Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NEUL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NEUL1_HUMAN
GO:0003723 RNA binding 41.1765 4 no
GO:0031625 ubiquitin protein ligase binding 41.1765 5 no
GO:0044389 ubiquitin-like protein ligase binding 41.1765 4 no
GO:0046872 metal ion binding 35.2941 4 yes
GO:0004842 ubiquitin-protein transferase activity 23.5294 4 yes
GO:0005524 ATP binding 23.5294 5 no
GO:0017076 purine nucleotide binding 23.5294 4 no
GO:0030554 adenyl nucleotide binding 23.5294 5 no
GO:0032555 purine ribonucleotide binding 23.5294 4 no
GO:0032559 adenyl ribonucleotide binding 23.5294 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.5294 4 no
GO:0061630 ubiquitin protein ligase activity 11.7647 5 yes
GO:0061659 ubiquitin-like protein ligase activity 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NEUL1_HUMAN
GO:0048522 positive regulation of cellular process 64.7059 4 yes
GO:0036211 protein modification process 58.8235 4 yes
GO:0043412 macromolecule modification 58.8235 4 yes
GO:0009893 positive regulation of metabolic process 52.9412 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 52.9412 5 yes
GO:0010646 regulation of cell communication 52.9412 4 yes
GO:0060255 regulation of macromolecule metabolic process 52.9412 4 yes
GO:0016567 protein ubiquitination 47.0588 7 yes
GO:0032446 protein modification by small protein conjugation 47.0588 6 yes
GO:0048523 negative regulation of cellular process 47.0588 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 47.0588 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 47.0588 5 yes
GO:0070647 protein modification by small protein conjugation or removal 47.0588 5 yes
GO:0080090 regulation of primary metabolic process 47.0588 4 yes
GO:0031323 regulation of cellular metabolic process 41.1765 4 yes
GO:0031325 positive regulation of cellular metabolic process 41.1765 5 yes
GO:0048584 positive regulation of response to stimulus 41.1765 4 yes
GO:0051246 regulation of protein metabolic process 41.1765 5 yes
GO:0051247 positive regulation of protein metabolic process 41.1765 6 yes
GO:0009966 regulation of signal transduction 35.2941 4 yes
GO:0009967 positive regulation of signal transduction 35.2941 5 yes
GO:0010243 response to organonitrogen compound 35.2941 4 yes
GO:0010647 positive regulation of cell communication 35.2941 5 yes
GO:0023056 positive regulation of signaling 35.2941 4 yes
GO:0045595 regulation of cell differentiation 35.2941 4 yes
GO:0006508 proteolysis 35.2941 4 no
GO:0009057 macromolecule catabolic process 35.2941 4 no
GO:0010468 regulation of gene expression 35.2941 5 no
GO:0019941 modification-dependent protein catabolic process 35.2941 6 no
GO:0043632 modification-dependent macromolecule catabolic process 35.2941 5 no
GO:0044265 cellular macromolecule catabolic process 35.2941 4 no
GO:0051603 proteolysis involved in protein catabolic process 35.2941 5 no
GO:0010648 negative regulation of cell communication 29.4118 5 yes
GO:0023057 negative regulation of signaling 29.4118 4 yes
GO:0031399 regulation of protein modification process 29.4118 6 yes
GO:0031401 positive regulation of protein modification process 29.4118 7 yes
GO:0050804 modulation of chemical synaptic transmission 29.4118 5 yes
GO:0051094 positive regulation of developmental process 29.4118 4 yes
GO:0051128 regulation of cellular component organization 29.4118 4 yes
GO:0051130 positive regulation of cellular component organization 29.4118 5 yes
GO:0051240 positive regulation of multicellular organismal process 29.4118 4 yes
GO:0071310 cellular response to organic substance 29.4118 4 yes
GO:0099177 regulation of trans-synaptic signaling 29.4118 4 yes
GO:2000026 regulation of multicellular organismal development 29.4118 4 yes
GO:0009889 regulation of biosynthetic process 29.4118 4 no
GO:0010556 regulation of macromolecule biosynthetic process 29.4118 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.4118 5 no
GO:0031326 regulation of cellular biosynthetic process 29.4118 5 no
GO:0006996 organelle organization 23.5294 4 yes
GO:0010941 regulation of cell death 23.5294 4 yes
GO:0022607 cellular component assembly 23.5294 4 yes
GO:0031344 regulation of cell projection organization 23.5294 5 yes
GO:0042981 regulation of apoptotic process 23.5294 6 yes
GO:0043067 regulation of programmed cell death 23.5294 5 yes
GO:0043085 positive regulation of catalytic activity 23.5294 4 yes
GO:0045597 positive regulation of cell differentiation 23.5294 5 yes
GO:0050767 regulation of neurogenesis 23.5294 6 yes
GO:0051338 regulation of transferase activity 23.5294 4 yes
GO:0051347 positive regulation of transferase activity 23.5294 5 yes
GO:0051960 regulation of nervous system development 23.5294 5 yes
GO:0060284 regulation of cell development 23.5294 5 yes
GO:0060998 regulation of dendritic spine development 23.5294 4 yes
GO:0060999 positive regulation of dendritic spine development 23.5294 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.5294 6 yes
GO:1901701 cellular response to oxygen-containing compound 23.5294 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 23.5294 6 no
GO:0051252 regulation of RNA metabolic process 23.5294 5 no
GO:0009891 positive regulation of biosynthetic process 23.5294 5 no
GO:0009892 negative regulation of metabolic process 23.5294 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0010605 negative regulation of macromolecule metabolic process 23.5294 5 no
GO:0010628 positive regulation of gene expression 23.5294 6 no
GO:0010629 negative regulation of gene expression 23.5294 6 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0031328 positive regulation of cellular biosynthetic process 23.5294 6 no
GO:0051049 regulation of transport 23.5294 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.5294 5 no
GO:0009894 regulation of catabolic process 23.5294 4 no
GO:0001932 regulation of protein phosphorylation 17.6471 7 yes
GO:0001934 positive regulation of protein phosphorylation 17.6471 8 yes
GO:0007219 Notch signaling pathway 17.6471 4 yes
GO:0007420 brain development 17.6471 4 yes
GO:0008593 regulation of Notch signaling pathway 17.6471 5 yes
GO:0009968 negative regulation of signal transduction 17.6471 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 17.6471 6 yes
GO:0010720 positive regulation of cell development 17.6471 6 yes
GO:0010942 positive regulation of cell death 17.6471 5 yes
GO:0019220 regulation of phosphate metabolic process 17.6471 6 yes
GO:0031346 positive regulation of cell projection organization 17.6471 6 yes
GO:0033674 positive regulation of kinase activity 17.6471 6 yes
GO:0042325 regulation of phosphorylation 17.6471 7 yes
GO:0042327 positive regulation of phosphorylation 17.6471 8 yes
GO:0043065 positive regulation of apoptotic process 17.6471 7 yes
GO:0043068 positive regulation of programmed cell death 17.6471 6 yes
GO:0043200 response to amino acid 17.6471 4 yes
GO:0043549 regulation of kinase activity 17.6471 5 yes
GO:0045859 regulation of protein kinase activity 17.6471 6 yes
GO:0045860 positive regulation of protein kinase activity 17.6471 7 yes
GO:0045937 positive regulation of phosphate metabolic process 17.6471 7 yes
GO:0048168 regulation of neuronal synaptic plasticity 17.6471 4 yes
GO:0048169 regulation of long-term neuronal synaptic plasticity 17.6471 5 yes
GO:0048585 negative regulation of response to stimulus 17.6471 4 yes
GO:0050769 positive regulation of neurogenesis 17.6471 6 yes
GO:0050807 regulation of synapse organization 17.6471 5 yes
GO:0051174 regulation of phosphorus metabolic process 17.6471 5 yes
GO:0051962 positive regulation of nervous system development 17.6471 5 yes
GO:0071229 cellular response to acid chemical 17.6471 4 yes
GO:0071230 cellular response to amino acid stimulus 17.6471 5 yes
GO:0071417 cellular response to organonitrogen compound 17.6471 4 yes
GO:0090128 regulation of synapse maturation 17.6471 4 yes
GO:0090129 positive regulation of synapse maturation 17.6471 5 yes
GO:1901699 cellular response to nitrogen compound 17.6471 4 yes
GO:0001578 microtubule bundle formation 11.7647 4 yes
GO:0006513 protein monoubiquitination 11.7647 8 yes
GO:0007010 cytoskeleton organization 11.7647 5 yes
GO:0007176 regulation of epidermal growth factor-activated receptor activity 11.7647 4 yes
GO:0007399 nervous system development 11.7647 4 yes
GO:0007519 skeletal muscle tissue development 11.7647 5 yes
GO:0007589 body fluid secretion 11.7647 4 yes
GO:0007595 lactation 11.7647 5 yes
GO:0008285 negative regulation of cell population proliferation 11.7647 5 yes
GO:0035082 axoneme assembly 11.7647 5 yes
GO:0042058 regulation of epidermal growth factor receptor signaling pathway 11.7647 6 yes
GO:0042127 regulation of cell population proliferation 11.7647 4 yes
GO:0044087 regulation of cellular component biogenesis 11.7647 4 yes
GO:0044089 positive regulation of cellular component biogenesis 11.7647 5 yes
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity 11.7647 5 yes
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 11.7647 7 yes
GO:0045746 negative regulation of Notch signaling pathway 11.7647 6 yes
GO:0046903 secretion 11.7647 4 yes
GO:0048170 positive regulation of long-term neuronal synaptic plasticity 11.7647 6 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 11.7647 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 11.7647 9 yes
GO:0051489 regulation of filopodium assembly 11.7647 7 yes
GO:0051491 positive regulation of filopodium assembly 11.7647 7 yes
GO:0060491 regulation of cell projection assembly 11.7647 5 yes
GO:0060537 muscle tissue development 11.7647 4 yes
GO:0061097 regulation of protein tyrosine kinase activity 11.7647 7 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 11.7647 8 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 11.7647 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 11.7647 6 yes
GO:1901184 regulation of ERBB signaling pathway 11.7647 5 yes
GO:1901186 positive regulation of ERBB signaling pathway 11.7647 6 yes
GO:2000273 positive regulation of signaling receptor activity 11.7647 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CPEB3_HUMAN [view entry] [view interactions] Low throughput yes no
JAG1_HUMAN [view interactions] Low throughput no no
DLL1_HUMAN [view interactions] Low throughput no no
DLL4_HUMAN [view interactions] Low throughput no no
APBB1_HUMAN [view interactions] Low throughput no yes
PDE9A_HUMAN [view interactions] Low throughput no yes
UB2D1_HUMAN [view interactions] Low throughput no yes
NEUL1_HUMAN [view entry] [view interactions] Low throughput yes yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
EPN2_HUMAN [view entry] [view interactions] High throughput yes yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
BRWD3_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
ARFP2_HUMAN [view interactions] High throughput no no
NOTC2_HUMAN [view interactions] Computational no yes
RS27A_HUMAN [view entry] [view interactions] Computational yes yes
UBB_HUMAN [view entry] [view interactions] Computational yes yes
UBC_HUMAN [view entry] [view interactions] Computational yes yes
RL40_HUMAN [view entry] [view interactions] Computational yes yes
MIB1_HUMAN [view entry] [view interactions] Computational yes yes
NOTC3_HUMAN [view interactions] Computational no yes
JAG2_HUMAN [view interactions] Computational no yes