CAN2_HUMAN
Evidence for PS localization
Functions
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at Arg-226 (PubMed). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAN2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 40.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 30.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.0000 | 4 | no |
| GO:0043168 | anion binding | 28.0000 | 4 | no |
| GO:0043169 | cation binding | 26.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 26.0000 | 5 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 24.0000 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 24.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.0000 | 6 | no |
| GO:0005509 | calcium ion binding | 12.0000 | 6 | yes |
| GO:0004175 | endopeptidase activity | 4.0000 | 4 | yes |
| GO:0004197 | cysteine-type endopeptidase activity | 4.0000 | 5 | yes |
| GO:0004198 | calcium-dependent cysteine-type endopeptidase activity | 4.0000 | 6 | yes |
| GO:0008234 | cysteine-type peptidase activity | 4.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAN2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 56.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 52.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 52.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 48.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 38.0000 | 5 | no |
| GO:0006996 | organelle organization | 38.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.0000 | 6 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 36.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 34.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 34.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 32.0000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 32.0000 | 5 | yes |
| GO:0043067 | regulation of programmed cell death | 30.0000 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 30.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 30.0000 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.0000 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 30.0000 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0008104 | protein localization | 30.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0051049 | regulation of transport | 30.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 28.0000 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 28.0000 | 5 | yes |
| GO:0022607 | cellular component assembly | 28.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 28.0000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.0000 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 26.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.0000 | 5 | no |
| GO:0036211 | protein modification process | 26.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 26.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.0000 | 6 | no |
| GO:0060341 | regulation of cellular localization | 26.0000 | 4 | no |
| GO:0080134 | regulation of response to stress | 26.0000 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.0000 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.0000 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 24.0000 | 4 | no |
| GO:0032880 | regulation of protein localization | 24.0000 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.0000 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.0000 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.0000 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 22.0000 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.0000 | 5 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 22.0000 | 5 | no |
| GO:0009896 | positive regulation of catabolic process | 22.0000 | 5 | no |
| GO:0009057 | macromolecule catabolic process | 22.0000 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.0000 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.0000 | 6 | yes |
| GO:0051094 | positive regulation of developmental process | 20.0000 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 20.0000 | 6 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 18.0000 | 4 | yes |
| GO:0006508 | proteolysis | 18.0000 | 4 | yes |
| GO:0033993 | response to lipid | 16.0000 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 14.0000 | 5 | yes |
| GO:0071396 | cellular response to lipid | 14.0000 | 5 | yes |
| GO:0034097 | response to cytokine | 10.0000 | 4 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 10.0000 | 7 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 10.0000 | 5 | yes |
| GO:0001817 | regulation of cytokine production | 10.0000 | 4 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 10.0000 | 6 | yes |
| GO:0036293 | response to decreased oxygen levels | 8.0000 | 4 | yes |
| GO:0043068 | positive regulation of programmed cell death | 6.0000 | 5 | yes |
| GO:0051604 | protein maturation | 6.0000 | 4 | yes |
| GO:0000302 | response to reactive oxygen species | 6.0000 | 4 | yes |
| GO:0019216 | regulation of lipid metabolic process | 6.0000 | 5 | yes |
| GO:0043065 | positive regulation of apoptotic process | 4.0000 | 6 | yes |
| GO:0043200 | response to amino acid | 4.0000 | 4 | yes |
| GO:0045834 | positive regulation of lipid metabolic process | 4.0000 | 5 | yes |
| GO:0071229 | cellular response to acid chemical | 4.0000 | 4 | yes |
| GO:0071230 | cellular response to amino acid stimulus | 4.0000 | 5 | yes |
| GO:0010660 | regulation of muscle cell apoptotic process | 4.0000 | 6 | yes |
| GO:0010662 | regulation of striated muscle cell apoptotic process | 4.0000 | 7 | yes |
| GO:0010665 | regulation of cardiac muscle cell apoptotic process | 4.0000 | 8 | yes |
| GO:0016485 | protein processing | 4.0000 | 5 | yes |
| GO:0016540 | protein autoprocessing | 4.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SUMO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LOXL2_HUMAN | [view interactions] | Low throughput | no | yes |
| ICAL_HUMAN | [view interactions] | Low throughput | no | yes |
| NMT1_HUMAN | [view interactions] | Low throughput | no | yes |
| CPNS1_HUMAN | [view interactions] | Low throughput | no | yes |
| TYY1_HUMAN | [view interactions] | Low throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TENS1_HUMAN | [view interactions] | Low throughput | no | no |
| TIRAP_HUMAN | [view interactions] | Low throughput | no | no |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TLN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBC9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CPEB3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PBIP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ZFY21_HUMAN | [view interactions] | Low throughput | no | yes |
| RAPSN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BID_HUMAN | [view interactions] | Low throughput | no | no |
| PTPRN_HUMAN | [view interactions] | Low throughput | no | yes |
| ATG5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ATX3_HUMAN | [view interactions] | Low throughput | no | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| CAN8_HUMAN | [view interactions] | Low throughput | no | no |
| NFAC2_HUMAN | [view interactions] | High throughput | no | yes |
| CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
| JAK3_HUMAN | [view interactions] | High throughput | no | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| LSP1_HUMAN | [view interactions] | High throughput | no | no |
| PSG8_HUMAN | [view interactions] | High throughput | no | no |
| GNS_HUMAN | [view interactions] | High throughput | no | yes |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC1_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP6_HUMAN | [view interactions] | High throughput | no | no |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEBPA_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| DCP2_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| DNS2B_HUMAN | [view interactions] | High throughput | no | no |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| FXL12_HUMAN | [view interactions] | High throughput | no | yes |
| DUS19_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| DUS28_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A2_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CD109_HUMAN | [view interactions] | High throughput | no | no |
| AFG2B_HUMAN | [view interactions] | High throughput | no | yes |
| PI51A_HUMAN | [view interactions] | High throughput | no | yes |
| WDR37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| FNTA_HUMAN | [view interactions] | High throughput | no | yes |
| STAT2_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9C_HUMAN | [view interactions] | High throughput | no | no |
| WDR36_HUMAN | [view interactions] | High throughput | no | no |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| MYO9A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKS1_HUMAN | [view interactions] | High throughput | no | no |
| ERC6L_HUMAN | [view interactions] | High throughput | no | yes |
| TASOR_HUMAN | [view interactions] | High throughput | no | yes |
| LZTR1_HUMAN | [view interactions] | High throughput | no | no |
| TEDC1_HUMAN | [view interactions] | High throughput | no | no |
| TUT4_HUMAN | [view interactions] | High throughput | no | yes |
| CF410_HUMAN | [view interactions] | High throughput | no | yes |
| FNTB_HUMAN | [view interactions] | High throughput | no | no |
| SMG8_HUMAN | [view interactions] | High throughput | no | yes |
| SPXN4_HUMAN | [view interactions] | High throughput | no | no |
| VIP2_HUMAN | [view interactions] | High throughput | no | yes |
| PMS1_HUMAN | [view interactions] | High throughput | no | no |
| MCM8_HUMAN | [view interactions] | High throughput | no | no |
| MTO1_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| FMN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPC1_HUMAN | [view interactions] | High throughput | no | no |
| NPRL3_HUMAN | [view interactions] | High throughput | no | yes |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| CSTFT_HUMAN | [view interactions] | High throughput | no | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| E2AK4_HUMAN | [view interactions] | High throughput | no | yes |
| CCZ1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TLS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| ATAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| CAN12_HUMAN | [view interactions] | High throughput | no | no |
| CAN9_HUMAN | [view interactions] | High throughput | no | no |
| CAN11_HUMAN | [view interactions] | High throughput | no | no |
| CAN3_HUMAN | [view interactions] | High throughput | no | no |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL7A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CGL_HUMAN | [view interactions] | High throughput | no | yes |
| GMDS_HUMAN | [view interactions] | High throughput | no | yes |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| ULA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCY2_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| TWF2_HUMAN | [view interactions] | High throughput | no | no |
| UBA3_HUMAN | [view interactions] | High throughput | no | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PLPHP_HUMAN | [view interactions] | High throughput | no | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| RUXE_HUMAN | [view interactions] | High throughput | no | no |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MA2A2_HUMAN | [view interactions] | High throughput | no | no |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| TPM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSU72_HUMAN | [view interactions] | High throughput | no | yes |
| BCCIP_HUMAN | [view interactions] | High throughput | no | no |
| RBM8A_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACD1_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |