Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CO3_HUMAN

GO
G2C
SynGO

adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CO3_HUMAN
GO:0043169 cation binding 30.3030 4 no
GO:0046872 metal ion binding 30.3030 5 no
GO:0043168 anion binding 30.3030 4 no
GO:0001664 G protein-coupled receptor binding 21.2121 4 yes
GO:0000166 nucleotide binding 21.2121 4 no
GO:0017076 purine nucleotide binding 21.2121 5 no
GO:0032555 purine ribonucleotide binding 21.2121 4 no
GO:0003723 RNA binding 21.2121 4 no
GO:0019900 kinase binding 21.2121 4 no
GO:0019901 protein kinase binding 21.2121 5 no
GO:0004866 endopeptidase inhibitor activity 9.0909 5 yes
GO:0030414 peptidase inhibitor activity 9.0909 4 yes
GO:0061135 endopeptidase regulator activity 9.0909 4 yes
GO:0031714 C5a anaphylatoxin chemotactic receptor binding 6.0606 5 yes
GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding 6.0606 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CO3_HUMAN
GO:0048522 positive regulation of cellular process 63.6364 4 yes
GO:0031323 regulation of cellular metabolic process 57.5758 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.5455 4 yes
GO:0009893 positive regulation of metabolic process 54.5455 4 yes
GO:0009889 regulation of biosynthetic process 51.5152 4 yes
GO:0010468 regulation of gene expression 48.4848 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 48.4848 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 48.4848 5 yes
GO:0031325 positive regulation of cellular metabolic process 48.4848 5 yes
GO:0031326 regulation of cellular biosynthetic process 48.4848 5 yes
GO:0051128 regulation of cellular component organization 45.4545 4 yes
GO:0080090 regulation of primary metabolic process 42.4242 4 yes
GO:0022607 cellular component assembly 42.4242 4 no
GO:0048523 negative regulation of cellular process 39.3939 4 no
GO:0009891 positive regulation of biosynthetic process 39.3939 5 yes
GO:0010646 regulation of cell communication 39.3939 4 yes
GO:0051049 regulation of transport 36.3636 4 yes
GO:0009966 regulation of signal transduction 36.3636 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 36.3636 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 36.3636 6 yes
GO:0051130 positive regulation of cellular component organization 33.3333 5 yes
GO:0006996 organelle organization 33.3333 4 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0010243 response to organonitrogen compound 33.3333 4 no
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:0051094 positive regulation of developmental process 30.3030 4 yes
GO:0051246 regulation of protein metabolic process 30.3030 5 yes
GO:0008104 protein localization 30.3030 4 no
GO:0009892 negative regulation of metabolic process 30.3030 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.3030 5 no
GO:0031324 negative regulation of cellular metabolic process 30.3030 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.3030 5 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 yes
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 yes
GO:0051247 positive regulation of protein metabolic process 27.2727 6 yes
GO:0014070 response to organic cyclic compound 27.2727 4 no
GO:0042981 regulation of apoptotic process 27.2727 5 no
GO:0043067 regulation of programmed cell death 27.2727 4 no
GO:0071702 organic substance transport 27.2727 4 no
GO:0071705 nitrogen compound transport 27.2727 4 no
GO:0009890 negative regulation of biosynthetic process 27.2727 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 27.2727 6 no
GO:0031327 negative regulation of cellular biosynthetic process 27.2727 6 no
GO:0071310 cellular response to organic substance 27.2727 4 no
GO:0031399 regulation of protein modification process 27.2727 6 yes
GO:0051050 positive regulation of transport 24.2424 4 yes
GO:0051174 regulation of phosphorus metabolic process 24.2424 5 yes
GO:0065003 protein-containing complex assembly 24.2424 5 no
GO:0051252 regulation of RNA metabolic process 24.2424 5 no
GO:0010648 negative regulation of cell communication 24.2424 5 no
GO:0023057 negative regulation of signaling 24.2424 4 no
GO:1902531 regulation of intracellular signal transduction 24.2424 5 no
GO:0010628 positive regulation of gene expression 24.2424 7 yes
GO:0019220 regulation of phosphate metabolic process 24.2424 6 yes
GO:0034762 regulation of transmembrane transport 21.2121 4 yes
GO:0042325 regulation of phosphorylation 21.2121 7 yes
GO:0080134 regulation of response to stress 21.2121 4 yes
GO:0044057 regulation of system process 21.2121 4 no
GO:0009894 regulation of catabolic process 21.2121 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.2121 5 no
GO:0060341 regulation of cellular localization 21.2121 4 no
GO:0033043 regulation of organelle organization 21.2121 5 no
GO:0006355 regulation of DNA-templated transcription 21.2121 7 no
GO:0009968 negative regulation of signal transduction 21.2121 5 no
GO:0010629 negative regulation of gene expression 21.2121 7 no
GO:0048585 negative regulation of response to stimulus 21.2121 4 no
GO:0071417 cellular response to organonitrogen compound 21.2121 4 no
GO:1901699 cellular response to nitrogen compound 21.2121 4 no
GO:2001141 regulation of RNA biosynthetic process 21.2121 6 no
GO:0009967 positive regulation of signal transduction 21.2121 5 yes
GO:0010647 positive regulation of cell communication 21.2121 5 yes
GO:0023056 positive regulation of signaling 21.2121 4 yes
GO:0031401 positive regulation of protein modification process 21.2121 7 yes
GO:0034330 cell junction organization 18.1818 4 yes
GO:0045937 positive regulation of phosphate metabolic process 18.1818 7 yes
GO:0050776 regulation of immune response 18.1818 4 yes
GO:0140546 defense response to symbiont 18.1818 4 yes
GO:2000026 regulation of multicellular organismal development 18.1818 4 yes
GO:0001817 regulation of cytokine production 18.1818 4 yes
GO:0001932 regulation of protein phosphorylation 18.1818 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 18.1818 6 yes
GO:0022603 regulation of anatomical structure morphogenesis 18.1818 4 yes
GO:0034764 positive regulation of transmembrane transport 15.1515 5 yes
GO:0042327 positive regulation of phosphorylation 15.1515 8 yes
GO:0050778 positive regulation of immune response 15.1515 5 yes
GO:0002684 positive regulation of immune system process 15.1515 4 yes
GO:0032103 positive regulation of response to external stimulus 12.1212 5 yes
GO:0043436 oxoacid metabolic process 12.1212 4 yes
GO:0050808 synapse organization 12.1212 5 yes
GO:0001934 positive regulation of protein phosphorylation 12.1212 8 yes
GO:0006954 inflammatory response 12.1212 4 yes
GO:0006958 complement activation, classical pathway 12.1212 4 yes
GO:0019216 regulation of lipid metabolic process 12.1212 5 yes
GO:0022411 cellular component disassembly 12.1212 4 yes
GO:0031347 regulation of defense response 12.1212 5 yes
GO:0032101 regulation of response to external stimulus 12.1212 4 yes
GO:0045765 regulation of angiogenesis 9.0909 5 yes
GO:0045766 positive regulation of angiogenesis 9.0909 6 yes
GO:0046890 regulation of lipid biosynthetic process 9.0909 5 yes
GO:0060627 regulation of vesicle-mediated transport 9.0909 4 yes
GO:1901342 regulation of vasculature development 9.0909 5 yes
GO:1904018 positive regulation of vasculature development 9.0909 5 yes
GO:1905952 regulation of lipid localization 9.0909 4 yes
GO:0001819 positive regulation of cytokine production 9.0909 5 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 9.0909 4 yes
GO:0002697 regulation of immune effector process 9.0909 4 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 9.0909 4 yes
GO:0002920 regulation of humoral immune response 9.0909 5 yes
GO:0019752 carboxylic acid metabolic process 9.0909 5 yes
GO:0030100 regulation of endocytosis 9.0909 5 yes
GO:0030449 regulation of complement activation 9.0909 5 yes
GO:0031349 positive regulation of defense response 9.0909 5 yes
GO:0032787 monocarboxylic acid metabolic process 6.0606 6 yes
GO:0042551 neuron maturation 6.0606 4 yes
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway 6.0606 6 yes
GO:0045807 positive regulation of endocytosis 6.0606 5 yes
GO:0045917 positive regulation of complement activation 6.0606 6 yes
GO:0048259 regulation of receptor-mediated endocytosis 6.0606 6 yes
GO:0048260 positive regulation of receptor-mediated endocytosis 6.0606 6 yes
GO:0050727 regulation of inflammatory response 6.0606 5 yes
GO:0050729 positive regulation of inflammatory response 6.0606 6 yes
GO:0050764 regulation of phagocytosis 6.0606 6 yes
GO:0050766 positive regulation of phagocytosis 6.0606 6 yes
GO:0060099 regulation of phagocytosis, engulfment 6.0606 6 yes
GO:0060100 positive regulation of phagocytosis, engulfment 6.0606 7 yes
GO:0060429 epithelium development 6.0606 4 yes
GO:0090207 regulation of triglyceride metabolic process 6.0606 5 yes
GO:0098883 synapse pruning 6.0606 6 yes
GO:0150062 complement-mediated synapse pruning 6.0606 7 yes
GO:0150064 vertebrate eye-specific patterning 6.0606 4 yes
GO:0150146 cell junction disassembly 6.0606 5 yes
GO:1905153 regulation of membrane invagination 6.0606 5 yes
GO:1905155 positive regulation of membrane invagination 6.0606 6 yes
GO:1905954 positive regulation of lipid localization 6.0606 4 yes
GO:2000425 regulation of apoptotic cell clearance 6.0606 7 yes
GO:2000427 positive regulation of apoptotic cell clearance 6.0606 7 yes
GO:0001796 regulation of type IIa hypersensitivity 6.0606 8 yes
GO:0001798 positive regulation of type IIa hypersensitivity 6.0606 9 yes
GO:0001969 regulation of activation of membrane attack complex 6.0606 6 yes
GO:0001970 positive regulation of activation of membrane attack complex 6.0606 7 yes
GO:0002430 complement receptor mediated signaling pathway 6.0606 5 yes
GO:0002673 regulation of acute inflammatory response 6.0606 6 yes
GO:0002675 positive regulation of acute inflammatory response 6.0606 7 yes
GO:0002699 positive regulation of immune effector process 6.0606 5 yes
GO:0002703 regulation of leukocyte mediated immunity 6.0606 5 yes
GO:0002705 positive regulation of leukocyte mediated immunity 6.0606 6 yes
GO:0002706 regulation of lymphocyte mediated immunity 6.0606 6 yes
GO:0002708 positive regulation of lymphocyte mediated immunity 6.0606 7 yes
GO:0002712 regulation of B cell mediated immunity 6.0606 7 yes
GO:0002714 positive regulation of B cell mediated immunity 6.0606 8 yes
GO:0002819 regulation of adaptive immune response 6.0606 5 yes
GO:0002821 positive regulation of adaptive immune response 6.0606 6 yes
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 6.0606 6 yes
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 6.0606 7 yes
GO:0002861 regulation of inflammatory response to antigenic stimulus 6.0606 5 yes
GO:0002863 positive regulation of inflammatory response to antigenic stimulus 6.0606 6 yes
GO:0002864 regulation of acute inflammatory response to antigenic stimulus 6.0606 6 yes
GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus 6.0606 7 yes
GO:0002883 regulation of hypersensitivity 6.0606 7 yes
GO:0002885 positive regulation of hypersensitivity 6.0606 8 yes
GO:0002886 regulation of myeloid leukocyte mediated immunity 6.0606 6 yes
GO:0002888 positive regulation of myeloid leukocyte mediated immunity 6.0606 7 yes
GO:0002889 regulation of immunoglobulin mediated immune response 6.0606 8 yes
GO:0002891 positive regulation of immunoglobulin mediated immune response 6.0606 9 yes
GO:0002892 regulation of type II hypersensitivity 6.0606 7 yes
GO:0002894 positive regulation of type II hypersensitivity 6.0606 8 yes
GO:0002922 positive regulation of humoral immune response 6.0606 6 yes
GO:0006631 fatty acid metabolic process 6.0606 4 yes
GO:0006957 complement activation, alternative pathway 6.0606 4 yes
GO:0008277 regulation of G protein-coupled receptor signaling pathway 6.0606 5 yes
GO:0010574 regulation of vascular endothelial growth factor production 6.0606 5 yes
GO:0010575 positive regulation of vascular endothelial growth factor production 6.0606 6 yes
GO:0010827 regulation of glucose transmembrane transport 6.0606 5 yes
GO:0010828 positive regulation of glucose transmembrane transport 6.0606 6 yes
GO:0010866 regulation of triglyceride biosynthetic process 6.0606 6 yes
GO:0010883 regulation of lipid storage 6.0606 4 yes
GO:0010884 positive regulation of lipid storage 6.0606 5 yes
GO:0016322 neuron remodeling 6.0606 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
VSIG4_HUMAN [view interactions] Low throughput no no
MCP_HUMAN [view interactions] Low throughput no no
CFAH_HUMAN [view interactions] Low throughput no no
FHR4_HUMAN [view interactions] Low throughput no no
CR1_HUMAN [view interactions] Low throughput no no
CO3_HUMAN [view entry] [view interactions] Low throughput yes no
CR2_HUMAN [view interactions] Low throughput no no
CFAB_HUMAN [view interactions] Low throughput no no
PROP_HUMAN [view interactions] Low throughput no no
CFAI_HUMAN [view interactions] Low throughput no no
ITAM_HUMAN [view interactions] Low throughput no no
FHR5_HUMAN [view interactions] Low throughput no no
FHR3_HUMAN [view interactions] Low throughput no no
ITAX_HUMAN [view entry] [view interactions] Low throughput yes no
ITB2_HUMAN [view interactions] Low throughput no no
CO5_HUMAN [view interactions] Low throughput no no
A16L1_HUMAN [view entry] [view interactions] Low throughput yes yes
CBPN_HUMAN [view interactions] Low throughput no no
CFAD_HUMAN [view interactions] Low throughput no no
DAF_HUMAN [view interactions] Low throughput no no
FA10_HUMAN [view interactions] Low throughput no no
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
C3AR_HUMAN [view interactions] Low throughput no no
GNAO_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
TGM2_HUMAN [view interactions] High throughput no no
HMGB1_HUMAN [view interactions] High throughput no yes
NPHP1_HUMAN [view interactions] High throughput no yes
CAH8_HUMAN [view interactions] High throughput no no
DDX31_HUMAN [view interactions] High throughput no no
MK06_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
MOT11_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
MED23_HUMAN [view interactions] High throughput no no
MED20_HUMAN [view interactions] High throughput no no
PERM_HUMAN [view entry] [view interactions] High throughput yes no
CATG_HUMAN [view interactions] High throughput no no
CRP_HUMAN [view interactions] High throughput no no
DMBT1_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
ASF1B_HUMAN [view interactions] High throughput no yes
IGHM_HUMAN [view entry] [view interactions] High throughput yes no
DMD_HUMAN [view entry] [view interactions] High throughput yes no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
F13B_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
HDAC5_HUMAN [view interactions] High throughput no yes
RYBP_HUMAN [view interactions] High throughput no no
BICD1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
ANK2_HUMAN [view entry] [view interactions] High throughput yes yes
FA20C_HUMAN [view interactions] High throughput no no
K1H1_HUMAN [view interactions] High throughput no no
KR108_HUMAN [view interactions] High throughput no no
FBLN4_HUMAN [view interactions] High throughput no no
GG6L9_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
PKHF2_HUMAN [view interactions] High throughput no yes
IFT27_HUMAN [view interactions] High throughput no yes
ING4_HUMAN [view interactions] High throughput no no
TRFE_HUMAN [view interactions] High throughput no no
RAD21_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
GDPD1_HUMAN [view interactions] High throughput no no
ASCC1_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
WDTC1_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
CDK15_HUMAN [view interactions] High throughput no no
MYOME_HUMAN [view interactions] High throughput no no
ZSC20_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
TISD_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
NHLC2_HUMAN [view interactions] High throughput no yes
EYA1_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
SAMH1_HUMAN [view interactions] High throughput no yes
ANT3_HUMAN [view interactions] High throughput no no
HRG_HUMAN [view interactions] High throughput no no
H2B1O_HUMAN [view interactions] High throughput no yes
ITIH4_HUMAN [view interactions] High throughput no no
IC1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
WDR5_HUMAN [view interactions] High throughput no no
SRRT_HUMAN [view interactions] High throughput no yes
PTSS1_HUMAN [view interactions] High throughput no no
OR2A4_HUMAN [view interactions] High throughput no no
FNDC1_HUMAN [view interactions] High throughput no yes
STX17_HUMAN [view interactions] High throughput no yes
DSCR6_HUMAN [view interactions] High throughput no no
2ABB_HUMAN [view interactions] High throughput no yes
CRDL2_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
MBD4_HUMAN [view interactions] High throughput no yes
GBG8_HUMAN [view interactions] High throughput no no
SIA7F_HUMAN [view interactions] High throughput no yes
UBE2U_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
CIR1_HUMAN [view interactions] High throughput no yes
ADT3_HUMAN [view entry] [view interactions] High throughput yes yes
PDE6D_HUMAN [view interactions] High throughput no yes
CR021_HUMAN [view interactions] High throughput no no
RHBL4_HUMAN [view interactions] High throughput no no
SARAF_HUMAN [view interactions] High throughput no no
MBNL1_HUMAN [view interactions] High throughput no yes
SSUH2_HUMAN [view interactions] High throughput no no
SSBP2_HUMAN [view interactions] High throughput no yes
EGFL8_HUMAN [view interactions] High throughput no no
CERS3_HUMAN [view interactions] High throughput no no
PLCA_HUMAN [view interactions] High throughput no yes
SFXN4_HUMAN [view interactions] High throughput no yes
MATN2_HUMAN [view interactions] High throughput no no
ITLN2_HUMAN [view interactions] High throughput no no
PIGT_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
HMGC2_HUMAN [view interactions] High throughput no no
SG1D1_HUMAN [view interactions] High throughput no no
P2RX6_HUMAN [view entry] [view interactions] High throughput yes no
NRSN1_HUMAN [view interactions] High throughput no yes
KLK10_HUMAN [view interactions] High throughput no no
PRKX_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
GP141_HUMAN [view interactions] High throughput no no
PHF11_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
SOX2_HUMAN [view interactions] High throughput no yes
COPE_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
DYL2_HUMAN [view entry] [view interactions] High throughput yes no
MYCN_HUMAN [view interactions] High throughput no no
ZRAN1_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
ASXL2_HUMAN [view interactions] High throughput no no
ASXL1_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
UBP36_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
VTDB_HUMAN [view interactions] High throughput no yes
HPT_HUMAN [view interactions] High throughput no no
HPTR_HUMAN [view interactions] High throughput no no
EFGM_HUMAN [view interactions] High throughput no yes
T106B_HUMAN [view interactions] High throughput no yes
FOXO1_HUMAN [view interactions] High throughput no yes