ANK2_HUMAN
Evidence for PS localization
Functions
Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) . Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 3740 | Leu | Ile | LongQTsyndrome4(LQT4) | - |
| 3744 | Thr | Asn | LongQTsyndrome4(LQT4) | - |
| 3906 | Arg | Trp | LongQTsyndrome4(LQT4) | - |
| 3931 | Glu | Lys | LongQTsyndrome4(LQT4) | - |
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004464 | LIG_LIR_Gen_1 | LIG | 1591 | 1600 | - |
| ELMI004464 | LIG_LIR_Gen_1 | LIG | 1591 | 1600 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANK2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 33.8346 | 4 | no |
| GO:0000166 | nucleotide binding | 29.3233 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.5714 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.0677 | 4 | no |
| GO:0003723 | RNA binding | 26.3158 | 4 | no |
| GO:0045296 | cadherin binding | 26.3158 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 21.8045 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.8045 | 5 | no |
| GO:0003779 | actin binding | 20.3008 | 4 | no |
| GO:0005524 | ATP binding | 20.3008 | 5 | no |
| GO:0019900 | kinase binding | 15.0376 | 4 | yes |
| GO:0019901 | protein kinase binding | 13.5338 | 5 | yes |
| GO:0051117 | ATPase binding | 3.0075 | 4 | yes |
| GO:0140031 | phosphorylation-dependent protein binding | 1.5038 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANK2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 51.8797 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.3759 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.1128 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 43.6090 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.6090 | 4 | no |
| GO:0022607 | cellular component assembly | 42.1053 | 4 | yes |
| GO:0006996 | organelle organization | 42.1053 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.3534 | 4 | no |
| GO:0010646 | regulation of cell communication | 39.0977 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 33.8346 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 33.0827 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 33.0827 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.3308 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.3308 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 32.3308 | 5 | yes |
| GO:0010468 | regulation of gene expression | 30.8271 | 6 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.8271 | 5 | yes |
| GO:0030030 | cell projection organization | 30.8271 | 4 | no |
| GO:0008104 | protein localization | 29.3233 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.3233 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 28.5714 | 5 | no |
| GO:0051049 | regulation of transport | 27.8195 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 27.0677 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 26.3158 | 4 | no |
| GO:0031399 | regulation of protein modification process | 25.5639 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.5639 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.8120 | 6 | no |
| GO:0033043 | regulation of organelle organization | 24.8120 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.3083 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.3083 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.3083 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.3083 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 22.5564 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 21.8045 | 7 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.8045 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.8045 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.8045 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.8045 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.0526 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 21.0526 | 4 | no |
| GO:0060341 | regulation of cellular localization | 21.0526 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.3008 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.3008 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.3008 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.3008 | 4 | no |
| GO:0034330 | cell junction organization | 18.7970 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 18.0451 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 18.0451 | 6 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 17.2932 | 6 | yes |
| GO:0071702 | organic substance transport | 17.2932 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 16.5414 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 16.5414 | 4 | yes |
| GO:0032970 | regulation of actin filament-based process | 15.0376 | 4 | yes |
| GO:0015031 | protein transport | 14.2857 | 4 | yes |
| GO:0051050 | positive regulation of transport | 14.2857 | 4 | yes |
| GO:0010628 | positive regulation of gene expression | 12.7820 | 7 | yes |
| GO:0072657 | protein localization to membrane | 12.7820 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 12.0301 | 5 | yes |
| GO:0034329 | cell junction assembly | 11.2782 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 11.2782 | 4 | yes |
| GO:0061024 | membrane organization | 11.2782 | 4 | yes |
| GO:0072659 | protein localization to plasma membrane | 10.5263 | 5 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 9.7744 | 5 | yes |
| GO:0098657 | import into cell | 9.7744 | 4 | yes |
| GO:0044057 | regulation of system process | 9.0226 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 8.2707 | 4 | yes |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 8.2707 | 5 | yes |
| GO:0010959 | regulation of metal ion transport | 7.5188 | 6 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 6.7669 | 5 | yes |
| GO:0045216 | cell-cell junction organization | 6.7669 | 5 | yes |
| GO:0007043 | cell-cell junction assembly | 6.0150 | 6 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 6.0150 | 5 | yes |
| GO:0050821 | protein stabilization | 6.0150 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 6.0150 | 7 | yes |
| GO:1904062 | regulation of monoatomic cation transmembrane transport | 6.0150 | 6 | yes |
| GO:0008016 | regulation of heart contraction | 5.2632 | 6 | yes |
| GO:0033365 | protein localization to organelle | 5.2632 | 5 | yes |
| GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 5.2632 | 6 | yes |
| GO:0043270 | positive regulation of monoatomic ion transport | 5.2632 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 5.2632 | 4 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 5.2632 | 7 | yes |
| GO:1903522 | regulation of blood circulation | 5.2632 | 5 | yes |
| GO:0032411 | positive regulation of transporter activity | 4.5113 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 4.5113 | 5 | yes |
| GO:0001508 | action potential | 3.7594 | 4 | yes |
| GO:0006811 | monoatomic ion transport | 3.7594 | 4 | yes |
| GO:0006937 | regulation of muscle contraction | 3.7594 | 6 | yes |
| GO:0061337 | cardiac conduction | 3.7594 | 7 | yes |
| GO:0090257 | regulation of muscle system process | 3.7594 | 5 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 3.7594 | 7 | yes |
| GO:0006812 | monoatomic cation transport | 3.0075 | 5 | yes |
| GO:0006873 | intracellular monoatomic ion homeostasis | 3.0075 | 4 | yes |
| GO:0006942 | regulation of striated muscle contraction | 3.0075 | 7 | yes |
| GO:0030001 | metal ion transport | 3.0075 | 6 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 3.0075 | 5 | yes |
| GO:0043266 | regulation of potassium ion transport | 3.0075 | 7 | yes |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 3.0075 | 5 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 3.0075 | 4 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 3.0075 | 6 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 3.0075 | 7 | yes |
| GO:0086091 | regulation of heart rate by cardiac conduction | 3.0075 | 4 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 3.0075 | 6 | yes |
| GO:1901379 | regulation of potassium ion transmembrane transport | 3.0075 | 7 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 3.0075 | 7 | yes |
| GO:2001257 | regulation of cation channel activity | 3.0075 | 6 | yes |
| GO:2001259 | positive regulation of cation channel activity | 3.0075 | 6 | yes |
| GO:0019722 | calcium-mediated signaling | 2.2556 | 5 | yes |
| GO:0055074 | calcium ion homeostasis | 2.2556 | 4 | yes |
| GO:0098901 | regulation of cardiac muscle cell action potential | 2.2556 | 4 | yes |
| GO:1901016 | regulation of potassium ion transmembrane transporter activity | 2.2556 | 6 | yes |
| GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 2.2556 | 6 | yes |
| GO:0006816 | calcium ion transport | 1.5038 | 7 | yes |
| GO:0006874 | intracellular calcium ion homeostasis | 1.5038 | 5 | yes |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 1.5038 | 6 | yes |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 1.5038 | 7 | yes |
| GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 1.5038 | 6 | yes |
| GO:0030913 | paranodal junction assembly | 1.5038 | 4 | yes |
| GO:0034394 | protein localization to cell surface | 1.5038 | 5 | yes |
| GO:0051899 | membrane depolarization | 1.5038 | 4 | yes |
| GO:0060307 | regulation of ventricular cardiac muscle cell membrane repolarization | 1.5038 | 5 | yes |
| GO:0070972 | protein localization to endoplasmic reticulum | 1.5038 | 6 | yes |
| GO:0086001 | cardiac muscle cell action potential | 1.5038 | 5 | yes |
| GO:0086002 | cardiac muscle cell action potential involved in contraction | 1.5038 | 6 | yes |
| GO:0086004 | regulation of cardiac muscle cell contraction | 1.5038 | 6 | yes |
| GO:0086010 | membrane depolarization during action potential | 1.5038 | 5 | yes |
| GO:0086012 | membrane depolarization during cardiac muscle cell action potential | 1.5038 | 6 | yes |
| GO:0099623 | regulation of cardiac muscle cell membrane repolarization | 1.5038 | 4 | yes |
| GO:1903115 | regulation of actin filament-based movement | 1.5038 | 5 | yes |
| GO:1903779 | regulation of cardiac conduction | 1.5038 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRL1_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EHD2_HUMAN | [view interactions] | Low throughput | no | no |
| EHD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCJ11_HUMAN | [view interactions] | Low throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SGMR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPB42_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRAP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MLP3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
| MLP3C_HUMAN | [view interactions] | Low throughput | no | no |
| SPTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE120_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| CRNL1_HUMAN | [view interactions] | High throughput | no | no |
| FARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCC8_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| LN28A_HUMAN | [view interactions] | High throughput | no | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTBL_HUMAN | [view interactions] | High throughput | no | no |
| ACTH_HUMAN | [view interactions] | High throughput | no | no |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| VATB1_HUMAN | [view interactions] | High throughput | no | no |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CO3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| COR2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RABP1_HUMAN | [view interactions] | High throughput | no | no |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FMNL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HP1B3_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| IGHG2_HUMAN | [view interactions] | High throughput | no | no |
| KV240_HUMAN | [view interactions] | High throughput | no | no |
| IGLL5_HUMAN | [view interactions] | High throughput | no | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSAMP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PABP3_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PXDC2_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RABL6_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL10A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R4RL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
| SNX9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CA2D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CO1A1_HUMAN | [view interactions] | High throughput | no | yes |
| CTNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYH3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LV208_HUMAN | [view interactions] | High throughput | no | no |
| AINX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K22E_HUMAN | [view interactions] | High throughput | no | no |
| MACF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NONO_HUMAN | [view interactions] | High throughput | no | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| PSD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFC1_HUMAN | [view interactions] | High throughput | no | yes |
| RL18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL34_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUSD3_HUMAN | [view interactions] | High throughput | no | yes |
| RTP1_HUMAN | [view interactions] | High throughput | no | no |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TANC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP42_HUMAN | [view interactions] | High throughput | no | no |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
| CHD8_HUMAN | [view interactions] | High throughput | no | no |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| DNJB5_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| MTEF1_HUMAN | [view interactions] | High throughput | no | yes |
| TAF9_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| POPD2_HUMAN | [view interactions] | High throughput | no | no |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| PLAK2_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RPGF5_HUMAN | [view interactions] | High throughput | no | yes |
| NCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| MYPT2_HUMAN | [view interactions] | High throughput | no | no |
| CHST5_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTU7A_HUMAN | [view interactions] | High throughput | no | no |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAST_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| RED1_HUMAN | [view interactions] | High throughput | no | no |