CPEB3_HUMAN
Evidence for PS localization
Functions
Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator . In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3-UTR, but binds to a U-rich loop within a stem-loop structure . Required for the consolidation and maintenance of hippocampal-based long term memory . In the basal state, binds to the mRNA 3-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation . Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B . When activated, acts as a translational activator of GRIA1 and GRIA2 . In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation . Binds to the 3-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception . Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation . Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CPEB3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 50.0000 | 4 | no |
| GO:0046872 | metal ion binding | 50.0000 | 5 | no |
| GO:0003723 | RNA binding | 40.0000 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 40.0000 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 40.0000 | 4 | no |
| GO:0003729 | mRNA binding | 20.0000 | 5 | yes |
| GO:0003730 | mRNA 3-UTR binding | 20.0000 | 6 | yes |
| GO:0043022 | ribosome binding | 20.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CPEB3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | yes |
| GO:0036211 | protein modification process | 60.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 60.0000 | 4 | no |
| GO:0006508 | proteolysis | 60.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 50.0000 | 4 | no |
| GO:0016567 | protein ubiquitination | 50.0000 | 8 | no |
| GO:0032446 | protein modification by small protein conjugation | 50.0000 | 7 | no |
| GO:0043687 | post-translational protein modification | 50.0000 | 5 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 50.0000 | 5 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 50.0000 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | yes |
| GO:0043200 | response to amino acid | 40.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | yes |
| GO:0071229 | cellular response to acid chemical | 40.0000 | 4 | yes |
| GO:0071230 | cellular response to amino acid stimulus | 40.0000 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0019941 | modification-dependent protein catabolic process | 40.0000 | 6 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 40.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 40.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 40.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.0000 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 30.0000 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 30.0000 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 30.0000 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | yes |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | no |
| GO:0043065 | positive regulation of apoptotic process | 30.0000 | 6 | no |
| GO:0043068 | positive regulation of programmed cell death | 30.0000 | 5 | no |
| GO:0006417 | regulation of translation | 20.0000 | 6 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 20.0000 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 20.0000 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 20.0000 | 4 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.0000 | 6 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.0000 | 5 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 20.0000 | 7 | yes |
| GO:0010629 | negative regulation of gene expression | 20.0000 | 7 | yes |
| GO:0017148 | negative regulation of translation | 20.0000 | 7 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 20.0000 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.0000 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.0000 | 6 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 20.0000 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 20.0000 | 6 | yes |
| GO:0060998 | regulation of dendritic spine development | 20.0000 | 4 | yes |
| GO:0060999 | positive regulation of dendritic spine development | 20.0000 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 20.0000 | 4 | yes |
| GO:2000765 | regulation of cytoplasmic translation | 20.0000 | 7 | yes |
| GO:2000766 | negative regulation of cytoplasmic translation | 20.0000 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TOB1_HUMAN | [view interactions] | Low throughput | no | yes |
| CNOT7_HUMAN | [view interactions] | Low throughput | no | no |
| TOB2_HUMAN | [view interactions] | Low throughput | no | yes |
| NEUL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CPEB4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |