Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ANK1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
463 Val Ile Spherocytosis1(SPH1) -
276 Leu Arg Spherocytosis1(SPH1) -
1054 Ile Thr Spherocytosis1(SPH1) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ANK1_HUMAN
GO:0019900 kinase binding 27.2727 4 no
GO:0019901 protein kinase binding 22.7273 5 no
GO:0030506 ankyrin binding 22.7273 4 no
GO:0051117 ATPase binding 13.6364 4 yes
GO:0019902 phosphatase binding 9.0909 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ANK1_HUMAN
GO:0048522 positive regulation of cellular process 63.6364 4 no
GO:0048523 negative regulation of cellular process 54.5455 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0008104 protein localization 45.4545 4 yes
GO:0010468 regulation of gene expression 40.9091 5 no
GO:0071702 organic substance transport 40.9091 4 no
GO:0031323 regulation of cellular metabolic process 40.9091 4 no
GO:0051128 regulation of cellular component organization 40.9091 4 no
GO:0072657 protein localization to membrane 36.3636 4 yes
GO:0072659 protein localization to plasma membrane 36.3636 5 yes
GO:1990778 protein localization to cell periphery 36.3636 5 yes
GO:0009893 positive regulation of metabolic process 36.3636 4 no
GO:0010646 regulation of cell communication 36.3636 4 no
GO:0022607 cellular component assembly 36.3636 4 no
GO:0061024 membrane organization 36.3636 4 no
GO:0051171 regulation of nitrogen compound metabolic process 36.3636 4 no
GO:0080090 regulation of primary metabolic process 36.3636 4 no
GO:0016192 vesicle-mediated transport 31.8182 4 yes
GO:0051049 regulation of transport 31.8182 4 no
GO:0030030 cell projection organization 31.8182 4 no
GO:0009892 negative regulation of metabolic process 31.8182 4 no
GO:0006811 ion transport 27.2727 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.2727 5 no
GO:0071705 nitrogen compound transport 27.2727 4 no
GO:0009966 regulation of signal transduction 27.2727 4 no
GO:0010605 negative regulation of macromolecule metabolic process 27.2727 5 no
GO:0010941 regulation of cell death 27.2727 4 no
GO:0019220 regulation of phosphate metabolic process 27.2727 6 no
GO:0031324 negative regulation of cellular metabolic process 27.2727 5 no
GO:0042325 regulation of phosphorylation 27.2727 7 no
GO:0042981 regulation of apoptotic process 27.2727 6 no
GO:0043067 regulation of programmed cell death 27.2727 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 27.2727 5 no
GO:0051174 regulation of phosphorus metabolic process 27.2727 5 no
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 no
GO:0006996 organelle organization 22.7273 4 yes
GO:0007010 cytoskeleton organization 22.7273 5 yes
GO:0008016 regulation of heart contraction 22.7273 6 no
GO:0010959 regulation of metal ion transport 22.7273 6 no
GO:0015031 protein transport 22.7273 4 no
GO:0043269 regulation of ion transport 22.7273 5 no
GO:0044057 regulation of system process 22.7273 4 no
GO:0048878 chemical homeostasis 22.7273 4 no
GO:0050801 ion homeostasis 22.7273 5 no
GO:0051050 positive regulation of transport 22.7273 4 no
GO:0055080 cation homeostasis 22.7273 6 no
GO:0098771 inorganic ion homeostasis 22.7273 6 no
GO:1903522 regulation of blood circulation 22.7273 5 no
GO:0031399 regulation of protein modification process 22.7273 6 no
GO:0051246 regulation of protein metabolic process 22.7273 5 no
GO:0033043 regulation of organelle organization 22.7273 5 no
GO:0051094 positive regulation of developmental process 22.7273 4 no
GO:0048193 Golgi vesicle transport 18.1818 5 yes
GO:0046903 secretion 13.6364 4 yes
GO:0006887 exocytosis 9.0909 4 yes
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 9.0909 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RHAG_HUMAN [view interactions] Low throughput no no
OBSCN_HUMAN [view interactions] Low throughput no yes
TITIN_HUMAN [view interactions] Low throughput no no
KCTD6_HUMAN [view interactions] Low throughput no yes
B3AT_HUMAN [view entry] [view interactions] Low throughput yes no
B3A3_HUMAN [view entry] [view interactions] Low throughput yes no
TIAM1_HUMAN [view entry] [view interactions] Low throughput yes yes
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTB1_HUMAN [view entry] [view interactions] Low throughput yes yes
SPTA1_HUMAN [view interactions] Low throughput no no
RYR1_HUMAN [view interactions] Low throughput no no
CD44_HUMAN [view interactions] Low throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
FXYD3_HUMAN [view interactions] High throughput no yes
RBFA_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
EMP1_HUMAN [view interactions] High throughput no no
NRM_HUMAN [view interactions] High throughput no no
ZNT8_HUMAN [view interactions] High throughput no no
TM203_HUMAN [view interactions] High throughput no no
RTP2_HUMAN [view interactions] High throughput no no
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
TGFR1_HUMAN [view interactions] High throughput no no
RPGF5_HUMAN [view interactions] High throughput no yes
NCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
FIG4_HUMAN [view interactions] High throughput no yes
FYV1_HUMAN [view interactions] High throughput no no
MYG_HUMAN [view interactions] High throughput no no
PDS5B_HUMAN [view interactions] High throughput no yes
VAC14_HUMAN [view entry] [view interactions] High throughput yes yes
NELFB_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
EP300_HUMAN [view interactions] High throughput no yes
MYPT2_HUMAN [view interactions] High throughput no no
ANO6_HUMAN [view entry] [view interactions] High throughput yes no
BRI3B_HUMAN [view interactions] High throughput no yes
FGFR1_HUMAN [view interactions] High throughput no yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR3_HUMAN [view interactions] Computational no yes
NRCAM_HUMAN [view entry] [view interactions] Computational yes no
ITPR2_HUMAN [view interactions] Computational no yes
NFASC_HUMAN [view entry] [view interactions] Computational yes yes
ANK3_HUMAN [view entry] [view interactions] Computational yes yes
SPTN4_HUMAN [view entry] [view interactions] Computational yes no
TRPV1_HUMAN [view entry] [view interactions] Computational yes no
ITAM_HUMAN [view interactions] Computational no no
ANK2_HUMAN [view entry] [view interactions] Computational yes yes