Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SYCP1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SYCP1_HUMAN
GO:0005524 ATP binding 37.5000 5 no
GO:0017076 purine nucleotide binding 37.5000 4 no
GO:0030554 adenyl nucleotide binding 37.5000 5 no
GO:0032555 purine ribonucleotide binding 37.5000 4 no
GO:0032559 adenyl ribonucleotide binding 37.5000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 no
GO:0003677 DNA binding 25.0000 4 yes
GO:0003690 double-stranded DNA binding 25.0000 5 yes
GO:0005509 calcium ion binding 25.0000 5 no
GO:0046872 metal ion binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SYCP1_HUMAN
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0051130 positive regulation of cellular component organization 50.0000 5 no
GO:0006996 organelle organization 37.5000 4 yes
GO:0009059 macromolecule biosynthetic process 37.5000 4 yes
GO:0018130 heterocycle biosynthetic process 37.5000 4 yes
GO:0019438 aromatic compound biosynthetic process 37.5000 4 yes
GO:0022607 cellular component assembly 37.5000 4 yes
GO:0034654 nucleobase-containing compound biosynthetic process 37.5000 4 yes
GO:0043933 protein-containing complex organization 37.5000 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 37.5000 4 yes
GO:0060341 regulation of cellular localization 37.5000 4 yes
GO:0065003 protein-containing complex assembly 37.5000 5 yes
GO:0090304 nucleic acid metabolic process 37.5000 4 yes
GO:1901362 organic cyclic compound biosynthetic process 37.5000 4 yes
GO:0006355 regulation of DNA-templated transcription 37.5000 6 no
GO:0006357 regulation of transcription by RNA polymerase II 37.5000 7 no
GO:0009889 regulation of biosynthetic process 37.5000 4 no
GO:0009891 positive regulation of biosynthetic process 37.5000 5 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0009966 regulation of signal transduction 37.5000 4 no
GO:0010468 regulation of gene expression 37.5000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 37.5000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 37.5000 6 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0030334 regulation of cell migration 37.5000 5 no
GO:0030335 positive regulation of cell migration 37.5000 6 no
GO:0031323 regulation of cellular metabolic process 37.5000 4 no
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0031326 regulation of cellular biosynthetic process 37.5000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 37.5000 6 no
GO:0040017 positive regulation of locomotion 37.5000 4 no
GO:0043085 positive regulation of catalytic activity 37.5000 4 no
GO:0045893 positive regulation of DNA-templated transcription 37.5000 7 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 37.5000 6 no
GO:0045944 positive regulation of transcription by RNA polymerase II 37.5000 8 no
GO:0051171 regulation of nitrogen compound metabolic process 37.5000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0051252 regulation of RNA metabolic process 37.5000 5 no
GO:0051254 positive regulation of RNA metabolic process 37.5000 6 no
GO:0060255 regulation of macromolecule metabolic process 37.5000 4 no
GO:0080090 regulation of primary metabolic process 37.5000 4 no
GO:1902680 positive regulation of RNA biosynthetic process 37.5000 7 no
GO:1903506 regulation of nucleic acid-templated transcription 37.5000 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 37.5000 8 no
GO:2000145 regulation of cell motility 37.5000 4 no
GO:2000147 positive regulation of cell motility 37.5000 5 no
GO:2001141 regulation of RNA biosynthetic process 37.5000 6 no
GO:0031344 regulation of cell projection organization 37.5000 5 no
GO:0031346 positive regulation of cell projection organization 37.5000 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 37.5000 6 no
GO:0000711 meiotic DNA repair synthesis 25.0000 4 yes
GO:0000731 DNA synthesis involved in DNA repair 25.0000 6 yes
GO:0006259 DNA metabolic process 25.0000 4 yes
GO:0006310 DNA recombination 25.0000 5 yes
GO:0006325 chromatin organization 25.0000 4 yes
GO:0007129 homologous chromosome pairing at meiosis 25.0000 4 yes
GO:0007130 synaptonemal complex assembly 25.0000 4 yes
GO:0032880 regulation of protein localization 25.0000 5 yes
GO:0035825 homologous recombination 25.0000 6 yes
GO:0048232 male gamete generation 25.0000 4 yes
GO:0051259 protein complex oligomerization 25.0000 6 yes
GO:0051260 protein homooligomerization 25.0000 7 yes
GO:0051262 protein tetramerization 25.0000 7 yes
GO:0051276 chromosome organization 25.0000 5 yes
GO:0051289 protein homotetramerization 25.0000 8 yes
GO:0070193 synaptonemal complex organization 25.0000 6 yes
GO:0071897 DNA biosynthetic process 25.0000 5 yes
GO:0140527 reciprocal homologous recombination 25.0000 7 yes
GO:0006915 apoptotic process 25.0000 4 no
GO:0006974 cellular response to DNA damage stimulus 25.0000 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 25.0000 4 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0009267 cellular response to starvation 25.0000 4 no
GO:0010038 response to metal ion 25.0000 4 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0031667 response to nutrient levels 25.0000 4 no
GO:0031669 cellular response to nutrient levels 25.0000 4 no
GO:0034097 response to cytokine 25.0000 4 no
GO:0036211 protein modification process 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0043393 regulation of protein binding 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0070848 response to growth factor 25.0000 4 no
GO:0071241 cellular response to inorganic substance 25.0000 4 no
GO:0071248 cellular response to metal ion 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0071345 cellular response to cytokine stimulus 25.0000 5 no
GO:0071407 cellular response to organic cyclic compound 25.0000 5 no
GO:0071417 cellular response to organonitrogen compound 25.0000 4 no
GO:0080134 regulation of response to stress 25.0000 4 no
GO:0080135 regulation of cellular response to stress 25.0000 4 no
GO:1901699 cellular response to nitrogen compound 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0043087 regulation of GTPase activity 25.0000 5 no
GO:0043547 positive regulation of GTPase activity 25.0000 6 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 no
GO:0051345 positive regulation of hydrolase activity 25.0000 5 no
GO:0051960 regulation of nervous system development 25.0000 5 no
GO:0051962 positive regulation of nervous system development 25.0000 5 no
GO:2000026 regulation of multicellular organismal development 25.0000 4 no
GO:0008104 protein localization 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0061024 membrane organization 25.0000 4 no
GO:0006508 proteolysis 25.0000 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 25.0000 7 no
GO:0009057 macromolecule catabolic process 25.0000 4 no
GO:0019941 modification-dependent protein catabolic process 25.0000 6 no
GO:0043632 modification-dependent macromolecule catabolic process 25.0000 5 no
GO:0044265 cellular macromolecule catabolic process 25.0000 4 no
GO:0051603 proteolysis involved in protein catabolic process 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PSMA8_HUMAN [view interactions] Low throughput no no
SYCP1_HUMAN [view entry] [view interactions] Low throughput yes no
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
SYCE1_HUMAN [view interactions] Low throughput no no
SYCE2_HUMAN [view interactions] Low throughput no no
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4A_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
EGFEM_HUMAN [view interactions] High throughput no no
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
MCM2_HUMAN [view interactions] High throughput no no
CREB1_HUMAN [view interactions] High throughput no yes
SYCE3_HUMAN [view interactions] Computational no no
SMC1B_HUMAN [view interactions] Computational no no
REC8_HUMAN [view interactions] Computational no yes
SPO11_HUMAN [view interactions] Computational no no
RD21L_HUMAN [view interactions] Computational no no
RAD21_HUMAN [view interactions] Computational no yes
SYCP2_HUMAN [view interactions] Computational no no
TEX12_HUMAN [view interactions] Computational no no
SYCP3_HUMAN [view interactions] Computational no no
HORM1_HUMAN [view interactions] Computational no no