VP26A_HUMAN
Evidence for PS localization
Functions
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R (PubMed, PubMed). Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed). Required for the endosomal localization of WASHC2A (indicative for the WASH complex) (PubMed). Required for the endosomal localization of TBC1D5 (PubMed). Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP (PubMed). Involved in retromer-independent lysosomal sorting of F2R (PubMed). Involved in recycling of ADRB2 (PubMed). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in VP26A_HUMAN |
|---|---|---|---|---|
| GO:0045296 | cadherin binding | 26.9231 | 4 | no |
| GO:0043168 | anion binding | 21.1538 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in VP26A_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 53.8462 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 48.0769 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.2308 | 4 | no |
| GO:0071702 | organic substance transport | 42.3077 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 42.3077 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.3077 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.3846 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 40.3846 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.3846 | 4 | no |
| GO:0015031 | protein transport | 38.4615 | 4 | yes |
| GO:0010646 | regulation of cell communication | 38.4615 | 4 | no |
| GO:0006886 | intracellular protein transport | 34.6154 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 34.6154 | 4 | no |
| GO:0022607 | cellular component assembly | 34.6154 | 4 | no |
| GO:0006996 | organelle organization | 32.6923 | 4 | no |
| GO:0009894 | regulation of catabolic process | 30.7692 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 30.7692 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.7692 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.7692 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.7692 | 5 | no |
| GO:0051049 | regulation of transport | 30.7692 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.8462 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.8462 | 5 | no |
| GO:0016482 | cytosolic transport | 26.9231 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 26.9231 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 26.9231 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.9231 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.9231 | 5 | no |
| GO:0033043 | regulation of organelle organization | 26.9231 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.9231 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.0769 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 23.0769 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.0769 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.0769 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.0769 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 23.0769 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.1538 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.1538 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.1538 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.1538 | 6 | no |
| GO:0043933 | protein-containing complex organization | 21.1538 | 4 | no |
| GO:0033365 | protein localization to organelle | 21.1538 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 21.1538 | 4 | no |
| GO:0010506 | regulation of autophagy | 19.2308 | 6 | yes |
| GO:0031329 | regulation of cellular catabolic process | 19.2308 | 5 | yes |
| GO:0032456 | endocytic recycling | 19.2308 | 4 | yes |
| GO:0016241 | regulation of macroautophagy | 13.4615 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SNX27_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SNX3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RAB7A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NRAM2_HUMAN | [view interactions] | Low throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VPS29_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBCD5_HUMAN | [view interactions] | Low throughput | no | yes |
| VP26B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MPRI_HUMAN | [view interactions] | Low throughput | no | yes |
| MUL1_HUMAN | [view interactions] | Low throughput | no | no |
| ANFY1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EHD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VP26A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MPIP3_HUMAN | [view interactions] | High throughput | no | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| IFT20_HUMAN | [view interactions] | High throughput | no | yes |
| LRC73_HUMAN | [view interactions] | High throughput | no | yes |
| GPSM3_HUMAN | [view interactions] | High throughput | no | no |
| FAXC_HUMAN | [view interactions] | High throughput | no | no |
| T2R19_HUMAN | [view interactions] | High throughput | no | no |
| TM154_HUMAN | [view interactions] | High throughput | no | no |
| S10A6_HUMAN | [view interactions] | High throughput | no | yes |
| KXDL1_HUMAN | [view interactions] | High throughput | no | yes |
| CITE1_HUMAN | [view interactions] | High throughput | no | no |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| RPGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| MAP7_HUMAN | [view interactions] | High throughput | no | yes |
| MOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| VPS36_HUMAN | [view interactions] | High throughput | no | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| VPS25_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE4B_HUMAN | [view interactions] | High throughput | no | yes |
| UBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TTC4_HUMAN | [view interactions] | High throughput | no | yes |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| VPS4B_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| THUM3_HUMAN | [view interactions] | High throughput | no | yes |
| PUM1_HUMAN | [view interactions] | High throughput | no | yes |
| XPF_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| ACPH_HUMAN | [view interactions] | High throughput | no | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERF1_HUMAN | [view interactions] | High throughput | no | yes |
| NIBA2_HUMAN | [view interactions] | High throughput | no | no |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
| NMI_HUMAN | [view interactions] | High throughput | no | yes |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| PSMG3_HUMAN | [view interactions] | High throughput | no | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| SYTC_HUMAN | [view interactions] | High throughput | no | yes |
| ZTRF1_HUMAN | [view interactions] | High throughput | no | no |
| TM276_HUMAN | [view interactions] | High throughput | no | no |
| DDI2_HUMAN | [view interactions] | High throughput | no | no |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H1X_HUMAN | [view interactions] | High throughput | no | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| NAA15_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBC15_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IRF6_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B_HUMAN | [view interactions] | High throughput | no | yes |
| IF2G_HUMAN | [view interactions] | High throughput | no | yes |
| RB6I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRLF3_HUMAN | [view interactions] | High throughput | no | yes |
| NU205_HUMAN | [view interactions] | High throughput | no | no |
| PGTA_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| BHE41_HUMAN | [view interactions] | High throughput | no | no |
| SYMPK_HUMAN | [view interactions] | High throughput | no | yes |
| UBL4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZER1_HUMAN | [view interactions] | High throughput | no | no |
| ANR27_HUMAN | [view interactions] | High throughput | no | yes |
| TYW4_HUMAN | [view interactions] | High throughput | no | yes |
| CB069_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRTAP_HUMAN | [view interactions] | High throughput | no | yes |
| RBM26_HUMAN | [view interactions] | High throughput | no | yes |
| WASC5_HUMAN | [view interactions] | High throughput | no | yes |
| WAC2A_HUMAN | [view interactions] | High throughput | no | yes |
| FKB15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| UTP4_HUMAN | [view interactions] | High throughput | no | yes |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASC4_HUMAN | [view interactions] | High throughput | no | yes |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| RBM4_HUMAN | [view interactions] | High throughput | no | yes |
| BCS1_HUMAN | [view interactions] | High throughput | no | yes |
| RHG44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TB22A_HUMAN | [view interactions] | High throughput | no | yes |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMYD2_HUMAN | [view interactions] | High throughput | no | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| ZSC12_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIOK2_HUMAN | [view interactions] | High throughput | no | yes |
| VP26C_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| MO4L1_HUMAN | [view interactions] | High throughput | no | yes |
| RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOLC1_HUMAN | [view interactions] | High throughput | no | yes |
| CELF1_HUMAN | [view interactions] | High throughput | no | yes |
| ENTR1_HUMAN | [view interactions] | High throughput | no | no |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| INT7_HUMAN | [view interactions] | High throughput | no | no |
| C99L2_HUMAN | [view interactions] | High throughput | no | yes |
| WAC2C_HUMAN | [view interactions] | High throughput | no | yes |
| EEIG2_HUMAN | [view interactions] | High throughput | no | yes |
| DUS8_HUMAN | [view interactions] | High throughput | no | no |
| TINAG_HUMAN | [view interactions] | High throughput | no | no |
| WASH1_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH18_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |