Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SMCA1_HUMAN

Energy-transducing component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SMCA1_HUMAN
GO:0017076 purine nucleotide binding 42.1053 4 yes
GO:0032555 purine ribonucleotide binding 42.1053 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 42.1053 4 yes
GO:0005524 ATP binding 31.5789 5 yes
GO:0030554 adenyl nucleotide binding 31.5789 5 yes
GO:0032559 adenyl ribonucleotide binding 31.5789 5 yes
GO:0003723 RNA binding 31.5789 4 no
GO:0140297 DNA-binding transcription factor binding 26.3158 4 yes
GO:0019900 kinase binding 26.3158 4 no
GO:0019901 protein kinase binding 26.3158 5 no
GO:0046872 metal ion binding 26.3158 4 no
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 21.0526 5 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 21.0526 4 no
GO:0016301 kinase activity 21.0526 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 21.0526 4 no
GO:0003677 DNA binding 15.7895 4 yes
GO:0140666 annealing activity 10.5263 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SMCA1_HUMAN
GO:0048522 positive regulation of cellular process 68.4211 4 yes
GO:0009893 positive regulation of metabolic process 57.8947 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 57.8947 4 yes
GO:0060255 regulation of macromolecule metabolic process 57.8947 4 yes
GO:0080090 regulation of primary metabolic process 57.8947 4 yes
GO:0010646 regulation of cell communication 57.8947 4 no
GO:0010604 positive regulation of macromolecule metabolic process 52.6316 5 yes
GO:0031323 regulation of cellular metabolic process 52.6316 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 52.6316 5 yes
GO:0048523 negative regulation of cellular process 52.6316 4 no
GO:0010468 regulation of gene expression 47.3684 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 47.3684 5 yes
GO:0031325 positive regulation of cellular metabolic process 47.3684 5 yes
GO:0051128 regulation of cellular component organization 47.3684 4 no
GO:0009889 regulation of biosynthetic process 42.1053 4 yes
GO:0009891 positive regulation of biosynthetic process 42.1053 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 42.1053 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 42.1053 6 yes
GO:0031326 regulation of cellular biosynthetic process 42.1053 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 42.1053 6 yes
GO:0051252 regulation of RNA metabolic process 42.1053 5 yes
GO:0009966 regulation of signal transduction 42.1053 4 no
GO:0009892 negative regulation of metabolic process 42.1053 4 no
GO:0006355 regulation of DNA-templated transcription 36.8421 6 yes
GO:0045893 positive regulation of DNA-templated transcription 36.8421 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 36.8421 6 yes
GO:0051254 positive regulation of RNA metabolic process 36.8421 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 36.8421 7 yes
GO:1903506 regulation of nucleic acid-templated transcription 36.8421 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 36.8421 8 yes
GO:2001141 regulation of RNA biosynthetic process 36.8421 6 yes
GO:0006996 organelle organization 36.8421 4 no
GO:0010605 negative regulation of macromolecule metabolic process 36.8421 5 no
GO:0010647 positive regulation of cell communication 36.8421 5 no
GO:0023056 positive regulation of signaling 36.8421 4 no
GO:0031324 negative regulation of cellular metabolic process 36.8421 5 no
GO:0036211 protein modification process 36.8421 4 no
GO:0043412 macromolecule modification 36.8421 4 no
GO:0048584 positive regulation of response to stimulus 36.8421 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 36.8421 5 no
GO:0048585 negative regulation of response to stimulus 36.8421 4 no
GO:0010648 negative regulation of cell communication 36.8421 5 no
GO:0023057 negative regulation of signaling 36.8421 4 no
GO:0006357 regulation of transcription by RNA polymerase II 31.5789 7 yes
GO:0010941 regulation of cell death 31.5789 4 no
GO:0042981 regulation of apoptotic process 31.5789 6 no
GO:0043067 regulation of programmed cell death 31.5789 5 no
GO:0019220 regulation of phosphate metabolic process 31.5789 6 no
GO:0051174 regulation of phosphorus metabolic process 31.5789 5 no
GO:0051240 positive regulation of multicellular organismal process 31.5789 4 no
GO:0080134 regulation of response to stress 31.5789 4 no
GO:0016192 vesicle-mediated transport 31.5789 4 no
GO:0009968 negative regulation of signal transduction 31.5789 5 no
GO:0031399 regulation of protein modification process 31.5789 6 no
GO:0031401 positive regulation of protein modification process 31.5789 7 no
GO:0051246 regulation of protein metabolic process 31.5789 5 no
GO:0051247 positive regulation of protein metabolic process 31.5789 6 no
GO:0009059 macromolecule biosynthetic process 26.3158 4 no
GO:0009890 negative regulation of biosynthetic process 26.3158 5 no
GO:0009967 positive regulation of signal transduction 26.3158 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 26.3158 6 no
GO:0018193 peptidyl-amino acid modification 26.3158 5 no
GO:0031327 negative regulation of cellular biosynthetic process 26.3158 6 no
GO:0033043 regulation of organelle organization 26.3158 5 no
GO:0044087 regulation of cellular component biogenesis 26.3158 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 26.3158 6 no
GO:0051094 positive regulation of developmental process 26.3158 4 no
GO:0051253 negative regulation of RNA metabolic process 26.3158 6 no
GO:0071310 cellular response to organic substance 26.3158 4 no
GO:1902531 regulation of intracellular signal transduction 26.3158 5 no
GO:0031344 regulation of cell projection organization 26.3158 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.3158 6 no
GO:0001932 regulation of protein phosphorylation 26.3158 7 no
GO:0001934 positive regulation of protein phosphorylation 26.3158 8 no
GO:0010562 positive regulation of phosphorus metabolic process 26.3158 6 no
GO:0010628 positive regulation of gene expression 26.3158 6 no
GO:0042325 regulation of phosphorylation 26.3158 7 no
GO:0042327 positive regulation of phosphorylation 26.3158 8 no
GO:0043085 positive regulation of catalytic activity 26.3158 4 no
GO:0045937 positive regulation of phosphate metabolic process 26.3158 7 no
GO:0051248 negative regulation of protein metabolic process 26.3158 6 no
GO:0045944 positive regulation of transcription by RNA polymerase II 21.0526 8 yes
GO:0071702 organic substance transport 21.0526 4 no
GO:0071705 nitrogen compound transport 21.0526 4 no
GO:0006796 phosphate-containing compound metabolic process 21.0526 4 no
GO:0006974 cellular response to DNA damage stimulus 21.0526 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.0526 4 no
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0010942 positive regulation of cell death 21.0526 5 no
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 21.0526 5 no
GO:0044271 cellular nitrogen compound biosynthetic process 21.0526 4 no
GO:0045595 regulation of cell differentiation 21.0526 4 no
GO:0045892 negative regulation of DNA-templated transcription 21.0526 7 no
GO:0051129 negative regulation of cellular component organization 21.0526 5 no
GO:0080135 regulation of cellular response to stress 21.0526 4 no
GO:0090304 nucleic acid metabolic process 21.0526 4 no
GO:1901699 cellular response to nitrogen compound 21.0526 4 no
GO:1901701 cellular response to oxygen-containing compound 21.0526 4 no
GO:1902679 negative regulation of RNA biosynthetic process 21.0526 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 21.0526 8 no
GO:0002684 positive regulation of immune system process 21.0526 4 no
GO:0050776 regulation of immune response 21.0526 4 no
GO:0050778 positive regulation of immune response 21.0526 5 no
GO:0051241 negative regulation of multicellular organismal process 21.0526 4 no
GO:0006897 endocytosis 21.0526 5 no
GO:0050804 modulation of chemical synaptic transmission 21.0526 5 no
GO:0051049 regulation of transport 21.0526 4 no
GO:0060627 regulation of vesicle-mediated transport 21.0526 4 no
GO:0099177 regulation of trans-synaptic signaling 21.0526 4 no
GO:0051726 regulation of cell cycle 21.0526 4 no
GO:1902532 negative regulation of intracellular signal transduction 21.0526 6 no
GO:0051336 regulation of hydrolase activity 21.0526 4 no
GO:0051338 regulation of transferase activity 21.0526 4 no
GO:0051347 positive regulation of transferase activity 21.0526 5 no
GO:0031346 positive regulation of cell projection organization 21.0526 6 no
GO:0051130 positive regulation of cellular component organization 21.0526 5 no
GO:0030162 regulation of proteolysis 21.0526 6 no
GO:0045862 positive regulation of proteolysis 21.0526 7 no
GO:0006325 chromatin organization 10.5263 4 yes
GO:0006338 chromatin remodeling 10.5263 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RSF1_HUMAN [view interactions] Low throughput no yes
CECR2_HUMAN [view interactions] Low throughput no yes
RBBP4_HUMAN [view interactions] Low throughput no yes
BPTF_HUMAN [view interactions] Low throughput no yes
RBBP7_HUMAN [view interactions] Low throughput no yes
BAZ2B_HUMAN [view interactions] Low throughput no yes
H31_HUMAN [view interactions] Low throughput no yes
PARP1_HUMAN [view entry] [view interactions] Low throughput yes yes
PRGR_HUMAN [view interactions] Low throughput no no
ARI1B_HUMAN [view interactions] Low throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
WWP2_HUMAN [view interactions] High throughput no no
ERCC6_HUMAN [view interactions] High throughput no no
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
RAD18_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
BRD2_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
PWP2A_HUMAN [view interactions] High throughput no no
MYBB_HUMAN [view interactions] High throughput no yes
LIN37_HUMAN [view interactions] High throughput no yes
LIN9_HUMAN [view interactions] High throughput no yes
MBD2_HUMAN [view interactions] High throughput no yes
CDKA1_HUMAN [view interactions] High throughput no yes
MTA3_HUMAN [view interactions] High throughput no yes
MTA2_HUMAN [view interactions] High throughput no yes
P66B_HUMAN [view interactions] High throughput no yes
Z512B_HUMAN [view interactions] High throughput no yes
P66A_HUMAN [view interactions] High throughput no yes
SAP30_HUMAN [view interactions] High throughput no yes
MBD3_HUMAN [view interactions] High throughput no yes
SMCA5_HUMAN [view interactions] High throughput no yes
HMGX4_HUMAN [view interactions] High throughput no yes
BRM1L_HUMAN [view interactions] High throughput no no
MTA1_HUMAN [view interactions] High throughput no yes
PHF1_HUMAN [view interactions] High throughput no yes
GATD1_HUMAN [view interactions] High throughput no no
BC11A_HUMAN [view entry] [view interactions] High throughput yes yes
ARI4B_HUMAN [view interactions] High throughput no yes
HJURP_HUMAN [view interactions] High throughput no yes
MTF2_HUMAN [view interactions] High throughput no no
SDS3_HUMAN [view interactions] High throughput no yes
SP130_HUMAN [view interactions] High throughput no no
CAF1A_HUMAN [view interactions] High throughput no yes
SHPRH_HUMAN [view interactions] High throughput no yes
LIN52_HUMAN [view interactions] High throughput no no
SIN3A_HUMAN [view interactions] High throughput no yes
SIN3B_HUMAN [view interactions] High throughput no yes
CAF1B_HUMAN [view interactions] High throughput no no
SUZ12_HUMAN [view interactions] High throughput no no
HAT1_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
ZBTB2_HUMAN [view interactions] High throughput no yes
DPOE3_HUMAN [view interactions] High throughput no yes
IMA5_HUMAN [view entry] [view interactions] High throughput yes yes
ZN467_HUMAN [view interactions] High throughput no no
TEBP_HUMAN [view interactions] High throughput no yes
RS19_HUMAN [view entry] [view interactions] High throughput yes no
HNRC2_HUMAN [view interactions] High throughput no no
MAGA3_HUMAN [view interactions] High throughput no no
FRIL_HUMAN [view interactions] High throughput no yes
CTNA3_HUMAN [view interactions] High throughput no no
TXNIP_HUMAN [view interactions] High throughput no no
KLH20_HUMAN [view interactions] High throughput no yes
H2A1_HUMAN [view interactions] High throughput no yes
SLN11_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
EEA1_HUMAN [view entry] [view interactions] High throughput yes yes
EPN2_HUMAN [view entry] [view interactions] High throughput yes yes
H10_HUMAN [view interactions] High throughput no yes
H2B2E_HUMAN [view interactions] High throughput no yes
HMGA1_HUMAN [view interactions] High throughput no yes
HMGN5_HUMAN [view interactions] High throughput no no
M4K4_HUMAN [view interactions] High throughput no yes
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
NECP1_HUMAN [view interactions] High throughput no no
NUCKS_HUMAN [view interactions] High throughput no yes
NUMA1_HUMAN [view interactions] High throughput no yes
POGZ_HUMAN [view interactions] High throughput no yes
PRDM2_HUMAN [view interactions] High throughput no yes
BAZ1A_HUMAN [view interactions] High throughput no no
CHRC1_HUMAN [view interactions] High throughput no no
CBX1_HUMAN [view interactions] High throughput no yes
SSRP1_HUMAN [view interactions] High throughput no yes
TOP1_HUMAN [view interactions] High throughput no yes
VRK1_HUMAN [view interactions] High throughput no yes
SMRC2_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
SMCA4_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
DDX21_HUMAN [view interactions] High throughput no yes
TFPT_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
CBX3_HUMAN [view interactions] High throughput no yes
RPA34_HUMAN [view interactions] High throughput no yes
CENPA_HUMAN [view interactions] High throughput no no
COIL_HUMAN [view interactions] High throughput no yes
H2B1C_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
RPA49_HUMAN [view interactions] High throughput no yes
TE2IP_HUMAN [view interactions] High throughput no yes
ZN330_HUMAN [view interactions] High throughput no yes
BROMI_HUMAN [view interactions] High throughput no no
IFIX_HUMAN [view interactions] High throughput no no
DPY30_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
SRC_HUMAN [view entry] [view interactions] High throughput yes no
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
BAZ1B_HUMAN [view entry] [view interactions] High throughput yes yes
E2F3_HUMAN [view interactions] High throughput no no
DDX60_HUMAN [view interactions] High throughput no no
TF7L2_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
HMGB1_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
EWS_HUMAN [view interactions] High throughput no yes
FOXC1_HUMAN [view interactions] High throughput no no
FOXE1_HUMAN [view interactions] High throughput no no
FOXG1_HUMAN [view interactions] High throughput no no
FOXJ2_HUMAN [view interactions] High throughput no yes
FOXK2_HUMAN [view interactions] High throughput no yes
FOXL1_HUMAN [view interactions] High throughput no no
FOXQ1_HUMAN [view interactions] High throughput no no
MAX_HUMAN [view interactions] High throughput no yes
SUH_HUMAN [view interactions] High throughput no yes
TEAD2_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
FBRL_HUMAN [view interactions] High throughput no yes
KLF9_HUMAN [view interactions] High throughput no no
LHX2_HUMAN [view interactions] High throughput no no
VGFR2_HUMAN [view interactions] High throughput no no
TIE2_HUMAN [view interactions] High throughput no no
USF1_HUMAN [view interactions] High throughput no yes
SET1A_HUMAN [view interactions] High throughput no yes
GRK5_HUMAN [view interactions] High throughput no yes
BAP18_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
RS2_HUMAN [view entry] [view interactions] High throughput yes yes
DEFI6_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
NANOG_HUMAN [view interactions] High throughput no no
TM128_HUMAN [view interactions] High throughput no yes
I23O2_HUMAN [view interactions] High throughput no no
INAVA_HUMAN [view interactions] High throughput no yes
RFXK_HUMAN [view interactions] High throughput no yes
NF2IP_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
CGAS_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
H2AX_HUMAN [view interactions] High throughput no yes
H2AZ_HUMAN [view interactions] High throughput no yes
H2AY_HUMAN [view interactions] High throughput no yes