Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IGHM_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed, PubMed). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed, PubMed). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IGHM_HUMAN
GO:0000166 nucleotide binding 27.2727 4 no
GO:0017076 purine nucleotide binding 27.2727 5 no
GO:0019900 kinase binding 27.2727 4 no
GO:0019901 protein kinase binding 27.2727 5 no
GO:0030554 adenyl nucleotide binding 27.2727 6 no
GO:0032555 purine ribonucleotide binding 27.2727 4 no
GO:0032559 adenyl ribonucleotide binding 27.2727 5 no
GO:0043168 anion binding 27.2727 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in IGHM_HUMAN
GO:0031323 regulation of cellular metabolic process 81.8182 4 yes
GO:0060255 regulation of macromolecule metabolic process 81.8182 4 yes
GO:0009889 regulation of biosynthetic process 72.7273 4 yes
GO:0010468 regulation of gene expression 72.7273 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 72.7273 5 yes
GO:0031326 regulation of cellular biosynthetic process 72.7273 5 yes
GO:0080090 regulation of primary metabolic process 63.6364 4 no
GO:0048584 positive regulation of response to stimulus 54.5455 4 yes
GO:0048522 positive regulation of cellular process 54.5455 4 no
GO:0048523 negative regulation of cellular process 54.5455 4 no
GO:0009966 regulation of signal transduction 45.4545 4 no
GO:0010646 regulation of cell communication 45.4545 4 no
GO:0051049 regulation of transport 45.4545 4 no
GO:0051246 regulation of protein metabolic process 45.4545 5 no
GO:0009892 negative regulation of metabolic process 45.4545 4 no
GO:0010605 negative regulation of macromolecule metabolic process 45.4545 5 no
GO:0031324 negative regulation of cellular metabolic process 45.4545 5 no
GO:0002684 positive regulation of immune system process 36.3636 4 yes
GO:0006958 complement activation, classical pathway 36.3636 4 yes
GO:0050776 regulation of immune response 36.3636 4 yes
GO:0050778 positive regulation of immune response 36.3636 5 yes
GO:0140546 defense response to symbiont 36.3636 4 yes
GO:0009891 positive regulation of biosynthetic process 36.3636 5 no
GO:0009893 positive regulation of metabolic process 36.3636 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 36.3636 6 no
GO:0010604 positive regulation of macromolecule metabolic process 36.3636 5 no
GO:0019220 regulation of phosphate metabolic process 36.3636 6 no
GO:0031325 positive regulation of cellular metabolic process 36.3636 5 no
GO:0031328 positive regulation of cellular biosynthetic process 36.3636 6 no
GO:0031399 regulation of protein modification process 36.3636 6 no
GO:0051094 positive regulation of developmental process 36.3636 4 no
GO:0051128 regulation of cellular component organization 36.3636 4 no
GO:0051174 regulation of phosphorus metabolic process 36.3636 5 no
GO:0051240 positive regulation of multicellular organismal process 36.3636 4 no
GO:0080134 regulation of response to stress 36.3636 4 no
GO:0009890 negative regulation of biosynthetic process 36.3636 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 36.3636 6 no
GO:0031327 negative regulation of cellular biosynthetic process 36.3636 6 no
GO:0043933 protein-containing complex organization 36.3636 4 no
GO:0002429 immune response-activating cell surface receptor signaling pathway 27.2727 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 27.2727 4 yes
GO:0001932 regulation of protein phosphorylation 27.2727 7 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0010628 positive regulation of gene expression 27.2727 7 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0022411 cellular component disassembly 27.2727 4 no
GO:0022603 regulation of anatomical structure morphogenesis 27.2727 4 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0032101 regulation of response to external stimulus 27.2727 4 no
GO:0032103 positive regulation of response to external stimulus 27.2727 5 no
GO:0042325 regulation of phosphorylation 27.2727 7 no
GO:0051130 positive regulation of cellular component organization 27.2727 5 no
GO:0051247 positive regulation of protein metabolic process 27.2727 6 no
GO:0010563 negative regulation of phosphorus metabolic process 27.2727 6 no
GO:0010629 negative regulation of gene expression 27.2727 7 no
GO:0031400 negative regulation of protein modification process 27.2727 7 no
GO:0045936 negative regulation of phosphate metabolic process 27.2727 7 no
GO:0051248 negative regulation of protein metabolic process 27.2727 6 no
GO:0006355 regulation of DNA-templated transcription 27.2727 7 no
GO:0006996 organelle organization 27.2727 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.2727 5 no
GO:0051252 regulation of RNA metabolic process 27.2727 5 no
GO:0141124 intracellular signaling cassette 27.2727 4 no
GO:1902531 regulation of intracellular signal transduction 27.2727 5 no
GO:2001141 regulation of RNA biosynthetic process 27.2727 6 no
GO:0006796 phosphate-containing compound metabolic process 27.2727 4 no
GO:0016310 phosphorylation 27.2727 5 no
GO:0036211 protein modification process 27.2727 4 no
GO:0043412 macromolecule modification 27.2727 4 no
GO:0002331 pre-B cell allelic exclusion 18.1818 7 yes
GO:0019730 antimicrobial humoral response 18.1818 4 yes
GO:0019731 antibacterial humoral response 18.1818 5 yes
GO:0042742 defense response to bacterium 18.1818 4 yes
GO:0050829 defense response to Gram-negative bacterium 18.1818 5 yes
GO:0050851 antigen receptor-mediated signaling pathway 18.1818 5 yes
GO:0050853 B cell receptor signaling pathway 18.1818 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IGKC_HUMAN [view interactions] Low throughput no no
ARI3A_HUMAN [view interactions] Low throughput no yes
IGHM_HUMAN [view entry] [view interactions] Low throughput yes no
IGJ_HUMAN [view interactions] Low throughput no no
PIGR_HUMAN [view interactions] Low throughput no no
FCMR_HUMAN [view interactions] Low throughput no yes
CD79A_HUMAN [view interactions] Low throughput no no
CD79B_HUMAN [view interactions] Low throughput no no
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
GA45A_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
MAPK3_HUMAN [view interactions] High throughput no no
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
SMN_HUMAN [view interactions] High throughput no yes
KITH_HUMAN [view interactions] High throughput no yes
UFD1_HUMAN [view interactions] High throughput no no
M3K20_HUMAN [view interactions] High throughput no yes
SLX4_HUMAN [view interactions] High throughput no yes
GBRL1_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
SIM43_HUMAN [view interactions] High throughput no no
OR5H6_HUMAN [view interactions] High throughput no no
APOA1_HUMAN [view interactions] High throughput no no
CO3_HUMAN [view entry] [view interactions] High throughput yes no
HBB_HUMAN [view interactions] High throughput no no
PAPP1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
LV147_HUMAN [view interactions] High throughput no no
APOL1_HUMAN [view interactions] High throughput no no
K2C1_HUMAN [view interactions] High throughput no no
K1C9_HUMAN [view interactions] High throughput no no
BAZ1B_HUMAN [view entry] [view interactions] High throughput yes yes
RUNX1_HUMAN [view interactions] High throughput no yes
KVD40_HUMAN [view interactions] High throughput no no
PPAP_HUMAN [view interactions] High throughput no no
TIAM1_HUMAN [view entry] [view interactions] High throughput yes yes
CTR9_HUMAN [view interactions] High throughput no yes
BTK_HUMAN [view interactions] High throughput no no
CD19_HUMAN [view interactions] High throughput no no
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
UBQL4_HUMAN [view interactions] High throughput no yes
CD20_HUMAN [view interactions] High throughput no no
CD52_HUMAN [view interactions] High throughput no no