AGRIN_HUMAN
Evidence for PS localization
Functions
this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All z splice variants (z+) of this fragment also show an increase in the number of filopodia. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 73%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Interacting regions
Canonical [AGRIN_HUMAN]
Isoform [O00468-2] alignment
Isoform [O00468-3] alignment
Isoform [O00468-4] alignment
Isoform [O00468-5] alignment
Isoform [O00468-6] alignment
Isoform [O00468-7] alignment
Isoform [A0A494C1I6] alignment
Isoform [A0A494C0G5] alignment
Isoform [A0A087X208] alignment
LOADING 39%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AGRIN_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 36.4706 | 4 | no |
| GO:0043168 | anion binding | 32.9412 | 4 | yes |
| GO:0000166 | nucleotide binding | 30.5882 | 4 | no |
| GO:0043169 | cation binding | 29.4118 | 4 | yes |
| GO:0046872 | metal ion binding | 29.4118 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 28.2353 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.8824 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 23.5294 | 6 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.5294 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.1765 | 5 | no |
| GO:0005509 | calcium ion binding | 14.1176 | 6 | yes |
| GO:0031406 | carboxylic acid binding | 4.7059 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AGRIN_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.2353 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 47.0588 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 45.8824 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.8824 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.7059 | 4 | yes |
| GO:0010646 | regulation of cell communication | 38.8235 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 37.6471 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 35.2941 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 34.1176 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 34.1176 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 34.1176 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.9412 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 31.7647 | 4 | no |
| GO:0008104 | protein localization | 31.7647 | 4 | yes |
| GO:0010468 | regulation of gene expression | 31.7647 | 6 | yes |
| GO:0006996 | organelle organization | 30.5882 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.5882 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.5882 | 5 | yes |
| GO:0022607 | cellular component assembly | 27.0588 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.8824 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 24.7059 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.7059 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.7059 | 6 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.7059 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.7059 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5NT1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ABITM_HUMAN | [view interactions] | High throughput | no | yes |
| ACAP2_HUMAN | [view interactions] | High throughput | no | yes |
| ACBP_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| ADA17_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AGRIN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AIF1L_HUMAN | [view interactions] | High throughput | no | yes |
| AKA11_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP4AT_HUMAN | [view interactions] | High throughput | no | no |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR6P4_HUMAN | [view interactions] | High throughput | no | yes |
| ARMX5_HUMAN | [view interactions] | High throughput | no | yes |