ANK3_HUMAN
Evidence for PS localization
Functions
May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 91%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Interacting regions
Canonical [ANK3_HUMAN]
Isoform [D6RFK6] alignment
Isoform [D6RF31] alignment
Isoform [D6RHY3] alignment
Isoform [Q12955-4] alignment
Isoform [Q12955-5] alignment
Isoform [Q12955-6] alignment
Isoform [Q12955-7] alignment
Isoform [H0YA66] alignment
Isoform [H0YAH5] alignment
Isoform [D6RBY7] alignment
Isoform [H0Y9E9] alignment
LOADING 40%
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI001681 | LIG_EVH1_1 | LIG | 3254 | 3258 | - |
| ELMI001681 | LIG_EVH1_1 | LIG | 3254 | 3258 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANK3_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 31.5217 | 4 | no |
| GO:0019900 | kinase binding | 31.5217 | 4 | no |
| GO:0000166 | nucleotide binding | 29.3478 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.3478 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.2609 | 4 | no |
| GO:0019901 | protein kinase binding | 28.2609 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.1739 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 20.6522 | 6 | no |
| GO:0045296 | cadherin binding | 16.3043 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANK3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.5652 | 4 | yes |
| GO:0022607 | cellular component assembly | 57.6087 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.1739 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 51.0870 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 48.9130 | 4 | yes |
| GO:0006996 | organelle organization | 46.7391 | 4 | no |
| GO:0009966 | regulation of signal transduction | 45.6522 | 4 | no |
| GO:0008104 | protein localization | 45.6522 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 45.6522 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.5652 | 5 | yes |
| GO:0080090 | regulation of primary metabolic process | 42.3913 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 38.0435 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 38.0435 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 38.0435 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 36.9565 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.9565 | 5 | yes |
| GO:0030030 | cell projection organization | 36.9565 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 35.8696 | 4 | no |
| GO:0010468 | regulation of gene expression | 35.8696 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 34.7826 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 34.7826 | 5 | yes |
| GO:0051049 | regulation of transport | 34.7826 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 33.6957 | 5 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AJUBA_HUMAN | [view interactions] | High throughput | no | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| AP3B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL14_HUMAN | [view interactions] | High throughput | no | no |
| ARVC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| BCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BSND_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |