SMCA1_HUMAN
Energy-transducing component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facilitate the perturbation of chromatin structure in an ATP-dependent manner. Potentiates neurite outgrowth. May be involved in brain development by regulating En-1 and En-2 expression. May be involved in the development of luteal cells. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SMCA1_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 50.0000 | 4 | yes |
GO:0017076 | purine nucleotide binding | 50.0000 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 45.0000 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 45.0000 | 4 | yes |
GO:0043168 | anion binding | 45.0000 | 4 | yes |
GO:0030554 | adenyl nucleotide binding | 40.0000 | 6 | yes |
GO:0005524 | ATP binding | 35.0000 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 35.0000 | 5 | yes |
GO:0043169 | cation binding | 30.0000 | 4 | no |
GO:0046872 | metal ion binding | 30.0000 | 5 | no |
GO:0003723 | RNA binding | 30.0000 | 4 | no |
GO:0140297 | DNA-binding transcription factor binding | 25.0000 | 4 | yes |
GO:0016301 | kinase activity | 25.0000 | 4 | no |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 25.0000 | 4 | no |
GO:0019900 | kinase binding | 25.0000 | 4 | no |
GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 20.0000 | 5 | yes |
GO:0003677 | DNA binding | 15.0000 | 4 | yes |
GO:0031491 | nucleosome binding | 10.0000 | 4 | yes |
GO:0140666 | annealing activity | 10.0000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SMCA1_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 70.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 65.0000 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 60.0000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | yes |
GO:0010646 | regulation of cell communication | 60.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 55.0000 | 4 | yes |
GO:0010468 | regulation of gene expression | 55.0000 | 6 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 55.0000 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 55.0000 | 5 | yes |
GO:0031323 | regulation of cellular metabolic process | 55.0000 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 55.0000 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 50.0000 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 45.0000 | 5 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 45.0000 | 6 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 45.0000 | 6 | yes |
GO:0009966 | regulation of signal transduction | 45.0000 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 45.0000 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 45.0000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 45.0000 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 40.0000 | 5 | yes |
GO:0009968 | negative regulation of signal transduction | 40.0000 | 5 | no |
GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | no |
GO:0010648 | negative regulation of cell communication | 40.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
GO:0023057 | negative regulation of signaling | 40.0000 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 40.0000 | 5 | no |
GO:0006996 | organelle organization | 40.0000 | 4 | no |
GO:0009890 | negative regulation of biosynthetic process | 35.0000 | 5 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 35.0000 | 6 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 35.0000 | 6 | no |
GO:0006355 | regulation of DNA-templated transcription | 35.0000 | 7 | yes |
GO:0006357 | regulation of transcription by RNA polymerase II | 35.0000 | 8 | yes |
GO:0045893 | positive regulation of DNA-templated transcription | 35.0000 | 8 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 35.0000 | 5 | yes |
GO:0051254 | positive regulation of RNA metabolic process | 35.0000 | 6 | yes |
GO:1902680 | positive regulation of RNA biosynthetic process | 35.0000 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 35.0000 | 6 | yes |
GO:0019220 | regulation of phosphate metabolic process | 35.0000 | 6 | no |
GO:0031399 | regulation of protein modification process | 35.0000 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 35.0000 | 7 | no |
GO:0036211 | protein modification process | 35.0000 | 4 | no |
GO:0042981 | regulation of apoptotic process | 35.0000 | 5 | no |
GO:0043067 | regulation of programmed cell death | 35.0000 | 4 | no |
GO:0043412 | macromolecule modification | 35.0000 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 35.0000 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 35.0000 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 35.0000 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 35.0000 | 6 | no |
GO:0009059 | macromolecule biosynthetic process | 30.0000 | 4 | no |
GO:0043933 | protein-containing complex organization | 30.0000 | 4 | yes |
GO:0045944 | positive regulation of transcription by RNA polymerase II | 30.0000 | 9 | yes |
GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
GO:0001934 | positive regulation of protein phosphorylation | 30.0000 | 8 | no |
GO:0006796 | phosphate-containing compound metabolic process | 30.0000 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 30.0000 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 30.0000 | 6 | no |
GO:0042325 | regulation of phosphorylation | 30.0000 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 30.0000 | 8 | no |
GO:0043085 | positive regulation of catalytic activity | 30.0000 | 4 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 30.0000 | 7 | no |
GO:0051240 | positive regulation of multicellular organismal process | 30.0000 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 30.0000 | 6 | no |
GO:0080134 | regulation of response to stress | 30.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
GO:0008104 | protein localization | 30.0000 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
GO:0010628 | positive regulation of gene expression | 25.0000 | 7 | no |
GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
GO:0090304 | nucleic acid metabolic process | 25.0000 | 4 | no |
GO:0002831 | regulation of response to biotic stimulus | 25.0000 | 4 | no |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 25.0000 | 4 | no |
GO:0016310 | phosphorylation | 25.0000 | 5 | no |
GO:0030162 | regulation of proteolysis | 25.0000 | 6 | no |
GO:0031344 | regulation of cell projection organization | 25.0000 | 5 | no |
GO:0031347 | regulation of defense response | 25.0000 | 5 | no |
GO:0032101 | regulation of response to external stimulus | 25.0000 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
GO:0045088 | regulation of innate immune response | 25.0000 | 5 | no |
GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
GO:0050776 | regulation of immune response | 25.0000 | 4 | no |
GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
GO:0051241 | negative regulation of multicellular organismal process | 25.0000 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 25.0000 | 4 | no |
GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
GO:0071702 | organic substance transport | 25.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.0000 | 6 | no |
GO:0140546 | defense response to symbiont | 25.0000 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | no |
GO:0006325 | chromatin organization | 15.0000 | 6 | yes |
GO:0006338 | chromatin remodeling | 15.0000 | 7 | yes |
GO:0071824 | protein-DNA complex organization | 15.0000 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
BAZ2B_HUMAN | [view interactions] | Low throughput | no | yes |
H31_HUMAN | [view interactions] | Low throughput | no | yes |
PARP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRGR_HUMAN | [view interactions] | Low throughput | no | no |
ARI1B_HUMAN | [view interactions] | Low throughput | no | yes |
BPTF_HUMAN | [view interactions] | Low throughput | no | yes |
RBBP4_HUMAN | [view interactions] | Low throughput | no | yes |
CECR2_HUMAN | [view interactions] | Low throughput | no | yes |
RSF1_HUMAN | [view interactions] | Low throughput | no | yes |
RBBP7_HUMAN | [view interactions] | Low throughput | no | yes |
DPY30_HUMAN | [view interactions] | High throughput | no | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BAZ1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E2F3_HUMAN | [view interactions] | High throughput | no | no |
DDX60_HUMAN | [view interactions] | High throughput | no | no |
TF7L2_HUMAN | [view interactions] | High throughput | no | yes |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
RYBP_HUMAN | [view interactions] | High throughput | no | no |
EWS_HUMAN | [view interactions] | High throughput | no | yes |
FOXC1_HUMAN | [view interactions] | High throughput | no | no |
FOXE1_HUMAN | [view interactions] | High throughput | no | no |
FOXG1_HUMAN | [view interactions] | High throughput | no | no |
FOXJ2_HUMAN | [view interactions] | High throughput | no | yes |
FOXK2_HUMAN | [view interactions] | High throughput | no | yes |
FOXL1_HUMAN | [view interactions] | High throughput | no | no |
FOXQ1_HUMAN | [view interactions] | High throughput | no | no |
MAX_HUMAN | [view interactions] | High throughput | no | yes |
SUH_HUMAN | [view interactions] | High throughput | no | yes |
TEAD2_HUMAN | [view interactions] | High throughput | no | no |
FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBRL_HUMAN | [view interactions] | High throughput | no | yes |
KLF9_HUMAN | [view interactions] | High throughput | no | no |
LHX2_HUMAN | [view interactions] | High throughput | no | no |
VGFR2_HUMAN | [view interactions] | High throughput | no | no |
TIE2_HUMAN | [view interactions] | High throughput | no | no |
USF1_HUMAN | [view interactions] | High throughput | no | yes |
SET1A_HUMAN | [view interactions] | High throughput | no | yes |
GRK5_HUMAN | [view interactions] | High throughput | no | yes |
BAP18_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
RS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DEFI6_HUMAN | [view interactions] | High throughput | no | no |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
IF16_HUMAN | [view interactions] | High throughput | no | no |
NANOG_HUMAN | [view interactions] | High throughput | no | no |
TM128_HUMAN | [view interactions] | High throughput | no | yes |
I23O2_HUMAN | [view interactions] | High throughput | no | no |
INAVA_HUMAN | [view interactions] | High throughput | no | yes |
RFXK_HUMAN | [view interactions] | High throughput | no | yes |
NF2IP_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
CHD3_HUMAN | [view interactions] | High throughput | no | yes |
EZH2_HUMAN | [view interactions] | High throughput | no | no |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
CGAS_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H2AX_HUMAN | [view interactions] | High throughput | no | yes |
H2AZ_HUMAN | [view interactions] | High throughput | no | yes |
H2AY_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WWP2_HUMAN | [view interactions] | High throughput | no | no |
ERCC6_HUMAN | [view interactions] | High throughput | no | no |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
RAD18_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
BRD2_HUMAN | [view interactions] | High throughput | no | yes |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
PWP2A_HUMAN | [view interactions] | High throughput | no | no |
MYBB_HUMAN | [view interactions] | High throughput | no | yes |
LIN37_HUMAN | [view interactions] | High throughput | no | yes |
LIN9_HUMAN | [view interactions] | High throughput | no | yes |
MBD2_HUMAN | [view interactions] | High throughput | no | yes |
CDKA1_HUMAN | [view interactions] | High throughput | no | yes |
MTA3_HUMAN | [view interactions] | High throughput | no | yes |
MTA2_HUMAN | [view interactions] | High throughput | no | yes |
P66B_HUMAN | [view interactions] | High throughput | no | yes |
Z512B_HUMAN | [view interactions] | High throughput | no | yes |
P66A_HUMAN | [view interactions] | High throughput | no | yes |
SAP30_HUMAN | [view interactions] | High throughput | no | yes |
MBD3_HUMAN | [view interactions] | High throughput | no | yes |
SMCA5_HUMAN | [view interactions] | High throughput | no | yes |
HMGX4_HUMAN | [view interactions] | High throughput | no | yes |
BRM1L_HUMAN | [view interactions] | High throughput | no | no |
MTA1_HUMAN | [view interactions] | High throughput | no | yes |
PHF1_HUMAN | [view interactions] | High throughput | no | yes |
GATD1_HUMAN | [view interactions] | High throughput | no | no |
BC11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARI4B_HUMAN | [view interactions] | High throughput | no | yes |
HJURP_HUMAN | [view interactions] | High throughput | no | yes |
MTF2_HUMAN | [view interactions] | High throughput | no | no |
SDS3_HUMAN | [view interactions] | High throughput | no | yes |
SP130_HUMAN | [view interactions] | High throughput | no | no |
CAF1A_HUMAN | [view interactions] | High throughput | no | yes |
SHPRH_HUMAN | [view interactions] | High throughput | no | yes |
LIN52_HUMAN | [view interactions] | High throughput | no | no |
SIN3A_HUMAN | [view interactions] | High throughput | no | yes |
SIN3B_HUMAN | [view interactions] | High throughput | no | yes |
CAF1B_HUMAN | [view interactions] | High throughput | no | no |
SUZ12_HUMAN | [view interactions] | High throughput | no | no |
HAT1_HUMAN | [view interactions] | High throughput | no | yes |
CHD4_HUMAN | [view interactions] | High throughput | no | yes |
UFL1_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
DPOE3_HUMAN | [view interactions] | High throughput | no | yes |
IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZN467_HUMAN | [view interactions] | High throughput | no | no |
TEBP_HUMAN | [view interactions] | High throughput | no | yes |
RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HNRC2_HUMAN | [view interactions] | High throughput | no | no |
MAGA3_HUMAN | [view interactions] | High throughput | no | no |
FRIL_HUMAN | [view interactions] | High throughput | no | yes |
CTNA3_HUMAN | [view interactions] | High throughput | no | no |
TXNIP_HUMAN | [view interactions] | High throughput | no | no |
KLH20_HUMAN | [view interactions] | High throughput | no | yes |
H2A1_HUMAN | [view interactions] | High throughput | no | yes |
SLN11_HUMAN | [view interactions] | High throughput | no | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
DDB1_HUMAN | [view interactions] | High throughput | no | yes |
BRD3_HUMAN | [view interactions] | High throughput | no | yes |
EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H10_HUMAN | [view interactions] | High throughput | no | yes |
H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
HMGN5_HUMAN | [view interactions] | High throughput | no | no |
M4K4_HUMAN | [view interactions] | High throughput | no | yes |
MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCK1_HUMAN | [view interactions] | High throughput | no | yes |
NECP1_HUMAN | [view interactions] | High throughput | no | no |
NUCKS_HUMAN | [view interactions] | High throughput | no | yes |
NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
POGZ_HUMAN | [view interactions] | High throughput | no | yes |
PRDM2_HUMAN | [view interactions] | High throughput | no | yes |
BAZ1A_HUMAN | [view interactions] | High throughput | no | no |
CHRC1_HUMAN | [view interactions] | High throughput | no | no |
CBX1_HUMAN | [view interactions] | High throughput | no | yes |
SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
TOP1_HUMAN | [view interactions] | High throughput | no | yes |
VRK1_HUMAN | [view interactions] | High throughput | no | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
GATA4_HUMAN | [view interactions] | High throughput | no | no |
TBX5_HUMAN | [view interactions] | High throughput | no | no |
PARPT_HUMAN | [view interactions] | High throughput | no | no |
RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
RHG24_HUMAN | [view interactions] | High throughput | no | yes |
CL16A_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
SMRC2_HUMAN | [view interactions] | High throughput | no | yes |
SMRC1_HUMAN | [view interactions] | High throughput | no | yes |
SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
DDX21_HUMAN | [view interactions] | High throughput | no | yes |
TFPT_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
CBX3_HUMAN | [view interactions] | High throughput | no | yes |
RPA34_HUMAN | [view interactions] | High throughput | no | yes |
CENPA_HUMAN | [view interactions] | High throughput | no | no |
COIL_HUMAN | [view interactions] | High throughput | no | yes |
H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RPA49_HUMAN | [view interactions] | High throughput | no | yes |
TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
ZN330_HUMAN | [view interactions] | High throughput | no | yes |
BROMI_HUMAN | [view interactions] | High throughput | no | no |
H33_HUMAN | [view interactions] | High throughput | no | yes |
RED1_HUMAN | [view interactions] | High throughput | no | no |
NUP43_HUMAN | [view interactions] | High throughput | no | yes |
SNR40_HUMAN | [view interactions] | High throughput | no | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
RFA2_HUMAN | [view interactions] | High throughput | no | yes |
DUXA_HUMAN | [view interactions] | High throughput | no | no |
IFIX_HUMAN | [view interactions] | High throughput | no | no |