GNAO_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI000327 | MOD_SPalmitoyl_4 | MOD | 1 | 7 | - |
| ELMI000327 | MOD_SPalmitoyl_4 | MOD | 1 | 7 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GNAO_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 26.1905 | 4 | yes |
| GO:0043168 | anion binding | 26.1905 | 4 | yes |
| GO:0043169 | cation binding | 26.1905 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | yes |
| GO:0046872 | metal ion binding | 25.0000 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 23.8095 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.8095 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.8095 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 23.8095 | 4 | yes |
| GO:0003924 | GTPase activity | 20.2381 | 7 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.2381 | 4 | yes |
| GO:0001664 | G protein-coupled receptor binding | 17.8571 | 4 | yes |
| GO:0005525 | GTP binding | 10.7143 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 10.7143 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 10.7143 | 5 | yes |
| GO:0031821 | G protein-coupled serotonin receptor binding | 2.3810 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GNAO_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 59.5238 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 59.5238 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.5714 | 4 | no |
| GO:0051049 | regulation of transport | 47.6190 | 4 | no |
| GO:0009966 | regulation of signal transduction | 46.4286 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.0476 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 39.2857 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 35.7143 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.7143 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.7143 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 32.1429 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.1429 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.1429 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 32.1429 | 5 | no |
| GO:0023057 | negative regulation of signaling | 32.1429 | 4 | no |
| GO:0006996 | organelle organization | 30.9524 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 30.9524 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 30.9524 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.7619 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.7619 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.7619 | 4 | no |
| GO:0010468 | regulation of gene expression | 28.5714 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.3810 | 4 | no |
| GO:0051050 | positive regulation of transport | 26.1905 | 4 | no |
| GO:0060341 | regulation of cellular localization | 26.1905 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.1905 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 25.0000 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 23.8095 | 4 | yes |
| GO:0008104 | protein localization | 23.8095 | 4 | no |
| GO:0034762 | regulation of transmembrane transport | 23.8095 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 23.8095 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.8095 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 23.8095 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.8095 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.8095 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 22.6190 | 6 | no |
| GO:0051046 | regulation of secretion | 22.6190 | 5 | no |
| GO:0030030 | cell projection organization | 22.6190 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.6190 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.6190 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.6190 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 21.4286 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.4286 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.4286 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.4286 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 21.4286 | 4 | no |
| GO:0050890 | cognition | 21.4286 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.2381 | 4 | no |
| GO:0071702 | organic substance transport | 20.2381 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.2381 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 20.2381 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.2381 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.2381 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 20.2381 | 7 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CXCR5_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KAP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS18_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS16_HUMAN | [view interactions] | Low throughput | no | no |
| 5HT1B_HUMAN | [view interactions] | Low throughput | no | no |
| RGS1_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS10_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS17_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS19_HUMAN | [view interactions] | Low throughput | no | yes |
| RIC8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ZBT16_HUMAN | [view interactions] | Low throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GPSM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCP2_HUMAN | [view interactions] | Low throughput | no | no |
| CRFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS5_HUMAN | [view interactions] | Low throughput | no | no |
| OPRM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| OPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RGS9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRR_HUMAN | [view interactions] | Low throughput | no | yes |
| DRD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NGB_HUMAN | [view interactions] | Low throughput | no | yes |
| CAC1B_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS20_HUMAN | [view interactions] | Low throughput | no | no |
| APLP2_HUMAN | [view interactions] | Low throughput | no | yes |
| GABR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADA2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGRG3_HUMAN | [view interactions] | Low throughput | no | no |
| GHRL_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GHSR_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| OPRK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACM4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NTR1_HUMAN | [view interactions] | Low throughput | no | no |
| NEUT_HUMAN | [view interactions] | Low throughput | no | no |
| C5AR1_HUMAN | [view interactions] | Low throughput | no | yes |
| CO5_HUMAN | [view interactions] | Low throughput | no | no |
| C3AR_HUMAN | [view interactions] | Low throughput | no | no |
| CO3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GP156_HUMAN | [view interactions] | Low throughput | no | no |
| NEU1_HUMAN | [view interactions] | Low throughput | no | no |
| OXYR_HUMAN | [view interactions] | Low throughput | no | no |
| GALR1_HUMAN | [view interactions] | Low throughput | no | no |
| GALA_HUMAN | [view interactions] | Low throughput | no | no |
| SSR2_HUMAN | [view interactions] | Low throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| SPTCS_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCN2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| CALR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| CBX5_HUMAN | [view interactions] | High throughput | no | yes |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAUS4_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNT4_HUMAN | [view interactions] | High throughput | no | no |
| JSPR1_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| CD69_HUMAN | [view interactions] | High throughput | no | no |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| MYH4_HUMAN | [view interactions] | High throughput | no | no |
| GRAM4_HUMAN | [view interactions] | High throughput | no | no |
| GBG10_HUMAN | [view interactions] | High throughput | no | no |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MICA1_HUMAN | [view interactions] | High throughput | no | yes |
| P4K2A_HUMAN | [view interactions] | High throughput | no | yes |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| FXL22_HUMAN | [view interactions] | High throughput | no | no |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPAG6_HUMAN | [view interactions] | High throughput | no | no |
| GNAT2_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT1_HUMAN | [view interactions] | High throughput | no | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CX6A1_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VISL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLHL3_HUMAN | [view interactions] | High throughput | no | no |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEGR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNP25_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QCR6L_HUMAN | [view interactions] | High throughput | no | yes |
| QCR6_HUMAN | [view interactions] | High throughput | no | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
| FOXO1_HUMAN | [view interactions] | High throughput | no | yes |