042981 regulation of apoptotic process 33.3333 6 yes
GO:0043067 regulation of programmed cell death 33.3333 5 yes
GO:0080134 regulation of response to stress 33.3333 4 yes
GO:0030334 regulation of cell migration 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:2000145 regulation of cell motility 33.3333 4 no
GO:0007265 Ras protein signal transduction 33.3333 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0045785 positive regulation of cell adhesion 33.3333 5 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 29.1667 6 yes
GO:0030335 positive regulation of cell migration 29.1667 6 no
GO:0031344 regulation of cell projection organization 29.1667 5 no
GO:0040017 positive regulation of locomotion 29.1667 4 no
GO:0044089 positive regulation of cellular component biogenesis 29.1667 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.1667 6 no
GO:2000147 positive regulation of cell motility 29.1667 5 no
GO:0001932 regulation of protein phosphorylation 29.1667 7 no
GO:0010562 positive regulation of phosphorus metabolic process 29.1667 6 no
GO:0022603 regulation of anatomical structure morphogenesis 29.1667 4 no
GO:0031399 regulation of protein modification process 29.1667 6 no
GO:0042327 positive regulation of phosphorylation 29.1667 8 no
GO:0045937 positive regulation of phosphate metabolic process 29.1667 7 no
GO:0061024 membrane organization 29.1667 4 no
GO:1902533 positive regulation of intracellular signal transduction 29.1667 6 no
GO:0120036 plasma membrane bounded cell projection organization 29.1667 5 no
GO:0080135 regulation of cellular response to stress 25.0000 4 yes
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010638 positive regulation of organelle organization 25.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0034330 cell junction organization 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0110053 regulation of actin filament organization 25.0000 6 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0022604 regulation of cell morphogenesis 25.0000 5 no
GO:0030865 cortical cytoskeleton organization 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0009892 negative regulation of metabolic process 20.8333 4 yes
GO:0051052 regulation of DNA metabolic process 20.8333 5 yes
GO:0051054 positive regulation of DNA metabolic process 20.8333 6 yes
GO:0061640 cytoskeleton-dependent cytokinesis 20.8333 4 yes
GO:0006355 regulation of DNA-templated transcription 20.8333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 20.8333 5 no
GO:0010632 regulation of epithelial cell migration 20.8333 4 no
GO:0032231 regulation of actin filament bundle assembly 20.8333 5 no
GO:0043254 regulation of protein-containing complex assembly 20.8333 5 no
GO:0051252 regulation of RNA metabolic process 20.8333 5 no
GO:0051492 regulation of stress fiber assembly 20.8333 6 no
GO:0051495 positive regulation of cytoskeleton organization 20.8333 7 no
GO:0060491 regulation of cell projection assembly 20.8333 5 no
GO:0110020 regulation of actomyosin structure organization 20.8333 6 no
GO:0120032 regulation of plasma membrane bounded cell projection assembly 20.8333 6 no
GO:1902905 positive regulation of supramolecular fiber organization 20.8333 6 no
GO:1903506 regulation of nucleic acid-templated transcription 20.8333 7 no
GO:2001141 regulation of RNA biosynthetic process 20.8333 6 no
GO:0002009 morphogenesis of an epithelium 20.8333 4 no
GO:0002684 positive regulation of immune system process 20.8333 4 no
GO:0008360 regulation of cell shape 20.8333 6 no
GO:0010324 membrane invagination 20.8333 5 no
GO:0010810 regulation of cell-substrate adhesion 20.8333 5 no
GO:0010942 positive regulation of cell death 20.8333 5 no
GO:0022407 regulation of cell-cell adhesion 20.8333 5 no
GO:0022409 positive regulation of cell-cell adhesion 20.8333 6 no
GO:0043065 positive regulation of apoptotic process 20.8333 7 no
GO:0043068 positive regulation of programmed cell death 20.8333 6 no
GO:0043085 positive regulation of catalytic activity 20.8333 4 no
GO:0045597 positive regulation of cell differentiation 20.8333 5 no
GO:0048585 negative regulation of response to stimulus 20.8333 4 no
GO:0099024 plasma membrane invagination 20.8333 6 no
GO:1901888 regulation of cell junction assembly 20.8333 5 no
GO:0001894 tissue homeostasis 20.8333 5 no
GO:0006897 endocytosis 20.8333 5 no
GO:0060249 anatomical structure homeostasis 20.8333 4 no
GO:0036211 protein modification process 20.8333 4 no
GO:0043412 macromolecule modification 20.8333 4 no
GO:0051050 positive regulation of transport 20.8333 4 no
GO:0030031 cell projection assembly 20.8333 5 no
GO:0008284 positive regulation of cell population proliferation 20.8333 5 no
GO:0006282 regulation of DNA repair 16.6667 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 16.6667 5 yes
GO:0043066 negative regulation of apoptotic process 16.6667 7 yes
GO:0043069 negative regulation of programmed cell death 16.6667 6 yes
GO:0045739 positive regulation of DNA repair 16.6667 6 yes
GO:0051017 actin filament bundle assembly 16.6667 5 yes
GO:0060548 negative regulation of cell death 16.6667 5 yes
GO:0061572 actin filament bundle organization 16.6667 6 yes
GO:2000779 regulation of double-strand break repair 16.6667 7 yes
GO:2000781 positive regulation of double-strand break repair 16.6667 7 yes
GO:2001020 regulation of response to DNA damage stimulus 16.6667 5 yes
GO:2001022 positive regulation of response to DNA damage stimulus 16.6667 5 yes
GO:0006974 cellular response to DNA damage stimulus 12.5000 4 yes
GO:0009894 regulation of catabolic process 12.5000 4 yes
GO:0030046 parallel actin filament bundle assembly 12.5000 6 yes
GO:0036293 response to decreased oxygen levels 12.5000 4 yes
GO:0042176 regulation of protein catabolic process 12.5000 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 12.5000 5 yes
GO:0051248 negative regulation of protein metabolic process 12.5000 6 yes
GO:0051293 establishment of spindle localization 12.5000 4 yes
GO:0070649 formin-nucleated actin cable assembly 12.5000 7 yes
GO:0110009 formin-nucleated actin cable organization 12.5000 7 yes
GO:0007292 female gamete generation 8.3333 4 yes
GO:0009895 negative regulation of catabolic process 8.3333 5 yes
GO:0036294 cellular response to decreased oxygen levels 8.3333 5 yes
GO:0042177 negative regulation of protein catabolic process 8.3333 6 yes
GO:0048477 oogenesis 8.3333 4 yes
GO:0051758 homologous chromosome movement towards spindle pole in meiosis I anaphase 8.3333 4 yes
GO:0071453 cellular response to oxygen levels 8.3333 4 yes
GO:0071456 cellular response to hypoxia 8.3333 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SMUF1_HUMAN [view interactions] Low throughput no yes
SMUF2_HUMAN [view interactions] Low throughput no yes
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
FMN2_HUMAN [view entry] [view interactions] Low throughput yes no
SPIR1_HUMAN [view entry] [view interactions] Low throughput yes yes
YES_HUMAN [view entry] [view interactions] High throughput yes yes
AL3B1_HUMAN [view interactions] High throughput no yes
RAB2B_HUMAN [view interactions] High throughput no no
BT2A1_HUMAN [view interactions] High throughput no yes
KPTN_HUMAN [view entry] [view interactions] High throughput yes yes
TGFR2_HUMAN [view interactions] High throughput no no
TP4A2_HUMAN [view interactions] High throughput no yes
BOD1_HUMAN [view interactions] High throughput no yes
MANF_HUMAN [view interactions] High throughput no yes
HDAC4_HUMAN [view interactions] High throughput no yes
CTDSL_HUMAN [view interactions] High throughput no no
APBB2_HUMAN [view interactions] High throughput no yes
CASP1_HUMAN [view interactions] High throughput no yes
SPA5L_HUMAN [view interactions] High throughput no yes
GALD1_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
TIF1A_HUMAN [view interactions] High throughput no yes
NRBP_HUMAN [view interactions] High throughput no yes
COPT1_HUMAN [view interactions] High throughput no no
BD1L2_HUMAN [view interactions] High throughput no no
V1BR_HUMAN [view interactions] High throughput no no
IMP3_HUMAN [view interactions] High throughput no no
CAN2_HUMAN [view interactions] High throughput no no
AVR2B_HUMAN [view interactions] High throughput no no
CEP19_HUMAN [view interactions] High throughput no no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
DIAP3_HUMAN [view interactions] High throughput no no
FMN1_HUMAN [view interactions] High throughput no no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
DIRA3_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
LAMP1_HUMAN [view interactions] High throughput no yes
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
VASP_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SPIR2_HUMAN [view interactions] Computational no yes