BAZ1B_HUMAN
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating Tyr-142 of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at Tyr-142, and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI001455 | MOD_ProDKin_1 | MOD | 155 | 161 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in BAZ1B_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 42.8571 | 4 | no |
GO:0005524 | ATP binding | 33.3333 | 5 | yes |
GO:0017076 | purine nucleotide binding | 33.3333 | 4 | yes |
GO:0030554 | adenyl nucleotide binding | 33.3333 | 5 | yes |
GO:0032555 | purine ribonucleotide binding | 33.3333 | 4 | yes |
GO:0032559 | adenyl ribonucleotide binding | 33.3333 | 5 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | yes |
GO:0019900 | kinase binding | 33.3333 | 4 | no |
GO:0019901 | protein kinase binding | 33.3333 | 5 | no |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 19.0476 | 4 | yes |
GO:0016301 | kinase activity | 19.0476 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 19.0476 | 4 | yes |
GO:0046872 | metal ion binding | 19.0476 | 4 | yes |
GO:0008270 | zinc ion binding | 9.5238 | 6 | yes |
GO:0046914 | transition metal ion binding | 9.5238 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in BAZ1B_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 57.1429 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 52.3810 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 52.3810 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 52.3810 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 52.3810 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 47.6190 | 4 | yes |
GO:0010468 | regulation of gene expression | 47.6190 | 5 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 47.6190 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 47.6190 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 47.6190 | 5 | yes |
GO:0048523 | negative regulation of cellular process | 47.6190 | 4 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 42.8571 | 5 | yes |
GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 42.8571 | 5 | yes |
GO:0006996 | organelle organization | 42.8571 | 4 | no |
GO:0010646 | regulation of cell communication | 42.8571 | 4 | no |
GO:0006355 | regulation of DNA-templated transcription | 38.0952 | 6 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 38.0952 | 5 | yes |
GO:0033043 | regulation of organelle organization | 38.0952 | 5 | yes |
GO:0051252 | regulation of RNA metabolic process | 38.0952 | 5 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 38.0952 | 7 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 38.0952 | 6 | yes |
GO:0009966 | regulation of signal transduction | 38.0952 | 4 | no |
GO:0043933 | protein-containing complex organization | 38.0952 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 33.3333 | 5 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 33.3333 | 6 | yes |
GO:0022607 | cellular component assembly | 33.3333 | 4 | no |
GO:0065003 | protein-containing complex assembly | 33.3333 | 5 | no |
GO:0006357 | regulation of transcription by RNA polymerase II | 28.5714 | 7 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 28.5714 | 6 | yes |
GO:0045893 | positive regulation of DNA-templated transcription | 28.5714 | 7 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 28.5714 | 6 | yes |
GO:0051129 | negative regulation of cellular component organization | 28.5714 | 5 | yes |
GO:0051254 | positive regulation of RNA metabolic process | 28.5714 | 6 | yes |
GO:1902680 | positive regulation of RNA biosynthetic process | 28.5714 | 7 | yes |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 28.5714 | 8 | yes |
GO:0010941 | regulation of cell death | 28.5714 | 4 | no |
GO:0042981 | regulation of apoptotic process | 28.5714 | 6 | no |
GO:0043067 | regulation of programmed cell death | 28.5714 | 5 | no |
GO:0048585 | negative regulation of response to stimulus | 28.5714 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
GO:0010639 | negative regulation of organelle organization | 23.8095 | 6 | yes |
GO:0008104 | protein localization | 23.8095 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 23.8095 | 5 | no |
GO:0010648 | negative regulation of cell communication | 23.8095 | 5 | no |
GO:0023057 | negative regulation of signaling | 23.8095 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 23.8095 | 5 | no |
GO:0080134 | regulation of response to stress | 23.8095 | 4 | no |
GO:0009059 | macromolecule biosynthetic process | 23.8095 | 4 | no |
GO:0044271 | cellular nitrogen compound biosynthetic process | 23.8095 | 4 | no |
GO:0036211 | protein modification process | 23.8095 | 4 | no |
GO:0043412 | macromolecule modification | 23.8095 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 23.8095 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 23.8095 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 23.8095 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.8095 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 23.8095 | 5 | no |
GO:0010564 | regulation of cell cycle process | 19.0476 | 5 | yes |
GO:0033044 | regulation of chromosome organization | 19.0476 | 6 | yes |
GO:0051726 | regulation of cell cycle | 19.0476 | 4 | yes |
GO:0006325 | chromatin organization | 14.2857 | 4 | yes |
GO:0006338 | chromatin remodeling | 14.2857 | 5 | yes |
GO:0006974 | cellular response to DNA damage stimulus | 14.2857 | 4 | yes |
GO:0006359 | regulation of transcription by RNA polymerase III | 9.5238 | 7 | yes |
GO:0010948 | negative regulation of cell cycle process | 9.5238 | 6 | yes |
GO:0045786 | negative regulation of cell cycle | 9.5238 | 5 | yes |
GO:0045945 | positive regulation of transcription by RNA polymerase III | 9.5238 | 8 | yes |
GO:2001251 | negative regulation of chromosome organization | 9.5238 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
PCNA_HUMAN | [view interactions] | Low throughput | no | no |
SMCA5_HUMAN | [view interactions] | Low throughput | no | yes |
MYH1_HUMAN | [view interactions] | Low throughput | no | no |
RPA2_HUMAN | [view interactions] | Low throughput | no | no |
BAZ1A_HUMAN | [view interactions] | Low throughput | no | no |
BAZ2A_HUMAN | [view interactions] | Low throughput | no | no |
H31_HUMAN | [view interactions] | Low throughput | no | yes |
MYO1C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
BRD4_HUMAN | [view interactions] | Low throughput | no | yes |
KAT8_HUMAN | [view interactions] | Low throughput | no | no |
KANL1_HUMAN | [view interactions] | Low throughput | no | yes |
SIR1_HUMAN | [view interactions] | Low throughput | no | yes |
SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
SMRC2_HUMAN | [view interactions] | High throughput | no | yes |
TOP2B_HUMAN | [view interactions] | High throughput | no | yes |
SMRC1_HUMAN | [view interactions] | High throughput | no | yes |
SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
MBD3_HUMAN | [view interactions] | High throughput | no | yes |
SMRD2_HUMAN | [view interactions] | High throughput | no | no |
SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
ACL6A_HUMAN | [view interactions] | High throughput | no | yes |
PPAP_HUMAN | [view interactions] | High throughput | no | no |
ARI1A_HUMAN | [view interactions] | High throughput | no | yes |
PAPP1_HUMAN | [view interactions] | High throughput | no | no |
SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
SP16H_HUMAN | [view interactions] | High throughput | no | yes |
LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
RHBL4_HUMAN | [view interactions] | High throughput | no | no |
NSD2_HUMAN | [view interactions] | High throughput | no | yes |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
DNJC9_HUMAN | [view interactions] | High throughput | no | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
CBX3_HUMAN | [view interactions] | High throughput | no | yes |
CENPA_HUMAN | [view interactions] | High throughput | no | no |
H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
ZN330_HUMAN | [view interactions] | High throughput | no | yes |
NAA40_HUMAN | [view interactions] | High throughput | no | no |
SALL1_HUMAN | [view interactions] | High throughput | no | yes |
MTR1A_HUMAN | [view interactions] | High throughput | no | no |
TRI33_HUMAN | [view interactions] | High throughput | no | yes |
HDA11_HUMAN | [view interactions] | High throughput | no | no |
IFIX_HUMAN | [view interactions] | High throughput | no | no |
EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SET_HUMAN | [view interactions] | High throughput | no | yes |
HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
RRP1B_HUMAN | [view interactions] | High throughput | no | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
SMCA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
H12_HUMAN | [view interactions] | High throughput | no | yes |
H14_HUMAN | [view interactions] | High throughput | no | yes |
LYAR_HUMAN | [view interactions] | High throughput | no | no |
HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
PHLA3_HUMAN | [view interactions] | High throughput | no | yes |
IGHM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
NR4A2_HUMAN | [view interactions] | High throughput | no | yes |
FBRL_HUMAN | [view interactions] | High throughput | no | yes |
ETV3_HUMAN | [view interactions] | High throughput | no | yes |
KLF16_HUMAN | [view interactions] | High throughput | no | yes |
KLF8_HUMAN | [view interactions] | High throughput | no | no |
KLF9_HUMAN | [view interactions] | High throughput | no | no |
LHX2_HUMAN | [view interactions] | High throughput | no | no |
SOX2_HUMAN | [view interactions] | High throughput | no | yes |
UFO_HUMAN | [view interactions] | High throughput | no | no |
DDR2_HUMAN | [view interactions] | High throughput | no | no |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
VGFR1_HUMAN | [view interactions] | High throughput | no | no |
FLT3_HUMAN | [view interactions] | High throughput | no | no |
VGFR2_HUMAN | [view interactions] | High throughput | no | no |
LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MERTK_HUMAN | [view interactions] | High throughput | no | yes |
ROS1_HUMAN | [view interactions] | High throughput | no | no |
TIE2_HUMAN | [view interactions] | High throughput | no | no |
CDT1_HUMAN | [view interactions] | High throughput | no | yes |
ERCC6_HUMAN | [view interactions] | High throughput | no | no |
SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
RHD_HUMAN | [view interactions] | High throughput | no | no |
DEK_HUMAN | [view interactions] | High throughput | no | yes |
MBB1A_HUMAN | [view interactions] | High throughput | no | yes |
ATAD5_HUMAN | [view interactions] | High throughput | no | no |
HDGF_HUMAN | [view interactions] | High throughput | no | yes |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL7_HUMAN | [view interactions] | High throughput | no | yes |
OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
RING2_HUMAN | [view interactions] | High throughput | no | yes |
IF16_HUMAN | [view interactions] | High throughput | no | no |
DAXX_HUMAN | [view interactions] | High throughput | no | yes |
RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ING3_HUMAN | [view interactions] | High throughput | no | no |
EXOS1_HUMAN | [view interactions] | High throughput | no | yes |
CBX1_HUMAN | [view interactions] | High throughput | no | yes |
HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
ZCCHV_HUMAN | [view interactions] | High throughput | no | yes |
HBP1_HUMAN | [view interactions] | High throughput | no | yes |
RNF4_HUMAN | [view interactions] | High throughput | no | yes |
CHD3_HUMAN | [view interactions] | High throughput | no | yes |
CHD4_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
DCPS_HUMAN | [view interactions] | High throughput | no | yes |
CGAS_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
ATM_HUMAN | [view interactions] | High throughput | no | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
H4_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
RAD18_HUMAN | [view interactions] | High throughput | no | yes |
RPB1_HUMAN | [view interactions] | High throughput | no | no |
RPB3_HUMAN | [view interactions] | High throughput | no | yes |
SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
SPT6H_HUMAN | [view interactions] | High throughput | no | yes |
CDK12_HUMAN | [view interactions] | High throughput | no | yes |
RSF1_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
SEMG1_HUMAN | [view interactions] | High throughput | no | no |
TRI66_HUMAN | [view interactions] | High throughput | no | yes |
PPBT_HUMAN | [view interactions] | High throughput | no | yes |
ZN263_HUMAN | [view interactions] | High throughput | no | yes |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
REXO4_HUMAN | [view interactions] | High throughput | no | yes |
REPI1_HUMAN | [view interactions] | High throughput | no | yes |
RL7L_HUMAN | [view interactions] | High throughput | no | no |
RT10_HUMAN | [view interactions] | High throughput | no | yes |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
SKA3_HUMAN | [view interactions] | High throughput | no | no |
FZR1_HUMAN | [view interactions] | High throughput | no | no |
ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZN346_HUMAN | [view interactions] | High throughput | no | yes |
RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIC27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KRR1_HUMAN | [view interactions] | High throughput | no | yes |
UTP23_HUMAN | [view interactions] | High throughput | no | no |
HNRC2_HUMAN | [view interactions] | High throughput | no | no |
ANR50_HUMAN | [view interactions] | High throughput | no | no |
IMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KLH20_HUMAN | [view interactions] | High throughput | no | yes |
NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H2A1_HUMAN | [view interactions] | High throughput | no | yes |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
BRD2_HUMAN | [view interactions] | High throughput | no | yes |
BRD3_HUMAN | [view interactions] | High throughput | no | yes |
H10_HUMAN | [view interactions] | High throughput | no | yes |
H2AZ_HUMAN | [view interactions] | High throughput | no | yes |
H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
HMGN2_HUMAN | [view interactions] | High throughput | no | no |
HMGN5_HUMAN | [view interactions] | High throughput | no | no |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NCK1_HUMAN | [view interactions] | High throughput | no | yes |
NECP1_HUMAN | [view interactions] | High throughput | no | no |
NUCKS_HUMAN | [view interactions] | High throughput | no | yes |
NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOP1_HUMAN | [view interactions] | High throughput | no | yes |
TOP2A_HUMAN | [view interactions] | High throughput | no | no |
H2B1L_HUMAN | [view interactions] | Computational | no | yes |
CHRC1_HUMAN | [view interactions] | Computational | no | no |
H2B1M_HUMAN | [view interactions] | Computational | no | yes |
H2B1D_HUMAN | [view interactions] | Computational | no | yes |
DDX21_HUMAN | [view interactions] | Computational | no | yes |
H2AV_HUMAN | [view interactions] | Computational | no | yes |
H2A1C_HUMAN | [view interactions] | Computational | no | yes |
RXRA_HUMAN | [view interactions] | Computational | no | yes |
CAF1A_HUMAN | [view interactions] | Computational | no | yes |
H2B1B_HUMAN | [view interactions] | Computational | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
H2BFS_HUMAN | [view interactions] | Computational | no | yes |
H2A1J_HUMAN | [view interactions] | Computational | no | yes |
VDR_HUMAN | [view interactions] | Computational | no | no |
H2B1A_HUMAN | [view interactions] | Computational | no | no |
H2B1K_HUMAN | [view interactions] | Computational | no | yes |
H2AB1_HUMAN | [view interactions] | Computational | no | no |
H2B1O_HUMAN | [view interactions] | Computational | no | yes |
SMCE1_HUMAN | [view interactions] | Computational | no | yes |
RPA49_HUMAN | [view interactions] | Computational | no | yes |
H2A2C_HUMAN | [view interactions] | Computational | no | yes |
H31T_HUMAN | [view interactions] | Computational | no | yes |
H2A1D_HUMAN | [view interactions] | Computational | no | yes |
SMRD1_HUMAN | [view interactions] | Computational | no | yes |
H2AJ_HUMAN | [view interactions] | Computational | no | yes |
H2B1J_HUMAN | [view interactions] | Computational | no | yes |
H2B1N_HUMAN | [view interactions] | Computational | no | yes |