UB2V2_HUMAN
Evidence for PS localization
Functions
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UB2V2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 30.0000 | 4 | no |
| GO:0046872 | metal ion binding | 30.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.5000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.5000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.5000 | 4 | no |
| GO:0005524 | ATP binding | 22.5000 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 22.5000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.5000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UB2V2_HUMAN |
|---|---|---|---|---|
| GO:0036211 | protein modification process | 47.5000 | 4 | yes |
| GO:0043412 | macromolecule modification | 47.5000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 45.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 45.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 45.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 40.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 37.5000 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 35.0000 | 5 | yes |
| GO:0010646 | regulation of cell communication | 35.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 32.5000 | 6 | yes |
| GO:0032446 | protein modification by small protein conjugation | 32.5000 | 6 | yes |
| GO:0009966 | regulation of signal transduction | 32.5000 | 4 | no |
| GO:0016567 | protein ubiquitination | 30.0000 | 7 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | yes |
| GO:0006508 | proteolysis | 30.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.0000 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 27.5000 | 7 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 27.5000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 27.5000 | 5 | no |
| GO:0006974 | cellular response to DNA damage stimulus | 25.0000 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | yes |
| GO:0080134 | regulation of response to stress | 25.0000 | 4 | yes |
| GO:0080135 | regulation of cellular response to stress | 25.0000 | 4 | yes |
| GO:0090304 | nucleic acid metabolic process | 25.0000 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 25.0000 | 4 | no |
| GO:0019941 | modification-dependent protein catabolic process | 25.0000 | 6 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 25.0000 | 5 | no |
| GO:0044265 | cellular macromolecule catabolic process | 25.0000 | 4 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0006259 | DNA metabolic process | 22.5000 | 4 | yes |
| GO:0006281 | DNA repair | 22.5000 | 5 | yes |
| GO:2001020 | regulation of response to DNA damage stimulus | 22.5000 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 22.5000 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.0000 | 6 | yes |
| GO:0051052 | regulation of DNA metabolic process | 20.0000 | 5 | yes |
| GO:0006282 | regulation of DNA repair | 17.5000 | 6 | yes |
| GO:0051054 | positive regulation of DNA metabolic process | 17.5000 | 6 | yes |
| GO:0000209 | protein polyubiquitination | 15.0000 | 8 | yes |
| GO:0031396 | regulation of protein ubiquitination | 15.0000 | 8 | yes |
| GO:0031398 | positive regulation of protein ubiquitination | 15.0000 | 9 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 15.0000 | 7 | yes |
| GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 15.0000 | 8 | yes |
| GO:2000779 | regulation of double-strand break repair | 15.0000 | 7 | yes |
| GO:0006301 | postreplication repair | 12.5000 | 6 | yes |
| GO:0045739 | positive regulation of DNA repair | 12.5000 | 6 | yes |
| GO:0070534 | protein K63-linked ubiquitination | 12.5000 | 9 | yes |
| GO:2000781 | positive regulation of double-strand break repair | 12.5000 | 7 | yes |
| GO:2001022 | positive regulation of response to DNA damage stimulus | 12.5000 | 5 | yes |
| GO:1900044 | regulation of protein K63-linked ubiquitination | 10.0000 | 10 | yes |
| GO:1902523 | positive regulation of protein K63-linked ubiquitination | 10.0000 | 11 | yes |
| GO:1902914 | regulation of protein polyubiquitination | 10.0000 | 9 | yes |
| GO:1902916 | positive regulation of protein polyubiquitination | 10.0000 | 10 | yes |
| GO:0000729 | DNA double-strand break processing | 7.5000 | 5 | yes |
| GO:0042275 | error-free postreplication DNA repair | 5.0000 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in UB2V2_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 7.5000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 7.5000 | 5 | no |
| DOID:114 | heart disease | 7.5000 | 3 | no |
| DOID:2843 | long QT syndrome | 7.5000 | 6 | no |
| DOID:331 | central nervous system disease | 5.0000 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RNF4_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2V2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBE2N_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HLTF_HUMAN | [view interactions] | Low throughput | no | no |
| SHPRH_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF8_HUMAN | [view interactions] | Low throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF2_HUMAN | [view interactions] | Low throughput | no | yes |
| BCL10_HUMAN | [view interactions] | Low throughput | no | yes |
| MALT1_HUMAN | [view interactions] | Low throughput | no | no |
| MUL1_HUMAN | [view interactions] | Low throughput | no | no |
| SNTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MASU1_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| TRPM7_HUMAN | [view interactions] | High throughput | no | no |
| TIGD6_HUMAN | [view interactions] | High throughput | no | no |
| RTF2_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POLK_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN3_HUMAN | [view interactions] | High throughput | no | yes |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRF1_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM5_HUMAN | [view interactions] | High throughput | no | yes |
| IGS21_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHOCN_HUMAN | [view interactions] | High throughput | no | yes |
| RIF1_HUMAN | [view interactions] | High throughput | no | yes |
| SUV92_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RA1L2_HUMAN | [view interactions] | High throughput | no | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOIL1_HUMAN | [view interactions] | High throughput | no | no |
| TRADD_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRCH3_HUMAN | [view interactions] | High throughput | no | yes |
| EFR3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PR38A_HUMAN | [view interactions] | High throughput | no | no |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
| MINP1_HUMAN | [view interactions] | High throughput | no | yes |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| MYO5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH2_HUMAN | [view interactions] | High throughput | no | no |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2B_HUMAN | [view interactions] | High throughput | no | no |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| UBXN1_HUMAN | [view interactions] | High throughput | no | no |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP34_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPLX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANCHR_HUMAN | [view interactions] | High throughput | no | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
| RS21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | Computational | no | yes |
| UBE2S_HUMAN | [view interactions] | Computational | no | no |
| ERCC2_HUMAN | [view interactions] | Computational | no | yes |
| UBA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| REV1_HUMAN | [view interactions] | Computational | no | yes |
| UBE2K_HUMAN | [view interactions] | Computational | no | yes |
| UB2D1_HUMAN | [view interactions] | Computational | no | yes |
| PPP5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBE2H_HUMAN | [view interactions] | Computational | no | yes |
| RAD18_HUMAN | [view interactions] | Computational | no | yes |
| XPA_HUMAN | [view interactions] | Computational | no | yes |
| UB2D3_HUMAN | [view interactions] | Computational | no | yes |
| RD23A_HUMAN | [view interactions] | Computational | no | yes |
| RAD51_HUMAN | [view interactions] | Computational | no | yes |
| UBE2A_HUMAN | [view interactions] | Computational | no | no |
| CHD1L_HUMAN | [view interactions] | Computational | no | yes |
| SUMO2_HUMAN | [view interactions] | Computational | no | yes |
| UB2R2_HUMAN | [view interactions] | Computational | no | no |
| UB2G1_HUMAN | [view interactions] | Computational | no | yes |
| TRAF5_HUMAN | [view interactions] | Computational | no | yes |
| POLH_HUMAN | [view interactions] | Computational | no | yes |
| TF2H5_HUMAN | [view interactions] | Computational | no | no |
| CUL4A_HUMAN | [view interactions] | Computational | no | no |
| UB2E1_HUMAN | [view interactions] | Computational | no | yes |
| PSA2_HUMAN | [view interactions] | Computational | no | yes |
| UB2G2_HUMAN | [view interactions] | Computational | no | yes |
| TF2H1_HUMAN | [view interactions] | Computational | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBE2F_HUMAN | [view interactions] | Computational | no | yes |
| CETN2_HUMAN | [view interactions] | Computational | no | yes |
| XPC_HUMAN | [view interactions] | Computational | no | yes |
| TF2H3_HUMAN | [view interactions] | Computational | no | yes |
| UBA6_HUMAN | [view interactions] | Computational | no | no |
| TF2H4_HUMAN | [view interactions] | Computational | no | no |
| UB2Q2_HUMAN | [view interactions] | Computational | no | no |
| CHK2_HUMAN | [view interactions] | Computational | no | yes |
| SUMO3_HUMAN | [view interactions] | Computational | no | yes |
| UB2D4_HUMAN | [view interactions] | Computational | no | yes |
| UBE2U_HUMAN | [view interactions] | Computational | no | no |
| PSA3_HUMAN | [view interactions] | Computational | no | no |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBC9_HUMAN | [view interactions] | Computational | no | yes |
| DDB2_HUMAN | [view interactions] | Computational | no | yes |
| UB2J1_HUMAN | [view interactions] | Computational | no | yes |
| UBE2Z_HUMAN | [view interactions] | Computational | no | yes |
| ERCC3_HUMAN | [view interactions] | Computational | no | yes |
| UBA5_HUMAN | [view interactions] | Computational | no | yes |
| SUMO1_HUMAN | [view interactions] | Computational | no | yes |
| UB2E2_HUMAN | [view interactions] | Computational | no | yes |
| UBA7_HUMAN | [view interactions] | Computational | no | yes |
| UBE2C_HUMAN | [view interactions] | Computational | no | yes |
| UBA3_HUMAN | [view interactions] | Computational | no | yes |
| DDB1_HUMAN | [view interactions] | Computational | no | yes |
| UB2L6_HUMAN | [view interactions] | Computational | no | no |
| UB2R1_HUMAN | [view interactions] | Computational | no | yes |
| UB2E3_HUMAN | [view interactions] | Computational | no | yes |
| PARP2_HUMAN | [view interactions] | Computational | no | yes |
| TF2H2_HUMAN | [view interactions] | Computational | no | no |
| TP53B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UB2D2_HUMAN | [view interactions] | Computational | no | yes |
| PCNA_HUMAN | [view interactions] | Computational | no | no |
| UB2Q1_HUMAN | [view interactions] | Computational | no | no |
| UB2J2_HUMAN | [view interactions] | Computational | no | no |
| RAD52_HUMAN | [view interactions] | Computational | no | no |
| REV3L_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UBE2O_HUMAN | [view interactions] | Computational | no | yes |