RGS17_HUMAN
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins . [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RGS17_HUMAN |
---|---|---|---|---|
GO:0003924 | GTPase activity | 66.6667 | 7 | yes |
GO:0016462 | pyrophosphatase activity | 66.6667 | 5 | yes |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 66.6667 | 4 | yes |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 66.6667 | 6 | yes |
GO:0005096 | GTPase activator activity | 50.0000 | 4 | yes |
GO:0030695 | GTPase regulator activity | 50.0000 | 4 | yes |
GO:0001664 | G protein-coupled receptor binding | 33.3333 | 4 | no |
GO:0005525 | GTP binding | 27.7778 | 5 | no |
GO:0017076 | purine nucleotide binding | 27.7778 | 4 | no |
GO:0019001 | guanyl nucleotide binding | 27.7778 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 27.7778 | 4 | no |
GO:0032561 | guanyl ribonucleotide binding | 27.7778 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 27.7778 | 4 | no |
GO:0046872 | metal ion binding | 27.7778 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RGS17_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 77.7778 | 4 | yes |
GO:0009966 | regulation of signal transduction | 66.6667 | 4 | yes |
GO:0010646 | regulation of cell communication | 66.6667 | 4 | yes |
GO:0043085 | positive regulation of catalytic activity | 61.1111 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 55.5556 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 55.5556 | 5 | yes |
GO:0023057 | negative regulation of signaling | 55.5556 | 4 | yes |
GO:0048585 | negative regulation of response to stimulus | 55.5556 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0051336 | regulation of hydrolase activity | 44.4444 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 38.8889 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 38.8889 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 38.8889 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 38.8889 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 38.8889 | 4 | no |
GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
GO:0043086 | negative regulation of catalytic activity | 33.3333 | 4 | no |
GO:0051049 | regulation of transport | 33.3333 | 4 | no |
GO:0051345 | positive regulation of hydrolase activity | 33.3333 | 5 | no |
GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 33.3333 | 5 | no |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 33.3333 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 27.7778 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 27.7778 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 27.7778 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 27.7778 | 6 | no |
GO:0031325 | positive regulation of cellular metabolic process | 27.7778 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.7778 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 27.7778 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 27.7778 | 6 | no |
GO:0051338 | regulation of transferase activity | 27.7778 | 4 | no |
GO:0043087 | regulation of GTPase activity | 27.7778 | 5 | no |
GO:0043547 | positive regulation of GTPase activity | 27.7778 | 6 | no |
GO:0009416 | response to light stimulus | 27.7778 | 4 | no |
GO:0010243 | response to organonitrogen compound | 27.7778 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 22.2222 | 7 | no |
GO:0010563 | negative regulation of phosphorus metabolic process | 22.2222 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
GO:0031400 | negative regulation of protein modification process | 22.2222 | 7 | no |
GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
GO:0043549 | regulation of kinase activity | 22.2222 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 22.2222 | 6 | no |
GO:0045936 | negative regulation of phosphate metabolic process | 22.2222 | 7 | no |
GO:0051128 | regulation of cellular component organization | 22.2222 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 22.2222 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 22.2222 | 5 | no |
GO:0010959 | regulation of metal ion transport | 22.2222 | 6 | no |
GO:0043269 | regulation of ion transport | 22.2222 | 5 | no |
GO:0051050 | positive regulation of transport | 22.2222 | 4 | no |
GO:0071310 | cellular response to organic substance | 22.2222 | 4 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
OSTM1_HUMAN | [view interactions] | Low throughput | no | yes |
HXA1_HUMAN | [view interactions] | High throughput | no | no |
SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTIP_HUMAN | [view interactions] | High throughput | no | no |
RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUFP2_HUMAN | [view interactions] | High throughput | no | no |
GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AQP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OTX1_HUMAN | [view interactions] | High throughput | no | no |
MCSP_HUMAN | [view interactions] | High throughput | no | no |
RL10A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCE3C_HUMAN | [view interactions] | High throughput | no | no |
LCE4A_HUMAN | [view interactions] | High throughput | no | no |
LCE2A_HUMAN | [view interactions] | High throughput | no | no |
LCE3B_HUMAN | [view interactions] | High throughput | no | no |
LCE1E_HUMAN | [view interactions] | High throughput | no | no |
CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCE1A_HUMAN | [view interactions] | High throughput | no | no |
LCE2B_HUMAN | [view interactions] | High throughput | no | no |
KRA54_HUMAN | [view interactions] | High throughput | no | no |
LCE3D_HUMAN | [view interactions] | High throughput | no | no |
LCE2C_HUMAN | [view interactions] | High throughput | no | no |
KRA56_HUMAN | [view interactions] | High throughput | no | no |
KRA53_HUMAN | [view interactions] | High throughput | no | no |
LCE1B_HUMAN | [view interactions] | High throughput | no | no |
CRCT1_HUMAN | [view interactions] | High throughput | no | no |
VASN_HUMAN | [view interactions] | High throughput | no | yes |
LCE3A_HUMAN | [view interactions] | High throughput | no | no |
LCE5A_HUMAN | [view interactions] | High throughput | no | no |
LCE1D_HUMAN | [view interactions] | High throughput | no | no |
LCE3E_HUMAN | [view interactions] | High throughput | no | no |
KR511_HUMAN | [view interactions] | High throughput | no | no |
CHRD_HUMAN | [view interactions] | High throughput | no | no |
S39A7_HUMAN | [view interactions] | High throughput | no | yes |
3BHS7_HUMAN | [view interactions] | High throughput | no | no |
KR411_HUMAN | [view interactions] | High throughput | no | no |
GLE1_HUMAN | [view interactions] | High throughput | no | yes |
KLF11_HUMAN | [view interactions] | High throughput | no | no |
SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
PE2R3_HUMAN | [view interactions] | High throughput | no | no |
DHX37_HUMAN | [view interactions] | High throughput | no | yes |
TBC16_HUMAN | [view interactions] | High throughput | no | yes |
CREB5_HUMAN | [view interactions] | High throughput | no | no |
BOLA2_HUMAN | [view interactions] | High throughput | no | yes |
ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RGS18_HUMAN | [view interactions] | Computational | no | yes |
RGS19_HUMAN | [view interactions] | Computational | no | yes |
GNAI2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RGS3_HUMAN | [view interactions] | Computational | no | no |
RGS6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RGS1_HUMAN | [view interactions] | Computational | no | yes |
RGS2_HUMAN | [view interactions] | Computational | no | no |
RGS9_HUMAN | [view entry] [view interactions] | Computational | yes | no |
HINT1_HUMAN | [view interactions] | Computational | no | yes |
RGS21_HUMAN | [view interactions] | Computational | no | no |
RGS8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RGS4_HUMAN | [view interactions] | Computational | no | no |
RGS20_HUMAN | [view interactions] | Computational | no | no |
RGS10_HUMAN | [view interactions] | Computational | no | yes |
GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RGS5_HUMAN | [view interactions] | Computational | no | no |
GNB5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RGS13_HUMAN | [view interactions] | Computational | no | no |
RGS11_HUMAN | [view interactions] | Computational | no | yes |
RGS16_HUMAN | [view interactions] | Computational | no | no |
RGS7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RGS12_HUMAN | [view interactions] | Computational | no | no |
RGS14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |