SC24C_HUMAN
Evidence for PS localization
Functions
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed, PubMed, PubMed, PubMed). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed, PubMed, PubMed). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SC24C_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 27.1186 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.1186 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.4237 | 4 | no |
| GO:0046872 | metal ion binding | 15.2542 | 4 | yes |
| GO:0046914 | transition metal ion binding | 6.7797 | 5 | yes |
| GO:0008270 | zinc ion binding | 5.0847 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SC24C_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 59.3220 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 55.9322 | 4 | yes |
| GO:0071702 | organic substance transport | 54.2373 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 54.2373 | 4 | yes |
| GO:0015031 | protein transport | 50.8475 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.8475 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 49.1525 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 49.1525 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 49.1525 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 47.4576 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.7627 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.0678 | 4 | no |
| GO:0006996 | organelle organization | 42.3729 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.6780 | 4 | no |
| GO:0006886 | intracellular protein transport | 38.9831 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.2881 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 37.2881 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.5932 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 32.2034 | 4 | no |
| GO:0022607 | cellular component assembly | 32.2034 | 4 | no |
| GO:0051049 | regulation of transport | 32.2034 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.5085 | 5 | no |
| GO:0048193 | Golgi vesicle transport | 28.8136 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 28.8136 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 27.1186 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.1186 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.1186 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.1186 | 5 | no |
| GO:0010646 | regulation of cell communication | 27.1186 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.1186 | 6 | no |
| GO:0010468 | regulation of gene expression | 27.1186 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.4237 | 5 | no |
| GO:0051726 | regulation of cell cycle | 25.4237 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.4237 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.4237 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.4237 | 5 | no |
| GO:0036211 | protein modification process | 25.4237 | 4 | no |
| GO:0043412 | macromolecule modification | 25.4237 | 4 | no |
| GO:0043933 | protein-containing complex organization | 23.7288 | 4 | no |
| GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 22.0339 | 4 | yes |
| GO:0032880 | regulation of protein localization | 22.0339 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.0339 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.0339 | 4 | no |
| GO:0009966 | regulation of signal transduction | 22.0339 | 4 | no |
| GO:0006897 | endocytosis | 20.3390 | 5 | no |
| GO:0031329 | regulation of cellular catabolic process | 20.3390 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.3390 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.3390 | 4 | no |
| GO:0061024 | membrane organization | 20.3390 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.3390 | 5 | no |
| GO:0031399 | regulation of protein modification process | 20.3390 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.3390 | 5 | no |
| GO:0035459 | vesicle cargo loading | 11.8644 | 4 | yes |
| GO:0090110 | COPII-coated vesicle cargo loading | 10.1695 | 4 | yes |
| GO:0001701 | in utero embryonic development | 3.3898 | 6 | yes |
| GO:0009792 | embryo development ending in birth or egg hatching | 3.3898 | 4 | yes |
| GO:0043009 | chordate embryonic development | 3.3898 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SC24C_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.3898 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TGO1_HUMAN | [view interactions] | Low throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERN1_HUMAN | [view interactions] | Low throughput | no | yes |
| MIA2_HUMAN | [view interactions] | Low throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| RMC1_HUMAN | [view interactions] | High throughput | no | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| PRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| SRA1_HUMAN | [view interactions] | High throughput | no | yes |
| PIGR_HUMAN | [view interactions] | High throughput | no | no |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YIF1A_HUMAN | [view interactions] | High throughput | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MA1A1_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAZ1A_HUMAN | [view interactions] | High throughput | no | no |
| ARI2_HUMAN | [view interactions] | High throughput | no | no |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B4GT1_HUMAN | [view interactions] | High throughput | no | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| NCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| TPC11_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| VPS51_HUMAN | [view interactions] | High throughput | no | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| MA1B1_HUMAN | [view interactions] | High throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNT5_HUMAN | [view interactions] | High throughput | no | yes |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEPD5_HUMAN | [view interactions] | High throughput | no | yes |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| NPRL3_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2J1_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
| TPC12_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24D_HUMAN | [view interactions] | High throughput | no | yes |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICLN_HUMAN | [view interactions] | High throughput | no | yes |
| COG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANCHR_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC2_HUMAN | [view interactions] | High throughput | no | yes |
| MED15_HUMAN | [view interactions] | High throughput | no | yes |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIL3_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSDE1_HUMAN | [view interactions] | High throughput | no | yes |
| OTU6B_HUMAN | [view interactions] | High throughput | no | yes |
| SBNO1_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PBDC1_HUMAN | [view interactions] | High throughput | no | no |
| GMPR2_HUMAN | [view interactions] | High throughput | no | yes |
| PARVA_HUMAN | [view interactions] | High throughput | no | yes |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYB5_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| DJB11_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC4_HUMAN | [view interactions] | High throughput | no | yes |
| DNJ5G_HUMAN | [view interactions] | High throughput | no | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| P63_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| XPR1_HUMAN | [view interactions] | High throughput | no | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| CRTC3_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPVL_HUMAN | [view interactions] | High throughput | no | no |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA83A_HUMAN | [view interactions] | High throughput | no | no |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRTC2_HUMAN | [view interactions] | High throughput | no | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S35E1_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FA83B_HUMAN | [view interactions] | High throughput | no | no |
| VTI1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOAT1_HUMAN | [view interactions] | High throughput | no | no |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| FA83H_HUMAN | [view interactions] | High throughput | no | yes |
| TROAP_HUMAN | [view interactions] | High throughput | no | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| MB12A_HUMAN | [view interactions] | High throughput | no | yes |
| PKP3_HUMAN | [view interactions] | High throughput | no | yes |
| STON2_HUMAN | [view interactions] | High throughput | no | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| ACK1_HUMAN | [view interactions] | High throughput | no | yes |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| KAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CENPQ_HUMAN | [view interactions] | High throughput | no | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| USE1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| WIPF1_HUMAN | [view interactions] | High throughput | no | no |
| MOS_HUMAN | [view interactions] | High throughput | no | no |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| OSTP_HUMAN | [view interactions] | High throughput | no | yes |
| SC31B_HUMAN | [view interactions] | Computational | no | yes |
| STX5_HUMAN | [view interactions] | Computational | no | yes |
| PDCD6_HUMAN | [view interactions] | Computational | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ANR28_HUMAN | [view interactions] | Computational | no | no |
| LMAN1_HUMAN | [view interactions] | Computational | no | yes |
| SC16B_HUMAN | [view interactions] | Computational | no | no |
| PPP6_HUMAN | [view interactions] | Computational | no | yes |
| SAR1B_HUMAN | [view interactions] | Computational | no | yes |
| PP6R1_HUMAN | [view interactions] | Computational | no | no |
| GORS1_HUMAN | [view interactions] | Computational | no | yes |
| STX17_HUMAN | [view interactions] | Computational | no | yes |
| KLH12_HUMAN | [view interactions] | Computational | no | no |
| SCFD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADA2B_HUMAN | [view interactions] | Computational | no | no |
| PEF1_HUMAN | [view interactions] | Computational | no | no |
| TMED7_HUMAN | [view interactions] | Computational | no | yes |
| TFG_HUMAN | [view interactions] | Computational | no | yes |
| SC22B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GOSR2_HUMAN | [view interactions] | Computational | no | yes |
| BET1_HUMAN | [view interactions] | Computational | no | no |
| PREB_HUMAN | [view interactions] | Computational | no | yes |
| PP6R3_HUMAN | [view interactions] | Computational | no | yes |