VPS53_HUMAN
Evidence for PS localization
Functions
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed, PubMed). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 695 | Gln | Arg | Pontocerebellarhypoplasia2E(PCH2E) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VPS53_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 32.4324 | 4 | no |
| GO:0017076 | purine nucleotide binding | 32.4324 | 5 | no |
| GO:0043168 | anion binding | 32.4324 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 29.7297 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.0270 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 24.3243 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.3243 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.3243 | 6 | no |
| GO:0003924 | GTPase activity | 21.6216 | 7 | no |
| GO:0005525 | GTP binding | 21.6216 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 21.6216 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 21.6216 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VPS53_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 75.6757 | 4 | yes |
| GO:0071702 | organic substance transport | 72.9730 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 67.5676 | 4 | yes |
| GO:0015031 | protein transport | 64.8649 | 4 | yes |
| GO:0006886 | intracellular protein transport | 40.5405 | 4 | yes |
| GO:0006996 | organelle organization | 37.8378 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.8378 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 37.8378 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.1351 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.1351 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 32.4324 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 29.7297 | 5 | no |
| GO:0051049 | regulation of transport | 27.0270 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 27.0270 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 27.0270 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 27.0270 | 4 | no |
| GO:0010468 | regulation of gene expression | 24.3243 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.3243 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.3243 | 5 | no |
| GO:0009966 | regulation of signal transduction | 24.3243 | 4 | no |
| GO:0010646 | regulation of cell communication | 24.3243 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.3243 | 6 | no |
| GO:0031399 | regulation of protein modification process | 24.3243 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.3243 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.3243 | 5 | no |
| GO:0022607 | cellular component assembly | 21.6216 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.6216 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.6216 | 6 | no |
| GO:0032456 | endocytic recycling | 18.9189 | 4 | yes |
| GO:0033365 | protein localization to organelle | 16.2162 | 5 | yes |
| GO:0007034 | vacuolar transport | 10.8108 | 4 | yes |
| GO:0007041 | lysosomal transport | 10.8108 | 5 | yes |
| GO:0016482 | cytosolic transport | 10.8108 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 10.8108 | 4 | yes |
| GO:0072594 | establishment of protein localization to organelle | 10.8108 | 4 | yes |
| GO:0006605 | protein targeting | 8.1081 | 4 | yes |
| GO:0006869 | lipid transport | 8.1081 | 5 | yes |
| GO:0015850 | organic hydroxy compound transport | 8.1081 | 5 | yes |
| GO:0015918 | sterol transport | 8.1081 | 6 | yes |
| GO:0030301 | cholesterol transport | 8.1081 | 7 | yes |
| GO:0032365 | intracellular lipid transport | 8.1081 | 4 | yes |
| GO:0032366 | intracellular sterol transport | 8.1081 | 5 | yes |
| GO:0032367 | intracellular cholesterol transport | 8.1081 | 6 | yes |
| GO:0006622 | protein targeting to lysosome | 5.4054 | 6 | yes |
| GO:0006623 | protein targeting to vacuole | 5.4054 | 5 | yes |
| GO:0061462 | protein localization to lysosome | 5.4054 | 7 | yes |
| GO:0072665 | protein localization to vacuole | 5.4054 | 6 | yes |
| GO:0072666 | establishment of protein localization to vacuole | 5.4054 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VP33B_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS54_HUMAN | [view interactions] | Low throughput | no | no |
| VPS50_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS51_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS52_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EXOC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VPS53_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STX6_HUMAN | [view interactions] | Low throughput | no | yes |
| VAMP4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI66_HUMAN | [view interactions] | High throughput | no | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| TXND2_HUMAN | [view interactions] | High throughput | no | no |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BL1S6_HUMAN | [view interactions] | High throughput | no | yes |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| PSF2_HUMAN | [view interactions] | High throughput | no | no |
| ENTD1_HUMAN | [view interactions] | High throughput | no | no |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| EFNA4_HUMAN | [view interactions] | High throughput | no | no |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RHG24_HUMAN | [view interactions] | High throughput | no | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| ARMD3_HUMAN | [view interactions] | High throughput | no | yes |
| PTAR1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| CHRC1_HUMAN | [view interactions] | High throughput | no | no |
| GNT2A_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| MA2A1_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
| MTF2_HUMAN | [view interactions] | High throughput | no | no |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| NCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| DEPD5_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC8_HUMAN | [view interactions] | High throughput | no | yes |
| UB2J1_HUMAN | [view interactions] | High throughput | no | yes |
| ARL5A_HUMAN | [view interactions] | High throughput | no | yes |
| TBL1R_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MA1B1_HUMAN | [view interactions] | High throughput | no | yes |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
| NPRL3_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FITM2_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THOC2_HUMAN | [view interactions] | High throughput | no | yes |
| THOC1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| TXND9_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| IRF3_HUMAN | [view interactions] | High throughput | no | yes |
| TSG10_HUMAN | [view interactions] | High throughput | no | no |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPB3_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYCE3_HUMAN | [view interactions] | High throughput | no | no |
| PRAF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMAL1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| CLOCK_HUMAN | [view interactions] | High throughput | no | yes |
| YETS4_HUMAN | [view interactions] | High throughput | no | no |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| RABE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD93_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MS18B_HUMAN | [view interactions] | High throughput | no | no |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| GIT2_HUMAN | [view interactions] | High throughput | no | yes |
| PHLB3_HUMAN | [view interactions] | High throughput | no | yes |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| THA11_HUMAN | [view interactions] | High throughput | no | yes |
| TUFT1_HUMAN | [view interactions] | High throughput | no | no |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN1_HUMAN | [view interactions] | High throughput | no | no |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| HAUS6_HUMAN | [view interactions] | High throughput | no | yes |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| PF21A_HUMAN | [view interactions] | High throughput | no | yes |
| RPR1A_HUMAN | [view interactions] | High throughput | no | yes |
| NUF2_HUMAN | [view interactions] | High throughput | no | no |
| NCK5L_HUMAN | [view interactions] | High throughput | no | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD40_HUMAN | [view interactions] | High throughput | no | no |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ZUP1_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |