RGS17_HUMAN
Evidence for PS localization
Functions
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RGS17_HUMAN |
|---|---|---|---|---|
| GO:0003924 | GTPase activity | 40.0000 | 7 | yes |
| GO:0016462 | pyrophosphatase activity | 40.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 40.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 40.0000 | 6 | yes |
| GO:0001664 | G protein-coupled receptor binding | 40.0000 | 4 | no |
| GO:0043169 | cation binding | 40.0000 | 4 | no |
| GO:0000166 | nucleotide binding | 30.0000 | 4 | no |
| GO:0005525 | GTP binding | 30.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 30.0000 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 30.0000 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | no |
| GO:0032561 | guanyl ribonucleotide binding | 30.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.0000 | 4 | no |
| GO:0043168 | anion binding | 30.0000 | 4 | no |
| GO:0046872 | metal ion binding | 30.0000 | 5 | no |
| GO:0042803 | protein homodimerization activity | 30.0000 | 4 | no |
| GO:0005096 | GTPase activator activity | 20.0000 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 20.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RGS17_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 40.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 40.0000 | 4 | yes |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 40.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 40.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 30.0000 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 30.0000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 30.0000 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 30.0000 | 4 | yes |
| GO:0090304 | nucleic acid metabolic process | 30.0000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 30.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 30.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 30.0000 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
| GO:0043086 | negative regulation of catalytic activity | 30.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OSTM1_HUMAN | [view interactions] | Low throughput | no | yes |
| HINT1_HUMAN | [view interactions] | Low throughput | no | yes |
| HXA1_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTIP_HUMAN | [view interactions] | High throughput | no | no |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OTX1_HUMAN | [view interactions] | High throughput | no | no |
| MCSP_HUMAN | [view interactions] | High throughput | no | no |
| RL10A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCE3C_HUMAN | [view interactions] | High throughput | no | no |
| LCE4A_HUMAN | [view interactions] | High throughput | no | no |
| LCE2A_HUMAN | [view interactions] | High throughput | no | no |
| LCE3B_HUMAN | [view interactions] | High throughput | no | no |
| LCE1E_HUMAN | [view interactions] | High throughput | no | no |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCE1A_HUMAN | [view interactions] | High throughput | no | no |
| LCE2B_HUMAN | [view interactions] | High throughput | no | no |
| KRA54_HUMAN | [view interactions] | High throughput | no | no |
| LCE3D_HUMAN | [view interactions] | High throughput | no | no |
| LCE2C_HUMAN | [view interactions] | High throughput | no | no |
| KRA56_HUMAN | [view interactions] | High throughput | no | no |
| KRA53_HUMAN | [view interactions] | High throughput | no | no |
| LCE1B_HUMAN | [view interactions] | High throughput | no | no |
| CRCT1_HUMAN | [view interactions] | High throughput | no | no |
| VASN_HUMAN | [view interactions] | High throughput | no | yes |
| LCE3A_HUMAN | [view interactions] | High throughput | no | no |
| LCE5A_HUMAN | [view interactions] | High throughput | no | no |
| LCE1D_HUMAN | [view interactions] | High throughput | no | no |
| LCE3E_HUMAN | [view interactions] | High throughput | no | no |
| KR511_HUMAN | [view interactions] | High throughput | no | no |
| CHRD_HUMAN | [view interactions] | High throughput | no | no |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| KR411_HUMAN | [view interactions] | High throughput | no | no |
| GLE1_HUMAN | [view interactions] | High throughput | no | yes |
| KLF11_HUMAN | [view interactions] | High throughput | no | no |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| PE2R3_HUMAN | [view interactions] | High throughput | no | no |
| DHX37_HUMAN | [view interactions] | High throughput | no | yes |
| TBC16_HUMAN | [view interactions] | High throughput | no | yes |
| CREB5_HUMAN | [view interactions] | High throughput | no | no |
| BOLA2_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |