Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

B3AT_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI000605 MOD_N-GLC_1 MOD 641 646 -
ELMI000605 MOD_N-GLC_1 MOD 641 646 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in B3AT_HUMAN
GO:0043169 cation binding 34.6154 4 no
GO:0046872 metal ion binding 30.7692 5 no
GO:0000166 nucleotide binding 23.0769 4 no
GO:0022853 active monoatomic ion transmembrane transporter activity 19.2308 4 yes
GO:0008509 monoatomic anion transmembrane transporter activity 15.3846 4 yes
GO:0030506 ankyrin binding 11.5385 4 yes
GO:0042803 protein homodimerization activity 11.5385 4 yes
GO:0005452 solute:inorganic anion antiporter activity 7.6923 5 yes
GO:0015103 inorganic anion transmembrane transporter activity 7.6923 4 yes
GO:0015106 bicarbonate transmembrane transporter activity 7.6923 4 yes
GO:0015108 chloride transmembrane transporter activity 7.6923 5 yes
GO:0015291 secondary active transmembrane transporter activity 7.6923 4 yes
GO:0015297 antiporter activity 7.6923 5 yes
GO:0140829 bicarbonate:monoatomic anion antiporter activity 7.6923 5 yes
GO:0140900 chloride:bicarbonate antiporter activity 7.6923 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in B3AT_HUMAN
GO:0048523 negative regulation of cellular process 53.8462 4 yes
GO:0048522 positive regulation of cellular process 46.1538 4 no
GO:0051049 regulation of transport 42.3077 4 no
GO:0031323 regulation of cellular metabolic process 42.3077 4 yes
GO:0071702 organic substance transport 42.3077 4 yes
GO:0080090 regulation of primary metabolic process 42.3077 4 yes
GO:0009892 negative regulation of metabolic process 38.4615 4 yes
GO:0010646 regulation of cell communication 34.6154 4 no
GO:0060255 regulation of macromolecule metabolic process 34.6154 4 no
GO:0051128 regulation of cellular component organization 30.7692 4 no
GO:0006811 monoatomic ion transport 30.7692 4 yes
GO:0008104 protein localization 30.7692 4 yes
GO:0031324 negative regulation of cellular metabolic process 30.7692 5 yes
GO:0055080 monoatomic cation homeostasis 30.7692 4 yes
GO:0009889 regulation of biosynthetic process 30.7692 4 no
GO:0009966 regulation of signal transduction 30.7692 4 no
GO:0031326 regulation of cellular biosynthetic process 30.7692 5 no
GO:0051246 regulation of protein metabolic process 30.7692 5 no
GO:1902531 regulation of intracellular signal transduction 30.7692 5 no
GO:0006873 intracellular monoatomic ion homeostasis 26.9231 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 26.9231 5 yes
GO:0006996 organelle organization 26.9231 4 no
GO:0010468 regulation of gene expression 26.9231 6 no
GO:0010556 regulation of macromolecule biosynthetic process 26.9231 5 no
GO:0010605 negative regulation of macromolecule metabolic process 26.9231 5 no
GO:0010647 positive regulation of cell communication 26.9231 5 no
GO:0023056 positive regulation of signaling 26.9231 4 no
GO:0051240 positive regulation of multicellular organismal process 26.9231 4 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0071705 nitrogen compound transport 23.0769 4 no
GO:0009894 regulation of catabolic process 23.0769 4 yes
GO:0019220 regulation of phosphate metabolic process 23.0769 6 yes
GO:0051174 regulation of phosphorus metabolic process 23.0769 5 yes
GO:0061024 membrane organization 23.0769 4 yes
GO:0072657 protein localization to membrane 23.0769 4 yes
GO:0072659 protein localization to plasma membrane 23.0769 5 yes
GO:1990778 protein localization to cell periphery 23.0769 5 yes
GO:0009893 positive regulation of metabolic process 23.0769 4 no
GO:0009967 positive regulation of signal transduction 23.0769 5 no
GO:0010604 positive regulation of macromolecule metabolic process 23.0769 5 no
GO:0031325 positive regulation of cellular metabolic process 23.0769 5 no
GO:0048584 positive regulation of response to stimulus 23.0769 4 no
GO:0051248 negative regulation of protein metabolic process 23.0769 6 no
GO:0071310 cellular response to organic substance 23.0769 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.0769 6 no
GO:0034762 regulation of transmembrane transport 23.0769 4 no
GO:0043269 regulation of monoatomic ion transport 23.0769 5 no
GO:0006869 lipid transport 15.3846 5 yes
GO:0015711 organic anion transport 15.3846 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 15.3846 5 yes
GO:0006820 monoatomic anion transport 11.5385 5 yes
GO:0007009 plasma membrane organization 11.5385 5 yes
GO:0009895 negative regulation of catabolic process 11.5385 5 yes
GO:0010563 negative regulation of phosphorus metabolic process 11.5385 6 yes
GO:0015701 bicarbonate transport 11.5385 6 yes
GO:0030097 hemopoiesis 11.5385 4 yes
GO:0045936 negative regulation of phosphate metabolic process 11.5385 7 yes
GO:0061515 myeloid cell development 11.5385 5 yes
GO:0062012 regulation of small molecule metabolic process 11.5385 4 yes
GO:0062014 negative regulation of small molecule metabolic process 11.5385 5 yes
GO:0006109 regulation of carbohydrate metabolic process 7.6923 5 yes
GO:0006110 regulation of glycolytic process 7.6923 6 yes
GO:0006140 regulation of nucleotide metabolic process 7.6923 5 yes
GO:0006821 chloride transport 7.6923 5 yes
GO:0007599 hemostasis 7.6923 4 yes
GO:0015698 inorganic anion transport 7.6923 4 yes
GO:0015748 organophosphate ester transport 7.6923 5 yes
GO:0015914 phospholipid transport 7.6923 6 yes
GO:0017121 plasma membrane phospholipid scrambling 7.6923 6 yes
GO:0030811 regulation of nucleotide catabolic process 7.6923 5 yes
GO:0030812 negative regulation of nucleotide catabolic process 7.6923 6 yes
GO:0033121 regulation of purine nucleotide catabolic process 7.6923 6 yes
GO:0033122 negative regulation of purine nucleotide catabolic process 7.6923 7 yes
GO:0034204 lipid translocation 7.6923 4 yes
GO:0035809 regulation of urine volume 7.6923 4 yes
GO:0035811 negative regulation of urine volume 7.6923 5 yes
GO:0043467 regulation of generation of precursor metabolites and energy 7.6923 5 yes
GO:0043470 regulation of carbohydrate catabolic process 7.6923 5 yes
GO:0045332 phospholipid translocation 7.6923 5 yes
GO:0045820 negative regulation of glycolytic process 7.6923 6 yes
GO:0045912 negative regulation of carbohydrate metabolic process 7.6923 5 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 7.6923 5 yes
GO:0045980 negative regulation of nucleotide metabolic process 7.6923 6 yes
GO:0048821 erythrocyte development 7.6923 6 yes
GO:0098656 monoatomic anion transmembrane transport 7.6923 4 yes
GO:0098661 inorganic anion transmembrane transport 7.6923 4 yes
GO:1900542 regulation of purine nucleotide metabolic process 7.6923 6 yes
GO:1900543 negative regulation of purine nucleotide metabolic process 7.6923 7 yes
GO:1902476 chloride transmembrane transport 7.6923 5 yes
GO:1903578 regulation of ATP metabolic process 7.6923 7 yes
GO:1903579 negative regulation of ATP metabolic process 7.6923 8 yes
GO:1904538 regulation of glycolytic process through fructose-6-phosphate 7.6923 7 yes
GO:1904539 negative regulation of glycolytic process through fructose-6-phosphate 7.6923 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDN2A_HUMAN [view interactions] Low throughput no yes
AT1B1_HUMAN [view entry] [view interactions] Low throughput yes no
G3P_HUMAN [view entry] [view interactions] Low throughput yes yes
PERM_HUMAN [view entry] [view interactions] Low throughput yes no
PTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
EPB42_HUMAN [view entry] [view interactions] Low throughput yes no
FLOT2_HUMAN [view entry] [view interactions] Low throughput yes yes
GTR1_HUMAN [view entry] [view interactions] Low throughput yes no
STOM_HUMAN [view entry] [view interactions] Low throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] Low throughput yes no
GLPA_HUMAN [view interactions] Low throughput no no
B3AT_HUMAN [view entry] [view interactions] Low throughput yes no
NADAP_HUMAN [view interactions] Low throughput no yes
ANK1_HUMAN [view entry] [view interactions] Low throughput yes no
CALX_HUMAN [view entry] [view interactions] Low throughput yes yes
CLUS_HUMAN [view entry] [view interactions] Low throughput yes yes
HBA_HUMAN [view interactions] Low throughput no no
KAT2B_HUMAN [view interactions] Low throughput no yes
CAH2_HUMAN [view entry] [view interactions] Low throughput yes no
CAH4_HUMAN [view entry] [view interactions] Low throughput yes yes
KSYK_HUMAN [view interactions] Low throughput no no
ZAP70_HUMAN [view interactions] Low throughput no no
RHAG_HUMAN [view interactions] Low throughput no no
RHCE_HUMAN [view interactions] Low throughput no no
GLPB_HUMAN [view interactions] Low throughput no no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
KELL_HUMAN [view entry] [view interactions] High throughput yes no
S40A1_HUMAN [view interactions] High throughput no no
UT1_HUMAN [view interactions] High throughput no no
BCAM_HUMAN [view interactions] High throughput no yes
ICAM4_HUMAN [view interactions] High throughput no no
SPTA1_HUMAN [view interactions] High throughput no no
SPTB1_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
AQP1_HUMAN [view entry] [view interactions] High throughput yes no
AT2B4_HUMAN [view entry] [view interactions] High throughput yes yes
KCNQ1_HUMAN [view interactions] High throughput no yes
CAV3_HUMAN [view interactions] High throughput no no
TMM60_HUMAN [view interactions] High throughput no no
FHR5_HUMAN [view interactions] High throughput no no
BMP10_HUMAN [view interactions] High throughput no no
ADA33_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
BRD2_HUMAN [view interactions] High throughput no yes
BRD3_HUMAN [view interactions] High throughput no yes
NIPS2_HUMAN [view interactions] High throughput no yes
TOM40_HUMAN [view interactions] High throughput no yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC3_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes