EPN2_HUMAN
Evidence for PS localization
Functions
Plays a role in the formation of clathrin-coated invaginations and endocytosis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001148 | LIG_EH_1 | LIG | 536 | 540 | - |
| ELMI001149 | LIG_EH_1 | LIG | 551 | 555 | - |
| ELMI001150 | LIG_EH_1 | LIG | 636 | 640 | - |
| ELMI001210 | TRG_AP2beta_CARGO_1 | TRG | 456 | 465 | - |
| ELMI001148 | LIG_EH_1 | LIG | 536 | 540 | - |
| ELMI001149 | LIG_EH_1 | LIG | 551 | 555 | - |
| ELMI001150 | LIG_EH_1 | LIG | 636 | 640 | - |
| ELMI001210 | TRG_AP2beta_CARGO_1 | TRG | 456 | 465 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EPN2_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
| GO:0043168 | anion binding | 25.0000 | 4 | no |
| GO:0043169 | cation binding | 22.5000 | 4 | no |
| GO:0046872 | metal ion binding | 22.5000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 22.5000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.5000 | 4 | no |
| GO:0045296 | cadherin binding | 20.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EPN2_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 55.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 52.5000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 45.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.5000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.5000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 37.5000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 37.5000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 37.5000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.5000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 37.5000 | 5 | no |
| GO:0098657 | import into cell | 35.0000 | 4 | yes |
| GO:0010468 | regulation of gene expression | 35.0000 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 35.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.0000 | 5 | no |
| GO:0015031 | protein transport | 32.5000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 32.5000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.5000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 32.5000 | 5 | no |
| GO:0022607 | cellular component assembly | 32.5000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.5000 | 5 | no |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.5000 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 27.5000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 27.5000 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.5000 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 27.5000 | 6 | no |
| GO:0051049 | regulation of transport | 27.5000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.5000 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.5000 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 27.5000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | yes |
| GO:0006886 | intracellular protein transport | 25.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 22.5000 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 22.5000 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 22.5000 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 22.5000 | 4 | yes |
| GO:0006898 | receptor-mediated endocytosis | 22.5000 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 22.5000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.5000 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.5000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.5000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.5000 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 20.0000 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 20.0000 | 5 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.0000 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 20.0000 | 4 | yes |
| GO:0051093 | negative regulation of developmental process | 15.0000 | 4 | yes |
| GO:0008593 | regulation of Notch signaling pathway | 5.0000 | 5 | yes |
| GO:0045765 | regulation of angiogenesis | 5.0000 | 5 | yes |
| GO:0090287 | regulation of cellular response to growth factor stimulus | 5.0000 | 4 | yes |
| GO:1901342 | regulation of vasculature development | 5.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CLH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBQL2_HUMAN | [view interactions] | Low throughput | no | yes |
| VGFR3_HUMAN | [view interactions] | Low throughput | no | yes |
| RBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MSRE_HUMAN | [view interactions] | Low throughput | no | no |
| EPS15_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB3I_HUMAN | [view interactions] | High throughput | no | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WBP2_HUMAN | [view interactions] | High throughput | no | yes |
| F168A_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| CDIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI18_HUMAN | [view interactions] | High throughput | no | no |
| EIF3E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRD2_HUMAN | [view interactions] | High throughput | no | no |
| RNF8_HUMAN | [view interactions] | High throughput | no | yes |
| ARRD3_HUMAN | [view interactions] | High throughput | no | no |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| PKHB2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI62_HUMAN | [view interactions] | High throughput | no | no |
| MAR1_HUMAN | [view interactions] | High throughput | no | no |
| PMEPA_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| SPART_HUMAN | [view interactions] | High throughput | no | yes |
| LFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAPK2_HUMAN | [view interactions] | High throughput | no | yes |
| PP4P1_HUMAN | [view interactions] | High throughput | no | yes |
| WBP1L_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD1_HUMAN | [view interactions] | High throughput | no | yes |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| DAZP2_HUMAN | [view interactions] | High throughput | no | no |
| FANCM_HUMAN | [view interactions] | High throughput | no | no |
| LITAF_HUMAN | [view interactions] | High throughput | no | yes |
| ARRD1_HUMAN | [view interactions] | High throughput | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| WBP1_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| EPN3_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM47_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| H2A2A_HUMAN | [view interactions] | High throughput | no | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| H1X_HUMAN | [view interactions] | High throughput | no | yes |
| RAD50_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSD2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| RN214_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| OPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EREP1_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |