PERM_HUMAN
Evidence for PS localization
Functions
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PERM_HUMAN |
|---|---|---|---|---|
| GO:0042803 | protein homodimerization activity | 36.3636 | 4 | no |
| GO:0020037 | heme binding | 27.2727 | 4 | yes |
| GO:0043169 | cation binding | 27.2727 | 4 | yes |
| GO:0046872 | metal ion binding | 27.2727 | 5 | yes |
| GO:0019900 | kinase binding | 27.2727 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PERM_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 90.9091 | 4 | yes |
| GO:0010646 | regulation of cell communication | 72.7273 | 4 | no |
| GO:0009966 | regulation of signal transduction | 63.6364 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 63.6364 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 63.6364 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 63.6364 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 54.5455 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 54.5455 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 54.5455 | 4 | yes |
| GO:0043069 | negative regulation of programmed cell death | 54.5455 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 54.5455 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 54.5455 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 54.5455 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 45.4545 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 45.4545 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 45.4545 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 45.4545 | 6 | no |
| GO:0051128 | regulation of cellular component organization | 45.4545 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 45.4545 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 45.4545 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 45.4545 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 45.4545 | 5 | no |
| GO:0033993 | response to lipid | 36.3636 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 36.3636 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 36.3636 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 36.3636 | 5 | no |
| GO:0023057 | negative regulation of signaling | 36.3636 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 36.3636 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 36.3636 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 36.3636 | 5 | no |
| GO:0010468 | regulation of gene expression | 36.3636 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.3636 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 36.3636 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.3636 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.3636 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 36.3636 | 6 | no |
| GO:0031399 | regulation of protein modification process | 36.3636 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.3636 | 4 | no |
| GO:0051049 | regulation of transport | 36.3636 | 4 | no |
| GO:0051050 | positive regulation of transport | 36.3636 | 4 | no |
| GO:0080134 | regulation of response to stress | 36.3636 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 36.3636 | 6 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 36.3636 | 7 | no |
| GO:0009894 | regulation of catabolic process | 36.3636 | 4 | no |
| GO:0042743 | hydrogen peroxide metabolic process | 27.2727 | 4 | yes |
| GO:0042744 | hydrogen peroxide catabolic process | 27.2727 | 4 | yes |
| GO:0043436 | oxoacid metabolic process | 27.2727 | 4 | yes |
| GO:0006996 | organelle organization | 27.2727 | 4 | no |
| GO:1902532 | negative regulation of intracellular signal transduction | 27.2727 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 27.2727 | 7 | no |
| GO:0010647 | positive regulation of cell communication | 27.2727 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 27.2727 | 4 | no |
| GO:0023056 | positive regulation of signaling | 27.2727 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 27.2727 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 27.2727 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 27.2727 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 27.2727 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.2727 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 27.2727 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0080135 | regulation of cellular response to stress | 27.2727 | 4 | no |
| GO:2001233 | regulation of apoptotic signaling pathway | 27.2727 | 5 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 27.2727 | 4 | no |
| GO:0007169 | cell surface receptor protein tyrosine kinase signaling pathway | 27.2727 | 5 | no |
| GO:0001878 | response to yeast | 18.1818 | 4 | yes |
| GO:0002148 | hypochlorous acid metabolic process | 18.1818 | 4 | yes |
| GO:0002149 | hypochlorous acid biosynthetic process | 18.1818 | 4 | yes |
| GO:0002237 | response to molecule of bacterial origin | 18.1818 | 4 | yes |
| GO:0006801 | superoxide metabolic process | 18.1818 | 4 | yes |
| GO:0019430 | removal of superoxide radicals | 18.1818 | 4 | yes |
| GO:0032496 | response to lipopolysaccharide | 18.1818 | 4 | yes |
| GO:0034367 | protein-containing complex remodeling | 18.1818 | 5 | yes |
| GO:0034368 | protein-lipid complex remodeling | 18.1818 | 6 | yes |
| GO:0034374 | low-density lipoprotein particle remodeling | 18.1818 | 4 | yes |
| GO:0042742 | defense response to bacterium | 18.1818 | 4 | yes |
| GO:0050832 | defense response to fungus | 18.1818 | 4 | yes |
| GO:0071825 | protein-lipid complex organization | 18.1818 | 5 | yes |
| GO:1990268 | response to gold nanoparticle | 18.1818 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| B3AT_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GLPB_HUMAN | [view interactions] | Low throughput | no | no |
| GLPA_HUMAN | [view interactions] | Low throughput | no | no |
| PERM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CERU_HUMAN | [view interactions] | Low throughput | no | no |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK1_HUMAN | [view interactions] | High throughput | no | yes |
| PROP_HUMAN | [view interactions] | High throughput | no | no |
| CO3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CO9_HUMAN | [view interactions] | High throughput | no | no |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB22A_HUMAN | [view interactions] | High throughput | no | yes |
| PF21B_HUMAN | [view interactions] | High throughput | no | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| A2MG_HUMAN | [view interactions] | High throughput | no | yes |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| ICE2_HUMAN | [view interactions] | High throughput | no | no |
| FRMD1_HUMAN | [view interactions] | High throughput | no | no |
| APCD1_HUMAN | [view interactions] | High throughput | no | no |
| PLB1_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| EYA1_HUMAN | [view interactions] | High throughput | no | no |
| FBXW8_HUMAN | [view interactions] | High throughput | no | yes |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| PRTN3_HUMAN | [view interactions] | High throughput | no | no |
| TRFL_HUMAN | [view interactions] | High throughput | no | no |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| CX001_HUMAN | [view interactions] | High throughput | no | no |
| ERO1A_HUMAN | [view interactions] | High throughput | no | yes |
| MAEA_HUMAN | [view interactions] | High throughput | no | yes |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| STK11_HUMAN | [view interactions] | High throughput | no | yes |
| ELOA2_HUMAN | [view interactions] | High throughput | no | yes |
| GOG8A_HUMAN | [view interactions] | High throughput | no | no |
| MAGB4_HUMAN | [view interactions] | High throughput | no | no |
| H1BP3_HUMAN | [view interactions] | High throughput | no | yes |
| CLCN2_HUMAN | [view interactions] | High throughput | no | yes |
| CP343_HUMAN | [view interactions] | High throughput | no | no |
| TIM10_HUMAN | [view interactions] | High throughput | no | yes |
| LRC17_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| PRKX_HUMAN | [view interactions] | High throughput | no | yes |
| EGFL8_HUMAN | [view interactions] | High throughput | no | no |
| ITLN2_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| SMIM8_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| KLK10_HUMAN | [view interactions] | High throughput | no | no |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP36_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A2_HUMAN | [view interactions] | High throughput | no | yes |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| ELNE_HUMAN | [view interactions] | High throughput | no | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S10A8_HUMAN | [view interactions] | High throughput | no | no |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |