Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AGRIN_HUMAN

this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All z splice variants (z+) of this fragment also show an increase in the number of filopodia. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in AGRIN_HUMAN
GO:0003723 RNA binding 36.4706 4 no
GO:0043168 anion binding 32.9412 4 yes
GO:0000166 nucleotide binding 30.5882 4 no
GO:0043169 cation binding 29.4118 4 yes
GO:0046872 metal ion binding 29.4118 5 yes
GO:0017076 purine nucleotide binding 28.2353 5 no
GO:0032555 purine ribonucleotide binding 25.8824 4 no
GO:0030554 adenyl nucleotide binding 23.5294 6 no
GO:0035639 purine ribonucleoside triphosphate binding 23.5294 4 no
GO:0032559 adenyl ribonucleotide binding 21.1765 5 no
GO:0005509 calcium ion binding 14.1176 6 yes
GO:0031406 carboxylic acid binding 4.7059 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AGRIN_HUMAN
GO:0048522 positive regulation of cellular process 48.2353 4 yes
GO:0060255 regulation of macromolecule metabolic process 47.0588 4 yes
GO:0048523 negative regulation of cellular process 45.8824 4 no
GO:0031323 regulation of cellular metabolic process 45.8824 4 yes
GO:0080090 regulation of primary metabolic process 44.7059 4 yes
GO:0010646 regulation of cell communication 38.8235 4 no
GO:0051128 regulation of cellular component organization 37.6471 4 yes
GO:0009889 regulation of biosynthetic process 35.2941 4 yes
GO:0009893 positive regulation of metabolic process 34.1176 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 34.1176 5 yes
GO:0031326 regulation of cellular biosynthetic process 34.1176 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 32.9412 5 yes
GO:0009966 regulation of signal transduction 31.7647 4 no
GO:0008104 protein localization 31.7647 4 yes
GO:0010468 regulation of gene expression 31.7647 6 yes
GO:0006996 organelle organization 30.5882 4 no
GO:0051246 regulation of protein metabolic process 30.5882 5 no
GO:0031325 positive regulation of cellular metabolic process 30.5882 5 yes
GO:0022607 cellular component assembly 27.0588 4 no
GO:0009891 positive regulation of biosynthetic process 25.8824 5 yes
GO:0009892 negative regulation of metabolic process 24.7059 4 no
GO:0010605 negative regulation of macromolecule metabolic process 24.7059 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 24.7059 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 24.7059 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 24.7059 6 yes
GO:0006796 phosphate-containing compound metabolic process 23.5294 4 no
GO:0010647 positive regulation of cell communication 23.5294 5 no
GO:0048584 positive regulation of response to stimulus 23.5294 4 no
GO:1902531 regulation of intracellular signal transduction 23.5294 5 no
GO:0042981 regulation of apoptotic process 23.5294 5 no
GO:0043067 regulation of programmed cell death 23.5294 4 no
GO:0007010 cytoskeleton organization 22.3529 5 no
GO:0019220 regulation of phosphate metabolic process 22.3529 6 no
GO:0023056 positive regulation of signaling 22.3529 4 no
GO:0051174 regulation of phosphorus metabolic process 22.3529 5 no
GO:0031324 negative regulation of cellular metabolic process 22.3529 5 no
GO:0051130 positive regulation of cellular component organization 22.3529 5 yes
GO:0009967 positive regulation of signal transduction 21.1765 5 no
GO:0051247 positive regulation of protein metabolic process 21.1765 6 no
GO:0060341 regulation of cellular localization 21.1765 4 no
GO:0051252 regulation of RNA metabolic process 21.1765 5 yes
GO:2001141 regulation of RNA biosynthetic process 17.6471 6 yes
GO:0006355 regulation of DNA-templated transcription 17.6471 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 17.6471 5 yes
GO:0051094 positive regulation of developmental process 15.2941 4 yes
GO:0051240 positive regulation of multicellular organismal process 15.2941 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 14.1176 6 yes
GO:0031344 regulation of cell projection organization 14.1176 5 yes
GO:0044087 regulation of cellular component biogenesis 14.1176 4 yes
GO:0050807 regulation of synapse organization 14.1176 5 yes
GO:0034330 cell junction organization 12.9412 4 yes
GO:0072657 protein localization to membrane 11.7647 4 yes
GO:2000026 regulation of multicellular organismal development 11.7647 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 11.7647 8 yes
GO:0043085 positive regulation of catalytic activity 11.7647 4 yes
GO:0051254 positive regulation of RNA metabolic process 11.7647 6 yes
GO:0051336 regulation of hydrolase activity 11.7647 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 10.5882 7 yes
GO:0045893 positive regulation of DNA-templated transcription 10.5882 8 yes
GO:0031346 positive regulation of cell projection organization 9.4118 6 yes
GO:0050808 synapse organization 9.4118 5 yes
GO:0051345 positive regulation of hydrolase activity 9.4118 5 yes
GO:0044089 positive regulation of cellular component biogenesis 8.2353 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 8.2353 9 yes
GO:0051960 regulation of nervous system development 8.2353 5 yes
GO:0061024 membrane organization 7.0588 4 yes
GO:0048638 regulation of developmental growth 7.0588 4 yes
GO:0051962 positive regulation of nervous system development 7.0588 5 yes
GO:0007528 neuromuscular junction development 5.8824 6 yes
GO:0043113 receptor clustering 5.8824 5 yes
GO:0045927 positive regulation of growth 5.8824 4 yes
GO:0051963 regulation of synapse assembly 4.7059 6 yes
GO:1901888 regulation of cell junction assembly 4.7059 5 yes
GO:0048639 positive regulation of developmental growth 4.7059 5 yes
GO:0051965 positive regulation of synapse assembly 3.5294 6 yes
GO:1901890 positive regulation of cell junction assembly 3.5294 6 yes
GO:1904396 regulation of neuromuscular junction development 3.5294 6 yes
GO:0008582 regulation of synaptic assembly at neuromuscular junction 3.5294 5 yes
GO:0060491 regulation of cell projection assembly 2.3529 5 yes
GO:0095500 acetylcholine receptor signaling pathway 2.3529 4 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 2.3529 6 yes
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly 2.3529 6 yes
GO:1904398 positive regulation of neuromuscular junction development 2.3529 6 yes
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 2.3529 4 yes
GO:0043087 regulation of GTPase activity 2.3529 5 yes
GO:0043547 positive regulation of GTPase activity 2.3529 6 yes
GO:0045161 neuronal ion channel clustering 2.3529 5 yes
GO:0045162 clustering of voltage-gated sodium channels 2.3529 6 yes
GO:0045887 positive regulation of synaptic assembly at neuromuscular junction 2.3529 6 yes
GO:0051489 regulation of filopodium assembly 2.3529 7 yes
GO:0051491 positive regulation of filopodium assembly 2.3529 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DAG1_HUMAN [view entry] [view interactions] Low throughput yes no
LRP4_HUMAN [view entry] [view interactions] Low throughput yes yes
MUSK_HUMAN [view entry] [view interactions] Low throughput yes no
NPNT_HUMAN [view interactions] Low throughput no no
AGRIN_HUMAN [view entry] [view interactions] Low throughput yes yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
LPIN1_HUMAN [view interactions] High throughput no no
MPRD_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1S_HUMAN [view interactions] High throughput no no
MT1G_HUMAN [view interactions] High throughput no no
C1TC_HUMAN [view entry] [view interactions] High throughput yes yes
MYPC1_HUMAN [view interactions] High throughput no no
MYH11_HUMAN [view entry] [view interactions] High throughput yes no
MYH14_HUMAN [view entry] [view interactions] High throughput yes no
MYH3_HUMAN [view interactions] High throughput no no
MYH7_HUMAN [view interactions] High throughput no no
MYH8_HUMAN [view interactions] High throughput no no
ML12B_HUMAN [view interactions] High throughput no no
MYL3_HUMAN [view interactions] High throughput no no
MYOTI_HUMAN [view interactions] High throughput no no
NAA15_HUMAN [view interactions] High throughput no yes
NCOR2_HUMAN [view interactions] High throughput no yes
NEIL2_HUMAN [view interactions] High throughput no no
NID2_HUMAN [view interactions] High throughput no yes
NPM_HUMAN [view entry] [view interactions] High throughput yes yes
NSF1C_HUMAN [view entry] [view interactions] High throughput yes yes
5NT1B_HUMAN [view entry] [view interactions] High throughput yes no
NUP98_HUMAN [view interactions] High throughput no no
OLFL3_HUMAN [view interactions] High throughput no no
OSER1_HUMAN [view interactions] High throughput no yes
PA2G4_HUMAN [view interactions] High throughput no yes
PABP1_HUMAN [view entry] [view interactions] High throughput yes yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
PYC_HUMAN [view entry] [view interactions] High throughput yes yes
PCX3_HUMAN [view interactions] High throughput no no
PCOC1_HUMAN [view interactions] High throughput no yes
PGAM1_HUMAN [view entry] [view interactions] High throughput yes yes
6PGD_HUMAN [view entry] [view interactions] High throughput yes no
PGM1_HUMAN [view interactions] High throughput no no
PGRC1_HUMAN [view entry] [view interactions] High throughput yes yes
PHC2_HUMAN [view interactions] High throughput no yes
PI51A_HUMAN [view interactions] High throughput no yes
KPYM_HUMAN [view interactions] High throughput no yes
PLTP_HUMAN [view interactions] High throughput no no
PLPL6_HUMAN [view entry] [view interactions] High throughput yes yes
IPYR2_HUMAN [view interactions] High throughput no yes
CANB1_HUMAN [view entry] [view interactions] High throughput yes yes
KAP2_HUMAN [view entry] [view interactions] High throughput yes yes
PRP8_HUMAN [view interactions] High throughput no yes
TRY1_HUMAN [view interactions] High throughput no no
PSMD4_HUMAN [view interactions] High throughput no yes
PTMA_HUMAN [view interactions] High throughput no yes
PTMS_HUMAN [view interactions] High throughput no yes
PYGM_HUMAN [view entry] [view interactions] High throughput yes no
QPCT_HUMAN [view interactions] High throughput no no
RBGP1_HUMAN [view interactions] High throughput no yes
RANG_HUMAN [view interactions] High throughput no no
RECQ5_HUMAN [view interactions] High throughput no no
REST_HUMAN [view interactions] High throughput no yes
RFC3_HUMAN [view interactions] High throughput no yes
RN180_HUMAN [view interactions] High throughput no yes
RNF31_HUMAN [view interactions] High throughput no yes
RL22_HUMAN [view entry] [view interactions] High throughput yes no
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
RS27L_HUMAN [view entry] [view interactions] High throughput yes no
RS3_HUMAN [view entry] [view interactions] High throughput yes yes
RRAGA_HUMAN [view interactions] High throughput no yes
S10A9_HUMAN [view entry] [view interactions] High throughput yes no
SAC1_HUMAN [view entry] [view interactions] High throughput yes yes
UTER_HUMAN [view interactions] High throughput no no
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
SPB3_HUMAN [view interactions] High throughput no no
S12A4_HUMAN [view interactions] High throughput no yes
S39A7_HUMAN [view interactions] High throughput no yes
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
U520_HUMAN [view interactions] High throughput no yes
SNX14_HUMAN [view entry] [view interactions] High throughput yes yes
OSTP_HUMAN [view interactions] High throughput no yes
SPR2G_HUMAN [view interactions] High throughput no no
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
SRP72_HUMAN [view interactions] High throughput no yes
STK4_HUMAN [view interactions] High throughput no yes
SUGP1_HUMAN [view interactions] High throughput no yes
SP16H_HUMAN [view interactions] High throughput no yes
SYCP1_HUMAN [view entry] [view interactions] High throughput yes no
SYNE1_HUMAN [view entry] [view interactions] High throughput yes yes
SYT12_HUMAN [view interactions] High throughput no yes
RBP56_HUMAN [view interactions] High throughput no yes
TEN3_HUMAN [view interactions] High throughput no yes
THOC1_HUMAN [view interactions] High throughput no yes
TYB4_HUMAN [view interactions] High throughput no yes
TENN_HUMAN [view interactions] High throughput no no
TNNI1_HUMAN [view interactions] High throughput no no
TNNT1_HUMAN [view interactions] High throughput no no
TNNT3_HUMAN [view interactions] High throughput no no
TPM2_HUMAN [view entry] [view interactions] High throughput yes yes
TPM3_HUMAN [view entry] [view interactions] High throughput yes yes
TRI11_HUMAN [view interactions] High throughput no yes
RO52_HUMAN [view interactions] High throughput no yes
TRPC3_HUMAN [view interactions] High throughput no no
TITIN_HUMAN [view interactions] High throughput no no
TTYH2_HUMAN [view interactions] High throughput no no
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBB5_HUMAN [view interactions] High throughput no yes
UE2NL_HUMAN [view interactions] High throughput no no
UBP24_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
VP13D_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT7B_HUMAN [view interactions] High throughput no no
ZC3HF_HUMAN [view interactions] High throughput no yes
ZCHC8_HUMAN [view interactions] High throughput no yes
ZMIZ1_HUMAN [view interactions] High throughput no no
ZN394_HUMAN [view interactions] High throughput no yes
ZRAB2_HUMAN [view interactions] High throughput no yes
ZWINT_HUMAN [view entry] [view interactions] High throughput yes no
WDR76_HUMAN [view interactions] High throughput no no
FBX6_HUMAN [view interactions] High throughput no yes
IGFL3_HUMAN [view interactions] High throughput no no
MANEA_HUMAN [view interactions] High throughput no yes
PGFRA_HUMAN [view interactions] High throughput no no
FBLN5_HUMAN [view interactions] High throughput no no
LCFC1_HUMAN [view interactions] High throughput no no
CCL4_HUMAN [view interactions] High throughput no no
SG2A2_HUMAN [view interactions] High throughput no no
MAX_HUMAN [view interactions] High throughput no yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
CL3L1_HUMAN [view interactions] High throughput no no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
CA054_HUMAN [view interactions] High throughput no yes
FGF4_HUMAN [view interactions] High throughput no no
C1QT7_HUMAN [view interactions] High throughput no no
CCL3_HUMAN [view interactions] High throughput no no
LAIR2_HUMAN [view interactions] High throughput no no
PI15_HUMAN [view interactions] High throughput no no
CFC1_HUMAN [view interactions] High throughput no no
DNJB9_HUMAN [view interactions] High throughput no yes
SDF2L_HUMAN [view interactions] High throughput no yes
ESPB1_HUMAN [view interactions] High throughput no no
ATN1_HUMAN [view interactions] High throughput no yes
CBLN4_HUMAN [view interactions] High throughput no no
GFI1B_HUMAN [view interactions] High throughput no no
EDN3_HUMAN [view interactions] High throughput no no
ATX7_HUMAN [view interactions] High throughput no no
DVL2_HUMAN [view interactions] High throughput no yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
IFIX_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
OS9_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
ZFP41_HUMAN [view interactions] High throughput no no
EZH2_HUMAN [view interactions] High throughput no no
CRP_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
NIN_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
CAC1A_HUMAN [view entry] [view interactions] High throughput yes no
TRI63_HUMAN [view interactions] High throughput no no
MGLYR_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
HXA1_HUMAN [view interactions] High throughput no no
NUFP2_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
FHI1B_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
BOLL_HUMAN [view interactions] High throughput no no
AP4AT_HUMAN [view interactions] High throughput no no
MAGD1_HUMAN [view interactions] High throughput no no
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
SKI_HUMAN [view interactions] High throughput no yes
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
NOE3_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
ACAP2_HUMAN [view interactions] High throughput no yes
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
ACTS_HUMAN [view interactions] High throughput no no
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
ADA17_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
AIF1L_HUMAN [view interactions] High throughput no yes
AKA11_HUMAN [view interactions] High throughput no yes
ALDOC_HUMAN [view entry] [view interactions] High throughput yes yes
AMFR_HUMAN [view interactions] High throughput no yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] High throughput yes yes
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
GDIR1_HUMAN [view entry] [view interactions] High throughput yes yes
AR6P4_HUMAN [view interactions] High throughput no yes
ARMX5_HUMAN [view interactions] High throughput no yes
ASAP2_HUMAN [view interactions] High throughput no yes
ASPH_HUMAN [view interactions] High throughput no yes
B4GA1_HUMAN [view interactions] High throughput no yes
PGS1_HUMAN [view interactions] High throughput no no
TF3B_HUMAN [view interactions] High throughput no yes
CZIB_HUMAN [view interactions] High throughput no no
CO3_HUMAN [view entry] [view interactions] High throughput yes no
PAXX_HUMAN [view interactions] High throughput no yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
CDC37_HUMAN [view interactions] High throughput no yes
MIA40_HUMAN [view interactions] High throughput no yes
KCRB_HUMAN [view entry] [view interactions] High throughput yes no
KCRS_HUMAN [view interactions] High throughput no no
CLCF1_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
CO4A2_HUMAN [view interactions] High throughput no no
CO6A1_HUMAN [view interactions] High throughput no no
CO6A2_HUMAN [view interactions] High throughput no no
CSN2_HUMAN [view interactions] High throughput no yes
CREB5_HUMAN [view interactions] High throughput no no
CTBL1_HUMAN [view interactions] High throughput no yes
ACBP_HUMAN [view interactions] High throughput no yes
DDX5_HUMAN [view entry] [view interactions] High throughput yes yes
DLG5_HUMAN [view entry] [view interactions] High throughput yes no
DMD_HUMAN [view entry] [view interactions] High throughput yes no
DJC21_HUMAN [view interactions] High throughput no yes
EF1A2_HUMAN [view entry] [view interactions] High throughput yes yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
IF4A2_HUMAN [view entry] [view interactions] High throughput yes yes
IF5_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
ENOA_HUMAN [view entry] [view interactions] High throughput yes yes
ENOB_HUMAN [view entry] [view interactions] High throughput yes no
EWS_HUMAN [view interactions] High throughput no yes
ABITM_HUMAN [view interactions] High throughput no yes
FBLN1_HUMAN [view interactions] High throughput no yes
FHL1_HUMAN [view interactions] High throughput no no
FLNB_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
FSTL1_HUMAN [view interactions] High throughput no yes
GLSK_HUMAN [view entry] [view interactions] High throughput yes yes
GNS_HUMAN [view interactions] High throughput no yes
GRN_HUMAN [view interactions] High throughput no no
TF2AA_HUMAN [view interactions] High throughput no yes
HDGF_HUMAN [view interactions] High throughput no yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
H2A1_HUMAN [view interactions] High throughput no yes
H2B1A_HUMAN [view interactions] High throughput no no
HMGA1_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
ROAA_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
HNRL2_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
IPO4_HUMAN [view interactions] High throughput no no
IPO9_HUMAN [view interactions] High throughput no no
IQGA2_HUMAN [view interactions] High throughput no yes
IRS4_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
K1C19_HUMAN [view interactions] High throughput no no
K2C78_HUMAN [view interactions] High throughput no no