RABE1_HUMAN
Evidence for PS localization
Functions
Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RABE1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 35.5932 | 4 | no |
| GO:0000166 | nucleotide binding | 27.1186 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.1186 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.1186 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.1186 | 4 | no |
| GO:0030695 | GTPase regulator activity | 10.1695 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 6.7797 | 4 | yes |
| GO:0005096 | GTPase activator activity | 5.0847 | 4 | yes |
| GO:0008083 | growth factor activity | 3.3898 | 5 | yes |
| GO:0048018 | receptor ligand activity | 3.3898 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RABE1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 54.2373 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 45.7627 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.3729 | 4 | no |
| GO:0071702 | organic substance transport | 38.9831 | 4 | yes |
| GO:0015031 | protein transport | 37.2881 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 37.2881 | 4 | yes |
| GO:0006996 | organelle organization | 37.2881 | 4 | no |
| GO:0051049 | regulation of transport | 33.8983 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.2034 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.2034 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.5085 | 4 | no |
| GO:0022607 | cellular component assembly | 28.8136 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 28.8136 | 4 | no |
| GO:0098657 | import into cell | 27.1186 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 27.1186 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.7288 | 4 | no |
| GO:0006886 | intracellular protein transport | 22.0339 | 4 | no |
| GO:0033043 | regulation of organelle organization | 20.3390 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.3390 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 20.3390 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.3390 | 6 | no |
| GO:0061024 | membrane organization | 15.2542 | 4 | yes |
| GO:0033365 | protein localization to organelle | 13.5593 | 5 | yes |
| GO:0072657 | protein localization to membrane | 13.5593 | 4 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 11.8644 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 11.8644 | 5 | yes |
| GO:0006915 | apoptotic process | 10.1695 | 4 | yes |
| GO:0006893 | Golgi to plasma membrane transport | 8.4746 | 4 | yes |
| GO:0061025 | membrane fusion | 5.0847 | 5 | yes |
| GO:0061512 | protein localization to cilium | 5.0847 | 6 | yes |
| GO:1903441 | protein localization to ciliary membrane | 3.3898 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HUNK_HUMAN | [view interactions] | Low throughput | no | yes |
| ITSN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | Low throughput | no | no |
| RABX5_HUMAN | [view interactions] | Low throughput | no | no |
| EEA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RABE2_HUMAN | [view interactions] | Low throughput | no | yes |
| NEUM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB33B_HUMAN | [view interactions] | Low throughput | no | no |
| RAB1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RUFY1_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA2_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1G2_HUMAN | [view interactions] | Low throughput | no | yes |
| KCNH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RABE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB5B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| CLOCK_HUMAN | [view interactions] | High throughput | no | yes |
| YETS4_HUMAN | [view interactions] | High throughput | no | no |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| TUFT1_HUMAN | [view interactions] | High throughput | no | no |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| GRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| NCK5L_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| ABI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP57_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC183_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD7_HUMAN | [view interactions] | High throughput | no | no |
| TM266_HUMAN | [view interactions] | High throughput | no | no |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNCI_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| VPS52_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM74_HUMAN | [view interactions] | High throughput | no | no |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| CC186_HUMAN | [view interactions] | High throughput | no | yes |
| K22E_HUMAN | [view interactions] | High throughput | no | no |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMRC1_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF7_HUMAN | [view interactions] | High throughput | no | yes |
| FAM9C_HUMAN | [view interactions] | High throughput | no | no |
| R9BP_HUMAN | [view interactions] | High throughput | no | no |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM31_HUMAN | [view interactions] | High throughput | no | no |
| AP180_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYCE1_HUMAN | [view interactions] | High throughput | no | no |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| FOSL1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TP4A3_HUMAN | [view interactions] | High throughput | no | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| SMU1_HUMAN | [view interactions] | High throughput | no | yes |
| UACA_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1A_HUMAN | [view interactions] | High throughput | no | yes |
| SHRM2_HUMAN | [view interactions] | High throughput | no | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRSK2_HUMAN | [view interactions] | High throughput | no | no |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | High throughput | no | no |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX7_HUMAN | [view interactions] | High throughput | no | no |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| SLMAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSF4_HUMAN | [view interactions] | High throughput | no | no |
| HSFY1_HUMAN | [view interactions] | High throughput | no | no |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TRI26_HUMAN | [view interactions] | High throughput | no | yes |
| RGS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODAD3_HUMAN | [view interactions] | High throughput | no | no |
| MAT2B_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN438_HUMAN | [view interactions] | High throughput | no | no |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| TENS4_HUMAN | [view interactions] | High throughput | no | no |
| Z512B_HUMAN | [view interactions] | High throughput | no | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| CDKL3_HUMAN | [view interactions] | High throughput | no | no |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN774_HUMAN | [view interactions] | High throughput | no | no |
| LENG1_HUMAN | [view interactions] | High throughput | no | no |
| TSH2_HUMAN | [view interactions] | High throughput | no | yes |
| FA50B_HUMAN | [view interactions] | High throughput | no | yes |
| ESCO2_HUMAN | [view interactions] | High throughput | no | no |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| MCRS1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF39_HUMAN | [view interactions] | High throughput | no | no |
| PELI2_HUMAN | [view interactions] | High throughput | no | yes |
| UT14C_HUMAN | [view interactions] | High throughput | no | yes |
| CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBFL1_HUMAN | [view interactions] | High throughput | no | no |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| STAR_HUMAN | [view interactions] | High throughput | no | no |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CFA53_HUMAN | [view interactions] | High throughput | no | no |
| ELOA1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| SNAPN_HUMAN | [view interactions] | High throughput | no | yes |
| NRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |