Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

BAZ1B_HUMAN

Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating Tyr-142 of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at Tyr-142, and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

ELM instance Name Type Start End Partner
ELMI001455 MOD_ProDKin_1 MOD 155 161 -

Molecular function

Term Name % Distance from the top of the tree Annotated in BAZ1B_HUMAN
GO:0003723 RNA binding 42.8571 4 no
GO:0005524 ATP binding 33.3333 5 yes
GO:0017076 purine nucleotide binding 33.3333 4 yes
GO:0030554 adenyl nucleotide binding 33.3333 5 yes
GO:0032555 purine ribonucleotide binding 33.3333 4 yes
GO:0032559 adenyl ribonucleotide binding 33.3333 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 19.0476 4 yes
GO:0016301 kinase activity 19.0476 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 19.0476 4 yes
GO:0046872 metal ion binding 19.0476 4 yes
GO:0008270 zinc ion binding 9.5238 6 yes
GO:0046914 transition metal ion binding 9.5238 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in BAZ1B_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 yes
GO:0009893 positive regulation of metabolic process 52.3810 4 yes
GO:0031323 regulation of cellular metabolic process 52.3810 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 52.3810 4 yes
GO:0080090 regulation of primary metabolic process 52.3810 4 yes
GO:0009889 regulation of biosynthetic process 47.6190 4 yes
GO:0010468 regulation of gene expression 47.6190 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 47.6190 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 47.6190 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 47.6190 5 yes
GO:0048523 negative regulation of cellular process 47.6190 4 yes
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 yes
GO:0051128 regulation of cellular component organization 42.8571 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 42.8571 5 yes
GO:0006996 organelle organization 42.8571 4 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0006355 regulation of DNA-templated transcription 38.0952 6 yes
GO:0031325 positive regulation of cellular metabolic process 38.0952 5 yes
GO:0033043 regulation of organelle organization 38.0952 5 yes
GO:0051252 regulation of RNA metabolic process 38.0952 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 38.0952 7 yes
GO:2001141 regulation of RNA biosynthetic process 38.0952 6 yes
GO:0009966 regulation of signal transduction 38.0952 4 no
GO:0043933 protein-containing complex organization 38.0952 4 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 yes
GO:0022607 cellular component assembly 33.3333 4 no
GO:0065003 protein-containing complex assembly 33.3333 5 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 7 yes
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 yes
GO:0045893 positive regulation of DNA-templated transcription 28.5714 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 28.5714 6 yes
GO:0051129 negative regulation of cellular component organization 28.5714 5 yes
GO:0051254 positive regulation of RNA metabolic process 28.5714 6 yes
GO:1902680 positive regulation of RNA biosynthetic process 28.5714 7 yes
GO:1903508 positive regulation of nucleic acid-templated transcription 28.5714 8 yes
GO:0010941 regulation of cell death 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 5 no
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010639 negative regulation of organelle organization 23.8095 6 yes
GO:0008104 protein localization 23.8095 4 no
GO:0009968 negative regulation of signal transduction 23.8095 5 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:0051246 regulation of protein metabolic process 23.8095 5 no
GO:0080134 regulation of response to stress 23.8095 4 no
GO:0009059 macromolecule biosynthetic process 23.8095 4 no
GO:0044271 cellular nitrogen compound biosynthetic process 23.8095 4 no
GO:0036211 protein modification process 23.8095 4 no
GO:0043412 macromolecule modification 23.8095 4 no
GO:0044087 regulation of cellular component biogenesis 23.8095 4 no
GO:0010605 negative regulation of macromolecule metabolic process 23.8095 5 no
GO:0031324 negative regulation of cellular metabolic process 23.8095 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 23.8095 5 no
GO:1902531 regulation of intracellular signal transduction 23.8095 5 no
GO:0010564 regulation of cell cycle process 19.0476 5 yes
GO:0033044 regulation of chromosome organization 19.0476 6 yes
GO:0051726 regulation of cell cycle 19.0476 4 yes
GO:0006325 chromatin organization 14.2857 4 yes
GO:0006338 chromatin remodeling 14.2857 5 yes
GO:0006974 cellular response to DNA damage stimulus 14.2857 4 yes
GO:0006359 regulation of transcription by RNA polymerase III 9.5238 7 yes
GO:0010948 negative regulation of cell cycle process 9.5238 6 yes
GO:0045786 negative regulation of cell cycle 9.5238 5 yes
GO:0045945 positive regulation of transcription by RNA polymerase III 9.5238 8 yes
GO:2001251 negative regulation of chromosome organization 9.5238 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PCNA_HUMAN [view interactions] Low throughput no no
SMCA5_HUMAN [view interactions] Low throughput no yes
MYH1_HUMAN [view interactions] Low throughput no no
RPA2_HUMAN [view interactions] Low throughput no no
BAZ1A_HUMAN [view interactions] Low throughput no no
BAZ2A_HUMAN [view interactions] Low throughput no no
H31_HUMAN [view interactions] Low throughput no yes
MYO1C_HUMAN [view entry] [view interactions] Low throughput yes yes
H2AX_HUMAN [view interactions] Low throughput no yes
BRD4_HUMAN [view interactions] Low throughput no yes
KAT8_HUMAN [view interactions] Low throughput no no
KANL1_HUMAN [view interactions] Low throughput no yes
SIR1_HUMAN [view interactions] Low throughput no yes
SUMO2_HUMAN [view interactions] High throughput no yes
SMRC2_HUMAN [view interactions] High throughput no yes
TOP2B_HUMAN [view interactions] High throughput no yes
SMRC1_HUMAN [view interactions] High throughput no yes
SMCA4_HUMAN [view interactions] High throughput no yes
MBD3_HUMAN [view interactions] High throughput no yes
SMRD2_HUMAN [view interactions] High throughput no no
SRRM2_HUMAN [view interactions] High throughput no yes
ACL6A_HUMAN [view interactions] High throughput no yes
PPAP_HUMAN [view interactions] High throughput no no
ARI1A_HUMAN [view interactions] High throughput no yes
PAPP1_HUMAN [view interactions] High throughput no no
SMCA2_HUMAN [view interactions] High throughput no yes
SP16H_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
XRCC6_HUMAN [view interactions] High throughput no yes
RHBL4_HUMAN [view interactions] High throughput no no
NSD2_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
DNJC9_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
CBX3_HUMAN [view interactions] High throughput no yes
CENPA_HUMAN [view interactions] High throughput no no
H2B1C_HUMAN [view interactions] High throughput no yes
ZN330_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
SALL1_HUMAN [view interactions] High throughput no yes
MTR1A_HUMAN [view interactions] High throughput no no
TRI33_HUMAN [view interactions] High throughput no yes
HDA11_HUMAN [view interactions] High throughput no no
IFIX_HUMAN [view interactions] High throughput no no
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
SET_HUMAN [view interactions] High throughput no yes
HNRPU_HUMAN [view interactions] High throughput no yes
RRP1B_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
SMCA1_HUMAN [view entry] [view interactions] High throughput yes yes
H2B1H_HUMAN [view interactions] High throughput no yes
H12_HUMAN [view interactions] High throughput no yes
H14_HUMAN [view interactions] High throughput no yes
LYAR_HUMAN [view interactions] High throughput no no
HMGA2_HUMAN [view interactions] High throughput no yes
PHLA3_HUMAN [view interactions] High throughput no yes
IGHM_HUMAN [view entry] [view interactions] High throughput yes no
ESR1_HUMAN [view interactions] High throughput no no
NR4A2_HUMAN [view interactions] High throughput no yes
FBRL_HUMAN [view interactions] High throughput no yes
ETV3_HUMAN [view interactions] High throughput no yes
KLF16_HUMAN [view interactions] High throughput no yes
KLF8_HUMAN [view interactions] High throughput no no
KLF9_HUMAN [view interactions] High throughput no no
LHX2_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
DDR2_HUMAN [view interactions] High throughput no no
FGFR3_HUMAN [view interactions] High throughput no yes
VGFR1_HUMAN [view interactions] High throughput no no
FLT3_HUMAN [view interactions] High throughput no no
VGFR2_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
MERTK_HUMAN [view interactions] High throughput no yes
ROS1_HUMAN [view interactions] High throughput no no
TIE2_HUMAN [view interactions] High throughput no no
CDT1_HUMAN [view interactions] High throughput no yes
ERCC6_HUMAN [view interactions] High throughput no no
SF3B1_HUMAN [view interactions] High throughput no yes
RHD_HUMAN [view interactions] High throughput no no
DEK_HUMAN [view interactions] High throughput no yes
MBB1A_HUMAN [view interactions] High throughput no yes
ATAD5_HUMAN [view interactions] High throughput no no
HDGF_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
RING2_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
DAXX_HUMAN [view interactions] High throughput no yes
RL10_HUMAN [view entry] [view interactions] High throughput yes yes
ING3_HUMAN [view interactions] High throughput no no
EXOS1_HUMAN [view interactions] High throughput no yes
CBX1_HUMAN [view interactions] High throughput no yes
HS105_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
ZCCHV_HUMAN [view interactions] High throughput no yes
HBP1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
DCPS_HUMAN [view interactions] High throughput no yes
CGAS_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
ATM_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
RAD18_HUMAN [view interactions] High throughput no yes
RPB1_HUMAN [view interactions] High throughput no no
RPB3_HUMAN [view interactions] High throughput no yes
SPT5H_HUMAN [view interactions] High throughput no yes
SPT6H_HUMAN [view interactions] High throughput no yes
CDK12_HUMAN [view interactions] High throughput no yes
RSF1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
SEMG1_HUMAN [view interactions] High throughput no no
TRI66_HUMAN [view interactions] High throughput no yes
PPBT_HUMAN [view interactions] High throughput no yes
ZN263_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
TFAM_HUMAN [view entry] [view interactions] High throughput yes yes
REXO4_HUMAN [view interactions] High throughput no yes
REPI1_HUMAN [view interactions] High throughput no yes
RL7L_HUMAN [view interactions] High throughput no no
RT10_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
SKA3_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
ZBTB2_HUMAN [view interactions] High throughput no yes
RS19_HUMAN [view entry] [view interactions] High throughput yes no
ZN346_HUMAN [view interactions] High throughput no yes
RS10_HUMAN [view entry] [view interactions] High throughput yes yes
MIC27_HUMAN [view entry] [view interactions] High throughput yes yes
KRR1_HUMAN [view interactions] High throughput no yes
UTP23_HUMAN [view interactions] High throughput no no
HNRC2_HUMAN [view interactions] High throughput no no
ANR50_HUMAN [view interactions] High throughput no no
IMA5_HUMAN [view entry] [view interactions] High throughput yes yes
KLH20_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
H2A1_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
BRD2_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
H10_HUMAN [view interactions] High throughput no yes
H2AZ_HUMAN [view interactions] High throughput no yes
H2B2E_HUMAN [view interactions] High throughput no yes
HMGA1_HUMAN [view interactions] High throughput no yes
HMGN2_HUMAN [view interactions] High throughput no no
HMGN5_HUMAN [view interactions] High throughput no no
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
NCK1_HUMAN [view interactions] High throughput no yes
NECP1_HUMAN [view interactions] High throughput no no
NUCKS_HUMAN [view interactions] High throughput no yes
NUMA1_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
TOP1_HUMAN [view interactions] High throughput no yes
TOP2A_HUMAN [view interactions] High throughput no no
H2B1L_HUMAN [view interactions] Computational no yes
CHRC1_HUMAN [view interactions] Computational no no
H2B1M_HUMAN [view interactions] Computational no yes
H2B1D_HUMAN [view interactions] Computational no yes
DDX21_HUMAN [view interactions] Computational no yes
H2AV_HUMAN [view interactions] Computational no yes
H2A1C_HUMAN [view interactions] Computational no yes
RXRA_HUMAN [view interactions] Computational no yes
CAF1A_HUMAN [view interactions] Computational no yes
H2B1B_HUMAN [view interactions] Computational no yes
GSK3B_HUMAN [view entry] [view interactions] Computational yes yes
H2BFS_HUMAN [view interactions] Computational no yes
H2A1J_HUMAN [view interactions] Computational no yes
VDR_HUMAN [view interactions] Computational no no
H2B1A_HUMAN [view interactions] Computational no no
H2B1K_HUMAN [view interactions] Computational no yes
H2AB1_HUMAN [view interactions] Computational no no
H2B1O_HUMAN [view interactions] Computational no yes
SMCE1_HUMAN [view interactions] Computational no yes
RPA49_HUMAN [view interactions] Computational no yes
H2A2C_HUMAN [view interactions] Computational no yes
H31T_HUMAN [view interactions] Computational no yes
H2A1D_HUMAN [view interactions] Computational no yes
SMRD1_HUMAN [view interactions] Computational no yes
H2AJ_HUMAN [view interactions] Computational no yes
H2B1J_HUMAN [view interactions] Computational no yes
H2B1N_HUMAN [view interactions] Computational no yes