PERM_HUMAN
Evidence for PS localization
Functions
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PERM_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 41.6667 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 33.3333 | 4 | no |
| GO:0020037 | heme binding | 25.0000 | 4 | yes |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PERM_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 75.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 75.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 66.6667 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 66.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 66.6667 | 4 | no |
| GO:0010941 | regulation of cell death | 58.3333 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 50.0000 | 6 | yes |
| GO:0043066 | negative regulation of apoptotic process | 50.0000 | 7 | yes |
| GO:0043067 | regulation of programmed cell death | 50.0000 | 5 | yes |
| GO:0043069 | negative regulation of programmed cell death | 50.0000 | 6 | yes |
| GO:0060548 | negative regulation of cell death | 50.0000 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 50.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 50.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.6667 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 41.6667 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 41.6667 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.6667 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.6667 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 41.6667 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 41.6667 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 41.6667 | 5 | no |
| GO:0033993 | response to lipid | 33.3333 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0071310 | cellular response to organic substance | 33.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0009894 | regulation of catabolic process | 33.3333 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 33.3333 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 33.3333 | 7 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 33.3333 | 7 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0080134 | regulation of response to stress | 33.3333 | 4 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0031667 | response to nutrient levels | 25.0000 | 4 | yes |
| GO:0042743 | hydrogen peroxide metabolic process | 25.0000 | 4 | yes |
| GO:0042744 | hydrogen peroxide catabolic process | 25.0000 | 4 | yes |
| GO:0043436 | oxoacid metabolic process | 25.0000 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0015980 | energy derivation by oxidation of organic compounds | 25.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0042326 | negative regulation of phosphorylation | 25.0000 | 8 | no |
| GO:0043086 | negative regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 25.0000 | 4 | no |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 25.0000 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 25.0000 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.0000 | 4 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 25.0000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 25.0000 | 4 | no |
| GO:2001233 | regulation of apoptotic signaling pathway | 25.0000 | 5 | no |
| GO:0022411 | cellular component disassembly | 25.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0031334 | positive regulation of protein-containing complex assembly | 25.0000 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 25.0000 | 5 | no |
| GO:0001878 | response to yeast | 16.6667 | 4 | yes |
| GO:0002148 | hypochlorous acid metabolic process | 16.6667 | 4 | yes |
| GO:0002149 | hypochlorous acid biosynthetic process | 16.6667 | 4 | yes |
| GO:0002237 | response to molecule of bacterial origin | 16.6667 | 4 | yes |
| GO:0006801 | superoxide metabolic process | 16.6667 | 4 | yes |
| GO:0019430 | removal of superoxide radicals | 16.6667 | 4 | yes |
| GO:0032496 | response to lipopolysaccharide | 16.6667 | 4 | yes |
| GO:0034367 | protein-containing complex remodeling | 16.6667 | 5 | yes |
| GO:0034368 | protein-lipid complex remodeling | 16.6667 | 6 | yes |
| GO:0034374 | low-density lipoprotein particle remodeling | 16.6667 | 4 | yes |
| GO:0042742 | defense response to bacterium | 16.6667 | 4 | yes |
| GO:0050832 | defense response to fungus | 16.6667 | 4 | yes |
| GO:0071825 | protein-lipid complex subunit organization | 16.6667 | 5 | yes |
| GO:1990268 | response to gold nanoparticle | 16.6667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CERU_HUMAN | [view interactions] | Low throughput | no | no |
| PERM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| B3AT_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GLPB_HUMAN | [view interactions] | Low throughput | no | no |
| GLPA_HUMAN | [view interactions] | Low throughput | no | no |
| ELOA2_HUMAN | [view interactions] | High throughput | no | yes |
| GOG8A_HUMAN | [view interactions] | High throughput | no | no |
| MAGB4_HUMAN | [view interactions] | High throughput | no | no |
| H1BP3_HUMAN | [view interactions] | High throughput | no | yes |
| CLCN2_HUMAN | [view interactions] | High throughput | no | yes |
| CP343_HUMAN | [view interactions] | High throughput | no | no |
| TIM10_HUMAN | [view interactions] | High throughput | no | yes |
| LRC17_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| PRKX_HUMAN | [view interactions] | High throughput | no | yes |
| EGFL8_HUMAN | [view interactions] | High throughput | no | no |
| ITLN2_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| SMIM8_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| KLK10_HUMAN | [view interactions] | High throughput | no | no |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| ELNE_HUMAN | [view interactions] | High throughput | no | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S10A8_HUMAN | [view interactions] | High throughput | no | no |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| PROP_HUMAN | [view interactions] | High throughput | no | no |
| CO3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CO9_HUMAN | [view interactions] | High throughput | no | no |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB22A_HUMAN | [view interactions] | High throughput | no | yes |
| PF21B_HUMAN | [view interactions] | High throughput | no | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| ICE2_HUMAN | [view interactions] | High throughput | no | no |
| FRMD1_HUMAN | [view interactions] | High throughput | no | no |
| APCD1_HUMAN | [view interactions] | High throughput | no | no |
| PLB1_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| EYA1_HUMAN | [view interactions] | High throughput | no | no |
| FBXW8_HUMAN | [view interactions] | High throughput | no | yes |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| PRTN3_HUMAN | [view interactions] | High throughput | no | no |
| TRFL_HUMAN | [view interactions] | High throughput | no | no |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| CX001_HUMAN | [view interactions] | High throughput | no | no |
| ERO1A_HUMAN | [view interactions] | High throughput | no | yes |
| MAEA_HUMAN | [view interactions] | High throughput | no | yes |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| CRP_HUMAN | [view interactions] | Computational | no | no |
| CAP7_HUMAN | [view interactions] | Computational | no | no |
| APOA1_HUMAN | [view interactions] | Computational | no | no |
| IL1B_HUMAN | [view interactions] | Computational | no | no |
| IL6_HUMAN | [view interactions] | Computational | no | no |
| PGH1_HUMAN | [view interactions] | Computational | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARY2_HUMAN | [view interactions] | Computational | no | no |
| PON1_HUMAN | [view interactions] | Computational | no | no |
| ECP_HUMAN | [view interactions] | Computational | no | no |
| FINC_HUMAN | [view interactions] | Computational | no | yes |
| DEF4_HUMAN | [view interactions] | Computational | no | no |
| ITAM_HUMAN | [view interactions] | Computational | no | no |
| CATG_HUMAN | [view interactions] | Computational | no | no |
| RUNX1_HUMAN | [view interactions] | Computational | no | yes |
| PLSL_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| EST1_HUMAN | [view interactions] | Computational | no | no |
| TNFA_HUMAN | [view interactions] | Computational | no | no |
| BPI_HUMAN | [view interactions] | Computational | no | no |