FUMH_HUMAN
Catalyzes the dehydration of L-malate to fumarate . Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism . Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ) (PubMed, PubMed). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 Lys-36 (H3K36me2) (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in FUMH_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 25.9259 | 4 | no |
GO:0046872 | metal ion binding | 20.9877 | 4 | no |
GO:0016836 | hydro-lyase activity | 4.9383 | 4 | yes |
GO:0004333 | fumarate hydratase activity | 2.4691 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in FUMH_HUMAN |
---|---|---|---|---|
GO:0019752 | carboxylic acid metabolic process | 38.2716 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 38.2716 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 32.0988 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 30.8642 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 30.8642 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 29.6296 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 29.6296 | 4 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 29.6296 | 4 | no |
GO:0048523 | negative regulation of cellular process | 27.1605 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 24.6914 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 23.4568 | 4 | yes |
GO:0010646 | regulation of cell communication | 23.4568 | 4 | no |
GO:0022607 | cellular component assembly | 22.2222 | 4 | no |
GO:0006753 | nucleoside phosphate metabolic process | 22.2222 | 4 | no |
GO:0009117 | nucleotide metabolic process | 22.2222 | 5 | no |
GO:0009966 | regulation of signal transduction | 22.2222 | 4 | no |
GO:0032787 | monocarboxylic acid metabolic process | 20.9877 | 6 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 19.7531 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 19.7531 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 17.2840 | 5 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 17.2840 | 5 | yes |
GO:0031399 | regulation of protein modification process | 17.2840 | 6 | yes |
GO:0043648 | dicarboxylic acid metabolic process | 16.0494 | 6 | yes |
GO:0009892 | negative regulation of metabolic process | 14.8148 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 14.8148 | 5 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 14.8148 | 5 | yes |
GO:1901566 | organonitrogen compound biosynthetic process | 14.8148 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 13.5802 | 5 | yes |
GO:0048584 | positive regulation of response to stimulus | 13.5802 | 4 | yes |
GO:0044271 | cellular nitrogen compound biosynthetic process | 12.3457 | 4 | yes |
GO:0080134 | regulation of response to stress | 12.3457 | 4 | yes |
GO:0080135 | regulation of cellular response to stress | 12.3457 | 4 | yes |
GO:0043603 | cellular amide metabolic process | 11.1111 | 4 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 11.1111 | 6 | yes |
GO:0051248 | negative regulation of protein metabolic process | 11.1111 | 6 | yes |
GO:0006974 | cellular response to DNA damage stimulus | 9.8765 | 4 | yes |
GO:0031400 | negative regulation of protein modification process | 9.8765 | 7 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 9.8765 | 4 | yes |
GO:0051052 | regulation of DNA metabolic process | 8.6420 | 5 | yes |
GO:0090304 | nucleic acid metabolic process | 8.6420 | 4 | yes |
GO:0051054 | positive regulation of DNA metabolic process | 7.4074 | 6 | yes |
GO:0006259 | DNA metabolic process | 6.1728 | 4 | yes |
GO:0043604 | amide biosynthetic process | 6.1728 | 5 | yes |
GO:0006106 | fumarate metabolic process | 4.9383 | 7 | yes |
GO:0006281 | DNA repair | 4.9383 | 5 | yes |
GO:0006282 | regulation of DNA repair | 4.9383 | 6 | yes |
GO:0031056 | regulation of histone modification | 4.9383 | 7 | yes |
GO:0045739 | positive regulation of DNA repair | 4.9383 | 6 | yes |
GO:0048872 | homeostasis of number of cells | 4.9383 | 4 | yes |
GO:0060249 | anatomical structure homeostasis | 4.9383 | 4 | yes |
GO:0062012 | regulation of small molecule metabolic process | 4.9383 | 4 | yes |
GO:2000779 | regulation of double-strand break repair | 4.9383 | 7 | yes |
GO:2000781 | positive regulation of double-strand break repair | 4.9383 | 7 | yes |
GO:2001020 | regulation of response to DNA damage stimulus | 4.9383 | 5 | yes |
GO:2001022 | positive regulation of response to DNA damage stimulus | 4.9383 | 5 | yes |
GO:0001894 | tissue homeostasis | 3.7037 | 5 | yes |
GO:0006108 | malate metabolic process | 3.7037 | 7 | yes |
GO:0031060 | regulation of histone methylation | 3.7037 | 5 | yes |
GO:0033238 | regulation of cellular amine metabolic process | 3.7037 | 5 | yes |
GO:0048873 | homeostasis of number of cells within a tissue | 3.7037 | 5 | yes |
GO:0120162 | positive regulation of cold-induced thermogenesis | 3.7037 | 4 | yes |
GO:2001032 | regulation of double-strand break repair via nonhomologous end joining | 3.7037 | 8 | yes |
GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining | 3.7037 | 8 | yes |
GO:0000050 | urea cycle | 2.4691 | 4 | yes |
GO:0000414 | regulation of histone H3-K36 methylation | 2.4691 | 6 | yes |
GO:0000415 | negative regulation of histone H3-K36 methylation | 2.4691 | 7 | yes |
GO:0000820 | regulation of glutamine family amino acid metabolic process | 2.4691 | 6 | yes |
GO:0000821 | regulation of arginine metabolic process | 2.4691 | 7 | yes |
GO:0006521 | regulation of cellular amino acid metabolic process | 2.4691 | 5 | yes |
GO:0010565 | regulation of cellular ketone metabolic process | 2.4691 | 5 | yes |
GO:0031057 | negative regulation of histone modification | 2.4691 | 8 | yes |
GO:0031061 | negative regulation of histone methylation | 2.4691 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in FUMH_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 3.7037 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
FUMH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
H2A1H_HUMAN | [view interactions] | Low throughput | no | yes |
H2AZ_HUMAN | [view interactions] | Low throughput | no | yes |
H4_HUMAN | [view interactions] | Low throughput | no | yes |
H33_HUMAN | [view interactions] | Low throughput | no | yes |
H2B1B_HUMAN | [view interactions] | Low throughput | no | yes |
H2B1C_HUMAN | [view interactions] | Low throughput | no | yes |
XPO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MDHM_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRKDC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IQCB1_HUMAN | [view interactions] | High throughput | no | no |
ATF2_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APBB1_HUMAN | [view interactions] | High throughput | no | yes |
IF6_HUMAN | [view interactions] | High throughput | no | yes |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
IKKE_HUMAN | [view interactions] | High throughput | no | yes |
KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TX101_HUMAN | [view interactions] | High throughput | no | no |
OSMR_HUMAN | [view interactions] | High throughput | no | yes |
PIM1_HUMAN | [view interactions] | High throughput | no | yes |
DGCR6_HUMAN | [view interactions] | High throughput | no | no |
C102B_HUMAN | [view interactions] | High throughput | no | yes |
EXOS5_HUMAN | [view interactions] | High throughput | no | yes |
LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAT1_HUMAN | [view interactions] | High throughput | no | yes |
TTC19_HUMAN | [view interactions] | High throughput | no | yes |
KLHL6_HUMAN | [view interactions] | High throughput | no | no |
RPAC1_HUMAN | [view interactions] | High throughput | no | no |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FTM_HUMAN | [view interactions] | High throughput | no | yes |
CCDB1_HUMAN | [view interactions] | High throughput | no | yes |
TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
CK049_HUMAN | [view interactions] | High throughput | no | yes |
CCD57_HUMAN | [view interactions] | High throughput | no | yes |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
CDK2_HUMAN | [view interactions] | High throughput | no | yes |
HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
ODB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGD5_HUMAN | [view interactions] | High throughput | no | yes |
CLU_HUMAN | [view interactions] | High throughput | no | yes |
TOP1_HUMAN | [view interactions] | High throughput | no | yes |
TOP2A_HUMAN | [view interactions] | High throughput | no | no |
TOP3A_HUMAN | [view interactions] | High throughput | no | yes |
WEE1_HUMAN | [view interactions] | High throughput | no | yes |
MP2K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADPRM_HUMAN | [view interactions] | High throughput | no | yes |
SYCM_HUMAN | [view interactions] | High throughput | no | yes |
COPE_HUMAN | [view interactions] | High throughput | no | yes |
COQ2_HUMAN | [view interactions] | High throughput | no | yes |
COX16_HUMAN | [view interactions] | High throughput | no | no |
COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HUS1_HUMAN | [view interactions] | High throughput | no | yes |
NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUB1_HUMAN | [view interactions] | High throughput | no | yes |
NDUB2_HUMAN | [view interactions] | High throughput | no | yes |
LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLP1_HUMAN | [view interactions] | High throughput | no | no |
GATB_HUMAN | [view interactions] | High throughput | no | yes |
DMAC1_HUMAN | [view interactions] | High throughput | no | no |
ZN830_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CPSM_HUMAN | [view interactions] | High throughput | no | no |
SERC_HUMAN | [view interactions] | High throughput | no | yes |
HEM6_HUMAN | [view interactions] | High throughput | no | no |
PGM1_HUMAN | [view interactions] | High throughput | no | no |
THIC_HUMAN | [view interactions] | High throughput | no | yes |
SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASB6_HUMAN | [view interactions] | High throughput | no | yes |
PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DHX15_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
HEXB_HUMAN | [view interactions] | High throughput | no | no |
OGFD1_HUMAN | [view interactions] | High throughput | no | yes |
PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TATD1_HUMAN | [view interactions] | High throughput | no | yes |
UBR7_HUMAN | [view interactions] | High throughput | no | yes |
H2AV_HUMAN | [view interactions] | High throughput | no | yes |
MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MTRR_HUMAN | [view interactions] | High throughput | no | yes |
NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
PTMA_HUMAN | [view interactions] | High throughput | no | yes |
PYGL_HUMAN | [view interactions] | High throughput | no | yes |
UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPP1_HUMAN | [view interactions] | High throughput | no | yes |
ANX11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASSY_HUMAN | [view interactions] | High throughput | no | yes |
CK054_HUMAN | [view interactions] | High throughput | no | no |
QSPP_HUMAN | [view interactions] | High throughput | no | yes |
CAB39_HUMAN | [view interactions] | High throughput | no | yes |
CBR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CRIP1_HUMAN | [view interactions] | High throughput | no | yes |
ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAH2A_HUMAN | [view interactions] | High throughput | no | yes |
SSDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ISOC2_HUMAN | [view interactions] | High throughput | no | yes |
LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIR_HUMAN | [view interactions] | High throughput | no | no |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
PNPO_HUMAN | [view interactions] | High throughput | no | yes |
SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TKT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GLOD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNPI1_HUMAN | [view interactions] | High throughput | no | yes |
GNPI2_HUMAN | [view interactions] | High throughput | no | yes |
GNA1_HUMAN | [view interactions] | High throughput | no | no |
AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPDA_HUMAN | [view interactions] | High throughput | no | yes |
GPD1L_HUMAN | [view interactions] | High throughput | no | no |
HIBCH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KYNU_HUMAN | [view interactions] | High throughput | no | no |
SIAS_HUMAN | [view interactions] | High throughput | no | yes |
NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSMD5_HUMAN | [view interactions] | High throughput | no | yes |
PTGR1_HUMAN | [view interactions] | High throughput | no | yes |
UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WDFY1_HUMAN | [view interactions] | High throughput | no | yes |
ACADM_HUMAN | [view interactions] | High throughput | no | yes |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SUCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THIM_HUMAN | [view interactions] | High throughput | no | yes |
SH3L3_HUMAN | [view interactions] | High throughput | no | no |
UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ETHE1_HUMAN | [view interactions] | High throughput | no | yes |
SUCB2_HUMAN | [view interactions] | High throughput | no | no |
AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
ECHM_HUMAN | [view interactions] | High throughput | no | yes |
ADRO_HUMAN | [view interactions] | High throughput | no | no |
SYYM_HUMAN | [view interactions] | High throughput | no | no |
ATPF1_HUMAN | [view interactions] | High throughput | no | yes |
GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
6PGD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALDH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
DBLOH_HUMAN | [view interactions] | High throughput | no | no |
SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAFA2_HUMAN | [view interactions] | High throughput | no | yes |
RD23A_HUMAN | [view interactions] | High throughput | no | yes |
SPRC_HUMAN | [view interactions] | High throughput | no | yes |
SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PFD3_HUMAN | [view interactions] | High throughput | no | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HEXA_HUMAN | [view interactions] | High throughput | no | yes |
MMP20_HUMAN | [view interactions] | High throughput | no | no |
NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DHSD_HUMAN | [view interactions] | High throughput | no | yes |
NDUAA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SDHA_HUMAN | [view interactions] | High throughput | no | yes |
SDHB_HUMAN | [view interactions] | High throughput | no | yes |
ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MIC26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
ATPK_HUMAN | [view interactions] | High throughput | no | yes |
UCRI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALAT2_HUMAN | [view interactions] | Computational | no | yes |
C560_HUMAN | [view interactions] | Computational | no | no |
FAHD1_HUMAN | [view interactions] | Computational | no | yes |
OGDHL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DHTK1_HUMAN | [view interactions] | Computational | no | no |
MAOM_HUMAN | [view interactions] | Computational | no | yes |
TALDO_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GABT_HUMAN | [view interactions] | Computational | no | yes |
CISY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PAHX_HUMAN | [view interactions] | Computational | no | yes |
MAOX_HUMAN | [view interactions] | Computational | no | yes |
MAON_HUMAN | [view interactions] | Computational | no | yes |
ACOHC_HUMAN | [view interactions] | Computational | no | yes |
PEPD_HUMAN | [view interactions] | Computational | no | yes |
IDHP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AATM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AL7A1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
IDH3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
AATC2_HUMAN | [view interactions] | Computational | no | no |
SPYA_HUMAN | [view interactions] | Computational | no | no |
CATA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
FAAA_HUMAN | [view interactions] | Computational | no | no |
ACLY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KFA_HUMAN | [view interactions] | Computational | no | no |
ALAT1_HUMAN | [view interactions] | Computational | no | no |
ODO1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ODO2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IDHC_HUMAN | [view interactions] | Computational | no | no |
ARLY_HUMAN | [view interactions] | Computational | no | no |
ATPA_HUMAN | [view interactions] | Computational | no | yes |
TPIS_HUMAN | [view entry] [view interactions] | Computational | yes | yes |