Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CPEB3_HUMAN

Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator . In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3-UTR, but binds to a U-rich loop within a stem-loop structure . Required for the consolidation and maintenance of hippocampal-based long term memory . In the basal state, binds to the mRNA 3-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation . Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B . When activated, acts as a translational activator of GRIA1 and GRIA2 . In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation . Binds to the 3-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception . Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation . Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CPEB3_HUMAN
GO:0031625 ubiquitin protein ligase binding 50.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 50.0000 4 no
GO:0003723 RNA binding 40.0000 4 yes
GO:0046872 metal ion binding 40.0000 4 no
GO:0003729 mRNA binding 20.0000 5 yes
GO:0003730 mRNA 3-UTR binding 20.0000 6 yes
GO:0043022 ribosome binding 20.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CPEB3_HUMAN
GO:0036211 protein modification process 70.0000 4 no
GO:0043412 macromolecule modification 70.0000 4 no
GO:0010646 regulation of cell communication 60.0000 4 yes
GO:0031323 regulation of cellular metabolic process 60.0000 4 yes
GO:0048522 positive regulation of cellular process 60.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 60.0000 4 yes
GO:0051246 regulation of protein metabolic process 60.0000 5 yes
GO:0060255 regulation of macromolecule metabolic process 60.0000 4 yes
GO:0080090 regulation of primary metabolic process 60.0000 4 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 50.0000 5 yes
GO:0051247 positive regulation of protein metabolic process 50.0000 6 yes
GO:0009966 regulation of signal transduction 50.0000 4 no
GO:0016567 protein ubiquitination 50.0000 7 no
GO:0032446 protein modification by small protein conjugation 50.0000 6 no
GO:0070647 protein modification by small protein conjugation or removal 50.0000 5 no
GO:0006508 proteolysis 50.0000 4 no
GO:0009057 macromolecule catabolic process 50.0000 4 no
GO:0009894 regulation of catabolic process 40.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 yes
GO:0048523 negative regulation of cellular process 40.0000 4 yes
GO:0010941 regulation of cell death 40.0000 4 no
GO:0042981 regulation of apoptotic process 40.0000 6 no
GO:0043067 regulation of programmed cell death 40.0000 5 no
GO:0006996 organelle organization 40.0000 4 no
GO:0019941 modification-dependent protein catabolic process 40.0000 6 no
GO:0043632 modification-dependent macromolecule catabolic process 40.0000 5 no
GO:0044265 cellular macromolecule catabolic process 40.0000 4 no
GO:0051603 proteolysis involved in protein catabolic process 40.0000 5 no
GO:0009892 negative regulation of metabolic process 30.0000 4 yes
GO:0010243 response to organonitrogen compound 30.0000 4 yes
GO:0010468 regulation of gene expression 30.0000 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 30.0000 5 yes
GO:0010629 negative regulation of gene expression 30.0000 6 yes
GO:0031329 regulation of cellular catabolic process 30.0000 5 yes
GO:0043200 response to amino acid 30.0000 4 yes
GO:0051094 positive regulation of developmental process 30.0000 4 yes
GO:0071229 cellular response to acid chemical 30.0000 4 yes
GO:0071230 cellular response to amino acid stimulus 30.0000 5 yes
GO:0071310 cellular response to organic substance 30.0000 4 yes
GO:0071417 cellular response to organonitrogen compound 30.0000 4 yes
GO:1901699 cellular response to nitrogen compound 30.0000 4 yes
GO:1901701 cellular response to oxygen-containing compound 30.0000 4 yes
GO:0007010 cytoskeleton organization 30.0000 5 no
GO:0009967 positive regulation of signal transduction 30.0000 5 no
GO:0010647 positive regulation of cell communication 30.0000 5 no
GO:0022607 cellular component assembly 30.0000 4 no
GO:0023056 positive regulation of signaling 30.0000 4 no
GO:0031399 regulation of protein modification process 30.0000 6 no
GO:0031401 positive regulation of protein modification process 30.0000 7 no
GO:0048584 positive regulation of response to stimulus 30.0000 4 no
GO:0051128 regulation of cellular component organization 30.0000 4 no
GO:1902531 regulation of intracellular signal transduction 30.0000 5 no
GO:0006417 regulation of translation 20.0000 6 yes
GO:0009889 regulation of biosynthetic process 20.0000 4 yes
GO:0009890 negative regulation of biosynthetic process 20.0000 5 yes
GO:0009896 positive regulation of catabolic process 20.0000 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 20.0000 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 20.0000 6 yes
GO:0010608 post-transcriptional regulation of gene expression 20.0000 6 yes
GO:0017148 negative regulation of translation 20.0000 7 yes
GO:0031324 negative regulation of cellular metabolic process 20.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 20.0000 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 20.0000 6 yes
GO:0031331 positive regulation of cellular catabolic process 20.0000 6 yes
GO:0034248 regulation of cellular amide metabolic process 20.0000 5 yes
GO:0034249 negative regulation of cellular amide metabolic process 20.0000 6 yes
GO:0050804 modulation of chemical synaptic transmission 20.0000 5 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 20.0000 5 yes
GO:0051248 negative regulation of protein metabolic process 20.0000 6 yes
GO:0060998 regulation of dendritic spine development 20.0000 4 yes
GO:0060999 positive regulation of dendritic spine development 20.0000 5 yes
GO:0099177 regulation of trans-synaptic signaling 20.0000 4 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 20.0000 6 yes
GO:2000113 negative regulation of cellular macromolecule biosynthetic process 20.0000 7 yes
GO:2000765 regulation of cytoplasmic translation 20.0000 7 yes
GO:2000766 negative regulation of cytoplasmic translation 20.0000 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CNOT7_HUMAN [view interactions] Low throughput no no
TOB1_HUMAN [view interactions] Low throughput no yes
TOB2_HUMAN [view interactions] Low throughput no yes
NEUL1_HUMAN [view entry] [view interactions] Low throughput yes yes
CAN2_HUMAN [view interactions] Low throughput no no
CAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
EGLN3_HUMAN [view interactions] High throughput no no
UBB_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
RS27A_HUMAN [view entry] [view interactions] High throughput yes yes
RL40_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
NXF1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
CPEB4_HUMAN [view entry] [view interactions] High throughput yes no
OTUD4_HUMAN [view interactions] High throughput no yes
TB182_HUMAN [view interactions] Computational no yes
CNOT1_HUMAN [view interactions] Computational no yes
CNO6L_HUMAN [view interactions] Computational no no
PLK1_HUMAN [view interactions] Computational no yes
CNOT2_HUMAN [view interactions] Computational no yes
CNOT9_HUMAN [view interactions] Computational no yes
CCNB2_HUMAN [view interactions] Computational no yes
AURKA_HUMAN [view entry] [view interactions] Computational yes no
OR4KF_HUMAN [view interactions] Computational no no
CNO10_HUMAN [view interactions] Computational no yes
CNO11_HUMAN [view interactions] Computational no yes
CDK1_HUMAN [view interactions] Computational no no
CNOT6_HUMAN [view interactions] Computational no yes
CNOT8_HUMAN [view interactions] Computational no yes
CNOT3_HUMAN [view interactions] Computational no yes