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TIAM1_HUMAN

Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration. [View more on UniProt]

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ELM instance Name Type Start End Partner
ELMI002569 LIG_CaMK_CASK_1 LIG 1572 1578 -

Molecular function

Term Name % Distance from the top of the tree Annotated in TIAM1_HUMAN
GO:0017076 purine nucleotide binding 47.5000 4 no
GO:0032555 purine ribonucleotide binding 47.5000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 47.5000 4 no
GO:0019900 kinase binding 30.0000 4 yes
GO:0016301 kinase activity 26.2500 4 no
GO:0019901 protein kinase binding 26.2500 5 no
GO:0005524 ATP binding 25.0000 5 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 25.0000 4 no
GO:0030554 adenyl nucleotide binding 25.0000 5 no
GO:0032559 adenyl ribonucleotide binding 25.0000 5 no
GO:0005525 GTP binding 23.7500 5 no
GO:0019001 guanyl nucleotide binding 23.7500 5 no
GO:0032561 guanyl ribonucleotide binding 23.7500 5 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 23.7500 4 no
GO:0003924 GTPase activity 22.5000 7 no
GO:0016462 pyrophosphatase activity 22.5000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.5000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.5000 6 no
GO:0030695 GTPase regulator activity 11.2500 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 5.0000 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TIAM1_HUMAN
GO:0048522 positive regulation of cellular process 72.5000 4 yes
GO:0010646 regulation of cell communication 62.5000 4 yes
GO:0048523 negative regulation of cellular process 58.7500 4 no
GO:0060255 regulation of macromolecule metabolic process 55.0000 4 no
GO:0009966 regulation of signal transduction 52.5000 4 yes
GO:0031323 regulation of cellular metabolic process 52.5000 4 no
GO:0080090 regulation of primary metabolic process 51.2500 4 no
GO:0051171 regulation of nitrogen compound metabolic process 50.0000 4 no
GO:0051128 regulation of cellular component organization 47.5000 4 yes
GO:0051049 regulation of transport 43.7500 4 no
GO:0048584 positive regulation of response to stimulus 43.7500 4 no
GO:1902531 regulation of intracellular signal transduction 41.2500 5 yes
GO:0009893 positive regulation of metabolic process 41.2500 4 no
GO:0010468 regulation of gene expression 41.2500 5 no
GO:0010647 positive regulation of cell communication 38.7500 5 no
GO:0051246 regulation of protein metabolic process 38.7500 5 no
GO:0023056 positive regulation of signaling 37.5000 4 no
GO:0022607 cellular component assembly 37.5000 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 36.2500 5 no
GO:0031399 regulation of protein modification process 36.2500 6 no
GO:0008104 protein localization 36.2500 4 no
GO:0009967 positive regulation of signal transduction 35.0000 5 no
GO:0006996 organelle organization 35.0000 4 no
GO:0031325 positive regulation of cellular metabolic process 35.0000 5 no
GO:0009892 negative regulation of metabolic process 33.7500 4 no
GO:0019220 regulation of phosphate metabolic process 33.7500 6 no
GO:0051174 regulation of phosphorus metabolic process 33.7500 5 no
GO:0060341 regulation of cellular localization 32.5000 4 no
GO:0071310 cellular response to organic substance 32.5000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 32.5000 5 no
GO:0050804 modulation of chemical synaptic transmission 31.2500 5 no
GO:0099177 regulation of trans-synaptic signaling 31.2500 4 no
GO:0042127 regulation of cell population proliferation 31.2500 4 yes
GO:0045595 regulation of cell differentiation 31.2500 4 yes
GO:0051094 positive regulation of developmental process 31.2500 4 yes
GO:0042325 regulation of phosphorylation 31.2500 7 no
GO:0030030 cell projection organization 30.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 30.0000 4 yes
GO:0031344 regulation of cell projection organization 30.0000 5 yes
GO:0043085 positive regulation of catalytic activity 30.0000 4 yes
GO:0051130 positive regulation of cellular component organization 30.0000 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.0000 6 yes
GO:0006796 phosphate-containing compound metabolic process 30.0000 4 no
GO:0036211 protein modification process 30.0000 4 no
GO:0043412 macromolecule modification 30.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 30.0000 5 no
GO:0071702 organic substance transport 30.0000 4 no
GO:0032880 regulation of protein localization 28.7500 5 no
GO:0030334 regulation of cell migration 28.7500 5 yes
GO:0051336 regulation of hydrolase activity 28.7500 4 yes
GO:2000145 regulation of cell motility 28.7500 4 yes
GO:0001932 regulation of protein phosphorylation 28.7500 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.7500 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 28.7500 5 no
GO:0071705 nitrogen compound transport 28.7500 4 no
GO:0044087 regulation of cellular component biogenesis 27.5000 4 no
GO:0007010 cytoskeleton organization 27.5000 5 no
GO:0010941 regulation of cell death 27.5000 4 no
GO:0051240 positive regulation of multicellular organismal process 27.5000 4 yes
GO:0009889 regulation of biosynthetic process 27.5000 4 no
GO:0042981 regulation of apoptotic process 26.2500 6 no
GO:0043067 regulation of programmed cell death 26.2500 5 no
GO:0031324 negative regulation of cellular metabolic process 26.2500 5 no
GO:0031326 regulation of cellular biosynthetic process 26.2500 5 no
GO:0051248 negative regulation of protein metabolic process 26.2500 6 no
GO:0051252 regulation of RNA metabolic process 26.2500 5 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0006468 protein phosphorylation 25.0000 5 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0051338 regulation of transferase activity 25.0000 4 no
GO:0002684 positive regulation of immune system process 25.0000 4 no
GO:0010243 response to organonitrogen compound 23.7500 4 no
GO:0043408 regulation of MAPK cascade 23.7500 6 no
GO:0033043 regulation of organelle organization 23.7500 5 no
GO:0016192 vesicle-mediated transport 23.7500 4 no
GO:0007264 small GTPase mediated signal transduction 23.7500 4 yes
GO:0045597 positive regulation of cell differentiation 23.7500 5 yes
GO:2000026 regulation of multicellular organismal development 23.7500 4 yes
GO:0006355 regulation of DNA-templated transcription 23.7500 6 no
GO:0010562 positive regulation of phosphorus metabolic process 23.7500 6 no
GO:0030155 regulation of cell adhesion 23.7500 4 no
GO:0031400 negative regulation of protein modification process 23.7500 7 no
GO:0042327 positive regulation of phosphorylation 23.7500 8 no
GO:0043549 regulation of kinase activity 23.7500 5 no
GO:0045937 positive regulation of phosphate metabolic process 23.7500 7 no
GO:0051247 positive regulation of protein metabolic process 23.7500 6 no
GO:1903506 regulation of nucleic acid-templated transcription 23.7500 7 no
GO:2001141 regulation of RNA biosynthetic process 23.7500 6 no
GO:0061024 membrane organization 23.7500 4 no
GO:0015031 protein transport 22.5000 4 no
GO:0044089 positive regulation of cellular component biogenesis 21.2500 5 no
GO:0120036 plasma membrane bounded cell projection organization 21.2500 5 no
GO:0043269 regulation of ion transport 21.2500 5 no
GO:0010975 regulation of neuron projection development 21.2500 7 yes
GO:0030335 positive regulation of cell migration 21.2500 6 yes
GO:0040017 positive regulation of locomotion 21.2500 4 yes
GO:2000147 positive regulation of cell motility 21.2500 5 yes
GO:0010648 negative regulation of cell communication 21.2500 5 no
GO:0023057 negative regulation of signaling 21.2500 4 no
GO:0031401 positive regulation of protein modification process 21.2500 7 no
GO:0050776 regulation of immune response 21.2500 4 no
GO:0007265 Ras protein signal transduction 20.0000 5 yes
GO:0031346 positive regulation of cell projection organization 20.0000 6 yes
GO:0051345 positive regulation of hydrolase activity 18.7500 5 yes
GO:0060284 regulation of cell development 18.7500 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 16.2500 4 yes
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 16.2500 5 yes
GO:0043087 regulation of GTPase activity 16.2500 5 yes
GO:0051960 regulation of nervous system development 16.2500 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 15.0000 6 yes
GO:0010720 positive regulation of cell development 13.7500 6 yes
GO:0043393 regulation of protein binding 13.7500 4 yes
GO:0050767 regulation of neurogenesis 13.7500 6 yes
GO:0016055 Wnt signaling pathway 11.2500 5 yes
GO:0043547 positive regulation of GTPase activity 11.2500 6 yes
GO:0043933 protein-containing complex organization 11.2500 4 yes
GO:0045664 regulation of neuron differentiation 11.2500 5 yes
GO:0051962 positive regulation of nervous system development 11.2500 5 yes
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 11.2500 4 yes
GO:0050769 positive regulation of neurogenesis 10.0000 6 yes
GO:0065003 protein-containing complex assembly 10.0000 5 yes
GO:0030111 regulation of Wnt signaling pathway 8.7500 5 yes
GO:0048013 ephrin receptor signaling pathway 8.7500 6 yes
GO:0050770 regulation of axonogenesis 8.7500 5 yes
GO:0051099 positive regulation of binding 8.7500 4 yes
GO:2000027 regulation of animal organ morphogenesis 8.7500 5 yes
GO:0035567 non-canonical Wnt signaling pathway 7.5000 6 yes
GO:0060071 Wnt signaling pathway, planar cell polarity pathway 7.5000 7 yes
GO:0090175 regulation of establishment of planar polarity 7.5000 6 yes
GO:0007160 cell-matrix adhesion 6.2500 4 yes
GO:0016601 Rac protein signal transduction 6.2500 6 yes
GO:0032092 positive regulation of protein binding 6.2500 5 yes
GO:0090630 activation of GTPase activity 6.2500 7 yes
GO:0010717 regulation of epithelial to mesenchymal transition 5.0000 5 yes
GO:0050772 positive regulation of axonogenesis 5.0000 6 yes
GO:0010718 positive regulation of epithelial to mesenchymal transition 3.7500 5 yes
GO:1904338 regulation of dopaminergic neuron differentiation 3.7500 6 yes
GO:2000050 regulation of non-canonical Wnt signaling pathway 3.7500 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in TIAM1_HUMAN
DOID:114 heart disease 3.7500 3 no
DOID:0050700 cardiomyopathy 2.5000 4 no
DOID:0060036 intrinsic cardiomyopathy 2.5000 5 no
DOID:0050686 organ system cancer 2.5000 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CD44_HUMAN [view interactions] Low throughput no yes
SDC1_HUMAN [view interactions] Low throughput no no
CNTP4_HUMAN [view interactions] Low throughput no no
SDC3_HUMAN [view interactions] Low throughput no yes
SDC4_HUMAN [view interactions] Low throughput no yes
SDC2_HUMAN [view interactions] Low throughput no yes
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
NEB2_HUMAN [view entry] [view interactions] Low throughput yes yes
OSBL1_HUMAN [view interactions] Low throughput no yes
ZKSC4_HUMAN [view interactions] Low throughput no yes
FND3B_HUMAN [view interactions] Low throughput no no
SRSF5_HUMAN [view interactions] Low throughput no yes
SYCP1_HUMAN [view entry] [view interactions] Low throughput yes no
SETB1_HUMAN [view interactions] Low throughput no yes
JIP2_HUMAN [view entry] [view interactions] Low throughput yes no
JIP1_HUMAN [view entry] [view interactions] Low throughput yes yes
MYC_HUMAN [view interactions] Low throughput no yes
ANK1_HUMAN [view entry] [view interactions] Low throughput yes no
ANK3_HUMAN [view entry] [view interactions] Low throughput yes yes
NDKA_HUMAN [view entry] [view interactions] Low throughput yes yes
NSD2_HUMAN [view interactions] Low throughput no yes
FBW1A_HUMAN [view interactions] Low throughput no yes
KC1A_HUMAN [view interactions] Low throughput no yes
KC1E_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCG_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
PP2AA_HUMAN [view entry] [view interactions] Low throughput yes yes
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
PARD3_HUMAN [view interactions] Low throughput no yes
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK2_HUMAN [view entry] [view interactions] Low throughput yes yes
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
CSKP_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDZ1_HUMAN [view entry] [view interactions] High throughput yes yes
RAN_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
IGHA1_HUMAN [view entry] [view interactions] High throughput yes yes
IGHM_HUMAN [view entry] [view interactions] High throughput yes no
ALBU_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
CTDSL_HUMAN [view interactions] High throughput no no
DCLK1_HUMAN [view entry] [view interactions] High throughput yes yes
SI1L1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF1C_HUMAN [view interactions] High throughput no yes
MAST3_HUMAN [view interactions] High throughput no yes
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
GGYF1_HUMAN [view interactions] High throughput no yes
NADK_HUMAN [view interactions] High throughput no yes
NF1_HUMAN [view entry] [view interactions] High throughput yes no
HDAC4_HUMAN [view interactions] High throughput no yes
PPM1H_HUMAN [view interactions] High throughput no yes
INP5E_HUMAN [view interactions] High throughput no yes
RTKN_HUMAN [view interactions] High throughput no yes
SIN1_HUMAN [view interactions] High throughput no yes
DEN1A_HUMAN [view interactions] High throughput no no
KSR1_HUMAN [view interactions] High throughput no yes
PHLB2_HUMAN [view interactions] High throughput no yes
DEN4C_HUMAN [view interactions] High throughput no yes
SPD2A_HUMAN [view entry] [view interactions] High throughput yes yes
M3K21_HUMAN [view interactions] High throughput no yes
ZN638_HUMAN [view interactions] High throughput no yes
CAMP2_HUMAN [view interactions] High throughput no yes
CDK16_HUMAN [view interactions] High throughput no yes
MPIP3_HUMAN [view interactions] High throughput no yes
MPIP2_HUMAN [view interactions] High throughput no no
IF4E2_HUMAN [view interactions] High throughput no no
AN34A_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
GGYF2_HUMAN [view interactions] High throughput no yes
SYDE1_HUMAN [view interactions] High throughput no yes
F110B_HUMAN [view interactions] High throughput no yes
SRS12_HUMAN [view interactions] High throughput no no
MAGI1_HUMAN [view interactions] High throughput no no
TESK2_HUMAN [view interactions] High throughput no yes
F110A_HUMAN [view interactions] High throughput no yes
KI13B_HUMAN [view interactions] High throughput no yes
FA53C_HUMAN [view interactions] High throughput no yes
LRFN1_HUMAN [view entry] [view interactions] High throughput yes no
CING_HUMAN [view interactions] High throughput no no
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
NGAP_HUMAN [view entry] [view interactions] High throughput yes yes
UBP21_HUMAN [view interactions] High throughput no no
ZBT21_HUMAN [view interactions] High throughput no yes
AGAP1_HUMAN [view entry] [view interactions] High throughput yes no
CBY1_HUMAN [view interactions] High throughput no no
KCTD3_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
FBW1B_HUMAN [view interactions] High throughput no yes
KBTB6_HUMAN [view interactions] High throughput no yes
KBTB7_HUMAN [view interactions] High throughput no yes
PSA7_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
P5CS_HUMAN [view interactions] High throughput no yes
ATIF1_HUMAN [view interactions] High throughput no yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
CCNT1_HUMAN [view interactions] High throughput no yes
CHCH2_HUMAN [view interactions] High throughput no yes
CTSL2_HUMAN [view interactions] High throughput no no
DDX42_HUMAN [view interactions] High throughput no yes
LIN7C_HUMAN [view entry] [view interactions] High throughput yes yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
SERPH_HUMAN [view interactions] High throughput no no
WDR33_HUMAN [view interactions] High throughput no yes
LRC31_HUMAN [view interactions] High throughput no no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
PIP_HUMAN [view interactions] High throughput no no
ABTB2_HUMAN [view interactions] High throughput no yes
SLN11_HUMAN [view interactions] High throughput no yes
SKP2_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
ILF3_HUMAN [view interactions] High throughput no yes
PHKG2_HUMAN [view interactions] High throughput no no
WNK1_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SYDC_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
DIRA3_HUMAN [view interactions] High throughput no yes
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view interactions] High throughput no yes
LYN_HUMAN [view entry] [view interactions] High throughput yes no
OCLN_HUMAN [view interactions] High throughput no no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
ZFPL1_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
MAZ_HUMAN [view interactions] High throughput no yes
SNTB2_HUMAN [view entry] [view interactions] High throughput yes no
PP1RA_HUMAN [view interactions] High throughput no yes
FIP1_HUMAN [view interactions] High throughput no yes
DTNA_HUMAN [view entry] [view interactions] High throughput yes yes
DMD_HUMAN [view entry] [view interactions] High throughput yes no
CUL4B_HUMAN [view interactions] High throughput no yes
EPHB1_HUMAN [view interactions] Computational no no
ANK2_HUMAN [view entry] [view interactions] Computational yes yes
EFNA1_HUMAN [view interactions] Computational no no
RRAS2_HUMAN [view interactions] Computational no yes
CADH5_HUMAN [view interactions] Computational no yes
PAR6A_HUMAN [view interactions] Computational no yes
AKT1_HUMAN [view entry] [view interactions] Computational yes yes
RASF1_HUMAN [view interactions] Computational no yes
RAC2_HUMAN [view entry] [view interactions] Computational yes yes
CADM1_HUMAN [view entry] [view interactions] Computational yes no
SRC_HUMAN [view entry] [view interactions] Computational yes no
NTF3_HUMAN [view interactions] Computational no no
BAIP2_HUMAN [view entry] [view interactions] Computational yes yes
PK3CB_HUMAN [view interactions] Computational no yes
VAV_HUMAN [view interactions] Computational no no
AGRB1_HUMAN [view entry] [view interactions] Computational yes no
NTRK3_HUMAN [view entry] [view interactions] Computational yes yes
RASM_HUMAN [view entry] [view interactions] Computational yes yes
PAK1_HUMAN [view entry] [view interactions] Computational yes yes
DVL1_HUMAN [view entry] [view interactions] Computational yes yes
EFNB1_HUMAN [view interactions] Computational no yes
RAP1A_HUMAN [view entry] [view interactions] Computational yes no
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
EPHA2_HUMAN [view interactions] Computational no no
VAV3_HUMAN [view interactions] Computational no yes
VAV2_HUMAN [view entry] [view interactions] Computational yes yes
RRAS_HUMAN [view interactions] Computational no yes
PAR3_HUMAN [view interactions] Computational no no
P85A_HUMAN [view interactions] Computational no yes
RAC3_HUMAN [view entry] [view interactions] Computational yes no
RAP1B_HUMAN [view entry] [view interactions] Computational yes no
MAP1B_HUMAN [view entry] [view interactions] Computational yes yes