Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SMCA1_HUMAN

Energy-transducing component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SMCA1_HUMAN
GO:0000166 nucleotide binding 50.0000 4 yes
GO:0017076 purine nucleotide binding 50.0000 5 yes
GO:0032555 purine ribonucleotide binding 45.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 45.0000 4 yes
GO:0043168 anion binding 45.0000 4 yes
GO:0030554 adenyl nucleotide binding 40.0000 6 yes
GO:0005524 ATP binding 35.0000 5 yes
GO:0032559 adenyl ribonucleotide binding 35.0000 5 yes
GO:0043169 cation binding 30.0000 4 no
GO:0046872 metal ion binding 30.0000 5 no
GO:0003723 RNA binding 30.0000 4 no
GO:0140297 DNA-binding transcription factor binding 25.0000 4 yes
GO:0016301 kinase activity 25.0000 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 25.0000 5 no
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 20.0000 5 yes
GO:0003677 DNA binding 15.0000 4 yes
GO:0031491 nucleosome binding 10.0000 4 yes
GO:0140666 annealing activity 10.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SMCA1_HUMAN
GO:0048522 positive regulation of cellular process 70.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.0000 4 yes
GO:0009893 positive regulation of metabolic process 60.0000 4 yes
GO:0080090 regulation of primary metabolic process 60.0000 4 yes
GO:0010646 regulation of cell communication 60.0000 4 no
GO:0048523 negative regulation of cellular process 60.0000 4 no
GO:0009889 regulation of biosynthetic process 55.0000 4 yes
GO:0010468 regulation of gene expression 55.0000 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 55.0000 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 55.0000 5 yes
GO:0031323 regulation of cellular metabolic process 55.0000 4 yes
GO:0031326 regulation of cellular biosynthetic process 55.0000 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 50.0000 5 yes
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0009891 positive regulation of biosynthetic process 45.0000 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 45.0000 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 45.0000 6 yes
GO:0009966 regulation of signal transduction 45.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 45.0000 5 no
GO:0048585 negative regulation of response to stimulus 45.0000 4 no
GO:0051128 regulation of cellular component organization 45.0000 4 no
GO:0051252 regulation of RNA metabolic process 40.0000 5 yes
GO:0009968 negative regulation of signal transduction 40.0000 5 no
GO:0010647 positive regulation of cell communication 40.0000 5 no
GO:0010648 negative regulation of cell communication 40.0000 5 no
GO:0023056 positive regulation of signaling 40.0000 4 no
GO:0023057 negative regulation of signaling 40.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 40.0000 5 no
GO:0006996 organelle organization 40.0000 4 no
GO:0009890 negative regulation of biosynthetic process 35.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 35.0000 6 no
GO:0031327 negative regulation of cellular biosynthetic process 35.0000 6 no
GO:0006355 regulation of DNA-templated transcription 35.0000 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 35.0000 8 yes
GO:0045893 positive regulation of DNA-templated transcription 35.0000 8 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 35.0000 5 yes
GO:0051254 positive regulation of RNA metabolic process 35.0000 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 35.0000 7 yes
GO:2001141 regulation of RNA biosynthetic process 35.0000 6 yes
GO:0019220 regulation of phosphate metabolic process 35.0000 6 no
GO:0031399 regulation of protein modification process 35.0000 6 no
GO:0031401 positive regulation of protein modification process 35.0000 7 no
GO:0036211 protein modification process 35.0000 4 no
GO:0042981 regulation of apoptotic process 35.0000 5 no
GO:0043067 regulation of programmed cell death 35.0000 4 no
GO:0043412 macromolecule modification 35.0000 4 no
GO:0048584 positive regulation of response to stimulus 35.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 35.0000 5 no
GO:0051246 regulation of protein metabolic process 35.0000 5 no
GO:0051247 positive regulation of protein metabolic process 35.0000 6 no
GO:0009059 macromolecule biosynthetic process 30.0000 4 no
GO:0043933 protein-containing complex organization 30.0000 4 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 30.0000 9 yes
GO:0001932 regulation of protein phosphorylation 30.0000 7 no
GO:0001934 positive regulation of protein phosphorylation 30.0000 8 no
GO:0006796 phosphate-containing compound metabolic process 30.0000 4 no
GO:0009967 positive regulation of signal transduction 30.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 30.0000 6 no
GO:0042325 regulation of phosphorylation 30.0000 7 no
GO:0042327 positive regulation of phosphorylation 30.0000 8 no
GO:0043085 positive regulation of catalytic activity 30.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 30.0000 7 no
GO:0051240 positive regulation of multicellular organismal process 30.0000 4 no
GO:0051248 negative regulation of protein metabolic process 30.0000 6 no
GO:0080134 regulation of response to stress 30.0000 4 no
GO:1902531 regulation of intracellular signal transduction 30.0000 5 no
GO:0008104 protein localization 30.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0090304 nucleic acid metabolic process 25.0000 4 no
GO:0002831 regulation of response to biotic stimulus 25.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0031347 regulation of defense response 25.0000 5 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0045088 regulation of innate immune response 25.0000 5 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0050776 regulation of immune response 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051241 negative regulation of multicellular organismal process 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0140546 defense response to symbiont 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0006325 chromatin organization 15.0000 6 yes
GO:0006338 chromatin remodeling 15.0000 7 yes
GO:0071824 protein-DNA complex organization 15.0000 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
BAZ2B_HUMAN [view interactions] Low throughput no yes
H31_HUMAN [view interactions] Low throughput no yes
PARP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PRGR_HUMAN [view interactions] Low throughput no no
ARI1B_HUMAN [view interactions] Low throughput no yes
BPTF_HUMAN [view interactions] Low throughput no yes
RBBP4_HUMAN [view interactions] Low throughput no yes
CECR2_HUMAN [view interactions] Low throughput no yes
RSF1_HUMAN [view interactions] Low throughput no yes
RBBP7_HUMAN [view interactions] Low throughput no yes
DPY30_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
BAZ1B_HUMAN [view entry] [view interactions] High throughput yes yes
E2F3_HUMAN [view interactions] High throughput no no
DDX60_HUMAN [view interactions] High throughput no no
TF7L2_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
HMGB1_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
EWS_HUMAN [view interactions] High throughput no yes
FOXC1_HUMAN [view interactions] High throughput no no
FOXE1_HUMAN [view interactions] High throughput no no
FOXG1_HUMAN [view interactions] High throughput no no
FOXJ2_HUMAN [view interactions] High throughput no yes
FOXK2_HUMAN [view interactions] High throughput no yes
FOXL1_HUMAN [view interactions] High throughput no no
FOXQ1_HUMAN [view interactions] High throughput no no
MAX_HUMAN [view interactions] High throughput no yes
SUH_HUMAN [view interactions] High throughput no yes
TEAD2_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FBRL_HUMAN [view interactions] High throughput no yes
KLF9_HUMAN [view interactions] High throughput no no
LHX2_HUMAN [view interactions] High throughput no no
VGFR2_HUMAN [view interactions] High throughput no no
TIE2_HUMAN [view interactions] High throughput no no
USF1_HUMAN [view interactions] High throughput no yes
SET1A_HUMAN [view interactions] High throughput no yes
GRK5_HUMAN [view interactions] High throughput no yes
BAP18_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
RS2_HUMAN [view entry] [view interactions] High throughput yes yes
DEFI6_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
NANOG_HUMAN [view interactions] High throughput no no
TM128_HUMAN [view interactions] High throughput no yes
I23O2_HUMAN [view interactions] High throughput no no
INAVA_HUMAN [view interactions] High throughput no yes
RFXK_HUMAN [view interactions] High throughput no yes
NF2IP_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
CGAS_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
H2AX_HUMAN [view interactions] High throughput no yes
H2AZ_HUMAN [view interactions] High throughput no yes
H2AY_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
WWP2_HUMAN [view interactions] High throughput no no
ERCC6_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
RAD18_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
BRD2_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
PWP2A_HUMAN [view interactions] High throughput no no
MYBB_HUMAN [view interactions] High throughput no yes
LIN37_HUMAN [view interactions] High throughput no yes
LIN9_HUMAN [view interactions] High throughput no yes
MBD2_HUMAN [view interactions] High throughput no yes
CDKA1_HUMAN [view interactions] High throughput no yes
MTA3_HUMAN [view interactions] High throughput no yes
MTA2_HUMAN [view interactions] High throughput no yes
P66B_HUMAN [view interactions] High throughput no yes
Z512B_HUMAN [view interactions] High throughput no yes
P66A_HUMAN [view interactions] High throughput no yes
SAP30_HUMAN [view interactions] High throughput no yes
MBD3_HUMAN [view interactions] High throughput no yes
SMCA5_HUMAN [view interactions] High throughput no yes
HMGX4_HUMAN [view interactions] High throughput no yes
BRM1L_HUMAN [view interactions] High throughput no no
MTA1_HUMAN [view interactions] High throughput no yes
PHF1_HUMAN [view interactions] High throughput no yes
GATD1_HUMAN [view interactions] High throughput no no
BC11A_HUMAN [view entry] [view interactions] High throughput yes yes
ARI4B_HUMAN [view interactions] High throughput no yes
HJURP_HUMAN [view interactions] High throughput no yes
MTF2_HUMAN [view interactions] High throughput no no
SDS3_HUMAN [view interactions] High throughput no yes
SP130_HUMAN [view interactions] High throughput no no
CAF1A_HUMAN [view interactions] High throughput no yes
SHPRH_HUMAN [view interactions] High throughput no yes
LIN52_HUMAN [view interactions] High throughput no no
SIN3A_HUMAN [view interactions] High throughput no yes
SIN3B_HUMAN [view interactions] High throughput no yes
CAF1B_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
HAT1_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
ZBTB2_HUMAN [view interactions] High throughput no yes
DPOE3_HUMAN [view interactions] High throughput no yes
IMA5_HUMAN [view entry] [view interactions] High throughput yes yes
ZN467_HUMAN [view interactions] High throughput no no
TEBP_HUMAN [view interactions] High throughput no yes
RS19_HUMAN [view entry] [view interactions] High throughput yes no
HNRC2_HUMAN [view interactions] High throughput no no
MAGA3_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
CTNA3_HUMAN [view interactions] High throughput no no
TXNIP_HUMAN [view interactions] High throughput no no
KLH20_HUMAN [view interactions] High throughput no yes
H2A1_HUMAN [view interactions] High throughput no yes
SLN11_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
EPN2_HUMAN [view entry] [view interactions] High throughput yes yes
H10_HUMAN [view interactions] High throughput no yes
H2B2E_HUMAN [view interactions] High throughput no yes
HMGA1_HUMAN [view interactions] High throughput no yes
HMGN5_HUMAN [view interactions] High throughput no no
M4K4_HUMAN [view interactions] High throughput no yes
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
NECP1_HUMAN [view interactions] High throughput no no
NUCKS_HUMAN [view interactions] High throughput no yes
NUMA1_HUMAN [view interactions] High throughput no yes
POGZ_HUMAN [view interactions] High throughput no yes
PRDM2_HUMAN [view interactions] High throughput no yes
BAZ1A_HUMAN [view interactions] High throughput no no
CHRC1_HUMAN [view interactions] High throughput no no
CBX1_HUMAN [view interactions] High throughput no yes
SSRP1_HUMAN [view interactions] High throughput no yes
TOP1_HUMAN [view interactions] High throughput no yes
VRK1_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
GATA4_HUMAN [view interactions] High throughput no no
TBX5_HUMAN [view interactions] High throughput no no
PARPT_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
RHG24_HUMAN [view interactions] High throughput no yes
CL16A_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
SMRC2_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
SMCA4_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
DDX21_HUMAN [view interactions] High throughput no yes
TFPT_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
CBX3_HUMAN [view interactions] High throughput no yes
RPA34_HUMAN [view interactions] High throughput no yes
CENPA_HUMAN [view interactions] High throughput no no
COIL_HUMAN [view interactions] High throughput no yes
H2B1C_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
RPA49_HUMAN [view interactions] High throughput no yes
TE2IP_HUMAN [view interactions] High throughput no yes
ZN330_HUMAN [view interactions] High throughput no yes
BROMI_HUMAN [view interactions] High throughput no no
H33_HUMAN [view interactions] High throughput no yes
RED1_HUMAN [view interactions] High throughput no no
NUP43_HUMAN [view interactions] High throughput no yes
SNR40_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
DUXA_HUMAN [view interactions] High throughput no no
IFIX_HUMAN [view interactions] High throughput no no