Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EPB42_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
112 Ala Thr Spherocytosis5(SPH5) -
280 Arg Gln Spherocytosis5(SPH5) -
145 Asp Tyr Spherocytosis5(SPH5) -
287 Arg Cys Spherocytosis5(SPH5) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EPB42_HUMAN
GO:0000166 nucleotide binding 40.0000 4 yes
GO:0017076 purine nucleotide binding 40.0000 5 yes
GO:0032555 purine ribonucleotide binding 40.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 40.0000 4 yes
GO:0043168 anion binding 40.0000 4 yes
GO:0005524 ATP binding 30.0000 5 yes
GO:0030554 adenyl nucleotide binding 30.0000 6 yes
GO:0032559 adenyl ribonucleotide binding 30.0000 5 yes
GO:0016755 aminoacyltransferase activity 20.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EPB42_HUMAN
GO:0048523 negative regulation of cellular process 60.0000 4 no
GO:0008104 protein localization 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0071702 organic substance transport 50.0000 4 no
GO:0080090 regulation of primary metabolic process 50.0000 4 no
GO:0055080 monoatomic cation homeostasis 40.0000 4 yes
GO:0009889 regulation of biosynthetic process 40.0000 4 no
GO:0010468 regulation of gene expression 40.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 40.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 40.0000 5 no
GO:0048522 positive regulation of cellular process 40.0000 4 no
GO:0071705 nitrogen compound transport 40.0000 4 no
GO:0009892 negative regulation of metabolic process 40.0000 4 no
GO:0006996 organelle organization 40.0000 4 no
GO:0007010 cytoskeleton organization 40.0000 5 no
GO:0022603 regulation of anatomical structure morphogenesis 30.0000 4 yes
GO:0006811 monoatomic ion transport 30.0000 4 no
GO:0010646 regulation of cell communication 30.0000 4 no
GO:0015031 protein transport 30.0000 4 no
GO:0051049 regulation of transport 30.0000 4 no
GO:0061024 membrane organization 30.0000 4 no
GO:0072657 protein localization to membrane 30.0000 4 no
GO:0072659 protein localization to plasma membrane 30.0000 5 no
GO:0141124 intracellular signaling cassette 30.0000 4 no
GO:1990778 protein localization to cell periphery 30.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.0000 5 no
GO:0019220 regulation of phosphate metabolic process 30.0000 6 no
GO:0031324 negative regulation of cellular metabolic process 30.0000 5 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 30.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 30.0000 5 no
GO:0051128 regulation of cellular component organization 30.0000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.0000 5 no
GO:0042981 regulation of apoptotic process 30.0000 5 no
GO:0043066 negative regulation of apoptotic process 30.0000 6 no
GO:0043067 regulation of programmed cell death 30.0000 4 no
GO:0043069 negative regulation of programmed cell death 30.0000 5 no
GO:0051246 regulation of protein metabolic process 30.0000 5 no
GO:0071310 cellular response to organic substance 30.0000 4 no
GO:0020027 hemoglobin metabolic process 20.0000 4 yes
GO:0022604 regulation of cell morphogenesis 20.0000 5 yes
GO:0043249 erythrocyte maturation 20.0000 4 yes
GO:0048534 hematopoietic or lymphoid organ development 20.0000 4 yes
GO:0048536 spleen development 20.0000 5 yes
GO:0060586 multicellular organismal-level iron ion homeostasis 20.0000 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ISK7_HUMAN [view interactions] Low throughput no no
B3AT_HUMAN [view entry] [view interactions] Low throughput yes no
ANK2_HUMAN [view entry] [view interactions] Low throughput yes yes
RASK_HUMAN [view entry] [view interactions] Low throughput yes no
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
GLPB_HUMAN [view interactions] Low throughput no no
GLPA_HUMAN [view interactions] Low throughput no no
ANK1_HUMAN [view entry] [view interactions] Low throughput yes no
RHCE_HUMAN [view interactions] Low throughput no no
RHAG_HUMAN [view interactions] Low throughput no no
EPB42_HUMAN [view entry] [view interactions] Low throughput yes no
MK14_HUMAN [view interactions] High throughput no yes
ZNF16_HUMAN [view interactions] High throughput no no
AQP1_HUMAN [view entry] [view interactions] High throughput yes no
KLK6_HUMAN [view interactions] High throughput no no
S4A7_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
FACD2_HUMAN [view interactions] High throughput no no
LARP7_HUMAN [view interactions] High throughput no yes