CBR1_HUMAN
Evidence for PS localization
Functions
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed, PubMed, PubMed, PubMed). Can convert prostaglandin E to prostaglandin F2-alpha . Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CBR1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 36.3636 | 4 | no |
| GO:0000166 | nucleotide binding | 30.3030 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.3030 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 30.3030 | 6 | no |
| GO:0005524 | ATP binding | 27.2727 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.2727 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.2727 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 27.2727 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 24.2424 | 5 | no |
| GO:0043169 | cation binding | 24.2424 | 4 | no |
| GO:0003723 | RNA binding | 24.2424 | 4 | no |
| GO:0019900 | kinase binding | 21.2121 | 4 | no |
| GO:0019901 | protein kinase binding | 21.2121 | 5 | no |
| GO:0046872 | metal ion binding | 21.2121 | 5 | no |
| GO:0004090 | carbonyl reductase (NADPH) activity | 9.0909 | 5 | yes |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 9.0909 | 4 | yes |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 9.0909 | 4 | yes |
| GO:0004033 | aldo-keto reductase (NADPH) activity | 6.0606 | 5 | yes |
| GO:0008106 | alcohol dehydrogenase (NADP+) activity | 6.0606 | 6 | yes |
| GO:0047020 | 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity | 6.0606 | 5 | yes |
| GO:0047021 | 15-hydroxyprostaglandin dehydrogenase (NADP+) activity | 6.0606 | 5 | yes |
| GO:0050221 | prostaglandin-E2 9-reductase activity | 6.0606 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CBR1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 69.6970 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 63.6364 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 57.5758 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 51.5152 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 48.4848 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.4848 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 45.4545 | 5 | yes |
| GO:0010646 | regulation of cell communication | 45.4545 | 4 | no |
| GO:0036211 | protein modification process | 45.4545 | 4 | no |
| GO:0043412 | macromolecule modification | 45.4545 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.4545 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 42.4242 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.3939 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.3939 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 39.3939 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.3939 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.3939 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 39.3939 | 5 | no |
| GO:0006996 | organelle organization | 36.3636 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.3636 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
| GO:0080134 | regulation of response to stress | 36.3636 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.3636 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 36.3636 | 5 | no |
| GO:0060341 | regulation of cellular localization | 36.3636 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0032880 | regulation of protein localization | 33.3333 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.3030 | 6 | no |
| GO:0022607 | cellular component assembly | 30.3030 | 4 | no |
| GO:0031399 | regulation of protein modification process | 30.3030 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.3030 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.3030 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.3030 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 30.3030 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 30.3030 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 30.3030 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 30.3030 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 30.3030 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 27.2727 | 4 | no |
| GO:0008104 | protein localization | 27.2727 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 27.2727 | 7 | no |
| GO:0009891 | positive regulation of biosynthetic process | 27.2727 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 27.2727 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.2727 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.2727 | 6 | no |
| GO:0080135 | regulation of cellular response to stress | 24.2424 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.2424 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.2424 | 6 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 24.2424 | 8 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 24.2424 | 6 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 24.2424 | 7 | no |
| GO:0051049 | regulation of transport | 24.2424 | 4 | no |
| GO:0043933 | protein-containing complex organization | 24.2424 | 4 | no |
| GO:0009894 | regulation of catabolic process | 24.2424 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.2121 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.2121 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 21.2121 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.2121 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 21.2121 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 21.2121 | 7 | no |
| GO:0043408 | regulation of MAPK cascade | 21.2121 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.2121 | 7 | no |
| GO:0032446 | protein modification by small protein conjugation | 21.2121 | 7 | no |
| GO:0043687 | post-translational protein modification | 21.2121 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 21.2121 | 4 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 21.2121 | 6 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.2121 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.2121 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.2121 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.2121 | 4 | no |
| GO:0010629 | negative regulation of gene expression | 21.2121 | 7 | no |
| GO:0022411 | cellular component disassembly | 21.2121 | 4 | no |
| GO:1903829 | positive regulation of protein localization | 21.2121 | 5 | no |
| GO:2000377 | regulation of reactive oxygen species metabolic process | 18.1818 | 5 | yes |
| GO:0019752 | carboxylic acid metabolic process | 15.1515 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 15.1515 | 4 | yes |
| GO:2000379 | positive regulation of reactive oxygen species metabolic process | 12.1212 | 6 | yes |
| GO:0006775 | fat-soluble vitamin metabolic process | 9.0909 | 4 | yes |
| GO:0030855 | epithelial cell differentiation | 9.0909 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 9.0909 | 6 | yes |
| GO:0042373 | vitamin K metabolic process | 9.0909 | 4 | yes |
| GO:0001676 | long-chain fatty acid metabolic process | 6.0606 | 5 | yes |
| GO:0006631 | fatty acid metabolic process | 6.0606 | 4 | yes |
| GO:0006690 | icosanoid metabolic process | 6.0606 | 6 | yes |
| GO:0008202 | steroid metabolic process | 6.0606 | 4 | yes |
| GO:0008211 | glucocorticoid metabolic process | 6.0606 | 5 | yes |
| GO:0019369 | arachidonic acid metabolic process | 6.0606 | 4 | yes |
| GO:0019371 | cyclooxygenase pathway | 6.0606 | 5 | yes |
| GO:0033559 | unsaturated fatty acid metabolic process | 6.0606 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| CBR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK13_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| DDA1_HUMAN | [view interactions] | High throughput | no | yes |
| ATGA1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| CBR3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| APBA3_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP2_HUMAN | [view interactions] | High throughput | no | yes |
| MYH1_HUMAN | [view interactions] | High throughput | no | no |
| TXN4A_HUMAN | [view interactions] | High throughput | no | no |
| Z518A_HUMAN | [view interactions] | High throughput | no | no |
| ICAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPHLN_HUMAN | [view interactions] | High throughput | no | yes |
| PKHM2_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3HD_HUMAN | [view interactions] | High throughput | no | yes |
| URM1_HUMAN | [view interactions] | High throughput | no | yes |
| SUCHY_HUMAN | [view interactions] | High throughput | no | yes |
| XPP3_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| NEK10_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYT11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| MYLK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CDKL3_HUMAN | [view interactions] | High throughput | no | no |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| SIM26_HUMAN | [view interactions] | High throughput | no | no |
| LACC1_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| ERCC8_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| 5HT2B_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| RANB9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| RS24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| LACTB_HUMAN | [view interactions] | High throughput | no | yes |
| OMA1_HUMAN | [view interactions] | High throughput | no | no |
| PARL_HUMAN | [view interactions] | High throughput | no | yes |
| YMEL1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| DEND3_HUMAN | [view interactions] | High throughput | no | no |
| TM208_HUMAN | [view interactions] | High throughput | no | yes |
| WAC_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
| MARH2_HUMAN | [view interactions] | High throughput | no | yes |
| MARH3_HUMAN | [view interactions] | High throughput | no | no |
| MARH4_HUMAN | [view interactions] | High throughput | no | yes |
| RN103_HUMAN | [view interactions] | High throughput | no | no |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| RNFT1_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| PHF11_HUMAN | [view interactions] | High throughput | no | no |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| P2RX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| CERS3_HUMAN | [view interactions] | High throughput | no | no |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| G6PT1_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| S2532_HUMAN | [view interactions] | High throughput | no | yes |
| ZC3C1_HUMAN | [view interactions] | High throughput | no | yes |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| G3PT_HUMAN | [view interactions] | High throughput | no | no |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| CR021_HUMAN | [view interactions] | High throughput | no | no |
| SSBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| ZDH19_HUMAN | [view interactions] | High throughput | no | no |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| NCF1_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| THB_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK7_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| PML_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM12_HUMAN | [view interactions] | High throughput | no | yes |
| K2C1B_HUMAN | [view interactions] | High throughput | no | yes |
| XDH_HUMAN | [view interactions] | High throughput | no | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAPR1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |