Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ANK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
463 Val Ile Spherocytosis1(SPH1) -
276 Leu Arg Spherocytosis1(SPH1) -
1054 Ile Thr Spherocytosis1(SPH1) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ANK1_HUMAN
GO:0019900 kinase binding 23.8095 4 no
GO:0019901 protein kinase binding 23.8095 5 no
GO:0051117 ATPase binding 14.2857 4 yes
GO:0019902 phosphatase binding 9.5238 4 yes
GO:0019903 protein phosphatase binding 9.5238 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ANK1_HUMAN
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0048522 positive regulation of cellular process 61.9048 4 yes
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0031323 regulation of cellular metabolic process 47.6190 4 no
GO:0008104 protein localization 42.8571 4 yes
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0060255 regulation of macromolecule metabolic process 42.8571 4 no
GO:0042981 regulation of apoptotic process 38.0952 5 no
GO:0043067 regulation of programmed cell death 38.0952 4 no
GO:1902531 regulation of intracellular signal transduction 38.0952 5 no
GO:0048584 positive regulation of response to stimulus 38.0952 4 no
GO:0009892 negative regulation of metabolic process 38.0952 4 no
GO:0080090 regulation of primary metabolic process 38.0952 4 no
GO:0006996 organelle organization 33.3333 4 yes
GO:0033043 regulation of organelle organization 33.3333 5 yes
GO:0072657 protein localization to membrane 33.3333 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0007010 cytoskeleton organization 28.5714 5 yes
GO:0051130 positive regulation of cellular component organization 28.5714 5 yes
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0022607 cellular component assembly 28.5714 4 no
GO:0051240 positive regulation of multicellular organismal process 28.5714 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0019220 regulation of phosphate metabolic process 28.5714 6 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0051174 regulation of phosphorus metabolic process 28.5714 5 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0072659 protein localization to plasma membrane 23.8095 5 yes
GO:1990778 protein localization to cell periphery 23.8095 5 yes
GO:0051049 regulation of transport 23.8095 4 no
GO:0009968 negative regulation of signal transduction 23.8095 5 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:0030030 cell projection organization 23.8095 4 no
GO:0043066 negative regulation of apoptotic process 23.8095 6 no
GO:0043069 negative regulation of programmed cell death 23.8095 5 no
GO:0043408 regulation of MAPK cascade 23.8095 6 no
GO:0048585 negative regulation of response to stimulus 23.8095 4 no
GO:1902532 negative regulation of intracellular signal transduction 23.8095 6 no
GO:0001817 regulation of cytokine production 23.8095 4 no
GO:0031325 positive regulation of cellular metabolic process 23.8095 5 no
GO:0030334 regulation of cell migration 23.8095 5 no
GO:0032101 regulation of response to external stimulus 23.8095 4 no
GO:0051094 positive regulation of developmental process 23.8095 4 no
GO:2000145 regulation of cell motility 23.8095 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 23.8095 4 no
GO:0001932 regulation of protein phosphorylation 23.8095 7 no
GO:0042325 regulation of phosphorylation 23.8095 7 no
GO:0009967 positive regulation of signal transduction 23.8095 5 no
GO:0010647 positive regulation of cell communication 23.8095 5 no
GO:0023056 positive regulation of signaling 23.8095 4 no
GO:0055080 monoatomic cation homeostasis 23.8095 4 no
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 14.2857 4 yes
GO:0010638 positive regulation of organelle organization 14.2857 6 yes
GO:0046903 secretion 14.2857 4 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 9.5238 4 yes
GO:0035090 maintenance of apical/basal cell polarity 9.5238 4 yes
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 9.5238 5 yes
GO:0045199 maintenance of epithelial cell apical/basal polarity 9.5238 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
B3AT_HUMAN [view entry] [view interactions] Low throughput yes no
B3A3_HUMAN [view entry] [view interactions] Low throughput yes no
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTA1_HUMAN [view interactions] Low throughput no no
RYR1_HUMAN [view interactions] Low throughput no no
CD44_HUMAN [view entry] [view interactions] Low throughput yes yes
GLPB_HUMAN [view interactions] Low throughput no no
GLPA_HUMAN [view interactions] Low throughput no no
EPB42_HUMAN [view entry] [view interactions] Low throughput yes no
RHCE_HUMAN [view interactions] Low throughput no no
ANK1_HUMAN [view entry] [view interactions] Low throughput yes no
RHAG_HUMAN [view interactions] Low throughput no no
OBSCN_HUMAN [view interactions] Low throughput no yes
TITIN_HUMAN [view interactions] Low throughput no no
KCTD6_HUMAN [view interactions] Low throughput no yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
TGFR1_HUMAN [view interactions] High throughput no no
RPGF5_HUMAN [view interactions] High throughput no yes
NCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
FIG4_HUMAN [view interactions] High throughput no yes
FYV1_HUMAN [view interactions] High throughput no no
MYG_HUMAN [view interactions] High throughput no no
PDS5B_HUMAN [view interactions] High throughput no yes
VAC14_HUMAN [view entry] [view interactions] High throughput yes yes
NELFB_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
EP300_HUMAN [view interactions] High throughput no yes
MYPT2_HUMAN [view interactions] High throughput no no
ANO6_HUMAN [view entry] [view interactions] High throughput yes no
BRI3B_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
FXYD3_HUMAN [view interactions] High throughput no yes
RBFA_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
EMP1_HUMAN [view interactions] High throughput no no
NRM_HUMAN [view interactions] High throughput no no
ZNT8_HUMAN [view interactions] High throughput no no
TM203_HUMAN [view interactions] High throughput no no
RTP2_HUMAN [view interactions] High throughput no no