BAZ1B_HUMAN
Evidence for PS localization
Functions
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating Tyr-142 of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at Tyr-142, and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001455 | MOD_ProDKin_1 | MOD | 155 | 161 | - |
| ELMI001455 | MOD_ProDKin_1 | MOD | 155 | 161 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in BAZ1B_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 45.4545 | 4 | no |
| GO:0000166 | nucleotide binding | 31.8182 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.8182 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 31.8182 | 6 | yes |
| GO:0005524 | ATP binding | 27.2727 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 27.2727 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.2727 | 4 | yes |
| GO:0043168 | anion binding | 27.2727 | 4 | yes |
| GO:0019900 | kinase binding | 22.7273 | 4 | no |
| GO:0019901 | protein kinase binding | 22.7273 | 5 | no |
| GO:0043169 | cation binding | 18.1818 | 4 | yes |
| GO:0046872 | metal ion binding | 18.1818 | 5 | yes |
| GO:0016301 | kinase activity | 13.6364 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 13.6364 | 4 | yes |
| GO:0008270 | zinc ion binding | 9.0909 | 7 | yes |
| GO:0046914 | transition metal ion binding | 9.0909 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in BAZ1B_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.6364 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 63.6364 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 59.0909 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 59.0909 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 59.0909 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 59.0909 | 5 | yes |
| GO:0010468 | regulation of gene expression | 54.5455 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 50.0000 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 50.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.4545 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 45.4545 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 40.9091 | 7 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 40.9091 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 40.9091 | 6 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 40.9091 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 40.9091 | 6 | yes |
| GO:0051252 | regulation of RNA metabolic process | 40.9091 | 5 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 40.9091 | 6 | yes |
| GO:0010646 | regulation of cell communication | 40.9091 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 36.3636 | 8 | yes |
| GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 31.8182 | 8 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 31.8182 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 31.8182 | 4 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 31.8182 | 6 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 31.8182 | 7 | yes |
| GO:0009059 | macromolecule biosynthetic process | 31.8182 | 4 | no |
| GO:0006996 | organelle organization | 31.8182 | 4 | no |
| GO:0008104 | protein localization | 31.8182 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 31.8182 | 4 | no |
| GO:0022607 | cellular component assembly | 31.8182 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 31.8182 | 5 | no |
| GO:0033043 | regulation of organelle organization | 27.2727 | 5 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 27.2727 | 9 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 27.2727 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 27.2727 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 27.2727 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.2727 | 4 | no |
| GO:0006325 | chromatin organization | 22.7273 | 6 | yes |
| GO:0006338 | chromatin remodeling | 22.7273 | 7 | yes |
| GO:0010639 | negative regulation of organelle organization | 22.7273 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 22.7273 | 5 | yes |
| GO:0071824 | protein-DNA complex organization | 22.7273 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 22.7273 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.7273 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.7273 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.7273 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.7273 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.7273 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.7273 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.7273 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 18.1818 | 4 | yes |
| GO:0010564 | regulation of cell cycle process | 18.1818 | 5 | yes |
| GO:0033044 | regulation of chromosome organization | 18.1818 | 6 | yes |
| GO:0036211 | protein modification process | 18.1818 | 4 | yes |
| GO:0043412 | macromolecule modification | 18.1818 | 4 | yes |
| GO:0043687 | post-translational protein modification | 18.1818 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 18.1818 | 4 | yes |
| GO:0006974 | DNA damage response | 13.6364 | 4 | yes |
| GO:0016310 | phosphorylation | 13.6364 | 5 | yes |
| GO:0006356 | regulation of transcription by RNA polymerase I | 9.0909 | 8 | yes |
| GO:0006359 | regulation of transcription by RNA polymerase III | 9.0909 | 8 | yes |
| GO:0010948 | negative regulation of cell cycle process | 9.0909 | 6 | yes |
| GO:0045786 | negative regulation of cell cycle | 9.0909 | 5 | yes |
| GO:0045943 | positive regulation of transcription by RNA polymerase I | 9.0909 | 9 | yes |
| GO:0045945 | positive regulation of transcription by RNA polymerase III | 9.0909 | 9 | yes |
| GO:2001251 | negative regulation of chromosome organization | 9.0909 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SMCA5_HUMAN | [view interactions] | Low throughput | no | yes |
| MYH1_HUMAN | [view interactions] | Low throughput | no | no |
| RPA2_HUMAN | [view interactions] | Low throughput | no | no |
| BAZ1A_HUMAN | [view interactions] | Low throughput | no | no |
| BAZ2A_HUMAN | [view interactions] | Low throughput | no | no |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
| BRD4_HUMAN | [view interactions] | Low throughput | no | yes |
| KAT8_HUMAN | [view interactions] | Low throughput | no | no |
| KANL1_HUMAN | [view interactions] | Low throughput | no | yes |
| SIR1_HUMAN | [view interactions] | Low throughput | no | yes |
| PCNA_HUMAN | [view interactions] | Low throughput | no | no |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| HDA11_HUMAN | [view interactions] | High throughput | no | no |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| LYAR_HUMAN | [view interactions] | High throughput | no | no |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
| IGHM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| NR4A2_HUMAN | [view interactions] | High throughput | no | yes |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| ETV3_HUMAN | [view interactions] | High throughput | no | yes |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| KLF8_HUMAN | [view interactions] | High throughput | no | no |
| KLF9_HUMAN | [view interactions] | High throughput | no | no |
| LHX2_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| DDR2_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| VGFR2_HUMAN | [view interactions] | High throughput | no | no |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SPAG6_HUMAN | [view interactions] | High throughput | no | no |
| CDT1_HUMAN | [view interactions] | High throughput | no | yes |
| ERCC6_HUMAN | [view interactions] | High throughput | no | no |
| SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
| RHD_HUMAN | [view interactions] | High throughput | no | no |
| DEK_HUMAN | [view interactions] | High throughput | no | yes |
| MBB1A_HUMAN | [view interactions] | High throughput | no | yes |
| ATAD5_HUMAN | [view interactions] | High throughput | no | no |
| HDGF_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| DAXX_HUMAN | [view interactions] | High throughput | no | yes |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ING3_HUMAN | [view interactions] | High throughput | no | no |
| EXOS1_HUMAN | [view interactions] | High throughput | no | yes |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCCHV_HUMAN | [view interactions] | High throughput | no | yes |
| HBP1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| CGAS_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ATM_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| RPB1_HUMAN | [view interactions] | High throughput | no | no |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| SPT6H_HUMAN | [view interactions] | High throughput | no | yes |
| CDK12_HUMAN | [view interactions] | High throughput | no | yes |
| RSF1_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| SEMG1_HUMAN | [view interactions] | High throughput | no | no |
| TRI66_HUMAN | [view interactions] | High throughput | no | no |
| PPBT_HUMAN | [view interactions] | High throughput | no | yes |
| ZN263_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REXO4_HUMAN | [view interactions] | High throughput | no | yes |
| REPI1_HUMAN | [view interactions] | High throughput | no | yes |
| RL7L_HUMAN | [view interactions] | High throughput | no | no |
| RT10_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN346_HUMAN | [view interactions] | High throughput | no | yes |
| RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRR1_HUMAN | [view interactions] | High throughput | no | yes |
| UTP23_HUMAN | [view interactions] | High throughput | no | no |
| HNRC2_HUMAN | [view interactions] | High throughput | no | no |
| ANR50_HUMAN | [view interactions] | High throughput | no | no |
| IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH20_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2A1_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| H10_HUMAN | [view interactions] | High throughput | no | yes |
| H2AZ_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| HMGN5_HUMAN | [view interactions] | High throughput | no | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| NECP1_HUMAN | [view interactions] | High throughput | no | no |
| NUCKS_HUMAN | [view interactions] | High throughput | no | yes |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| UBP53_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| MEN1_HUMAN | [view interactions] | High throughput | no | yes |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUMO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMRC2_HUMAN | [view interactions] | High throughput | no | yes |
| TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
| SMRC1_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
| MBD3_HUMAN | [view interactions] | High throughput | no | yes |
| SMRD2_HUMAN | [view interactions] | High throughput | no | no |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| ACL6A_HUMAN | [view interactions] | High throughput | no | yes |
| PPAP_HUMAN | [view interactions] | High throughput | no | no |
| ARI1A_HUMAN | [view interactions] | High throughput | no | yes |
| PAPP1_HUMAN | [view interactions] | High throughput | no | no |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| SP16H_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| SMCE1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| NSD2_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC9_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| CBX3_HUMAN | [view interactions] | High throughput | no | yes |
| CENPA_HUMAN | [view interactions] | High throughput | no | no |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| ZN330_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SALL1_HUMAN | [view interactions] | High throughput | no | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| DUXA_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |