Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SC24C_HUMAN

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed, PubMed, PubMed, PubMed). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed, PubMed, PubMed). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed). [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in SC24C_HUMAN
GO:0000166 nucleotide binding 31.4286 4 no
GO:0017076 purine nucleotide binding 31.4286 5 no
GO:0043168 anion binding 31.4286 4 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 27.1429 4 no
GO:0030554 adenyl nucleotide binding 21.4286 6 no
GO:0003723 RNA binding 21.4286 4 no
GO:0043169 cation binding 20.0000 4 yes
GO:0046872 metal ion binding 20.0000 5 yes
GO:0046914 transition metal ion binding 10.0000 6 yes
GO:0008270 zinc ion binding 8.5714 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SC24C_HUMAN
GO:0008104 protein localization 55.7143 4 yes
GO:0060255 regulation of macromolecule metabolic process 54.2857 4 no
GO:0080090 regulation of primary metabolic process 52.8571 4 no
GO:0051128 regulation of cellular component organization 48.5714 4 no
GO:0071702 organic substance transport 47.1429 4 yes
GO:0006996 organelle organization 47.1429 4 no
GO:0048522 positive regulation of cellular process 47.1429 4 no
GO:0048523 negative regulation of cellular process 45.7143 4 no
GO:0071705 nitrogen compound transport 44.2857 4 yes
GO:0031323 regulation of cellular metabolic process 42.8571 4 no
GO:0015031 protein transport 41.4286 4 yes
GO:0009893 positive regulation of metabolic process 41.4286 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0051246 regulation of protein metabolic process 40.0000 5 no
GO:0010646 regulation of cell communication 37.1429 4 no
GO:0009889 regulation of biosynthetic process 34.2857 4 no
GO:0022607 cellular component assembly 34.2857 4 no
GO:0031326 regulation of cellular biosynthetic process 34.2857 5 no
GO:0006886 intracellular protein transport 32.8571 4 yes
GO:0009892 negative regulation of metabolic process 32.8571 4 no
GO:0010556 regulation of macromolecule biosynthetic process 32.8571 5 no
GO:0009966 regulation of signal transduction 31.4286 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.4286 5 no
GO:0031325 positive regulation of cellular metabolic process 30.0000 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0009894 regulation of catabolic process 27.1429 4 no
GO:0031324 negative regulation of cellular metabolic process 27.1429 5 no
GO:0033043 regulation of organelle organization 27.1429 5 no
GO:0036211 protein modification process 25.7143 4 no
GO:0043412 macromolecule modification 25.7143 4 no
GO:0044087 regulation of cellular component biogenesis 25.7143 4 no
GO:0031399 regulation of protein modification process 24.2857 6 no
GO:0043933 protein-containing complex organization 24.2857 4 no
GO:0023056 positive regulation of signaling 24.2857 4 no
GO:0051252 regulation of RNA metabolic process 24.2857 5 no
GO:0051049 regulation of transport 24.2857 4 no
GO:0009891 positive regulation of biosynthetic process 22.8571 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.8571 6 no
GO:0009967 positive regulation of signal transduction 22.8571 5 no
GO:0010647 positive regulation of cell communication 22.8571 5 no
GO:0048584 positive regulation of response to stimulus 22.8571 4 no
GO:0098657 import into cell 21.4286 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0009890 negative regulation of biosynthetic process 21.4286 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.4286 6 no
GO:0031327 negative regulation of cellular biosynthetic process 21.4286 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.4286 5 no
GO:0060341 regulation of cellular localization 21.4286 4 no
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 15.7143 4 yes
GO:0035459 vesicle cargo loading 10.0000 4 yes
GO:0090110 COPII-coated vesicle cargo loading 8.5714 4 yes
GO:0001701 in utero embryonic development 4.2857 6 yes
GO:0009792 embryo development ending in birth or egg hatching 4.2857 4 yes
GO:0043009 chordate embryonic development 4.2857 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SC23A_HUMAN [view entry] [view interactions] Low throughput yes yes
ERN1_HUMAN [view interactions] Low throughput no yes
MIA2_HUMAN [view interactions] Low throughput no yes
TGO1_HUMAN [view interactions] Low throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
PRC1_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
PRRC1_HUMAN [view interactions] High throughput no yes
SRA1_HUMAN [view interactions] High throughput no yes
PIGR_HUMAN [view interactions] High throughput no no
SCYL1_HUMAN [view interactions] High throughput no yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
YIF1A_HUMAN [view interactions] High throughput no yes
ANM1_HUMAN [view interactions] High throughput no yes
MYCN_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2H_HUMAN [view interactions] High throughput no yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
MA1A1_HUMAN [view interactions] High throughput no yes
IF2B1_HUMAN [view interactions] High throughput no no
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
BAZ1A_HUMAN [view interactions] High throughput no no
ARI2_HUMAN [view interactions] High throughput no no
DAZP1_HUMAN [view interactions] High throughput no yes
DCAF7_HUMAN [view interactions] High throughput no yes
FUT8_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
B4GT1_HUMAN [view interactions] High throughput no yes
MPRI_HUMAN [view interactions] High throughput no yes
NCOR1_HUMAN [view interactions] High throughput no yes
RICTR_HUMAN [view interactions] High throughput no yes
SC24A_HUMAN [view interactions] High throughput no no
TPC11_HUMAN [view interactions] High throughput no no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
EP300_HUMAN [view interactions] High throughput no yes
SC24B_HUMAN [view interactions] High throughput no yes
VPS51_HUMAN [view interactions] High throughput no yes
RABX5_HUMAN [view interactions] High throughput no no
MA1B1_HUMAN [view interactions] High throughput no yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
ZNT5_HUMAN [view interactions] High throughput no yes
S39A7_HUMAN [view interactions] High throughput no yes
NPRL2_HUMAN [view interactions] High throughput no yes
VPS45_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
DEPD5_HUMAN [view interactions] High throughput no yes
ACATN_HUMAN [view interactions] High throughput no yes
TPC13_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
NPRL3_HUMAN [view interactions] High throughput no yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
VPS53_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
UB2J1_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
TPPC5_HUMAN [view interactions] High throughput no yes
TPC12_HUMAN [view interactions] High throughput no yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
TPC2A_HUMAN [view interactions] High throughput no yes
SAR1A_HUMAN [view entry] [view interactions] High throughput yes yes
TPC2L_HUMAN [view interactions] High throughput no yes
TSC2_HUMAN [view entry] [view interactions] High throughput yes yes
S39A9_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
CRYAA_HUMAN [view interactions] High throughput no no
SC24D_HUMAN [view interactions] High throughput no yes
DTNA_HUMAN [view entry] [view interactions] High throughput yes yes
SAHH2_HUMAN [view entry] [view interactions] High throughput yes yes
RUXF_HUMAN [view interactions] High throughput no no
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
CPLX1_HUMAN [view entry] [view interactions] High throughput yes yes
ICLN_HUMAN [view interactions] High throughput no yes
COG3_HUMAN [view entry] [view interactions] High throughput yes yes
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
PSA5_HUMAN [view interactions] High throughput no yes
COPA_HUMAN [view entry] [view interactions] High throughput yes yes
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
ANCHR_HUMAN [view interactions] High throughput no yes
NOTC2_HUMAN [view entry] [view interactions] High throughput yes yes
MED15_HUMAN [view interactions] High throughput no yes
SERPH_HUMAN [view interactions] High throughput no no
PSMD1_HUMAN [view entry] [view interactions] High throughput yes yes
PPIL3_HUMAN [view interactions] High throughput no yes
VATB2_HUMAN [view entry] [view interactions] High throughput yes yes
CSDE1_HUMAN [view interactions] High throughput no yes
OTU6B_HUMAN [view interactions] High throughput no yes
SBNO1_HUMAN [view interactions] High throughput no yes
DPYL1_HUMAN [view entry] [view interactions] High throughput yes yes
PBDC1_HUMAN [view interactions] High throughput no no
GMPR2_HUMAN [view interactions] High throughput no yes
PARVA_HUMAN [view interactions] High throughput no yes
SPT5H_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
ZYX_HUMAN [view interactions] High throughput no no
SSRP1_HUMAN [view interactions] High throughput no yes
CD2AP_HUMAN [view interactions] High throughput no no
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
CYB5_HUMAN [view interactions] High throughput no no
GGPPS_HUMAN [view interactions] High throughput no yes
ERCC3_HUMAN [view interactions] High throughput no yes
ILF3_HUMAN [view interactions] High throughput no yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
FA50A_HUMAN [view interactions] High throughput no yes
HERC4_HUMAN [view interactions] High throughput no no
THOC4_HUMAN [view interactions] High throughput no no
RENT1_HUMAN [view entry] [view interactions] High throughput yes yes
MGN2_HUMAN [view interactions] High throughput no yes
UN45A_HUMAN [view interactions] High throughput no yes
NT5D2_HUMAN [view interactions] High throughput no yes
PDP1_HUMAN [view interactions] High throughput no yes
ZN148_HUMAN [view interactions] High throughput no yes
LEG9_HUMAN [view interactions] High throughput no yes
DNJC7_HUMAN [view interactions] High throughput no yes
DJB11_HUMAN [view interactions] High throughput no yes
DNJC4_HUMAN [view interactions] High throughput no yes
DNJ5G_HUMAN [view interactions] High throughput no no
B3GA1_HUMAN [view interactions] High throughput no yes
VP33A_HUMAN [view entry] [view interactions] High throughput yes no
OPTN_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1B_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
P63_HUMAN [view interactions] High throughput no no
MLP3B_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
GBRL1_HUMAN [view interactions] High throughput no yes
GBRAP_HUMAN [view entry] [view interactions] High throughput yes no
TMED2_HUMAN [view interactions] High throughput no yes
MIS12_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
CDK1_HUMAN [view interactions] High throughput no no
KAP2_HUMAN [view entry] [view interactions] High throughput yes yes
OCRL_HUMAN [view interactions] High throughput no yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
SC16A_HUMAN [view interactions] High throughput no yes
MAP7_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
CLH2_HUMAN [view interactions] High throughput no no
STON2_HUMAN [view interactions] High throughput no yes
PKP3_HUMAN [view interactions] High throughput no yes
MB12A_HUMAN [view interactions] High throughput no yes
EPN4_HUMAN [view interactions] High throughput no yes
TROAP_HUMAN [view interactions] High throughput no yes
FA83H_HUMAN [view interactions] High throughput no yes
DAB2_HUMAN [view interactions] High throughput no yes
SOAT1_HUMAN [view interactions] High throughput no no
VTI1B_HUMAN [view entry] [view interactions] High throughput yes yes
FA83B_HUMAN [view interactions] High throughput no no
HIP1R_HUMAN [view entry] [view interactions] High throughput yes yes
KC1A_HUMAN [view interactions] High throughput no yes
BMP2K_HUMAN [view interactions] High throughput no yes
RBM14_HUMAN [view interactions] High throughput no yes
GTSE1_HUMAN [view interactions] High throughput no no
S35E1_HUMAN [view interactions] High throughput no yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
STX8_HUMAN [view interactions] High throughput no yes
CRTC2_HUMAN [view interactions] High throughput no yes
GAK_HUMAN [view entry] [view interactions] High throughput yes yes
P3C2A_HUMAN [view interactions] High throughput no yes
FA83A_HUMAN [view interactions] High throughput no no
SEC13_HUMAN [view entry] [view interactions] High throughput yes yes
DEN1A_HUMAN [view interactions] High throughput no no
CPVL_HUMAN [view interactions] High throughput no no
EPS15_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
CRTC3_HUMAN [view interactions] High throughput no no
S23IP_HUMAN [view interactions] High throughput no yes
S53A1_HUMAN [view interactions] High throughput no yes
SC23B_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
CENPQ_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
RMC1_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
H2A1B_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
CDC5L_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
USE1_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ADNP_HUMAN [view interactions] High throughput no yes
CHD8_HUMAN [view interactions] High throughput no no
FBX7_HUMAN [view interactions] High throughput no yes
WIPF1_HUMAN [view interactions] High throughput no no
MOS_HUMAN [view interactions] High throughput no no
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CNTRL_HUMAN [view interactions] High throughput no yes
STIL_HUMAN [view interactions] High throughput no no
OSTP_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
WWOX_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
EWS_HUMAN [view interactions] High throughput no yes
CENPE_HUMAN [view interactions] High throughput no no
G3BP1_HUMAN [view interactions] High throughput no yes
BRCA1_HUMAN [view interactions] High throughput no yes
SC31A_HUMAN [view entry] [view interactions] High throughput yes yes
LNP_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
PKHA2_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
DYR1A_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no