CPLX1_HUMAN
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CPLX1_HUMAN |
---|---|---|---|---|
GO:0019905 | syntaxin binding | 30.7692 | 4 | yes |
GO:0046872 | metal ion binding | 23.0769 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CPLX1_HUMAN |
---|---|---|---|---|
GO:0016192 | vesicle-mediated transport | 66.6667 | 4 | yes |
GO:0010646 | regulation of cell communication | 61.5385 | 4 | yes |
GO:0046903 | secretion | 61.5385 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 58.9744 | 4 | no |
GO:0051049 | regulation of transport | 58.9744 | 4 | yes |
GO:0006887 | exocytosis | 56.4103 | 4 | yes |
GO:0023061 | signal release | 51.2821 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 51.2821 | 4 | yes |
GO:0071702 | organic substance transport | 48.7179 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 48.7179 | 4 | yes |
GO:0099643 | signal release from synapse | 48.7179 | 5 | yes |
GO:1903530 | regulation of secretion by cell | 48.7179 | 4 | yes |
GO:0008104 | protein localization | 48.7179 | 4 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 48.7179 | 5 | yes |
GO:0051046 | regulation of secretion | 48.7179 | 5 | yes |
GO:0071705 | nitrogen compound transport | 46.1538 | 4 | yes |
GO:0015031 | protein transport | 46.1538 | 4 | yes |
GO:0006996 | organelle organization | 41.0256 | 4 | no |
GO:0045055 | regulated exocytosis | 38.4615 | 5 | yes |
GO:0060627 | regulation of vesicle-mediated transport | 38.4615 | 4 | yes |
GO:0022607 | cellular component assembly | 35.8974 | 4 | no |
GO:0023056 | positive regulation of signaling | 35.8974 | 4 | no |
GO:0032880 | regulation of protein localization | 35.8974 | 5 | no |
GO:0043933 | protein-containing complex organization | 35.8974 | 4 | no |
GO:0060341 | regulation of cellular localization | 35.8974 | 4 | no |
GO:0061024 | membrane organization | 35.8974 | 4 | no |
GO:0017157 | regulation of exocytosis | 35.8974 | 5 | yes |
GO:0006836 | neurotransmitter transport | 33.3333 | 4 | no |
GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
GO:0065003 | protein-containing complex assembly | 33.3333 | 5 | no |
GO:0070201 | regulation of establishment of protein localization | 33.3333 | 6 | no |
GO:0060255 | regulation of macromolecule metabolic process | 33.3333 | 4 | no |
GO:0051050 | positive regulation of transport | 33.3333 | 4 | no |
GO:0099003 | vesicle-mediated transport in synapse | 30.7692 | 5 | yes |
GO:0016050 | vesicle organization | 30.7692 | 5 | no |
GO:0051223 | regulation of protein transport | 30.7692 | 5 | no |
GO:0061025 | membrane fusion | 30.7692 | 5 | no |
GO:0017156 | calcium-ion regulated exocytosis | 30.7692 | 6 | no |
GO:0016079 | synaptic vesicle exocytosis | 30.7692 | 4 | yes |
GO:0009966 | regulation of signal transduction | 28.2051 | 4 | no |
GO:0048523 | negative regulation of cellular process | 28.2051 | 4 | no |
GO:0043269 | regulation of ion transport | 28.2051 | 5 | no |
GO:0048584 | positive regulation of response to stimulus | 28.2051 | 4 | no |
GO:0007269 | neurotransmitter secretion | 28.2051 | 4 | no |
GO:0046928 | regulation of neurotransmitter secretion | 28.2051 | 4 | yes |
GO:0051588 | regulation of neurotransmitter transport | 28.2051 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 25.6410 | 4 | yes |
GO:0006906 | vesicle fusion | 25.6410 | 6 | no |
GO:0048278 | vesicle docking | 25.6410 | 4 | no |
GO:0048284 | organelle fusion | 25.6410 | 5 | no |
GO:0090174 | organelle membrane fusion | 25.6410 | 6 | no |
GO:0009893 | positive regulation of metabolic process | 25.6410 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 25.6410 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 25.6410 | 4 | no |
GO:0051047 | positive regulation of secretion | 25.6410 | 5 | no |
GO:1903305 | regulation of regulated secretory pathway | 25.6410 | 6 | no |
GO:1903532 | positive regulation of secretion by cell | 25.6410 | 5 | no |
GO:0033043 | regulation of organelle organization | 25.6410 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 23.0769 | 5 | yes |
GO:0050806 | positive regulation of synaptic transmission | 23.0769 | 5 | no |
GO:0010468 | regulation of gene expression | 23.0769 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 23.0769 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 23.0769 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 23.0769 | 4 | no |
GO:0006886 | intracellular protein transport | 23.0769 | 4 | no |
GO:0072657 | protein localization to membrane | 23.0769 | 4 | no |
GO:0007268 | chemical synaptic transmission | 23.0769 | 6 | yes |
GO:0050708 | regulation of protein secretion | 20.5128 | 5 | no |
GO:0043254 | regulation of protein-containing complex assembly | 20.5128 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 20.5128 | 5 | no |
GO:0045921 | positive regulation of exocytosis | 20.5128 | 6 | no |
GO:1990778 | protein localization to cell periphery | 20.5128 | 5 | no |
GO:0031338 | regulation of vesicle fusion | 15.3846 | 5 | yes |
GO:1901632 | regulation of synaptic vesicle membrane organization | 12.8205 | 5 | yes |
GO:0031630 | regulation of synaptic vesicle fusion to presynaptic active zone membrane | 12.8205 | 6 | yes |
GO:0098967 | exocytic insertion of neurotransmitter receptor to postsynaptic membrane | 10.2564 | 4 | yes |
GO:0071692 | protein localization to extracellular region | 7.6923 | 5 | yes |
GO:0009306 | protein secretion | 7.6923 | 4 | yes |
GO:0009914 | hormone transport | 7.6923 | 4 | yes |
GO:0035592 | establishment of protein localization to extracellular region | 7.6923 | 4 | yes |
GO:0046879 | hormone secretion | 7.6923 | 5 | yes |
GO:0002790 | peptide secretion | 5.1282 | 5 | yes |
GO:0015833 | peptide transport | 5.1282 | 5 | yes |
GO:0030072 | peptide hormone secretion | 5.1282 | 6 | yes |
GO:0030073 | insulin secretion | 5.1282 | 5 | yes |
GO:0042886 | amide transport | 5.1282 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in CPLX1_HUMAN |
---|---|---|---|---|
DOID:1826 | epilepsy | 5.1282 | 5 | yes |
DOID:331 | central nervous system disease | 5.1282 | 3 | yes |
DOID:936 | brain disease | 5.1282 | 4 | yes |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VAMP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SYT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
IQCB1_HUMAN | [view interactions] | High throughput | no | no |
GLPB_HUMAN | [view interactions] | High throughput | no | no |
CPLX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
OPRM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RXRB_HUMAN | [view interactions] | High throughput | no | yes |
ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FUBP2_HUMAN | [view interactions] | High throughput | no | yes |
PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STAM1_HUMAN | [view interactions] | High throughput | no | yes |
GGA2_HUMAN | [view interactions] | High throughput | no | yes |
TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPY30_HUMAN | [view interactions] | High throughput | no | yes |
LGUL_HUMAN | [view interactions] | High throughput | no | yes |
NDRG3_HUMAN | [view interactions] | High throughput | no | yes |
PFD5_HUMAN | [view interactions] | High throughput | no | yes |
S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SGTA_HUMAN | [view interactions] | High throughput | no | yes |
UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBE2B_HUMAN | [view interactions] | High throughput | no | no |
PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
POMP_HUMAN | [view interactions] | High throughput | no | yes |
TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RN114_HUMAN | [view interactions] | High throughput | no | no |
TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
HBS1L_HUMAN | [view interactions] | High throughput | no | yes |
JUPI1_HUMAN | [view interactions] | High throughput | no | yes |
NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
NENF_HUMAN | [view interactions] | High throughput | no | yes |
NUBP2_HUMAN | [view interactions] | High throughput | no | yes |
PSF3_HUMAN | [view interactions] | High throughput | no | yes |
GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CPLX3_HUMAN | [view interactions] | High throughput | no | no |
SYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STXB5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SNP29_HUMAN | [view interactions] | Computational | no | yes |
STX4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
VAMP1_HUMAN | [view interactions] | Computational | no | no |
LIN7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
STX1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
VAMP8_HUMAN | [view interactions] | Computational | no | no |
SNP23_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SYT7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
LIN7B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SNAA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
STXB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
UN13B_HUMAN | [view interactions] | Computational | no | no |
SYT2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RIMS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
STX3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RAB3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
APBA1_HUMAN | [view interactions] | Computational | no | no |
LIN7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SYN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
VGLU1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CPLX4_HUMAN | [view interactions] | Computational | no | no |
SYT4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |