Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

LMNB2_HUMAN

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. [View more on UniProt]

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No data found.

Position Amino acid Mutation Disease Overlap with binding region
427 Ala Thr Partialacquiredlipodystrophy(APLD) -
157 His Tyr Epilepsy,progressivemyoclonic9(EPM9) -
252 Tyr His Partialacquiredlipodystrophy(APLD) -
54 Asn His Microcephaly27,primary,autosomaldominant(MCPH27) -
398 Glu Lys Microcephaly27,primary,autosomaldominant(MCPH27) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in LMNB2_HUMAN
GO:0043168 anion binding 30.3571 4 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0019900 kinase binding 23.2143 4 no
GO:0019901 protein kinase binding 23.2143 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in LMNB2_HUMAN
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0048523 negative regulation of cellular process 55.3571 4 yes
GO:0031323 regulation of cellular metabolic process 53.5714 4 yes
GO:0060255 regulation of macromolecule metabolic process 51.7857 4 yes
GO:0006996 organelle organization 46.4286 4 yes
GO:0051128 regulation of cellular component organization 46.4286 4 no
GO:0010646 regulation of cell communication 44.6429 4 no
GO:0009889 regulation of biosynthetic process 41.0714 4 yes
GO:0080090 regulation of primary metabolic process 41.0714 4 no
GO:0009966 regulation of signal transduction 41.0714 4 no
GO:0008104 protein localization 39.2857 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 39.2857 5 yes
GO:0031326 regulation of cellular biosynthetic process 39.2857 5 yes
GO:0009893 positive regulation of metabolic process 37.5000 4 no
GO:0009892 negative regulation of metabolic process 35.7143 4 yes
GO:0010468 regulation of gene expression 35.7143 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 35.7143 5 no
GO:0031324 negative regulation of cellular metabolic process 33.9286 5 yes
GO:0022607 cellular component assembly 33.9286 4 no
GO:1902531 regulation of intracellular signal transduction 32.1429 5 no
GO:0007010 cytoskeleton organization 30.3571 5 no
GO:0031325 positive regulation of cellular metabolic process 30.3571 5 no
GO:0033043 regulation of organelle organization 30.3571 5 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.7857 5 no
GO:0010605 negative regulation of macromolecule metabolic process 26.7857 5 yes
GO:0043933 protein-containing complex organization 26.7857 4 yes
GO:0044087 regulation of cellular component biogenesis 26.7857 4 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 yes
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0051130 positive regulation of cellular component organization 23.2143 5 no
GO:0051493 regulation of cytoskeleton organization 23.2143 6 no
GO:0032880 regulation of protein localization 23.2143 5 no
GO:0042981 regulation of apoptotic process 23.2143 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.2143 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 23.2143 6 yes
GO:0036211 protein modification process 23.2143 4 no
GO:0043412 macromolecule modification 23.2143 4 no
GO:0051247 positive regulation of protein metabolic process 23.2143 6 no
GO:2000145 regulation of cell motility 21.4286 4 no
GO:0009968 negative regulation of signal transduction 21.4286 5 no
GO:0010648 negative regulation of cell communication 21.4286 5 no
GO:0023057 negative regulation of signaling 21.4286 4 no
GO:0048585 negative regulation of response to stimulus 21.4286 4 no
GO:0061024 membrane organization 21.4286 4 yes
GO:0009894 regulation of catabolic process 21.4286 4 no
GO:0031399 regulation of protein modification process 21.4286 6 no
GO:0009967 positive regulation of signal transduction 21.4286 5 no
GO:0141124 intracellular signaling cassette 21.4286 4 no
GO:0030334 regulation of cell migration 21.4286 5 no
GO:0051049 regulation of transport 21.4286 4 no
GO:0010629 negative regulation of gene expression 19.6429 7 yes
GO:0033365 protein localization to organelle 17.8571 5 yes
GO:0006325 chromatin organization 10.7143 6 yes
GO:0034504 protein localization to nucleus 10.7143 6 yes
GO:0071824 protein-DNA complex organization 10.7143 5 yes
GO:0007097 nuclear migration 8.9286 4 yes
GO:0006338 chromatin remodeling 7.1429 7 yes
GO:0006997 nucleus organization 7.1429 5 yes
GO:0006998 nuclear envelope organization 7.1429 5 yes
GO:0031507 heterochromatin formation 7.1429 9 yes
GO:0040029 epigenetic regulation of gene expression 7.1429 7 yes
GO:0045814 negative regulation of gene expression, epigenetic 7.1429 8 yes
GO:0090435 protein localization to nuclear envelope 7.1429 7 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
OGT1_HUMAN [view entry] [view interactions] Low throughput yes yes
LMNA_HUMAN [view entry] [view interactions] Low throughput yes yes
LMNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PDE6D_HUMAN [view interactions] Low throughput no yes
LAP2A_HUMAN [view interactions] Low throughput no yes
SOX4_HUMAN [view interactions] Low throughput no yes
PAN2_HUMAN [view interactions] High throughput no no
GASP2_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
RING2_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
TSAP1_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
FOXB1_HUMAN [view interactions] High throughput no no
GAN_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
HYPK_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
ZN598_HUMAN [view interactions] High throughput no no
AKTIP_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RN123_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
DCPS_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
CCND1_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
CLUA1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
BACD3_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
ANR55_HUMAN [view interactions] High throughput no yes
DOCK8_HUMAN [view interactions] High throughput no yes
RHG01_HUMAN [view entry] [view interactions] High throughput yes yes
RHG44_HUMAN [view entry] [view interactions] High throughput yes yes
ARHG1_HUMAN [view interactions] High throughput no no
ARHG5_HUMAN [view interactions] High throughput no yes
DEP1B_HUMAN [view interactions] High throughput no yes
PKHG3_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
BRD4_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
CIC_HUMAN [view interactions] High throughput no yes
MT21E_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
WDR5_HUMAN [view interactions] High throughput no no
MTA70_HUMAN [view interactions] High throughput no no
REXO5_HUMAN [view interactions] High throughput no no
DPOA2_HUMAN [view interactions] High throughput no yes
MAT1_HUMAN [view interactions] High throughput no yes
SPOP_HUMAN [view interactions] High throughput no no
ING5_HUMAN [view interactions] High throughput no yes
DDX51_HUMAN [view interactions] High throughput no no
SYHM_HUMAN [view entry] [view interactions] High throughput yes yes
ERCC2_HUMAN [view interactions] High throughput no yes
ADRO_HUMAN [view interactions] High throughput no no
DDX59_HUMAN [view interactions] High throughput no yes
NSUN5_HUMAN [view interactions] High throughput no yes
PEX6_HUMAN [view interactions] High throughput no yes
XRCC4_HUMAN [view interactions] High throughput no yes
LRIF1_HUMAN [view interactions] High throughput no yes
TBB8_HUMAN [view interactions] High throughput no no
RHEB_HUMAN [view entry] [view interactions] High throughput yes yes
CCNH_HUMAN [view interactions] High throughput no yes
DIP2A_HUMAN [view entry] [view interactions] High throughput yes no
DHX40_HUMAN [view interactions] High throughput no yes
DDX28_HUMAN [view interactions] High throughput no yes
NSUN2_HUMAN [view interactions] High throughput no yes
TRM2B_HUMAN [view interactions] High throughput no yes
GTPB2_HUMAN [view interactions] High throughput no yes
RTEL1_HUMAN [view interactions] High throughput no no
TSR3_HUMAN [view interactions] High throughput no yes
SEN15_HUMAN [view interactions] High throughput no yes
AFG2B_HUMAN [view interactions] High throughput no yes
PALB2_HUMAN [view interactions] High throughput no yes
FNTA_HUMAN [view interactions] High throughput no yes
SLN11_HUMAN [view interactions] High throughput no yes
TOP3B_HUMAN [view interactions] High throughput no no
IFM1_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
ZN363_HUMAN [view interactions] High throughput no yes
RHOF_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
PRAF3_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
NOP10_HUMAN [view interactions] High throughput no yes
TOP2A_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
LOXL2_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
FND3A_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
MIDN_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
DYLT1_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
EXOS9_HUMAN [view interactions] High throughput no yes
IQEC1_HUMAN [view entry] [view interactions] High throughput yes yes
JCAD_HUMAN [view interactions] High throughput no yes
RSRC2_HUMAN [view interactions] High throughput no yes
TTC7A_HUMAN [view interactions] High throughput no yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
ULA1_HUMAN [view entry] [view interactions] High throughput yes yes
TRIP6_HUMAN [view interactions] High throughput no yes
KLC2_HUMAN [view entry] [view interactions] High throughput yes yes
R113A_HUMAN [view interactions] High throughput no yes
DPPA3_HUMAN [view interactions] High throughput no no
ST7_HUMAN [view interactions] High throughput no yes
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
DJC16_HUMAN [view interactions] High throughput no no
DNJC1_HUMAN [view interactions] High throughput no yes
DJC25_HUMAN [view interactions] High throughput no yes
SEC63_HUMAN [view interactions] High throughput no yes
B3GA1_HUMAN [view interactions] High throughput no yes
ELOV5_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
DHB11_HUMAN [view interactions] High throughput no yes
3BHS7_HUMAN [view interactions] High throughput no no
LNP_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
TMT1A_HUMAN [view interactions] High throughput no no
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SC61B_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
TMPS2_HUMAN [view interactions] High throughput no no
TM11B_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
LRRK2_HUMAN [view interactions] High throughput no yes
TYY1_HUMAN [view interactions] High throughput no yes
LEO1_HUMAN [view interactions] High throughput no yes
KDM3B_HUMAN [view interactions] High throughput no yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
FNTB_HUMAN [view interactions] High throughput no no
KI67_HUMAN [view interactions] High throughput no no
PRD16_HUMAN [view interactions] High throughput no no
MECOM_HUMAN [view interactions] High throughput no yes
MYLK2_HUMAN [view interactions] High throughput no no
ANRA2_HUMAN [view interactions] High throughput no no
RFXK_HUMAN [view interactions] High throughput no yes
CLC4G_HUMAN [view interactions] High throughput no no
COX15_HUMAN [view interactions] High throughput no yes
ODO2_HUMAN [view entry] [view interactions] High throughput yes yes
SDHA_HUMAN [view interactions] High throughput no yes
SODC_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBTB3_HUMAN [view interactions] High throughput no yes
GP101_HUMAN [view interactions] High throughput no no
SFI1_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
MCM7_HUMAN [view interactions] High throughput no no
JUN_HUMAN [view interactions] High throughput no yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
EGLN_HUMAN [view interactions] High throughput no no
SATB2_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
CC120_HUMAN [view interactions] High throughput no no
WASC3_HUMAN [view interactions] High throughput no yes
UBP2_HUMAN [view interactions] High throughput no yes
CC88B_HUMAN [view interactions] High throughput no no
LMNB2_HUMAN [view entry] [view interactions] High throughput yes yes
CAH8_HUMAN [view interactions] High throughput no no
TRI27_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
THAP1_HUMAN [view interactions] High throughput no no
LZTS1_HUMAN [view entry] [view interactions] High throughput yes yes
EFHC2_HUMAN [view interactions] High throughput no no
MFAP1_HUMAN [view interactions] High throughput no yes
PO6F2_HUMAN [view interactions] High throughput no no
ASPP1_HUMAN [view interactions] High throughput no yes
AMOL2_HUMAN [view interactions] High throughput no no
T10IP_HUMAN [view interactions] High throughput no no
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
OVOL1_HUMAN [view interactions] High throughput no no
PHC3_HUMAN [view interactions] High throughput no yes
FOXA3_HUMAN [view interactions] High throughput no yes
FOXL1_HUMAN [view interactions] High throughput no no
SVIL_HUMAN [view interactions] High throughput no yes
TRIM1_HUMAN [view interactions] High throughput no no
PIBF1_HUMAN [view interactions] High throughput no yes
ZC21C_HUMAN [view interactions] High throughput no yes
AMOT_HUMAN [view entry] [view interactions] High throughput yes no
ZFHX3_HUMAN [view interactions] High throughput no yes
ASPP2_HUMAN [view interactions] High throughput no yes
BAF_HUMAN [view entry] [view interactions] High throughput yes yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes