Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NCHL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NCHL1_HUMAN
GO:0051117 ATPase binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in NCHL1_HUMAN
GO:0048522 positive regulation of cellular process 71.4286 4 no
GO:0030030 cell projection organization 57.1429 4 yes
GO:0048523 negative regulation of cellular process 57.1429 4 yes
GO:0008104 protein localization 57.1429 4 no
GO:0009893 positive regulation of metabolic process 57.1429 4 no
GO:0010604 positive regulation of macromolecule metabolic process 57.1429 5 no
GO:0010646 regulation of cell communication 57.1429 4 no
GO:0022607 cellular component assembly 57.1429 4 no
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0031325 positive regulation of cellular metabolic process 57.1429 5 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0006811 monoatomic ion transport 42.8571 4 no
GO:0006812 monoatomic cation transport 42.8571 5 no
GO:0009889 regulation of biosynthetic process 42.8571 4 no
GO:0009891 positive regulation of biosynthetic process 42.8571 5 no
GO:0010468 regulation of gene expression 42.8571 6 no
GO:0010556 regulation of macromolecule biosynthetic process 42.8571 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 42.8571 6 no
GO:0010628 positive regulation of gene expression 42.8571 7 no
GO:0010959 regulation of metal ion transport 42.8571 6 no
GO:0022898 regulation of transmembrane transporter activity 42.8571 4 no
GO:0030001 metal ion transport 42.8571 6 no
GO:0031326 regulation of cellular biosynthetic process 42.8571 5 no
GO:0031328 positive regulation of cellular biosynthetic process 42.8571 6 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 42.8571 5 no
GO:0034330 cell junction organization 42.8571 4 no
GO:0034762 regulation of transmembrane transport 42.8571 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 42.8571 5 no
GO:0043266 regulation of potassium ion transport 42.8571 7 no
GO:0043269 regulation of monoatomic ion transport 42.8571 5 no
GO:0051049 regulation of transport 42.8571 4 no
GO:0051050 positive regulation of transport 42.8571 4 no
GO:0055080 monoatomic cation homeostasis 42.8571 4 no
GO:0071702 organic substance transport 42.8571 4 no
GO:0071705 nitrogen compound transport 42.8571 4 no
GO:0072657 protein localization to membrane 42.8571 4 no
GO:0072659 protein localization to plasma membrane 42.8571 5 no
GO:1904062 regulation of monoatomic cation transmembrane transport 42.8571 6 no
GO:1990778 protein localization to cell periphery 42.8571 5 no
GO:2001257 regulation of cation channel activity 42.8571 6 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0001764 neuron migration 28.5714 4 yes
GO:0007411 axon guidance 28.5714 8 yes
GO:0008344 adult locomotory behavior 28.5714 4 yes
GO:0031175 neuron projection development 28.5714 6 yes
GO:0042981 regulation of apoptotic process 28.5714 5 yes
GO:0043067 regulation of programmed cell death 28.5714 4 yes
GO:0043523 regulation of neuron apoptotic process 28.5714 6 yes
GO:0050890 cognition 28.5714 4 yes
GO:0097485 neuron projection guidance 28.5714 7 yes
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 yes
GO:0001508 action potential 28.5714 4 no
GO:0006816 calcium ion transport 28.5714 7 no
GO:0006873 intracellular monoatomic ion homeostasis 28.5714 4 no
GO:0006874 intracellular calcium ion homeostasis 28.5714 5 no
GO:0008016 regulation of heart contraction 28.5714 6 no
GO:0015031 protein transport 28.5714 4 no
GO:0030003 intracellular monoatomic cation homeostasis 28.5714 5 no
GO:0032411 positive regulation of transporter activity 28.5714 4 no
GO:0032414 positive regulation of ion transmembrane transporter activity 28.5714 5 no
GO:0034329 cell junction assembly 28.5714 5 no
GO:0034764 positive regulation of transmembrane transport 28.5714 5 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 28.5714 6 no
GO:0043270 positive regulation of monoatomic ion transport 28.5714 5 no
GO:0044057 regulation of system process 28.5714 4 no
GO:0051282 regulation of sequestering of calcium ion 28.5714 4 no
GO:0051924 regulation of calcium ion transport 28.5714 7 no
GO:0055074 calcium ion homeostasis 28.5714 4 no
GO:0061024 membrane organization 28.5714 4 no
GO:0098657 import into cell 28.5714 4 no
GO:0141124 intracellular signaling cassette 28.5714 4 no
GO:1901016 regulation of potassium ion transmembrane transporter activity 28.5714 6 no
GO:1901019 regulation of calcium ion transmembrane transporter activity 28.5714 6 no
GO:1901379 regulation of potassium ion transmembrane transport 28.5714 7 no
GO:1903169 regulation of calcium ion transmembrane transport 28.5714 7 no
GO:1903522 regulation of blood circulation 28.5714 5 no
GO:1904064 positive regulation of cation transmembrane transport 28.5714 7 no
GO:2001259 positive regulation of cation channel activity 28.5714 6 no
GO:0002028 regulation of sodium ion transport 28.5714 7 no
GO:0007409 axonogenesis 28.5714 6 no
GO:0010038 response to metal ion 28.5714 4 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0022407 regulation of cell-cell adhesion 28.5714 5 no
GO:0030155 regulation of cell adhesion 28.5714 4 no
GO:0032410 negative regulation of transporter activity 28.5714 4 no
GO:0032413 negative regulation of ion transmembrane transporter activity 28.5714 5 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0034763 negative regulation of transmembrane transport 28.5714 5 no
GO:0034766 negative regulation of monoatomic ion transmembrane transport 28.5714 6 no
GO:0043271 negative regulation of monoatomic ion transport 28.5714 5 no
GO:0048812 neuron projection morphogenesis 28.5714 5 no
GO:0050808 synapse organization 28.5714 5 no
GO:0051051 negative regulation of transport 28.5714 4 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0070201 regulation of establishment of protein localization 28.5714 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 4 no
GO:1904063 negative regulation of cation transmembrane transport 28.5714 7 no
GO:2001258 negative regulation of cation channel activity 28.5714 6 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0009966 regulation of signal transduction 28.5714 4 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0043408 regulation of MAPK cascade 28.5714 6 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0046903 secretion 28.5714 4 no
GO:0048638 regulation of developmental growth 28.5714 4 no
GO:0050767 regulation of neurogenesis 28.5714 6 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0050807 regulation of synapse organization 28.5714 5 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0051960 regulation of nervous system development 28.5714 5 no
GO:0060284 regulation of cell development 28.5714 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 28.5714 7 no
GO:0080090 regulation of primary metabolic process 28.5714 4 no
GO:0098655 monoatomic cation transmembrane transport 28.5714 4 no
GO:0098662 inorganic cation transmembrane transport 28.5714 4 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CNTN6_HUMAN [view interactions] Low throughput no yes
PTPRA_HUMAN [view interactions] Low throughput no yes
EPHA7_HUMAN [view entry] [view interactions] Low throughput yes no
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
LEG1_HUMAN [view interactions] High throughput no yes
FERM2_HUMAN [view interactions] High throughput no yes
E2F1_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
ANK1_HUMAN [view entry] [view interactions] High throughput yes no
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
RL1D1_HUMAN [view interactions] High throughput no yes