FUMH_HUMAN
Evidence for PS localization
Functions
Catalyzes the dehydration of L-malate to fumarate . Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism . Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed, PubMed). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 Lys-36 (H3K36me2) (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FUMH_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 27.7778 | 4 | no |
| GO:0043168 | anion binding | 26.3889 | 4 | no |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 20.8333 | 5 | no |
| GO:0016836 | hydro-lyase activity | 5.5556 | 4 | yes |
| GO:0004333 | fumarate hydratase activity | 2.7778 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FUMH_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 37.5000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 36.1111 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 36.1111 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 34.7222 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 30.5556 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 30.5556 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 29.1667 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 29.1667 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 29.1667 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 29.1667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 29.1667 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 27.7778 | 4 | no |
| GO:0019693 | ribose phosphate metabolic process | 26.3889 | 4 | no |
| GO:0022607 | cellular component assembly | 26.3889 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.3889 | 4 | no |
| GO:0010646 | regulation of cell communication | 26.3889 | 4 | no |
| GO:0009259 | ribonucleotide metabolic process | 25.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 23.6111 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 23.6111 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 23.6111 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.2222 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.2222 | 5 | no |
| GO:0006996 | organelle organization | 22.2222 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.2222 | 5 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 20.8333 | 4 | yes |
| GO:0010468 | regulation of gene expression | 20.8333 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.8333 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.8333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.8333 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 19.4444 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 15.2778 | 5 | yes |
| GO:0080134 | regulation of response to stress | 15.2778 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 12.5000 | 4 | yes |
| GO:0006974 | DNA damage response | 12.5000 | 4 | yes |
| GO:0080135 | regulation of cellular response to stress | 11.1111 | 4 | yes |
| GO:0090304 | nucleic acid metabolic process | 11.1111 | 4 | yes |
| GO:0043648 | dicarboxylic acid metabolic process | 9.7222 | 6 | yes |
| GO:0051052 | regulation of DNA metabolic process | 9.7222 | 5 | yes |
| GO:0051054 | positive regulation of DNA metabolic process | 8.3333 | 6 | yes |
| GO:0062012 | regulation of small molecule metabolic process | 6.9444 | 4 | yes |
| GO:0006259 | DNA metabolic process | 6.9444 | 5 | yes |
| GO:0033238 | regulation of amine metabolic process | 5.5556 | 4 | yes |
| GO:0045739 | positive regulation of DNA repair | 5.5556 | 5 | yes |
| GO:2000779 | regulation of double-strand break repair | 5.5556 | 6 | yes |
| GO:2000781 | positive regulation of double-strand break repair | 5.5556 | 6 | yes |
| GO:0006281 | DNA repair | 5.5556 | 5 | yes |
| GO:0006282 | regulation of DNA repair | 5.5556 | 5 | yes |
| GO:0048873 | homeostasis of number of cells within a tissue | 4.1667 | 4 | yes |
| GO:0120161 | regulation of cold-induced thermogenesis | 4.1667 | 4 | yes |
| GO:0120162 | positive regulation of cold-induced thermogenesis | 4.1667 | 5 | yes |
| GO:2001032 | regulation of double-strand break repair via nonhomologous end joining | 4.1667 | 7 | yes |
| GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining | 4.1667 | 7 | yes |
| GO:0001894 | tissue homeostasis | 4.1667 | 4 | yes |
| GO:0006106 | fumarate metabolic process | 4.1667 | 7 | yes |
| GO:0006108 | malate metabolic process | 4.1667 | 7 | yes |
| GO:0000050 | urea cycle | 2.7778 | 4 | yes |
| GO:0000821 | regulation of arginine metabolic process | 2.7778 | 6 | yes |
| GO:0006521 | regulation of cellular amino acid metabolic process | 2.7778 | 5 | yes |
| GO:0010565 | regulation of cellular ketone metabolic process | 2.7778 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PRKDC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | Low throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H2B1C_HUMAN | [view interactions] | Low throughput | no | yes |
| H2B1B_HUMAN | [view interactions] | Low throughput | no | yes |
| H33_HUMAN | [view interactions] | Low throughput | no | yes |
| H4_HUMAN | [view interactions] | Low throughput | no | yes |
| H2AZ_HUMAN | [view interactions] | Low throughput | no | yes |
| H2A1H_HUMAN | [view interactions] | Low throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAEL_HUMAN | [view interactions] | Low throughput | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPSM_HUMAN | [view interactions] | High throughput | no | no |
| SERC_HUMAN | [view interactions] | High throughput | no | yes |
| HEM6_HUMAN | [view interactions] | High throughput | no | no |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| THIC_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASB6_HUMAN | [view interactions] | High throughput | no | yes |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXB_HUMAN | [view interactions] | High throughput | no | no |
| OGFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBR7_HUMAN | [view interactions] | High throughput | no | yes |
| H2AV_HUMAN | [view interactions] | High throughput | no | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTRR_HUMAN | [view interactions] | High throughput | no | yes |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASSY_HUMAN | [view interactions] | High throughput | no | yes |
| CK054_HUMAN | [view interactions] | High throughput | no | no |
| QNG1_HUMAN | [view interactions] | High throughput | no | yes |
| CAB39_HUMAN | [view interactions] | High throughput | no | yes |
| CBR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
| SSDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISOC2_HUMAN | [view interactions] | High throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIR_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| PNPO_HUMAN | [view interactions] | High throughput | no | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLOD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNPI1_HUMAN | [view interactions] | High throughput | no | yes |
| GNPI2_HUMAN | [view interactions] | High throughput | no | yes |
| GNA1_HUMAN | [view interactions] | High throughput | no | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPDA_HUMAN | [view interactions] | High throughput | no | yes |
| GPD1L_HUMAN | [view interactions] | High throughput | no | no |
| HIBCH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KYNU_HUMAN | [view interactions] | High throughput | no | no |
| SIAS_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD5_HUMAN | [view interactions] | High throughput | no | yes |
| PTGR1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L3_HUMAN | [view interactions] | High throughput | no | no |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETHE1_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| ADRO_HUMAN | [view interactions] | High throughput | no | no |
| SYYM_HUMAN | [view interactions] | High throughput | no | no |
| ATPF1_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| 6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| SPRC_HUMAN | [view interactions] | High throughput | no | yes |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEXA_HUMAN | [view interactions] | High throughput | no | yes |
| MMP20_HUMAN | [view interactions] | High throughput | no | no |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DHSD_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| SDHB_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| ATPK_HUMAN | [view interactions] | High throughput | no | yes |
| UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| ATF2_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PIM1_HUMAN | [view interactions] | High throughput | no | yes |
| DGCR6_HUMAN | [view interactions] | High throughput | no | no |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS5_HUMAN | [view interactions] | High throughput | no | yes |
| LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAT1_HUMAN | [view interactions] | High throughput | no | yes |
| TTC19_HUMAN | [view interactions] | High throughput | no | yes |
| KLHL6_HUMAN | [view interactions] | High throughput | no | no |
| RPAC1_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| CCDB1_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| CSTP1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD57_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TET5C_HUMAN | [view interactions] | High throughput | no | yes |
| FND3A_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| TOP2A_HUMAN | [view interactions] | High throughput | no | no |
| TOP3A_HUMAN | [view interactions] | High throughput | no | yes |
| WEE1_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADPRM_HUMAN | [view interactions] | High throughput | no | yes |
| SYCM_HUMAN | [view interactions] | High throughput | no | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| COQ2_HUMAN | [view interactions] | High throughput | no | yes |
| COX16_HUMAN | [view interactions] | High throughput | no | no |
| COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUS1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUB1_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB2_HUMAN | [view interactions] | High throughput | no | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLP1_HUMAN | [view interactions] | High throughput | no | no |
| GATB_HUMAN | [view interactions] | High throughput | no | yes |
| DMAC1_HUMAN | [view interactions] | High throughput | no | no |
| ZN830_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |