RABE1_HUMAN
Evidence for PS localization
Functions
Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RABE1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 28.3019 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.4151 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.4151 | 4 | no |
| GO:0030695 | GTPase regulator activity | 11.3208 | 4 | yes |
| GO:0005096 | GTPase activator activity | 5.6604 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 5.6604 | 4 | yes |
| GO:0008083 | growth factor activity | 3.7736 | 5 | yes |
| GO:0048018 | receptor ligand activity | 3.7736 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RABE1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 60.3774 | 4 | yes |
| GO:0071702 | organic substance transport | 52.8302 | 4 | yes |
| GO:0015031 | protein transport | 50.9434 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 50.9434 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 47.1698 | 4 | yes |
| GO:0051049 | regulation of transport | 43.3962 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.5094 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 41.5094 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.6226 | 4 | no |
| GO:0006996 | organelle organization | 35.8491 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 33.9623 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.9623 | 4 | no |
| GO:0006886 | intracellular protein transport | 32.0755 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.0755 | 4 | no |
| GO:0006897 | endocytosis | 30.1887 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 28.3019 | 4 | no |
| GO:0010646 | regulation of cell communication | 26.4151 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 24.5283 | 4 | no |
| GO:0022607 | cellular component assembly | 24.5283 | 4 | no |
| GO:0009966 | regulation of signal transduction | 20.7547 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 20.7547 | 5 | no |
| GO:0010468 | regulation of gene expression | 20.7547 | 5 | no |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 18.8679 | 4 | yes |
| GO:0072657 | protein localization to membrane | 16.9811 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 16.9811 | 5 | yes |
| GO:0033365 | protein localization to organelle | 15.0943 | 5 | yes |
| GO:0048193 | Golgi vesicle transport | 15.0943 | 5 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 13.2075 | 6 | yes |
| GO:0061024 | membrane organization | 11.3208 | 4 | yes |
| GO:0006893 | Golgi to plasma membrane transport | 9.4340 | 5 | yes |
| GO:0006915 | apoptotic process | 9.4340 | 4 | yes |
| GO:0061025 | membrane fusion | 7.5472 | 5 | yes |
| GO:0061512 | protein localization to cilium | 7.5472 | 6 | yes |
| GO:1903441 | protein localization to ciliary membrane | 5.6604 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA2_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1G2_HUMAN | [view interactions] | Low throughput | no | yes |
| KCNH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB5B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HUNK_HUMAN | [view interactions] | Low throughput | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | Low throughput | no | no |
| RABX5_HUMAN | [view interactions] | Low throughput | no | no |
| EEA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RABE2_HUMAN | [view interactions] | Low throughput | no | yes |
| NEUM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB33B_HUMAN | [view interactions] | Low throughput | no | no |
| RAB1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RUFY1_HUMAN | [view interactions] | Low throughput | no | yes |
| ATX7_HUMAN | [view interactions] | High throughput | no | no |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSF4_HUMAN | [view interactions] | High throughput | no | no |
| HSFY1_HUMAN | [view interactions] | High throughput | no | no |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| RGS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODAD3_HUMAN | [view interactions] | High throughput | no | no |
| MAT2B_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN438_HUMAN | [view interactions] | High throughput | no | no |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| TENS4_HUMAN | [view interactions] | High throughput | no | no |
| Z512B_HUMAN | [view interactions] | High throughput | no | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL3_HUMAN | [view interactions] | High throughput | no | no |
| ZN774_HUMAN | [view interactions] | High throughput | no | no |
| LENG1_HUMAN | [view interactions] | High throughput | no | no |
| TSH2_HUMAN | [view interactions] | High throughput | no | yes |
| FA50B_HUMAN | [view interactions] | High throughput | no | yes |
| ESCO2_HUMAN | [view interactions] | High throughput | no | no |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| MCRS1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF39_HUMAN | [view interactions] | High throughput | no | no |
| PELI2_HUMAN | [view interactions] | High throughput | no | yes |
| UT14C_HUMAN | [view interactions] | High throughput | no | yes |
| CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBFL1_HUMAN | [view interactions] | High throughput | no | no |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| STAR_HUMAN | [view interactions] | High throughput | no | no |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CFA53_HUMAN | [view interactions] | High throughput | no | no |
| ELOA1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| CLOCK_HUMAN | [view interactions] | High throughput | no | yes |
| YETS4_HUMAN | [view interactions] | High throughput | no | no |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| TUFT1_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| GRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| NCK5L_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP57_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC183_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD7_HUMAN | [view interactions] | High throughput | no | no |
| TM266_HUMAN | [view interactions] | High throughput | no | no |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNCI_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM74_HUMAN | [view interactions] | High throughput | no | no |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| CC186_HUMAN | [view interactions] | High throughput | no | yes |
| K22E_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMRC1_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF7_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9C_HUMAN | [view interactions] | High throughput | no | no |
| R9BP_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM31_HUMAN | [view interactions] | High throughput | no | no |
| AP180_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| FOSL1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| SMU1_HUMAN | [view interactions] | High throughput | no | yes |
| UACA_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1A_HUMAN | [view interactions] | High throughput | no | yes |
| SHRM2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| GAPD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ZFAN4_HUMAN | [view interactions] | Computational | no | no |
| RAB8A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| IFT20_HUMAN | [view interactions] | Computational | no | yes |
| MIPT3_HUMAN | [view interactions] | Computational | no | yes |
| RBNS5_HUMAN | [view interactions] | Computational | no | yes |