Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

NCHL1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in NCHL1_HUMAN
GO:0046872 metal ion binding 30.7692 4 no
GO:0004713 protein tyrosine kinase activity 23.0769 4 no
GO:0005524 ATP binding 23.0769 5 no
GO:0016301 kinase activity 23.0769 4 no
GO:0016773 phosphotransferase activity, alcohol group as acceptor 23.0769 4 no
GO:0017076 purine nucleotide binding 23.0769 4 no
GO:0030554 adenyl nucleotide binding 23.0769 5 no
GO:0032555 purine ribonucleotide binding 23.0769 4 no
GO:0032559 adenyl ribonucleotide binding 23.0769 5 no
GO:0035639 purine ribonucleoside triphosphate binding 23.0769 4 no
GO:0035254 glutamate receptor binding 23.0769 4 no
GO:0001664 G protein-coupled receptor binding 23.0769 4 no
GO:0002020 protease binding 15.3846 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in NCHL1_HUMAN
GO:0048523 negative regulation of cellular process 69.2308 4 yes
GO:0048522 positive regulation of cellular process 69.2308 4 no
GO:0030030 cell projection organization 61.5385 4 yes
GO:0051049 regulation of transport 61.5385 4 no
GO:0009893 positive regulation of metabolic process 61.5385 4 no
GO:0010604 positive regulation of macromolecule metabolic process 61.5385 5 no
GO:0060255 regulation of macromolecule metabolic process 61.5385 4 no
GO:0010941 regulation of cell death 53.8462 4 yes
GO:0010646 regulation of cell communication 53.8462 4 no
GO:0060548 negative regulation of cell death 46.1538 5 yes
GO:1901214 regulation of neuron death 46.1538 5 yes
GO:0022607 cellular component assembly 46.1538 4 no
GO:0034762 regulation of transmembrane transport 46.1538 4 no
GO:0034765 regulation of ion transmembrane transport 46.1538 5 no
GO:0043269 regulation of ion transport 46.1538 5 no
GO:0031323 regulation of cellular metabolic process 46.1538 4 no
GO:0031325 positive regulation of cellular metabolic process 46.1538 5 no
GO:0051128 regulation of cellular component organization 46.1538 4 no
GO:0051171 regulation of nitrogen compound metabolic process 46.1538 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 46.1538 5 no
GO:0080090 regulation of primary metabolic process 46.1538 4 no
GO:0008104 protein localization 46.1538 4 no
GO:0010468 regulation of gene expression 46.1538 5 no
GO:0042981 regulation of apoptotic process 38.4615 6 yes
GO:0043067 regulation of programmed cell death 38.4615 5 yes
GO:0043523 regulation of neuron apoptotic process 38.4615 6 yes
GO:0050890 cognition 38.4615 4 yes
GO:0120036 plasma membrane bounded cell projection organization 38.4615 5 yes
GO:0001932 regulation of protein phosphorylation 38.4615 7 no
GO:0001934 positive regulation of protein phosphorylation 38.4615 8 no
GO:0009966 regulation of signal transduction 38.4615 4 no
GO:0010562 positive regulation of phosphorus metabolic process 38.4615 6 no
GO:0019220 regulation of phosphate metabolic process 38.4615 6 no
GO:0030155 regulation of cell adhesion 38.4615 4 no
GO:0031399 regulation of protein modification process 38.4615 6 no
GO:0031401 positive regulation of protein modification process 38.4615 7 no
GO:0042325 regulation of phosphorylation 38.4615 7 no
GO:0042327 positive regulation of phosphorylation 38.4615 8 no
GO:0045937 positive regulation of phosphate metabolic process 38.4615 7 no
GO:0050807 regulation of synapse organization 38.4615 5 no
GO:0051129 negative regulation of cellular component organization 38.4615 5 no
GO:0051174 regulation of phosphorus metabolic process 38.4615 5 no
GO:0051246 regulation of protein metabolic process 38.4615 5 no
GO:0051247 positive regulation of protein metabolic process 38.4615 6 no
GO:1902531 regulation of intracellular signal transduction 38.4615 5 no
GO:0010959 regulation of metal ion transport 38.4615 6 no
GO:0016192 vesicle-mediated transport 38.4615 4 no
GO:0032880 regulation of protein localization 38.4615 5 no
GO:0032990 cell part morphogenesis 38.4615 4 no
GO:0048812 neuron projection morphogenesis 38.4615 7 no
GO:0048858 cell projection morphogenesis 38.4615 5 no
GO:0051050 positive regulation of transport 38.4615 4 no
GO:0051223 regulation of protein transport 38.4615 5 no
GO:0060341 regulation of cellular localization 38.4615 4 no
GO:0070201 regulation of establishment of protein localization 38.4615 6 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 38.4615 6 no
GO:1904062 regulation of cation transmembrane transport 38.4615 6 no
GO:0071310 cellular response to organic substance 30.7692 4 no
GO:0001764 neuron migration 30.7692 4 yes
GO:0007411 axon guidance 30.7692 8 yes
GO:0031175 neuron projection development 30.7692 6 yes
GO:0043066 negative regulation of apoptotic process 30.7692 7 yes
GO:0043069 negative regulation of programmed cell death 30.7692 6 yes
GO:0097485 neuron projection guidance 30.7692 7 yes
GO:0006811 ion transport 30.7692 4 no
GO:0006812 cation transport 30.7692 5 no
GO:0030001 metal ion transport 30.7692 6 no
GO:0006796 phosphate-containing compound metabolic process 30.7692 4 no
GO:0022407 regulation of cell-cell adhesion 30.7692 5 no
GO:0031344 regulation of cell projection organization 30.7692 5 no
GO:0031345 negative regulation of cell projection organization 30.7692 6 no
GO:0043085 positive regulation of catalytic activity 30.7692 4 no
GO:0045595 regulation of cell differentiation 30.7692 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 30.7692 8 no
GO:0050767 regulation of neurogenesis 30.7692 6 no
GO:0051241 negative regulation of multicellular organismal process 30.7692 4 no
GO:0051960 regulation of nervous system development 30.7692 5 no
GO:0060284 regulation of cell development 30.7692 5 no
GO:0099175 regulation of postsynapse organization 30.7692 6 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 30.7692 6 no
GO:2000026 regulation of multicellular organismal development 30.7692 4 no
GO:0007409 axonogenesis 30.7692 8 no
GO:0009889 regulation of biosynthetic process 30.7692 4 no
GO:0009892 negative regulation of metabolic process 30.7692 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.7692 5 no
GO:0010628 positive regulation of gene expression 30.7692 6 no
GO:0010647 positive regulation of cell communication 30.7692 5 no
GO:0022898 regulation of transmembrane transporter activity 30.7692 4 no
GO:0031324 negative regulation of cellular metabolic process 30.7692 5 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0032412 regulation of ion transmembrane transporter activity 30.7692 5 no
GO:0042127 regulation of cell population proliferation 30.7692 4 no
GO:0043266 regulation of potassium ion transport 30.7692 7 no
GO:0048585 negative regulation of response to stimulus 30.7692 4 no
GO:0048878 chemical homeostasis 30.7692 4 no
GO:0050801 ion homeostasis 30.7692 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 30.7692 5 no
GO:0051924 regulation of calcium ion transport 30.7692 7 no
GO:0055065 metal ion homeostasis 30.7692 7 no
GO:0055080 cation homeostasis 30.7692 6 no
GO:0071702 organic substance transport 30.7692 4 no
GO:0098771 inorganic ion homeostasis 30.7692 6 no
GO:1903169 regulation of calcium ion transmembrane transport 30.7692 7 no
GO:0051222 positive regulation of protein transport 23.0769 5 no
GO:0090313 regulation of protein targeting to membrane 23.0769 7 no
GO:0090314 positive regulation of protein targeting to membrane 23.0769 7 no
GO:0090316 positive regulation of intracellular protein transport 23.0769 6 no
GO:1903533 regulation of protein targeting 23.0769 7 no
GO:1903829 positive regulation of protein localization 23.0769 5 no
GO:1904951 positive regulation of establishment of protein localization 23.0769 6 no
GO:1905475 regulation of protein localization to membrane 23.0769 6 no
GO:1905477 positive regulation of protein localization to membrane 23.0769 6 no
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 23.0769 9 no
GO:0099173 postsynapse organization 23.0769 4 no
GO:0043524 negative regulation of neuron apoptotic process 23.0769 7 yes
GO:1901215 negative regulation of neuron death 23.0769 6 yes
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 23.0769 4 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 23.0769 5 no
GO:0010942 positive regulation of cell death 23.0769 5 no
GO:0010975 regulation of neuron projection development 23.0769 7 no
GO:0022603 regulation of anatomical structure morphogenesis 23.0769 4 no
GO:0030162 regulation of proteolysis 23.0769 6 no
GO:0033674 positive regulation of kinase activity 23.0769 6 no
GO:0043408 regulation of MAPK cascade 23.0769 6 no
GO:0043549 regulation of kinase activity 23.0769 5 no
GO:0044087 regulation of cellular component biogenesis 23.0769 4 no
GO:0048638 regulation of developmental growth 23.0769 4 no
GO:0051336 regulation of hydrolase activity 23.0769 4 no
GO:0051338 regulation of transferase activity 23.0769 4 no
GO:0051347 positive regulation of transferase activity 23.0769 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 23.0769 7 no
GO:1901216 positive regulation of neuron death 23.0769 6 no
GO:0002683 negative regulation of immune system process 23.0769 4 no
GO:0006355 regulation of DNA-templated transcription 23.0769 6 no
GO:0006816 calcium ion transport 23.0769 7 no
GO:0006873 cellular ion homeostasis 23.0769 4 no
GO:0006875 cellular metal ion homeostasis 23.0769 6 no
GO:0009967 positive regulation of signal transduction 23.0769 5 no
GO:0009968 negative regulation of signal transduction 23.0769 5 no
GO:0010038 response to metal ion 23.0769 4 no
GO:0010243 response to organonitrogen compound 23.0769 4 no
GO:0010556 regulation of macromolecule biosynthetic process 23.0769 5 no
GO:0010648 negative regulation of cell communication 23.0769 5 no
GO:0010720 positive regulation of cell development 23.0769 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.0769 5 no
GO:0023056 positive regulation of signaling 23.0769 4 no
GO:0023057 negative regulation of signaling 23.0769 4 no
GO:0030003 cellular cation homeostasis 23.0769 5 no
GO:0031400 negative regulation of protein modification process 23.0769 7 no
GO:0032101 regulation of response to external stimulus 23.0769 4 no
GO:0032102 negative regulation of response to external stimulus 23.0769 5 no
GO:0034330 cell junction organization 23.0769 4 no
GO:0043270 positive regulation of ion transport 23.0769 5 no
GO:0045597 positive regulation of cell differentiation 23.0769 5 no
GO:0048584 positive regulation of response to stimulus 23.0769 4 no
GO:0050769 positive regulation of neurogenesis 23.0769 6 no
GO:0050776 regulation of immune response 23.0769 4 no
GO:0050804 modulation of chemical synaptic transmission 23.0769 5 no
GO:0051094 positive regulation of developmental process 23.0769 4 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0051248 negative regulation of protein metabolic process 23.0769 6 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 no
GO:0051962 positive regulation of nervous system development 23.0769 5 no
GO:0072507 divalent inorganic cation homeostasis 23.0769 7 no
GO:0099177 regulation of trans-synaptic signaling 23.0769 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.0769 6 no
GO:1903506 regulation of nucleic acid-templated transcription 23.0769 7 no
GO:2001141 regulation of RNA biosynthetic process 23.0769 6 no
GO:2001257 regulation of cation channel activity 23.0769 6 no
GO:0015031 protein transport 23.0769 4 no
GO:0033365 protein localization to organelle 23.0769 5 no
GO:0061024 membrane organization 23.0769 4 no
GO:0071705 nitrogen compound transport 23.0769 4 no
GO:0072657 protein localization to membrane 23.0769 4 no
GO:0072659 protein localization to plasma membrane 23.0769 5 no
GO:1901379 regulation of potassium ion transmembrane transport 23.0769 7 no
GO:1990778 protein localization to cell periphery 23.0769 5 no
GO:0032386 regulation of intracellular transport 23.0769 5 no
GO:0032388 positive regulation of intracellular transport 23.0769 5 no
GO:0033157 regulation of intracellular protein transport 23.0769 6 no
GO:0045785 positive regulation of cell adhesion 23.0769 5 no
GO:0008344 adult locomotory behavior 15.3846 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CNTN6_HUMAN [view interactions] Low throughput no yes
PTPRA_HUMAN [view interactions] Low throughput no yes
EPHA7_HUMAN [view entry] [view interactions] Low throughput yes no
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
LEG1_HUMAN [view interactions] High throughput no yes
ANK3_HUMAN [view entry] [view interactions] High throughput yes yes
FERM2_HUMAN [view interactions] High throughput no yes
E2F1_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
ANK1_HUMAN [view entry] [view interactions] High throughput yes no
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
KCNA3_HUMAN [view entry] [view interactions] High throughput yes no
RL1D1_HUMAN [view interactions] High throughput no yes
PTPRZ_HUMAN [view entry] [view interactions] Computational yes yes
GFRA1_HUMAN [view interactions] Computational no no
CD44_HUMAN [view interactions] Computational no yes
SIA8D_HUMAN [view interactions] Computational no yes
HSP7C_HUMAN [view entry] [view interactions] Computational yes yes
FYN_HUMAN [view entry] [view interactions] Computational yes no
NRP1_HUMAN [view entry] [view interactions] Computational yes yes
PRIO_HUMAN [view entry] [view interactions] Computational yes yes
RIPR2_HUMAN [view interactions] Computational no no
GDNF_HUMAN [view interactions] Computational no yes
NCAN_HUMAN [view entry] [view interactions] Computational yes no