RHG44_HUMAN
Evidence for PS localization
Functions
GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity . Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation . In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RHG44_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 45.0000 | 4 | no |
| GO:0019900 | kinase binding | 40.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 35.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 30.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0005096 | GTPase activator activity | 10.0000 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 10.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RHG44_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 55.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 55.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 55.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 55.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 55.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 50.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 45.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 45.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 45.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | yes |
| GO:0006996 | organelle organization | 40.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 35.0000 | 5 | yes |
| GO:0051050 | positive regulation of transport | 35.0000 | 4 | no |
| GO:0008104 | protein localization | 35.0000 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 35.0000 | 4 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.0000 | 6 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 30.0000 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | no |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 30.0000 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 30.0000 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 30.0000 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 30.0000 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 30.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 30.0000 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | yes |
| GO:0050807 | regulation of synapse organization | 25.0000 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 25.0000 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 25.0000 | 8 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0033674 | positive regulation of kinase activity | 25.0000 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0043269 | regulation of ion transport | 25.0000 | 5 | no |
| GO:0043270 | positive regulation of ion transport | 25.0000 | 5 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0044057 | regulation of system process | 25.0000 | 4 | no |
| GO:0051051 | negative regulation of transport | 25.0000 | 4 | no |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | no |
| GO:0051347 | positive regulation of transferase activity | 25.0000 | 5 | no |
| GO:0016310 | phosphorylation | 25.0000 | 5 | no |
| GO:0007010 | cytoskeleton organization | 25.0000 | 5 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0061024 | membrane organization | 25.0000 | 4 | no |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | yes |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | yes |
| GO:0051223 | regulation of protein transport | 20.0000 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 20.0000 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 20.0000 | 4 | yes |
| GO:0061001 | regulation of dendritic spine morphogenesis | 20.0000 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 20.0000 | 6 | yes |
| GO:0072657 | protein localization to membrane | 20.0000 | 4 | yes |
| GO:0099175 | regulation of postsynapse organization | 20.0000 | 6 | yes |
| GO:0010975 | regulation of neuron projection development | 20.0000 | 7 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 20.0000 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 20.0000 | 4 | yes |
| GO:0050808 | synapse organization | 15.0000 | 5 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 15.0000 | 6 | yes |
| GO:0060491 | regulation of cell projection assembly | 15.0000 | 5 | yes |
| GO:0071702 | organic substance transport | 15.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 15.0000 | 4 | yes |
| GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 15.0000 | 6 | yes |
| GO:0006886 | intracellular protein transport | 15.0000 | 4 | yes |
| GO:0015031 | protein transport | 15.0000 | 4 | yes |
| GO:0034330 | cell junction organization | 15.0000 | 4 | yes |
| GO:0046578 | regulation of Ras protein signal transduction | 10.0000 | 7 | yes |
| GO:0046903 | secretion | 10.0000 | 4 | yes |
| GO:0048585 | negative regulation of response to stimulus | 10.0000 | 4 | yes |
| GO:0051489 | regulation of filopodium assembly | 10.0000 | 7 | yes |
| GO:0072659 | protein localization to plasma membrane | 10.0000 | 5 | yes |
| GO:0090150 | establishment of protein localization to membrane | 10.0000 | 4 | yes |
| GO:0098876 | vesicle-mediated transport to the plasma membrane | 10.0000 | 4 | yes |
| GO:0099563 | modification of synaptic structure | 10.0000 | 6 | yes |
| GO:1990778 | protein localization to cell periphery | 10.0000 | 5 | yes |
| GO:0006887 | exocytosis | 10.0000 | 4 | yes |
| GO:0009968 | negative regulation of signal transduction | 10.0000 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 10.0000 | 5 | yes |
| GO:0016197 | endosomal transport | 10.0000 | 4 | yes |
| GO:0023057 | negative regulation of signaling | 10.0000 | 4 | yes |
| GO:0032386 | regulation of intracellular transport | 10.0000 | 5 | yes |
| GO:0032456 | endocytic recycling | 10.0000 | 5 | yes |
| GO:0033157 | regulation of intracellular protein transport | 10.0000 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RHG44_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 15.0000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 15.0000 | 5 | no |
| DOID:114 | heart disease | 15.0000 | 3 | no |
| DOID:2843 | long QT syndrome | 10.0000 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SHAN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| 3BP1_HUMAN | [view interactions] | High throughput | no | no |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2BC_HUMAN | [view interactions] | High throughput | no | yes |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| CASP5_HUMAN | [view interactions] | High throughput | no | no |
| ARHG6_HUMAN | [view interactions] | High throughput | no | no |
| CIP4_HUMAN | [view interactions] | High throughput | no | no |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| JUPI1_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FBP1L_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| BOLA2_HUMAN | [view interactions] | High throughput | no | yes |
| TM263_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUMA1_HUMAN | [view interactions] | High throughput | no | yes |
| SURF6_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASP4_HUMAN | [view interactions] | High throughput | no | yes |
| NAA25_HUMAN | [view interactions] | High throughput | no | yes |
| PUS7_HUMAN | [view interactions] | High throughput | no | yes |
| STK24_HUMAN | [view interactions] | High throughput | no | yes |
| BCL7B_HUMAN | [view interactions] | High throughput | no | yes |
| TIPRL_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| TCOF_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF1_HUMAN | [view interactions] | Computational | no | no |