UB2V2_HUMAN
Evidence for PS localization
Functions
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UB2V2_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 29.4118 | 4 | no |
| GO:0046872 | metal ion binding | 29.4118 | 5 | no |
| GO:0019900 | kinase binding | 26.4706 | 4 | no |
| GO:0000166 | nucleotide binding | 26.4706 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.4706 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.4706 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.4706 | 4 | no |
| GO:0043168 | anion binding | 26.4706 | 4 | no |
| GO:0003723 | RNA binding | 23.5294 | 4 | no |
| GO:0005524 | ATP binding | 20.5882 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 20.5882 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.5882 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UB2V2_HUMAN |
|---|---|---|---|---|
| GO:0051246 | regulation of protein metabolic process | 47.0588 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 47.0588 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 47.0588 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.1176 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 41.1765 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.1765 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 41.1765 | 4 | no |
| GO:0031399 | regulation of protein modification process | 38.2353 | 6 | yes |
| GO:0010646 | regulation of cell communication | 38.2353 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 35.2941 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 35.2941 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 35.2941 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 35.2941 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 32.3529 | 7 | yes |
| GO:0036211 | protein modification process | 32.3529 | 4 | yes |
| GO:0043412 | macromolecule modification | 32.3529 | 4 | yes |
| GO:0043687 | post-translational protein modification | 32.3529 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 32.3529 | 6 | yes |
| GO:0032446 | protein modification by small protein conjugation | 29.4118 | 7 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 29.4118 | 5 | no |
| GO:0016567 | protein ubiquitination | 26.4706 | 8 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.4706 | 5 | yes |
| GO:0080134 | regulation of response to stress | 26.4706 | 4 | yes |
| GO:0008104 | protein localization | 26.4706 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.4706 | 5 | no |
| GO:0080135 | regulation of cellular response to stress | 23.5294 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 23.5294 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
| GO:0000209 | protein polyubiquitination | 20.5882 | 9 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.5882 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.5882 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 20.5882 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 20.5882 | 4 | no |
| GO:0010468 | regulation of gene expression | 20.5882 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.5882 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.5882 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.5882 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.5882 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.5882 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.5882 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 20.5882 | 7 | no |
| GO:0043549 | regulation of kinase activity | 20.5882 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 20.5882 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.5882 | 5 | no |
| GO:0051338 | regulation of transferase activity | 20.5882 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.5882 | 4 | no |
| GO:0051049 | regulation of transport | 20.5882 | 4 | no |
| GO:0006974 | DNA damage response | 17.6471 | 4 | yes |
| GO:0031396 | regulation of protein ubiquitination | 17.6471 | 9 | yes |
| GO:0031398 | positive regulation of protein ubiquitination | 17.6471 | 10 | yes |
| GO:0051052 | regulation of DNA metabolic process | 17.6471 | 5 | yes |
| GO:0070534 | protein K63-linked ubiquitination | 17.6471 | 10 | yes |
| GO:0090304 | nucleic acid metabolic process | 17.6471 | 4 | yes |
| GO:1901873 | regulation of post-translational protein modification | 17.6471 | 7 | yes |
| GO:1901875 | positive regulation of post-translational protein modification | 17.6471 | 8 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 17.6471 | 8 | yes |
| GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 17.6471 | 9 | yes |
| GO:0006259 | DNA metabolic process | 14.7059 | 5 | yes |
| GO:0006281 | DNA repair | 14.7059 | 5 | yes |
| GO:0006282 | regulation of DNA repair | 14.7059 | 5 | yes |
| GO:0051054 | positive regulation of DNA metabolic process | 14.7059 | 6 | yes |
| GO:0006301 | postreplication repair | 11.7647 | 6 | yes |
| GO:0045739 | positive regulation of DNA repair | 11.7647 | 5 | yes |
| GO:1900044 | regulation of protein K63-linked ubiquitination | 11.7647 | 11 | yes |
| GO:1902523 | positive regulation of protein K63-linked ubiquitination | 11.7647 | 12 | yes |
| GO:1902914 | regulation of protein polyubiquitination | 11.7647 | 10 | yes |
| GO:1902916 | positive regulation of protein polyubiquitination | 11.7647 | 11 | yes |
| GO:2000779 | regulation of double-strand break repair | 11.7647 | 6 | yes |
| GO:2000781 | positive regulation of double-strand break repair | 11.7647 | 6 | yes |
| GO:0000729 | DNA double-strand break processing | 8.8235 | 6 | yes |
| GO:0042275 | error-free postreplication DNA repair | 5.8824 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| OTUB1_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF8_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF2_HUMAN | [view interactions] | Low throughput | no | yes |
| BCL10_HUMAN | [view interactions] | Low throughput | no | yes |
| MALT1_HUMAN | [view interactions] | Low throughput | no | no |
| MUL1_HUMAN | [view interactions] | Low throughput | no | no |
| RN111_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2V2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RNF4_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HLTF_HUMAN | [view interactions] | Low throughput | no | no |
| SHPRH_HUMAN | [view interactions] | Low throughput | no | yes |
| TRADD_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRCH3_HUMAN | [view interactions] | High throughput | no | yes |
| EFR3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PR38A_HUMAN | [view interactions] | High throughput | no | no |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
| MINP1_HUMAN | [view interactions] | High throughput | no | yes |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OVOL2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH2_HUMAN | [view interactions] | High throughput | no | no |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2B_HUMAN | [view interactions] | High throughput | no | no |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP34_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANCHR_HUMAN | [view interactions] | High throughput | no | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
| RS21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| TRPM7_HUMAN | [view interactions] | High throughput | no | no |
| TIGD6_HUMAN | [view interactions] | High throughput | no | no |
| RTF2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POLK_HUMAN | [view interactions] | High throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN3_HUMAN | [view interactions] | High throughput | no | yes |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRF1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM5_HUMAN | [view interactions] | High throughput | no | yes |
| IGS21_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHOCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIF1_HUMAN | [view interactions] | High throughput | no | yes |
| SUV92_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| RA1L2_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| HOIL1_HUMAN | [view interactions] | High throughput | no | no |