LMNB2_HUMAN
Evidence for PS localization
Functions
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 427 | Ala | Thr | Partialacquiredlipodystrophy(APLD) | - |
| 157 | His | Tyr | Epilepsy,progressivemyoclonic9(EPM9) | - |
| 252 | Tyr | His | Partialacquiredlipodystrophy(APLD) | - |
| 54 | Asn | His | Microcephaly27,primary,autosomaldominant(MCPH27) | - |
| 398 | Glu | Lys | Microcephaly27,primary,autosomaldominant(MCPH27) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LMNB2_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 32.6087 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 32.6087 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.6087 | 4 | no |
| GO:0019900 | kinase binding | 26.0870 | 4 | no |
| GO:0019901 | protein kinase binding | 26.0870 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LMNB2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.8696 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.8261 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.6522 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 43.4783 | 4 | no |
| GO:0010646 | regulation of cell communication | 41.3043 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.3043 | 4 | no |
| GO:0006996 | organelle organization | 39.1304 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.1304 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 39.1304 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.9565 | 4 | no |
| GO:0007010 | cytoskeleton organization | 32.6087 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 32.6087 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.6087 | 5 | no |
| GO:0033043 | regulation of organelle organization | 32.6087 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.6087 | 5 | no |
| GO:0022607 | cellular component assembly | 32.6087 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.4348 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.4348 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.4348 | 5 | no |
| GO:0036211 | protein modification process | 28.2609 | 4 | no |
| GO:0043412 | macromolecule modification | 28.2609 | 4 | no |
| GO:0010468 | regulation of gene expression | 28.2609 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.2609 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 28.2609 | 4 | no |
| GO:0008104 | protein localization | 26.0870 | 4 | no |
| GO:0031399 | regulation of protein modification process | 26.0870 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 26.0870 | 6 | no |
| GO:0010941 | regulation of cell death | 23.9130 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 23.9130 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.9130 | 6 | no |
| GO:0060341 | regulation of cellular localization | 23.9130 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.9130 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.9130 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.9130 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.9130 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.9130 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 21.7391 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 21.7391 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.7391 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.7391 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 21.7391 | 4 | no |
| GO:0030030 | cell projection organization | 21.7391 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.7391 | 4 | no |
| GO:0051049 | regulation of transport | 21.7391 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.7391 | 5 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in LMNB2_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 6.5217 | 3 | yes |
| DOID:936 | brain disease | 6.5217 | 4 | yes |
| DOID:0050701 | electroclinical syndrome | 4.3478 | 6 | yes |
| DOID:0050706 | variable age at onset electroclinical syndrome | 4.3478 | 7 | yes |
| DOID:0111450 | progressive myoclonus epilepsy 9 | 4.3478 | 9 | yes |
| DOID:1826 | epilepsy | 4.3478 | 5 | yes |
| DOID:891 | progressive myoclonus epilepsy | 4.3478 | 8 | yes |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| OGT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDE6D_HUMAN | [view interactions] | Low throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | Low throughput | no | yes |
| SOX4_HUMAN | [view interactions] | Low throughput | no | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOP10_HUMAN | [view interactions] | High throughput | no | yes |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOS9_HUMAN | [view interactions] | High throughput | no | yes |
| IQEC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JCAD_HUMAN | [view interactions] | High throughput | no | yes |
| RSRC2_HUMAN | [view interactions] | High throughput | no | yes |
| TTC7A_HUMAN | [view interactions] | High throughput | no | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJC16_HUMAN | [view interactions] | High throughput | no | no |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| TYY1_HUMAN | [view interactions] | High throughput | no | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| KDM3B_HUMAN | [view interactions] | High throughput | no | yes |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FNTB_HUMAN | [view interactions] | High throughput | no | no |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| MYLK2_HUMAN | [view interactions] | High throughput | no | no |
| ANRA2_HUMAN | [view interactions] | High throughput | no | no |
| RFXK_HUMAN | [view interactions] | High throughput | no | yes |
| COX15_HUMAN | [view interactions] | High throughput | no | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBTB3_HUMAN | [view interactions] | High throughput | no | yes |
| GP101_HUMAN | [view interactions] | High throughput | no | no |
| SFI1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| SATB2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| UBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CC88B_HUMAN | [view interactions] | High throughput | no | no |
| LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAH8_HUMAN | [view interactions] | High throughput | no | no |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| THAP1_HUMAN | [view interactions] | High throughput | no | no |
| LZTS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFHC2_HUMAN | [view interactions] | High throughput | no | no |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| PO6F2_HUMAN | [view interactions] | High throughput | no | no |
| ASPP1_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| T10IP_HUMAN | [view interactions] | High throughput | no | no |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OVOL1_HUMAN | [view interactions] | High throughput | no | no |
| PHC3_HUMAN | [view interactions] | High throughput | no | yes |
| FOXA3_HUMAN | [view interactions] | High throughput | no | yes |
| FOXL1_HUMAN | [view interactions] | High throughput | no | no |
| SVIL_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| PIBF1_HUMAN | [view interactions] | High throughput | no | yes |
| ZC21C_HUMAN | [view interactions] | High throughput | no | yes |
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| ZFHX3_HUMAN | [view interactions] | High throughput | no | yes |
| ASPP2_HUMAN | [view interactions] | High throughput | no | yes |
| BAF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| GASP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| TSAP1_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| FOXB1_HUMAN | [view interactions] | High throughput | no | no |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| HYPK_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| AKTIP_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BACD3_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| ANR55_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG1_HUMAN | [view interactions] | High throughput | no | no |
| ARHG5_HUMAN | [view interactions] | High throughput | no | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG3_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| MT21E_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| MTA70_HUMAN | [view interactions] | High throughput | no | no |
| REXO5_HUMAN | [view interactions] | High throughput | no | no |
| DPOA2_HUMAN | [view interactions] | High throughput | no | yes |
| MAT1_HUMAN | [view interactions] | High throughput | no | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| ING5_HUMAN | [view interactions] | High throughput | no | yes |
| DDX51_HUMAN | [view interactions] | High throughput | no | no |
| SYHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERCC2_HUMAN | [view interactions] | High throughput | no | yes |
| ADRO_HUMAN | [view interactions] | High throughput | no | no |
| DDX59_HUMAN | [view interactions] | High throughput | no | yes |
| NSUN5_HUMAN | [view interactions] | High throughput | no | yes |
| PEX6_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC4_HUMAN | [view interactions] | High throughput | no | yes |
| LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNH_HUMAN | [view interactions] | High throughput | no | yes |
| DIP2A_HUMAN | [view interactions] | High throughput | no | no |
| DHX40_HUMAN | [view interactions] | High throughput | no | yes |
| DDX28_HUMAN | [view interactions] | High throughput | no | yes |
| NSUN2_HUMAN | [view interactions] | High throughput | no | yes |
| TRM2_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB2_HUMAN | [view interactions] | High throughput | no | yes |
| RTEL1_HUMAN | [view interactions] | High throughput | no | no |
| TSR3_HUMAN | [view interactions] | High throughput | no | yes |
| SEN15_HUMAN | [view interactions] | High throughput | no | yes |
| SPA5L_HUMAN | [view interactions] | High throughput | no | yes |
| PALB2_HUMAN | [view interactions] | High throughput | no | yes |
| FNTA_HUMAN | [view interactions] | High throughput | no | yes |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| ZN363_HUMAN | [view interactions] | High throughput | no | yes |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| CASP2_HUMAN | [view interactions] | Computational | no | yes |
| MAN1_HUMAN | [view interactions] | Computational | no | yes |
| GRAB_HUMAN | [view interactions] | Computational | no | no |
| CASP6_HUMAN | [view interactions] | Computational | no | no |
| ERG24_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SUN1_HUMAN | [view interactions] | Computational | no | yes |
| LBR_HUMAN | [view interactions] | Computational | no | yes |
| SUN2_HUMAN | [view interactions] | Computational | no | yes |