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GNAO_HUMAN

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. [View more on UniProt]

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No data found.

ELM instance Name Type Start End Partner
ELMI000327 MOD_SPalmitoyl_4 MOD 1 7 -

Molecular function

Term Name % Distance from the top of the tree Annotated in GNAO_HUMAN
GO:0017076 purine nucleotide binding 34.0659 4 yes
GO:0032555 purine ribonucleotide binding 32.9670 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 30.7692 4 yes
GO:0016462 pyrophosphatase activity 28.5714 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.5714 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.5714 6 yes
GO:0003924 GTPase activity 27.4725 7 yes
GO:0046872 metal ion binding 27.4725 4 yes
GO:0019900 kinase binding 24.1758 4 no
GO:0019901 protein kinase binding 21.9780 5 no
GO:0001664 G protein-coupled receptor binding 18.6813 4 yes
GO:0005525 GTP binding 16.4835 5 yes
GO:0019001 guanyl nucleotide binding 16.4835 5 yes
GO:0032561 guanyl ribonucleotide binding 16.4835 5 yes
GO:0031821 G protein-coupled serotonin receptor binding 4.3956 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GNAO_HUMAN
GO:0010646 regulation of cell communication 60.4396 4 no
GO:0048522 positive regulation of cellular process 60.4396 4 no
GO:0048523 negative regulation of cellular process 56.0440 4 no
GO:0009966 regulation of signal transduction 51.6484 4 no
GO:0060255 regulation of macromolecule metabolic process 47.2527 4 no
GO:0031323 regulation of cellular metabolic process 46.1538 4 no
GO:0051049 regulation of transport 46.1538 4 no
GO:0051171 regulation of nitrogen compound metabolic process 45.0549 4 no
GO:0080090 regulation of primary metabolic process 45.0549 4 no
GO:0051128 regulation of cellular component organization 40.6593 4 no
GO:0009893 positive regulation of metabolic process 40.6593 4 no
GO:0031325 positive regulation of cellular metabolic process 36.2637 5 no
GO:0051246 regulation of protein metabolic process 36.2637 5 no
GO:0010647 positive regulation of cell communication 36.2637 5 no
GO:0023056 positive regulation of signaling 36.2637 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 32.9670 5 no
GO:0010468 regulation of gene expression 32.9670 5 no
GO:0010604 positive regulation of macromolecule metabolic process 32.9670 5 no
GO:0043085 positive regulation of catalytic activity 31.8681 4 no
GO:0050804 modulation of chemical synaptic transmission 31.8681 5 no
GO:0099177 regulation of trans-synaptic signaling 31.8681 4 no
GO:0019220 regulation of phosphate metabolic process 30.7692 6 no
GO:0048584 positive regulation of response to stimulus 30.7692 4 no
GO:0051174 regulation of phosphorus metabolic process 30.7692 5 no
GO:1902531 regulation of intracellular signal transduction 30.7692 5 no
GO:0051050 positive regulation of transport 30.7692 4 no
GO:0010941 regulation of cell death 30.7692 4 no
GO:0006996 organelle organization 30.7692 4 no
GO:0031399 regulation of protein modification process 29.6703 6 no
GO:0010648 negative regulation of cell communication 29.6703 5 no
GO:0023057 negative regulation of signaling 29.6703 4 no
GO:0043269 regulation of ion transport 29.6703 5 no
GO:0022607 cellular component assembly 29.6703 4 no
GO:0060341 regulation of cellular localization 29.6703 4 no
GO:0009892 negative regulation of metabolic process 29.6703 4 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0042981 regulation of apoptotic process 28.5714 6 no
GO:0043067 regulation of programmed cell death 28.5714 5 no
GO:0071310 cellular response to organic substance 28.5714 4 no
GO:0048585 negative regulation of response to stimulus 27.4725 4 no
GO:0051336 regulation of hydrolase activity 27.4725 4 no
GO:0010243 response to organonitrogen compound 27.4725 4 no
GO:0032880 regulation of protein localization 27.4725 5 no
GO:0051247 positive regulation of protein metabolic process 26.3736 6 no
GO:0009889 regulation of biosynthetic process 26.3736 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.3736 5 no
GO:0031326 regulation of cellular biosynthetic process 26.3736 5 no
GO:0001932 regulation of protein phosphorylation 26.3736 7 no
GO:0009967 positive regulation of signal transduction 26.3736 5 no
GO:0010605 negative regulation of macromolecule metabolic process 25.2747 5 no
GO:0051130 positive regulation of cellular component organization 25.2747 5 no
GO:0006796 phosphate-containing compound metabolic process 25.2747 4 no
GO:0030030 cell projection organization 24.1758 4 no
GO:0060548 negative regulation of cell death 24.1758 5 no
GO:0042127 regulation of cell population proliferation 24.1758 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 24.1758 4 yes
GO:0045937 positive regulation of phosphate metabolic process 23.0769 7 no
GO:0009968 negative regulation of signal transduction 23.0769 5 no
GO:0010556 regulation of macromolecule biosynthetic process 23.0769 5 no
GO:0051338 regulation of transferase activity 23.0769 4 no
GO:1901701 cellular response to oxygen-containing compound 23.0769 4 no
GO:0016192 vesicle-mediated transport 23.0769 4 no
GO:0010562 positive regulation of phosphorus metabolic process 23.0769 6 no
GO:0042327 positive regulation of phosphorylation 21.9780 8 no
GO:0051240 positive regulation of multicellular organismal process 21.9780 4 no
GO:0008104 protein localization 21.9780 4 no
GO:0044087 regulation of cellular component biogenesis 21.9780 4 no
GO:0006355 regulation of DNA-templated transcription 21.9780 6 no
GO:0051252 regulation of RNA metabolic process 21.9780 5 no
GO:1903506 regulation of nucleic acid-templated transcription 21.9780 7 no
GO:2001141 regulation of RNA biosynthetic process 21.9780 6 no
GO:0043066 negative regulation of apoptotic process 21.9780 7 no
GO:0043069 negative regulation of programmed cell death 21.9780 6 no
GO:0014070 response to organic cyclic compound 21.9780 4 no
GO:0031344 regulation of cell projection organization 21.9780 5 no
GO:0050890 cognition 21.9780 4 no
GO:0031401 positive regulation of protein modification process 20.8791 7 no
GO:0045595 regulation of cell differentiation 20.8791 4 no
GO:0051094 positive regulation of developmental process 20.8791 4 no
GO:0120036 plasma membrane bounded cell projection organization 20.8791 5 no
GO:0033043 regulation of organelle organization 20.8791 5 no
GO:0043549 regulation of kinase activity 20.8791 5 no
GO:0080134 regulation of response to stress 20.8791 4 no
GO:0051046 regulation of secretion 20.8791 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.8791 6 no

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CXCR5_HUMAN [view interactions] Low throughput no yes
RGS4_HUMAN [view interactions] Low throughput no no
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
KAP3_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS18_HUMAN [view interactions] Low throughput no yes
A4_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS16_HUMAN [view interactions] Low throughput no no
5HT1B_HUMAN [view interactions] Low throughput no no
RGS1_HUMAN [view interactions] Low throughput no yes
RGS7_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS10_HUMAN [view interactions] Low throughput no yes
RGS17_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS14_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS8_HUMAN [view entry] [view interactions] Low throughput yes yes
RGS19_HUMAN [view interactions] Low throughput no yes
RIC8A_HUMAN [view entry] [view interactions] Low throughput yes no
ZBT16_HUMAN [view interactions] Low throughput no yes
LDHA_HUMAN [view entry] [view interactions] Low throughput yes yes
GPSM2_HUMAN [view interactions] Low throughput no yes
PCP2_HUMAN [view interactions] Low throughput no no
CRFR1_HUMAN [view interactions] Low throughput no yes
RGS5_HUMAN [view interactions] Low throughput no no
OPRM_HUMAN [view entry] [view interactions] Low throughput yes no
OPRD_HUMAN [view entry] [view interactions] Low throughput yes no
RGS9_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRR_HUMAN [view interactions] Low throughput no yes
DRD3_HUMAN [view entry] [view interactions] Low throughput yes no
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
NGB_HUMAN [view interactions] Low throughput no yes
CAC1B_HUMAN [view interactions] Low throughput no yes
RGS20_HUMAN [view interactions] Low throughput no no
GABR1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADA2A_HUMAN [view entry] [view interactions] Low throughput yes no
ACM2_HUMAN [view entry] [view interactions] Low throughput yes yes
AGRG3_HUMAN [view interactions] Low throughput no no
GHRL_HUMAN [view entry] [view interactions] Low throughput yes no
GHSR_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
OCRL_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
ZBT18_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
LRRK2_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
VAMP2_HUMAN [view entry] [view interactions] High throughput yes no
AAPK1_HUMAN [view interactions] High throughput no no
AAKB1_HUMAN [view interactions] High throughput no yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
CALR_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
KS6A3_HUMAN [view entry] [view interactions] High throughput yes yes
TGFR2_HUMAN [view interactions] High throughput no no
CBX5_HUMAN [view interactions] High throughput no yes
NEK7_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
HAUS4_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
PCM1_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
HXB5_HUMAN [view interactions] High throughput no no
ARMC1_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
NUFP1_HUMAN [view interactions] High throughput no yes
DGUOK_HUMAN [view interactions] High throughput no yes
KTU_HUMAN [view interactions] High throughput no yes
GPR35_HUMAN [view interactions] High throughput no no
GNAI1_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
ZNT4_HUMAN [view interactions] High throughput no no
JSPR1_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
TMOD3_HUMAN [view interactions] High throughput no yes
GBG3_HUMAN [view entry] [view interactions] High throughput yes no
CXB7_HUMAN [view interactions] High throughput no no
CD69_HUMAN [view interactions] High throughput no no
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
DUS22_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
GLP1R_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
EMC5_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
GBG8_HUMAN [view interactions] High throughput no no
MYH4_HUMAN [view interactions] High throughput no no
GRAM4_HUMAN [view interactions] High throughput no no
GBG10_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
CERS2_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
MICA1_HUMAN [view interactions] High throughput no yes
P4K2A_HUMAN [view interactions] High throughput no yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
SNX1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTA_HUMAN [view interactions] High throughput no no
FXL22_HUMAN [view interactions] High throughput no no
DMWD_HUMAN [view entry] [view interactions] High throughput yes no
SGTB_HUMAN [view interactions] High throughput no yes
SNX5_HUMAN [view entry] [view interactions] High throughput yes yes
SPAG6_HUMAN [view interactions] High throughput no no
GNAT2_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
MOT1_HUMAN [view interactions] High throughput no no
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
ECHA_HUMAN [view entry] [view interactions] High throughput yes yes
CX6A1_HUMAN [view interactions] High throughput no yes
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
VISL1_HUMAN [view entry] [view interactions] High throughput yes no
GNA11_HUMAN [view entry] [view interactions] High throughput yes yes
GNA13_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL3_HUMAN [view interactions] High throughput no no
GNAQ_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
NEGR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYPR_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
SNP25_HUMAN [view entry] [view interactions] High throughput yes yes
SYPH_HUMAN [view entry] [view interactions] High throughput yes yes
QCR6L_HUMAN [view interactions] High throughput no yes
QCR6_HUMAN [view interactions] High throughput no yes
CNTN1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS5_HUMAN [view interactions] High throughput no yes
PLCB1_HUMAN [view entry] [view interactions] Computational yes yes
ADCY6_HUMAN [view interactions] Computational no yes
ADCY7_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
PAR1_HUMAN [view entry] [view interactions] Computational yes yes
PLF4_HUMAN [view interactions] Computational no no
AKT1_HUMAN [view entry] [view interactions] Computational yes yes
CD4_HUMAN [view interactions] Computational no no
EDNRB_HUMAN [view interactions] Computational no no
CD3E_HUMAN [view interactions] Computational no no
GBB3_HUMAN [view interactions] Computational no yes
DRA_HUMAN [view interactions] Computational no no
RGS6_HUMAN [view entry] [view interactions] Computational yes no
GBB4_HUMAN [view entry] [view interactions] Computational yes yes
ESR1_HUMAN [view interactions] Computational no no
ADCY8_HUMAN [view entry] [view interactions] Computational yes yes
CXCR3_HUMAN [view interactions] Computational no no
PLCB2_HUMAN [view interactions] Computational no no
GNAT3_HUMAN [view interactions] Computational no no
SMO_HUMAN [view interactions] Computational no yes
EDN1_HUMAN [view interactions] Computational no no
ADCY9_HUMAN [view interactions] Computational no yes
LCK_HUMAN [view entry] [view interactions] Computational yes no
PLCG1_HUMAN [view entry] [view interactions] Computational yes yes
DRB1_HUMAN [view interactions] Computational no no
SDF1_HUMAN [view interactions] Computational no no
CD3D_HUMAN [view interactions] Computational no no
GBG7_HUMAN [view entry] [view interactions] Computational yes yes
RHOA_HUMAN [view entry] [view interactions] Computational yes yes
GNB5_HUMAN [view entry] [view interactions] Computational yes yes
ADCY5_HUMAN [view interactions] Computational no no
RGS11_HUMAN [view interactions] Computational no yes
PAXI_HUMAN [view interactions] Computational no yes
GBG13_HUMAN [view interactions] Computational no no
ADCY2_HUMAN [view interactions] Computational no yes
RIC8B_HUMAN [view interactions] Computational no yes
PHLP_HUMAN [view interactions] Computational no yes
NOS3_HUMAN [view interactions] Computational no no
CDC42_HUMAN [view entry] [view interactions] Computational yes yes
CD3G_HUMAN [view interactions] Computational no no
LPAR1_HUMAN [view entry] [view interactions] Computational yes no
ADCY4_HUMAN [view interactions] Computational no yes
CD3Z_HUMAN [view interactions] Computational no no
GBGT2_HUMAN [view interactions] Computational no no
ADCY3_HUMAN [view interactions] Computational no yes
BCAR1_HUMAN [view interactions] Computational no yes
GNA15_HUMAN [view interactions] Computational no yes
S1PR5_HUMAN [view interactions] Computational no no
AXIN1_HUMAN [view interactions] Computational no yes
S1PR1_HUMAN [view interactions] Computational no no
MK14_HUMAN [view interactions] Computational no yes
RAC1_HUMAN [view entry] [view interactions] Computational yes no
GLI1_HUMAN [view interactions] Computational no no
GBG4_HUMAN [view interactions] Computational no no
ADCY1_HUMAN [view entry] [view interactions] Computational yes no
GNAT1_HUMAN [view interactions] Computational no no
GBG1_HUMAN [view interactions] Computational no no
CXCR4_HUMAN [view interactions] Computational no no
RASH_HUMAN [view entry] [view interactions] Computational yes no
S1PR3_HUMAN [view interactions] Computational no no
S1PR4_HUMAN [view interactions] Computational no no
MK03_HUMAN [view entry] [view interactions] Computational yes yes
GNA14_HUMAN [view entry] [view interactions] Computational yes yes
ANDR_HUMAN [view interactions] Computational no no
GBB2_HUMAN [view entry] [view interactions] Computational yes yes
GNAZ_HUMAN [view entry] [view interactions] Computational yes yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
MK08_HUMAN [view interactions] Computational no yes