ANK2_HUMAN
Evidence for PS localization
Functions
Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) . Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 3740 | Leu | Ile | LongQTsyndrome4(LQT4) | - |
| 3744 | Thr | Asn | LongQTsyndrome4(LQT4) | - |
| 3906 | Arg | Trp | LongQTsyndrome4(LQT4) | - |
| 3931 | Glu | Lys | LongQTsyndrome4(LQT4) | - |
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004464 | LIG_LIR_Gen_1 | LIG | 1591 | 1600 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANK2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.5625 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.4375 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.4375 | 4 | no |
| GO:0019900 | kinase binding | 21.8750 | 4 | yes |
| GO:0005524 | ATP binding | 21.8750 | 5 | no |
| GO:0003779 | actin binding | 20.3125 | 4 | no |
| GO:0019901 | protein kinase binding | 18.7500 | 5 | yes |
| GO:0051117 | ATPase binding | 7.8125 | 4 | yes |
| GO:0140031 | phosphorylation-dependent protein binding | 3.1250 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANK2_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 56.2500 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 54.6875 | 4 | yes |
| GO:0022607 | cellular component assembly | 51.5625 | 4 | yes |
| GO:0008104 | protein localization | 45.3125 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.3125 | 4 | yes |
| GO:0006996 | organelle organization | 45.3125 | 4 | no |
| GO:0030030 | cell projection organization | 45.3125 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.1875 | 4 | no |
| GO:0010646 | regulation of cell communication | 39.0625 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.0625 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.0625 | 4 | no |
| GO:0051049 | regulation of transport | 37.5000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 37.5000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 34.3750 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 34.3750 | 5 | no |
| GO:0009966 | regulation of signal transduction | 34.3750 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.8125 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 32.8125 | 5 | no |
| GO:0010468 | regulation of gene expression | 31.2500 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.2500 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 28.1250 | 5 | no |
| GO:0034330 | cell junction organization | 26.5625 | 4 | yes |
| GO:0007010 | cytoskeleton organization | 26.5625 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.5625 | 4 | no |
| GO:0031399 | regulation of protein modification process | 26.5625 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.5625 | 6 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | yes |
| GO:0072657 | protein localization to membrane | 25.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0043269 | regulation of ion transport | 23.4375 | 5 | yes |
| GO:1990778 | protein localization to cell periphery | 23.4375 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 23.4375 | 5 | no |
| GO:0031175 | neuron projection development | 23.4375 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.4375 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.4375 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.4375 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.4375 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.4375 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 23.4375 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.4375 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.4375 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.8750 | 4 | yes |
| GO:0032990 | cell part morphogenesis | 21.8750 | 4 | no |
| GO:0048812 | neuron projection morphogenesis | 21.8750 | 7 | no |
| GO:0048858 | cell projection morphogenesis | 21.8750 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.8750 | 6 | no |
| GO:0060341 | regulation of cellular localization | 21.8750 | 4 | no |
| GO:0120039 | plasma membrane bounded cell projection morphogenesis | 21.8750 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.8750 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 20.3125 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 20.3125 | 5 | yes |
| GO:0072659 | protein localization to plasma membrane | 20.3125 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 20.3125 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 20.3125 | 7 | no |
| GO:0032880 | regulation of protein localization | 20.3125 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.3125 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.3125 | 4 | no |
| GO:0010941 | regulation of cell death | 20.3125 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.3125 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 20.3125 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.3125 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.3125 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.3125 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 20.3125 | 5 | no |
| GO:0050808 | synapse organization | 20.3125 | 5 | no |
| GO:0015031 | protein transport | 17.1875 | 4 | yes |
| GO:0032970 | regulation of actin filament-based process | 17.1875 | 4 | yes |
| GO:0051050 | positive regulation of transport | 17.1875 | 4 | yes |
| GO:0061024 | membrane organization | 17.1875 | 4 | yes |
| GO:0034329 | cell junction assembly | 15.6250 | 5 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 15.6250 | 6 | yes |
| GO:0006897 | endocytosis | 14.0625 | 5 | yes |
| GO:0010628 | positive regulation of gene expression | 14.0625 | 6 | yes |
| GO:0010959 | regulation of metal ion transport | 14.0625 | 6 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 14.0625 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 12.5000 | 5 | yes |
| GO:0006811 | ion transport | 10.9375 | 4 | yes |
| GO:0006812 | cation transport | 10.9375 | 5 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 10.9375 | 5 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 10.9375 | 6 | yes |
| GO:0043270 | positive regulation of ion transport | 10.9375 | 5 | yes |
| GO:0048878 | chemical homeostasis | 10.9375 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 10.9375 | 7 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 10.9375 | 7 | yes |
| GO:0001508 | action potential | 9.3750 | 4 | yes |
| GO:0032411 | positive regulation of transporter activity | 9.3750 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 9.3750 | 5 | yes |
| GO:0033365 | protein localization to organelle | 9.3750 | 5 | yes |
| GO:0044057 | regulation of system process | 9.3750 | 4 | yes |
| GO:0050801 | ion homeostasis | 9.3750 | 5 | yes |
| GO:0055065 | metal ion homeostasis | 9.3750 | 7 | yes |
| GO:0055080 | cation homeostasis | 9.3750 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 9.3750 | 6 | yes |
| GO:1903169 | regulation of calcium ion transmembrane transport | 9.3750 | 7 | yes |
| GO:2001257 | regulation of cation channel activity | 9.3750 | 6 | yes |
| GO:0007043 | cell-cell junction assembly | 7.8125 | 6 | yes |
| GO:0030001 | metal ion transport | 7.8125 | 6 | yes |
| GO:0045216 | cell-cell junction organization | 7.8125 | 5 | yes |
| GO:2001259 | positive regulation of cation channel activity | 7.8125 | 6 | yes |
| GO:0008016 | regulation of heart contraction | 6.2500 | 6 | yes |
| GO:0019722 | calcium-mediated signaling | 6.2500 | 5 | yes |
| GO:0019932 | second-messenger-mediated signaling | 6.2500 | 4 | yes |
| GO:0050821 | protein stabilization | 6.2500 | 4 | yes |
| GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 6.2500 | 5 | yes |
| GO:0051282 | regulation of sequestering of calcium ion | 6.2500 | 4 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 6.2500 | 6 | yes |
| GO:1903522 | regulation of blood circulation | 6.2500 | 5 | yes |
| GO:1904427 | positive regulation of calcium ion transmembrane transport | 6.2500 | 7 | yes |
| GO:0006873 | cellular ion homeostasis | 4.6875 | 4 | yes |
| GO:0006875 | cellular metal ion homeostasis | 4.6875 | 6 | yes |
| GO:0006937 | regulation of muscle contraction | 4.6875 | 6 | yes |
| GO:0006942 | regulation of striated muscle contraction | 4.6875 | 7 | yes |
| GO:0030003 | cellular cation homeostasis | 4.6875 | 5 | yes |
| GO:0043266 | regulation of potassium ion transport | 4.6875 | 7 | yes |
| GO:0051899 | membrane depolarization | 4.6875 | 4 | yes |
| GO:0055117 | regulation of cardiac muscle contraction | 4.6875 | 7 | yes |
| GO:0070972 | protein localization to endoplasmic reticulum | 4.6875 | 6 | yes |
| GO:0072507 | divalent inorganic cation homeostasis | 4.6875 | 7 | yes |
| GO:0086010 | membrane depolarization during action potential | 4.6875 | 5 | yes |
| GO:0090257 | regulation of muscle system process | 4.6875 | 5 | yes |
| GO:1901019 | regulation of calcium ion transmembrane transporter activity | 4.6875 | 6 | yes |
| GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 4.6875 | 6 | yes |
| GO:1901379 | regulation of potassium ion transmembrane transport | 4.6875 | 7 | yes |
| GO:1903779 | regulation of cardiac conduction | 4.6875 | 4 | yes |
| GO:0006816 | calcium ion transport | 3.1250 | 7 | yes |
| GO:0006874 | cellular calcium ion homeostasis | 3.1250 | 7 | yes |
| GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 3.1250 | 6 | yes |
| GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 3.1250 | 7 | yes |
| GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 3.1250 | 6 | yes |
| GO:0030913 | paranodal junction assembly | 3.1250 | 4 | yes |
| GO:0034394 | protein localization to cell surface | 3.1250 | 5 | yes |
| GO:0055074 | calcium ion homeostasis | 3.1250 | 8 | yes |
| GO:0070296 | sarcoplasmic reticulum calcium ion transport | 3.1250 | 8 | yes |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 3.1250 | 6 | yes |
| GO:0086001 | cardiac muscle cell action potential | 3.1250 | 5 | yes |
| GO:0086002 | cardiac muscle cell action potential involved in contraction | 3.1250 | 6 | yes |
| GO:0086004 | regulation of cardiac muscle cell contraction | 3.1250 | 6 | yes |
| GO:0086005 | ventricular cardiac muscle cell action potential | 3.1250 | 7 | yes |
| GO:0098901 | regulation of cardiac muscle cell action potential | 3.1250 | 4 | yes |
| GO:0098907 | regulation of SA node cell action potential | 3.1250 | 5 | yes |
| GO:0098910 | regulation of atrial cardiac muscle cell action potential | 3.1250 | 5 | yes |
| GO:1901016 | regulation of potassium ion transmembrane transporter activity | 3.1250 | 6 | yes |
| GO:1903115 | regulation of actin filament-based movement | 3.1250 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ANK2_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 6.2500 | 3 | no |
| DOID:936 | brain disease | 6.2500 | 4 | no |
| DOID:0050701 | electroclinical syndrome | 4.6875 | 6 | no |
| DOID:0112202 | developmental and epileptic encephalopathy | 4.6875 | 7 | no |
| DOID:1826 | epilepsy | 4.6875 | 5 | no |
| DOID:114 | heart disease | 3.1250 | 3 | yes |
| DOID:0050703 | infancy electroclinical syndrome | 3.1250 | 7 | no |
| DOID:0060169 | benign familial infantile epilepsy | 3.1250 | 8 | no |
| DOID:12971 | hereditary spherocytosis | 3.1250 | 7 | no |
| DOID:2355 | anemia | 3.1250 | 3 | no |
| DOID:583 | hemolytic anemia | 3.1250 | 5 | no |
| DOID:589 | congenital hemolytic anemia | 3.1250 | 6 | no |
| DOID:720 | normocytic anemia | 3.1250 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EHD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRL1_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EHD2_HUMAN | [view interactions] | Low throughput | no | no |
| EHD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCJ11_HUMAN | [view interactions] | Low throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NDEL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SGMR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPB42_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBRAP_HUMAN | [view interactions] | Low throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
| MLP3C_HUMAN | [view interactions] | Low throughput | no | no |
| SPTN4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CE120_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRNL1_HUMAN | [view interactions] | High throughput | no | no |
| SPB1_HUMAN | [view interactions] | High throughput | no | yes |
| BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCC8_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX5R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNQ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| DNJB5_HUMAN | [view interactions] | High throughput | no | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| MTEF1_HUMAN | [view interactions] | High throughput | no | yes |
| TAF9_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MDC1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| POPD2_HUMAN | [view interactions] | High throughput | no | no |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| PALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| RPGF5_HUMAN | [view interactions] | High throughput | no | yes |
| NCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| KALRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACK1_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| MYPT2_HUMAN | [view interactions] | High throughput | no | no |
| CHST5_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| SCN8A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SCN4B_HUMAN | [view interactions] | Computational | no | yes |
| NFASC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SPTN5_HUMAN | [view interactions] | Computational | no | no |
| ANK3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ANK1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ITPR3_HUMAN | [view interactions] | Computational | no | yes |
| SCN1B_HUMAN | [view interactions] | Computational | no | no |
| 2A5A_HUMAN | [view interactions] | Computational | no | yes |
| NRCAM_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SPTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ITPR2_HUMAN | [view interactions] | Computational | no | yes |
| E41L3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KCNQ2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TKN1_HUMAN | [view interactions] | Computational | no | yes |
| CD44_HUMAN | [view interactions] | Computational | no | yes |
| SKP1_HUMAN | [view interactions] | Computational | no | yes |
| TIAM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SPTB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SCN2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1D_HUMAN | [view interactions] | Computational | no | yes |
| L1CAM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |