CBR1_HUMAN
Evidence for PS localization
Functions
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed, PubMed, PubMed, PubMed). Can convert prostaglandin E to prostaglandin F2-alpha . Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CBR1_HUMAN |
|---|---|---|---|---|
| GO:0005524 | ATP binding | 25.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 20.8333 | 4 | no |
| GO:0004090 | carbonyl reductase (NADPH) activity | 12.5000 | 5 | yes |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 12.5000 | 4 | yes |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 8.3333 | 4 | yes |
| GO:0047020 | 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity | 8.3333 | 5 | yes |
| GO:0047021 | 15-hydroxyprostaglandin dehydrogenase (NADP+) activity | 8.3333 | 5 | yes |
| GO:0050221 | prostaglandin-E2 9-reductase activity | 8.3333 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CBR1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.8333 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 58.3333 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 54.1667 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 54.1667 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.8333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.8333 | 4 | no |
| GO:0036211 | protein modification process | 41.6667 | 4 | no |
| GO:0043412 | macromolecule modification | 41.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 41.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
| GO:0010646 | regulation of cell communication | 37.5000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 37.5000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 37.5000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0010941 | regulation of cell death | 29.1667 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.1667 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 29.1667 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 29.1667 | 5 | no |
| GO:0006996 | organelle organization | 29.1667 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.1667 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.1667 | 5 | no |
| GO:0060341 | regulation of cellular localization | 29.1667 | 4 | no |
| GO:0080134 | regulation of response to stress | 29.1667 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.0000 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 25.0000 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 25.0000 | 6 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 25.0000 | 7 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 25.0000 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 25.0000 | 8 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.0000 | 6 | no |
| GO:0032880 | regulation of protein localization | 25.0000 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0080135 | regulation of cellular response to stress | 25.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 25.0000 | 5 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 20.8333 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 20.8333 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 20.8333 | 6 | no |
| GO:0009894 | regulation of catabolic process | 20.8333 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.8333 | 6 | no |
| GO:0033043 | regulation of organelle organization | 20.8333 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.8333 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.8333 | 7 | no |
| GO:0031401 | positive regulation of protein modification process | 20.8333 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.8333 | 4 | no |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 16.6667 | 5 | yes |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process | 16.6667 | 6 | yes |
| GO:0030855 | epithelial cell differentiation | 12.5000 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 12.5000 | 6 | yes |
| GO:0001676 | long-chain fatty acid metabolic process | 8.3333 | 5 | yes |
| GO:0006631 | fatty acid metabolic process | 8.3333 | 4 | yes |
| GO:0006690 | icosanoid metabolic process | 8.3333 | 6 | yes |
| GO:0006775 | fat-soluble vitamin metabolic process | 8.3333 | 4 | yes |
| GO:0019369 | arachidonic acid metabolic process | 8.3333 | 4 | yes |
| GO:0019371 | cyclooxygenase pathway | 8.3333 | 5 | yes |
| GO:0033559 | unsaturated fatty acid metabolic process | 8.3333 | 5 | yes |
| GO:0042373 | vitamin K metabolic process | 8.3333 | 5 | yes |
| GO:1901661 | quinone metabolic process | 8.3333 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in CBR1_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 8.3333 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| CBR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK13_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| DDA1_HUMAN | [view interactions] | High throughput | no | yes |
| ATGA1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| CBR3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZC3HD_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHM2_HUMAN | [view interactions] | High throughput | no | yes |
| PPHLN_HUMAN | [view interactions] | High throughput | no | yes |
| ICAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| Z518A_HUMAN | [view interactions] | High throughput | no | no |
| TXN4A_HUMAN | [view interactions] | High throughput | no | no |
| MYH1_HUMAN | [view interactions] | High throughput | no | no |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| URM1_HUMAN | [view interactions] | High throughput | no | yes |
| SUCHY_HUMAN | [view interactions] | High throughput | no | yes |
| XPP3_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| MYLK_HUMAN | [view interactions] | High throughput | no | no |
| CDKL3_HUMAN | [view interactions] | High throughput | no | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| LACC1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| ERCC8_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| 5HT2B_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DEND3_HUMAN | [view interactions] | High throughput | no | no |
| TM208_HUMAN | [view interactions] | High throughput | no | yes |
| WAC_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| MARH2_HUMAN | [view interactions] | High throughput | no | yes |
| MARH3_HUMAN | [view interactions] | High throughput | no | no |
| MARH4_HUMAN | [view interactions] | High throughput | no | yes |
| RN103_HUMAN | [view interactions] | High throughput | no | no |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| RNFT1_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| PHF11_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| P2RX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| CERS3_HUMAN | [view interactions] | High throughput | no | no |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| G6PT1_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| MFTC_HUMAN | [view interactions] | High throughput | no | yes |
| NIPA_HUMAN | [view interactions] | High throughput | no | yes |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| G3PT_HUMAN | [view interactions] | High throughput | no | no |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| ZDH19_HUMAN | [view interactions] | High throughput | no | no |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| NCF1_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| THB_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM12_HUMAN | [view interactions] | High throughput | no | yes |
| K2C1B_HUMAN | [view interactions] | High throughput | no | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| CP2AD_HUMAN | [view interactions] | Computational | no | no |
| PTPS_HUMAN | [view interactions] | Computational | no | yes |
| CP2A6_HUMAN | [view interactions] | Computational | no | no |
| DYR2_HUMAN | [view interactions] | Computational | no | yes |
| SPRE_HUMAN | [view interactions] | Computational | no | yes |
| ALDR_HUMAN | [view interactions] | Computational | no | no |
| AK1C3_HUMAN | [view interactions] | Computational | no | yes |
| PGES2_HUMAN | [view interactions] | Computational | no | yes |
| PTGES_HUMAN | [view interactions] | Computational | no | no |
| DYR_HUMAN | [view interactions] | Computational | no | yes |
| CP2E1_HUMAN | [view interactions] | Computational | no | no |
| CP1A1_HUMAN | [view interactions] | Computational | no | yes |
| AK1BA_HUMAN | [view interactions] | Computational | no | no |