Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IGHM_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed, PubMed). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed, PubMed). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IGHM_HUMAN
GO:0019900 kinase binding 41.6667 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0017076 purine nucleotide binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in IGHM_HUMAN
GO:0031323 regulation of cellular metabolic process 66.6667 4 no
GO:0051171 regulation of nitrogen compound metabolic process 66.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 no
GO:0080090 regulation of primary metabolic process 66.6667 4 no
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0048523 negative regulation of cellular process 58.3333 4 no
GO:0010468 regulation of gene expression 58.3333 5 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0050776 regulation of immune response 41.6667 4 yes
GO:0009892 negative regulation of metabolic process 41.6667 4 no
GO:0010605 negative regulation of macromolecule metabolic process 41.6667 5 no
GO:0031324 negative regulation of cellular metabolic process 41.6667 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 41.6667 5 no
GO:0051246 regulation of protein metabolic process 41.6667 5 no
GO:0009966 regulation of signal transduction 41.6667 4 no
GO:0022603 regulation of anatomical structure morphogenesis 41.6667 4 no
GO:0051094 positive regulation of developmental process 41.6667 4 no
GO:0051128 regulation of cellular component organization 41.6667 4 no
GO:0010556 regulation of macromolecule biosynthetic process 41.6667 5 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 yes
GO:0050778 positive regulation of immune response 33.3333 5 yes
GO:0061024 membrane organization 33.3333 4 yes
GO:0006996 organelle organization 33.3333 4 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031399 regulation of protein modification process 33.3333 6 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0006355 regulation of DNA-templated transcription 33.3333 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0045597 positive regulation of cell differentiation 33.3333 5 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0060284 regulation of cell development 33.3333 5 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:1903506 regulation of nucleic acid-templated transcription 33.3333 7 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0002684 positive regulation of immune system process 33.3333 4 yes
GO:0006958 complement activation, classical pathway 33.3333 4 yes
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 no
GO:0002697 regulation of immune effector process 25.0000 4 no
GO:0002831 regulation of response to biotic stimulus 25.0000 4 no
GO:0010628 positive regulation of gene expression 25.0000 6 no
GO:0022411 cellular component disassembly 25.0000 4 no
GO:0031347 regulation of defense response 25.0000 5 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0006357 regulation of transcription by RNA polymerase II 25.0000 7 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010629 negative regulation of gene expression 25.0000 6 no
GO:0010720 positive regulation of cell development 25.0000 6 no
GO:0010810 regulation of cell-substrate adhesion 25.0000 5 no
GO:0010811 positive regulation of cell-substrate adhesion 25.0000 6 no
GO:0030155 regulation of cell adhesion 25.0000 4 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0030335 positive regulation of cell migration 25.0000 6 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0040017 positive regulation of locomotion 25.0000 4 no
GO:0045785 positive regulation of cell adhesion 25.0000 5 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:2000147 positive regulation of cell motility 25.0000 5 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0043933 protein-containing complex organization 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 25.0000 5 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0031344 regulation of cell projection organization 25.0000 5 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043087 regulation of GTPase activity 25.0000 5 no
GO:0043393 regulation of protein binding 25.0000 4 no
GO:0043547 positive regulation of GTPase activity 25.0000 6 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 25.0000 6 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0050829 defense response to Gram-negative bacterium 16.6667 5 yes
GO:0050851 antigen receptor-mediated signaling pathway 16.6667 5 yes
GO:0050853 B cell receptor signaling pathway 16.6667 6 yes
GO:0050864 regulation of B cell activation 16.6667 6 yes
GO:0050865 regulation of cell activation 16.6667 4 yes
GO:0050867 positive regulation of cell activation 16.6667 5 yes
GO:0050871 positive regulation of B cell activation 16.6667 7 yes
GO:0051249 regulation of lymphocyte activation 16.6667 5 yes
GO:0051251 positive regulation of lymphocyte activation 16.6667 6 yes
GO:0099024 plasma membrane invagination 16.6667 6 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 16.6667 4 yes
GO:0002694 regulation of leukocyte activation 16.6667 4 yes
GO:0002696 positive regulation of leukocyte activation 16.6667 5 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 16.6667 4 yes
GO:0006911 phagocytosis, engulfment 16.6667 7 yes
GO:0010324 membrane invagination 16.6667 5 yes
GO:0019730 antimicrobial humoral response 16.6667 4 yes
GO:0019731 antibacterial humoral response 16.6667 5 yes
GO:0042742 defense response to bacterium 16.6667 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IGKC_HUMAN [view interactions] Low throughput no no
ARI3A_HUMAN [view interactions] Low throughput no yes
IGHM_HUMAN [view entry] [view interactions] Low throughput yes no
IGJ_HUMAN [view interactions] Low throughput no no
PIGR_HUMAN [view interactions] Low throughput no no
CRK_HUMAN [view entry] [view interactions] High throughput yes no
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
GA45A_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
MAPK3_HUMAN [view interactions] High throughput no no
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
SMN_HUMAN [view interactions] High throughput no yes
KITH_HUMAN [view interactions] High throughput no yes
UFD1_HUMAN [view interactions] High throughput no no
M3K20_HUMAN [view interactions] High throughput no yes
SLX4_HUMAN [view interactions] High throughput no yes
GBRL1_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
CTR9_HUMAN [view interactions] High throughput no yes
TIAM1_HUMAN [view entry] [view interactions] High throughput yes yes
PPAP_HUMAN [view interactions] High throughput no no
KVD40_HUMAN [view interactions] High throughput no no
RUNX1_HUMAN [view interactions] High throughput no yes
BAZ1B_HUMAN [view entry] [view interactions] High throughput yes yes
K1C9_HUMAN [view interactions] High throughput no no
K2C1_HUMAN [view interactions] High throughput no no
APOL1_HUMAN [view interactions] High throughput no no
LV147_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
PAPP1_HUMAN [view interactions] High throughput no no
HBB_HUMAN [view interactions] High throughput no no
CO3_HUMAN [view entry] [view interactions] High throughput yes no
APOA1_HUMAN [view interactions] High throughput no no
OR5H6_HUMAN [view interactions] High throughput no no
BTK_HUMAN [view interactions] High throughput no no
CD19_HUMAN [view interactions] High throughput no no
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
UBQL4_HUMAN [view interactions] High throughput no yes
CD20_HUMAN [view interactions] High throughput no no
CD52_HUMAN [view interactions] High throughput no no