Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RHG44_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity . Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation . In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RHG44_HUMAN
GO:0043169 cation binding 47.3684 4 no
GO:0046872 metal ion binding 47.3684 5 no
GO:0019900 kinase binding 42.1053 4 no
GO:0019901 protein kinase binding 36.8421 5 no
GO:0000166 nucleotide binding 31.5789 4 no
GO:0017076 purine nucleotide binding 31.5789 5 no
GO:0032555 purine ribonucleotide binding 31.5789 4 no
GO:0043168 anion binding 31.5789 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.3158 4 no
GO:0030554 adenyl nucleotide binding 21.0526 6 no
GO:0032559 adenyl ribonucleotide binding 21.0526 5 no
GO:0005096 GTPase activator activity 10.5263 4 yes
GO:0030695 GTPase regulator activity 10.5263 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RHG44_HUMAN
GO:0048523 negative regulation of cellular process 63.1579 4 yes
GO:0031323 regulation of cellular metabolic process 63.1579 4 no
GO:0048522 positive regulation of cellular process 63.1579 4 no
GO:0060255 regulation of macromolecule metabolic process 63.1579 4 no
GO:0010646 regulation of cell communication 57.8947 4 yes
GO:0080090 regulation of primary metabolic process 57.8947 4 no
GO:0009966 regulation of signal transduction 52.6316 4 yes
GO:0051049 regulation of transport 47.3684 4 yes
GO:0009893 positive regulation of metabolic process 47.3684 4 no
GO:0010604 positive regulation of macromolecule metabolic process 47.3684 5 no
GO:0006996 organelle organization 47.3684 4 no
GO:0051128 regulation of cellular component organization 42.1053 4 yes
GO:0031325 positive regulation of cellular metabolic process 42.1053 5 no
GO:0031344 regulation of cell projection organization 36.8421 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 36.8421 6 yes
GO:1902531 regulation of intracellular signal transduction 36.8421 5 yes
GO:0009892 negative regulation of metabolic process 36.8421 4 no
GO:0010605 negative regulation of macromolecule metabolic process 36.8421 5 no
GO:0031324 negative regulation of cellular metabolic process 36.8421 5 no
GO:0051050 positive regulation of transport 36.8421 4 no
GO:0009889 regulation of biosynthetic process 36.8421 4 no
GO:0010468 regulation of gene expression 36.8421 6 no
GO:0010556 regulation of macromolecule biosynthetic process 36.8421 5 no
GO:0031326 regulation of cellular biosynthetic process 36.8421 5 no
GO:0008104 protein localization 31.5789 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 31.5789 4 yes
GO:0010647 positive regulation of cell communication 31.5789 5 no
GO:0023056 positive regulation of signaling 31.5789 4 no
GO:0141124 intracellular signaling cassette 31.5789 4 no
GO:0007010 cytoskeleton organization 31.5789 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.5789 5 no
GO:0030334 regulation of cell migration 31.5789 5 no
GO:2000145 regulation of cell motility 31.5789 4 no
GO:0010975 regulation of neuron projection development 26.3158 7 yes
GO:0033043 regulation of organelle organization 26.3158 5 yes
GO:0044087 regulation of cellular component biogenesis 26.3158 4 yes
GO:0050807 regulation of synapse organization 26.3158 5 yes
GO:0051129 negative regulation of cellular component organization 26.3158 5 yes
GO:0051336 regulation of hydrolase activity 26.3158 4 yes
GO:0099175 regulation of postsynapse organization 26.3158 6 yes
GO:0001932 regulation of protein phosphorylation 26.3158 7 no
GO:0001934 positive regulation of protein phosphorylation 26.3158 8 no
GO:0009967 positive regulation of signal transduction 26.3158 5 no
GO:0010562 positive regulation of phosphorus metabolic process 26.3158 6 no
GO:0019220 regulation of phosphate metabolic process 26.3158 6 no
GO:0031399 regulation of protein modification process 26.3158 6 no
GO:0031401 positive regulation of protein modification process 26.3158 7 no
GO:0042325 regulation of phosphorylation 26.3158 7 no
GO:0042327 positive regulation of phosphorylation 26.3158 8 no
GO:0043269 regulation of monoatomic ion transport 26.3158 5 no
GO:0043270 positive regulation of monoatomic ion transport 26.3158 5 no
GO:0044057 regulation of system process 26.3158 4 no
GO:0045937 positive regulation of phosphate metabolic process 26.3158 7 no
GO:0048584 positive regulation of response to stimulus 26.3158 4 no
GO:0051174 regulation of phosphorus metabolic process 26.3158 5 no
GO:0051246 regulation of protein metabolic process 26.3158 5 no
GO:0051247 positive regulation of protein metabolic process 26.3158 6 no
GO:0061024 membrane organization 26.3158 4 no
GO:0032880 regulation of protein localization 21.0526 5 yes
GO:0032956 regulation of actin cytoskeleton organization 21.0526 5 yes
GO:0032970 regulation of actin filament-based process 21.0526 4 yes
GO:0051493 regulation of cytoskeleton organization 21.0526 6 yes
GO:0060341 regulation of cellular localization 21.0526 4 yes
GO:0061001 regulation of dendritic spine morphogenesis 21.0526 5 yes
GO:0001933 negative regulation of protein phosphorylation 21.0526 8 no
GO:0010563 negative regulation of phosphorus metabolic process 21.0526 6 no
GO:0010564 regulation of cell cycle process 21.0526 5 no
GO:0010959 regulation of metal ion transport 21.0526 6 no
GO:0021762 substantia nigra development 21.0526 4 no
GO:0022898 regulation of transmembrane transporter activity 21.0526 4 no
GO:0031400 negative regulation of protein modification process 21.0526 7 no
GO:0032411 positive regulation of transporter activity 21.0526 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 21.0526 5 no
GO:0032414 positive regulation of ion transmembrane transporter activity 21.0526 5 no
GO:0032465 regulation of cytokinesis 21.0526 5 no
GO:0033674 positive regulation of kinase activity 21.0526 6 no
GO:0034762 regulation of transmembrane transport 21.0526 4 no
GO:0034764 positive regulation of transmembrane transport 21.0526 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 21.0526 5 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 21.0526 6 no
GO:0042326 negative regulation of phosphorylation 21.0526 8 no
GO:0043085 positive regulation of catalytic activity 21.0526 4 no
GO:0043549 regulation of kinase activity 21.0526 5 no
GO:0044772 mitotic cell cycle phase transition 21.0526 4 no
GO:0045859 regulation of protein kinase activity 21.0526 6 no
GO:0045860 positive regulation of protein kinase activity 21.0526 7 no
GO:0045936 negative regulation of phosphate metabolic process 21.0526 7 no
GO:0051051 negative regulation of transport 21.0526 4 no
GO:0051248 negative regulation of protein metabolic process 21.0526 6 no
GO:0051302 regulation of cell division 21.0526 4 no
GO:0051338 regulation of transferase activity 21.0526 4 no
GO:0051347 positive regulation of transferase activity 21.0526 5 no
GO:0051726 regulation of cell cycle 21.0526 4 no
GO:0051924 regulation of calcium ion transport 21.0526 7 no
GO:0051928 positive regulation of calcium ion transport 21.0526 6 no
GO:0071310 cellular response to organic substance 21.0526 4 no
GO:0090257 regulation of muscle system process 21.0526 5 no
GO:0051130 positive regulation of cellular component organization 21.0526 5 no
GO:0051252 regulation of RNA metabolic process 21.0526 5 no
GO:0006796 phosphate-containing compound metabolic process 21.0526 4 no
GO:0042981 regulation of apoptotic process 21.0526 5 no
GO:0043067 regulation of programmed cell death 21.0526 4 no
GO:0006886 intracellular protein transport 15.7895 4 yes
GO:0015031 protein transport 15.7895 4 yes
GO:0034330 cell junction organization 15.7895 4 yes
GO:0050804 modulation of chemical synaptic transmission 15.7895 5 yes
GO:0050808 synapse organization 15.7895 5 yes
GO:0051056 regulation of small GTPase mediated signal transduction 15.7895 6 yes
GO:0051223 regulation of protein transport 15.7895 5 yes
GO:0060491 regulation of cell projection assembly 15.7895 5 yes
GO:0060627 regulation of vesicle-mediated transport 15.7895 4 yes
GO:0070201 regulation of establishment of protein localization 15.7895 6 yes
GO:0071702 organic substance transport 15.7895 4 yes
GO:0071705 nitrogen compound transport 15.7895 4 yes
GO:0099177 regulation of trans-synaptic signaling 15.7895 4 yes
GO:0120032 regulation of plasma membrane bounded cell projection assembly 15.7895 6 yes
GO:0009968 negative regulation of signal transduction 10.5263 5 yes
GO:0010648 negative regulation of cell communication 10.5263 5 yes
GO:0023057 negative regulation of signaling 10.5263 4 yes
GO:0032386 regulation of intracellular transport 10.5263 5 yes
GO:0032456 endocytic recycling 10.5263 4 yes
GO:0033157 regulation of intracellular protein transport 10.5263 6 yes
GO:0046903 secretion 10.5263 4 yes
GO:0048585 negative regulation of response to stimulus 10.5263 4 yes
GO:0051489 regulation of filopodium assembly 10.5263 7 yes
GO:0072657 protein localization to membrane 10.5263 4 yes
GO:0099563 modification of synaptic structure 10.5263 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
RHG17_HUMAN [view interactions] High throughput no no
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
PP2BC_HUMAN [view interactions] High throughput no yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
3BP1_HUMAN [view interactions] High throughput no no
CD2AP_HUMAN [view interactions] High throughput no no
CASP5_HUMAN [view interactions] High throughput no no
ARHG6_HUMAN [view interactions] High throughput no no
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
CIP4_HUMAN [view interactions] High throughput no no
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
MYOME_HUMAN [view interactions] High throughput no no
JUPI1_HUMAN [view interactions] High throughput no yes
NHRF2_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
FBP1L_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
CTBP2_HUMAN [view interactions] High throughput no no
BOLA2_HUMAN [view interactions] High throughput no yes
TM263_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
LMNB2_HUMAN [view entry] [view interactions] High throughput yes yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
NUMA1_HUMAN [view interactions] High throughput no yes
SURF6_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
CASP4_HUMAN [view interactions] High throughput no yes
NAA25_HUMAN [view interactions] High throughput no yes
PUS7_HUMAN [view interactions] High throughput no yes
STK24_HUMAN [view interactions] High throughput no yes
BCL7B_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
TIPRL_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
SRGP3_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE2_HUMAN [view interactions] High throughput no no
TCOF_HUMAN [view interactions] High throughput no yes