Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NEUL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NEUL1_HUMAN
GO:0003723 RNA binding 40.0000 4 no
GO:0031625 ubiquitin protein ligase binding 33.3333 5 no
GO:0044389 ubiquitin-like protein ligase binding 33.3333 4 no
GO:0043169 cation binding 26.6667 4 yes
GO:0046872 metal ion binding 26.6667 5 yes
GO:0000166 nucleotide binding 26.6667 4 no
GO:0005524 ATP binding 26.6667 5 no
GO:0017076 purine nucleotide binding 26.6667 5 no
GO:0030554 adenyl nucleotide binding 26.6667 6 no
GO:0032555 purine ribonucleotide binding 26.6667 4 no
GO:0032559 adenyl ribonucleotide binding 26.6667 5 no
GO:0035639 purine ribonucleoside triphosphate binding 26.6667 4 no
GO:0043168 anion binding 26.6667 4 no
GO:0045296 cadherin binding 26.6667 4 no
GO:0004842 ubiquitin-protein transferase activity 20.0000 4 yes
GO:0016755 aminoacyltransferase activity 20.0000 4 yes
GO:0061630 ubiquitin protein ligase activity 13.3333 5 yes
GO:0061659 ubiquitin-like protein ligase activity 13.3333 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NEUL1_HUMAN
GO:0048522 positive regulation of cellular process 86.6667 4 yes
GO:0048523 negative regulation of cellular process 73.3333 4 yes
GO:0031323 regulation of cellular metabolic process 60.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 60.0000 4 no
GO:0010646 regulation of cell communication 53.3333 4 yes
GO:0009889 regulation of biosynthetic process 53.3333 4 no
GO:0010556 regulation of macromolecule biosynthetic process 53.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 53.3333 5 no
GO:0080090 regulation of primary metabolic process 53.3333 4 no
GO:0051094 positive regulation of developmental process 46.6667 4 yes
GO:0009893 positive regulation of metabolic process 46.6667 4 no
GO:0010468 regulation of gene expression 46.6667 6 no
GO:0010604 positive regulation of macromolecule metabolic process 46.6667 5 no
GO:0009892 negative regulation of metabolic process 46.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 46.6667 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 46.6667 5 no
GO:0009966 regulation of signal transduction 40.0000 4 yes
GO:0045595 regulation of cell differentiation 40.0000 4 yes
GO:0045597 positive regulation of cell differentiation 40.0000 5 yes
GO:0051128 regulation of cellular component organization 40.0000 4 yes
GO:2000026 regulation of multicellular organismal development 40.0000 4 yes
GO:0009891 positive regulation of biosynthetic process 40.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 40.0000 6 no
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 40.0000 6 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 40.0000 5 no
GO:0051252 regulation of RNA metabolic process 40.0000 5 no
GO:0009968 negative regulation of signal transduction 33.3333 5 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0031344 regulation of cell projection organization 33.3333 5 yes
GO:0036211 protein modification process 33.3333 4 yes
GO:0042981 regulation of apoptotic process 33.3333 5 yes
GO:0043067 regulation of programmed cell death 33.3333 4 yes
GO:0043412 macromolecule modification 33.3333 4 yes
GO:0048585 negative regulation of response to stimulus 33.3333 4 yes
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 yes
GO:0051130 positive regulation of cellular component organization 33.3333 5 yes
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 yes
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 33.3333 6 yes
GO:0008104 protein localization 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0006355 regulation of DNA-templated transcription 33.3333 7 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 no
GO:0051049 regulation of transport 33.3333 4 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0006996 organelle organization 26.6667 4 yes
GO:0010720 positive regulation of cell development 26.6667 6 yes
GO:0022607 cellular component assembly 26.6667 4 yes
GO:0031346 positive regulation of cell projection organization 26.6667 6 yes
GO:0042127 regulation of cell population proliferation 26.6667 4 yes
GO:0050767 regulation of neurogenesis 26.6667 6 yes
GO:0051960 regulation of nervous system development 26.6667 5 yes
GO:0060284 regulation of cell development 26.6667 5 yes
GO:0060998 regulation of dendritic spine development 26.6667 4 yes
GO:0060999 positive regulation of dendritic spine development 26.6667 5 yes
GO:0002684 positive regulation of immune system process 26.6667 4 no
GO:0010628 positive regulation of gene expression 26.6667 7 no
GO:0033365 protein localization to organelle 26.6667 5 no
GO:0009967 positive regulation of signal transduction 26.6667 5 no
GO:0010647 positive regulation of cell communication 26.6667 5 no
GO:0023056 positive regulation of signaling 26.6667 4 no
GO:0031399 regulation of protein modification process 26.6667 6 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 no
GO:0051248 negative regulation of protein metabolic process 26.6667 6 no
GO:0051726 regulation of cell cycle 26.6667 4 no
GO:1903829 positive regulation of protein localization 26.6667 5 no
GO:0006357 regulation of transcription by RNA polymerase II 26.6667 8 no
GO:0051050 positive regulation of transport 26.6667 4 no
GO:0051223 regulation of protein transport 26.6667 5 no
GO:0070201 regulation of establishment of protein localization 26.6667 6 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 26.6667 5 no
GO:0051253 negative regulation of RNA metabolic process 26.6667 6 no
GO:0007399 nervous system development 20.0000 4 yes
GO:0008285 negative regulation of cell population proliferation 20.0000 5 yes
GO:0008593 regulation of Notch signaling pathway 20.0000 5 yes
GO:0016567 protein ubiquitination 20.0000 8 yes
GO:0032446 protein modification by small protein conjugation 20.0000 7 yes
GO:0043065 positive regulation of apoptotic process 20.0000 6 yes
GO:0043068 positive regulation of programmed cell death 20.0000 5 yes
GO:0043200 response to amino acid 20.0000 4 yes
GO:0043687 post-translational protein modification 20.0000 5 yes
GO:0048168 regulation of neuronal synaptic plasticity 20.0000 4 yes
GO:0048169 regulation of long-term neuronal synaptic plasticity 20.0000 5 yes
GO:0050769 positive regulation of neurogenesis 20.0000 6 yes
GO:0050807 regulation of synapse organization 20.0000 5 yes
GO:0051962 positive regulation of nervous system development 20.0000 5 yes
GO:0070647 protein modification by small protein conjugation or removal 20.0000 6 yes
GO:0071229 cellular response to acid chemical 20.0000 4 yes
GO:0071230 cellular response to amino acid stimulus 20.0000 5 yes
GO:0090128 regulation of synapse maturation 20.0000 4 yes
GO:0090129 positive regulation of synapse maturation 20.0000 5 yes
GO:0001578 microtubule bundle formation 13.3333 4 yes
GO:0006513 protein monoubiquitination 13.3333 9 yes
GO:0007010 cytoskeleton organization 13.3333 5 yes
GO:0007219 Notch signaling pathway 13.3333 4 yes
GO:0007519 skeletal muscle tissue development 13.3333 5 yes
GO:0007589 body fluid secretion 13.3333 4 yes
GO:0007595 lactation 13.3333 5 yes
GO:0035082 axoneme assembly 13.3333 5 yes
GO:0044087 regulation of cellular component biogenesis 13.3333 4 yes
GO:0044089 positive regulation of cellular component biogenesis 13.3333 5 yes
GO:0045746 negative regulation of Notch signaling pathway 13.3333 6 yes
GO:0046903 secretion 13.3333 4 yes
GO:0048170 positive regulation of long-term neuronal synaptic plasticity 13.3333 6 yes
GO:0051489 regulation of filopodium assembly 13.3333 7 yes
GO:0051491 positive regulation of filopodium assembly 13.3333 7 yes
GO:0060491 regulation of cell projection assembly 13.3333 5 yes
GO:0060537 muscle tissue development 13.3333 4 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 13.3333 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 13.3333 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CPEB3_HUMAN [view entry] [view interactions] Low throughput yes no
JAG1_HUMAN [view interactions] Low throughput no no
DLL1_HUMAN [view interactions] Low throughput no no
DLL4_HUMAN [view interactions] Low throughput no no
APBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PDE9A_HUMAN [view interactions] Low throughput no yes
UB2D1_HUMAN [view interactions] Low throughput no yes
NEUL1_HUMAN [view entry] [view interactions] Low throughput yes yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
EPN2_HUMAN [view entry] [view interactions] High throughput yes yes
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
BRWD3_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
ARFP2_HUMAN [view interactions] High throughput no no