Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EPB42_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Probably plays an important role in the regulation of erythrocyte shape and mechanical properties. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
112 Ala Thr Spherocytosis5(SPH5) -
280 Arg Gln Spherocytosis5(SPH5) -
145 Asp Tyr Spherocytosis5(SPH5) -
287 Arg Cys Spherocytosis5(SPH5) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EPB42_HUMAN
GO:0017076 purine nucleotide binding 37.5000 4 yes
GO:0032555 purine ribonucleotide binding 37.5000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 yes
GO:0005524 ATP binding 25.0000 5 yes
GO:0030554 adenyl nucleotide binding 25.0000 5 yes
GO:0032559 adenyl ribonucleotide binding 25.0000 5 yes
GO:0045296 cadherin binding 25.0000 4 no
GO:0042803 protein homodimerization activity 25.0000 4 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no

Biological process

Term Name % Distance from top the of the tree Annotated in EPB42_HUMAN
GO:0048523 negative regulation of cellular process 75.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 no
GO:0071702 organic substance transport 62.5000 4 no
GO:0051171 regulation of nitrogen compound metabolic process 62.5000 4 no
GO:0080090 regulation of primary metabolic process 62.5000 4 no
GO:0048878 chemical homeostasis 50.0000 4 yes
GO:0008104 protein localization 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 5 no
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0071705 nitrogen compound transport 50.0000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 50.0000 5 no
GO:0050801 ion homeostasis 37.5000 5 yes
GO:0055080 cation homeostasis 37.5000 6 yes
GO:0098771 inorganic ion homeostasis 37.5000 6 yes
GO:0006996 organelle organization 37.5000 4 no
GO:0007010 cytoskeleton organization 37.5000 5 no
GO:0006811 ion transport 37.5000 4 no
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 37.5000 5 no
GO:0010628 positive regulation of gene expression 37.5000 6 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0015031 protein transport 37.5000 4 no
GO:0016192 vesicle-mediated transport 37.5000 4 no
GO:0051049 regulation of transport 37.5000 4 no
GO:0061024 membrane organization 37.5000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0010941 regulation of cell death 37.5000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 37.5000 5 no
GO:0019220 regulation of phosphate metabolic process 37.5000 6 no
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 no
GO:0042325 regulation of phosphorylation 37.5000 7 no
GO:0042981 regulation of apoptotic process 37.5000 6 no
GO:0043066 negative regulation of apoptotic process 37.5000 7 no
GO:0043067 regulation of programmed cell death 37.5000 5 no
GO:0043069 negative regulation of programmed cell death 37.5000 6 no
GO:0043086 negative regulation of catalytic activity 37.5000 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 37.5000 6 no
GO:0051174 regulation of phosphorus metabolic process 37.5000 5 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0060548 negative regulation of cell death 37.5000 5 no
GO:0071310 cellular response to organic substance 37.5000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 yes
GO:0055065 metal ion homeostasis 25.0000 7 yes
GO:0032535 regulation of cellular component size 25.0000 4 no
GO:0032970 regulation of actin filament-based process 25.0000 4 no
GO:0043254 regulation of protein-containing complex assembly 25.0000 5 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0051128 regulation of cellular component organization 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:1902904 negative regulation of supramolecular fiber organization 25.0000 6 no
GO:0006812 cation transport 25.0000 5 no
GO:0006873 cellular ion homeostasis 25.0000 4 no
GO:0019932 second-messenger-mediated signaling 25.0000 4 no
GO:0030001 metal ion transport 25.0000 6 no
GO:0030003 cellular cation homeostasis 25.0000 5 no
GO:0033365 protein localization to organelle 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0051050 positive regulation of transport 25.0000 4 no
GO:0072657 protein localization to membrane 25.0000 4 no
GO:0072659 protein localization to plasma membrane 25.0000 5 no
GO:1990778 protein localization to cell periphery 25.0000 5 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0006355 regulation of DNA-templated transcription 25.0000 6 no
GO:0006886 intracellular protein transport 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0042326 negative regulation of phosphorylation 25.0000 8 no
GO:0043523 regulation of neuron apoptotic process 25.0000 6 no
GO:0043524 negative regulation of neuron apoptotic process 25.0000 7 no
GO:0045892 negative regulation of DNA-templated transcription 25.0000 7 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0051253 negative regulation of RNA metabolic process 25.0000 6 no
GO:0071417 cellular response to organonitrogen compound 25.0000 4 no
GO:1901214 regulation of neuron death 25.0000 5 no
GO:1901215 negative regulation of neuron death 25.0000 6 no
GO:1901699 cellular response to nitrogen compound 25.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 25.0000 4 no
GO:1902679 negative regulation of RNA biosynthetic process 25.0000 7 no
GO:1903506 regulation of nucleic acid-templated transcription 25.0000 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 25.0000 8 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0009416 response to light stimulus 25.0000 4 no
GO:0014070 response to organic cyclic compound 25.0000 4 no
GO:0032870 cellular response to hormone stimulus 25.0000 4 no
GO:0033993 response to lipid 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0048545 response to steroid hormone 25.0000 4 no
GO:0071383 cellular response to steroid hormone stimulus 25.0000 5 no
GO:0071396 cellular response to lipid 25.0000 5 no
GO:0071407 cellular response to organic cyclic compound 25.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 25.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 25.0000 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ISK7_HUMAN [view interactions] Low throughput no no
B3AT_HUMAN [view entry] [view interactions] Low throughput yes no
ANK2_HUMAN [view entry] [view interactions] Low throughput yes yes
RASK_HUMAN [view entry] [view interactions] Low throughput yes no
SPTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
MK14_HUMAN [view interactions] High throughput no yes
ZNF16_HUMAN [view interactions] High throughput no no
AQP1_HUMAN [view entry] [view interactions] High throughput yes no
KLK6_HUMAN [view interactions] High throughput no no
S4A7_HUMAN [view interactions] High throughput no no
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
FACD2_HUMAN [view interactions] High throughput no no
LARP7_HUMAN [view interactions] High throughput no yes