CPLX1_HUMAN
Evidence for PS localization
Functions
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CPLX1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 30.4348 | 4 | no |
| GO:0019905 | syntaxin binding | 26.0870 | 4 | yes |
| GO:0017075 | syntaxin-1 binding | 21.7391 | 5 | no |
| GO:0043169 | cation binding | 21.7391 | 4 | no |
| GO:0046872 | metal ion binding | 21.7391 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CPLX1_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 60.8696 | 4 | yes |
| GO:0051049 | regulation of transport | 56.5217 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.8261 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 47.8261 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.8261 | 4 | no |
| GO:0032880 | regulation of protein localization | 43.4783 | 5 | yes |
| GO:0051046 | regulation of secretion | 43.4783 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 43.4783 | 4 | yes |
| GO:0070201 | regulation of establishment of protein localization | 43.4783 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 43.4783 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 43.4783 | 4 | no |
| GO:0046903 | secretion | 39.1304 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 39.1304 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 39.1304 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 39.1304 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.1304 | 5 | no |
| GO:0008104 | protein localization | 34.7826 | 4 | yes |
| GO:0023061 | signal release | 34.7826 | 4 | yes |
| GO:0045055 | regulated exocytosis | 34.7826 | 4 | yes |
| GO:0051223 | regulation of protein transport | 34.7826 | 5 | yes |
| GO:0099643 | signal release from synapse | 34.7826 | 5 | yes |
| GO:0006996 | organelle organization | 34.7826 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 34.7826 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 34.7826 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 34.7826 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.7826 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.7826 | 4 | no |
| GO:0033043 | regulation of organelle organization | 30.4348 | 5 | yes |
| GO:0022607 | cellular component assembly | 30.4348 | 4 | no |
| GO:0043933 | protein-containing complex organization | 30.4348 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.4348 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.4348 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.4348 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.4348 | 5 | no |
| GO:0036211 | protein modification process | 30.4348 | 4 | no |
| GO:0043412 | macromolecule modification | 30.4348 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.4348 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.4348 | 4 | no |
| GO:0015031 | protein transport | 26.0870 | 4 | yes |
| GO:0016079 | synaptic vesicle exocytosis | 26.0870 | 4 | yes |
| GO:0017157 | regulation of exocytosis | 26.0870 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 26.0870 | 4 | yes |
| GO:0071702 | organic substance transport | 26.0870 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 26.0870 | 4 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 26.0870 | 5 | no |
| GO:0051050 | positive regulation of transport | 26.0870 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 26.0870 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 26.0870 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.0870 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.0870 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.0870 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.0870 | 5 | no |
| GO:0080134 | regulation of response to stress | 26.0870 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.0870 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 21.7391 | 7 | yes |
| GO:0046928 | regulation of neurotransmitter secretion | 21.7391 | 5 | yes |
| GO:0051588 | regulation of neurotransmitter transport | 21.7391 | 5 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 21.7391 | 6 | yes |
| GO:0099536 | synaptic signaling | 21.7391 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 21.7391 | 5 | yes |
| GO:0061024 | membrane organization | 21.7391 | 4 | no |
| GO:1904951 | positive regulation of establishment of protein localization | 21.7391 | 6 | no |
| GO:0048278 | vesicle docking | 21.7391 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.7391 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.7391 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.7391 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 21.7391 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.7391 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.7391 | 6 | no |
| GO:0080135 | regulation of cellular response to stress | 21.7391 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.7391 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.7391 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.7391 | 6 | no |
| GO:0031338 | regulation of vesicle fusion | 13.0435 | 5 | yes |
| GO:0031630 | regulation of synaptic vesicle fusion to presynaptic active zone membrane | 13.0435 | 6 | yes |
| GO:1901632 | regulation of synaptic vesicle membrane organization | 13.0435 | 5 | yes |
| GO:0002790 | peptide secretion | 8.6957 | 5 | yes |
| GO:0009306 | protein secretion | 8.6957 | 4 | yes |
| GO:0009914 | hormone transport | 8.6957 | 4 | yes |
| GO:0015833 | peptide transport | 8.6957 | 5 | yes |
| GO:0030072 | peptide hormone secretion | 8.6957 | 6 | yes |
| GO:0030073 | insulin secretion | 8.6957 | 5 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 8.6957 | 4 | yes |
| GO:0042886 | amide transport | 8.6957 | 5 | yes |
| GO:0046879 | hormone secretion | 8.6957 | 5 | yes |
| GO:0071692 | protein localization to extracellular region | 8.6957 | 5 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 8.6957 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 8.6957 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| GLPB_HUMAN | [view interactions] | High throughput | no | no |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPLX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RXRB_HUMAN | [view interactions] | High throughput | no | yes |
| ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAM1_HUMAN | [view interactions] | High throughput | no | yes |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPY30_HUMAN | [view interactions] | High throughput | no | yes |
| LGUL_HUMAN | [view interactions] | High throughput | no | yes |
| NDRG3_HUMAN | [view interactions] | High throughput | no | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2B_HUMAN | [view interactions] | High throughput | no | no |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POMP_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RN114_HUMAN | [view interactions] | High throughput | no | no |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| HBS1L_HUMAN | [view interactions] | High throughput | no | yes |
| JUPI1_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NENF_HUMAN | [view interactions] | High throughput | no | yes |
| NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| PSF3_HUMAN | [view interactions] | High throughput | no | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPLX3_HUMAN | [view interactions] | High throughput | no | no |
| SYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |