Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ICAM5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ICAM5_HUMAN
GO:0003723 RNA binding 21.0526 4 no
GO:0005216 ion channel activity 21.0526 4 no
GO:0015267 channel activity 21.0526 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in ICAM5_HUMAN
GO:0031323 regulation of cellular metabolic process 47.3684 4 no
GO:0051171 regulation of nitrogen compound metabolic process 47.3684 4 no
GO:0060255 regulation of macromolecule metabolic process 47.3684 4 no
GO:0080090 regulation of primary metabolic process 47.3684 4 no
GO:0048522 positive regulation of cellular process 47.3684 4 no
GO:0048523 negative regulation of cellular process 47.3684 4 no
GO:0009893 positive regulation of metabolic process 42.1053 4 no
GO:0010646 regulation of cell communication 42.1053 4 no
GO:0010468 regulation of gene expression 36.8421 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.8421 5 no
GO:0051252 regulation of RNA metabolic process 36.8421 5 no
GO:0006996 organelle organization 36.8421 4 no
GO:0009892 negative regulation of metabolic process 36.8421 4 no
GO:0010604 positive regulation of macromolecule metabolic process 36.8421 5 no
GO:0010605 negative regulation of macromolecule metabolic process 36.8421 5 no
GO:0010941 regulation of cell death 36.8421 4 no
GO:0022607 cellular component assembly 36.8421 4 no
GO:0031324 negative regulation of cellular metabolic process 36.8421 5 no
GO:0042981 regulation of apoptotic process 36.8421 6 no
GO:0043067 regulation of programmed cell death 36.8421 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 36.8421 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 36.8421 5 no
GO:0051246 regulation of protein metabolic process 36.8421 5 no
GO:0009966 regulation of signal transduction 36.8421 4 no
GO:0010648 negative regulation of cell communication 36.8421 5 no
GO:0023057 negative regulation of signaling 36.8421 4 no
GO:0051128 regulation of cellular component organization 36.8421 4 no
GO:0051049 regulation of transport 36.8421 4 no
GO:0009894 regulation of catabolic process 31.5789 4 no
GO:0009896 positive regulation of catabolic process 31.5789 5 no
GO:0010243 response to organonitrogen compound 31.5789 4 no
GO:0042176 regulation of protein catabolic process 31.5789 5 no
GO:0051247 positive regulation of protein metabolic process 31.5789 6 no
GO:0060548 negative regulation of cell death 31.5789 5 no
GO:0009968 negative regulation of signal transduction 31.5789 5 no
GO:0044087 regulation of cellular component biogenesis 31.5789 4 no
GO:0048585 negative regulation of response to stimulus 31.5789 4 no
GO:0009889 regulation of biosynthetic process 31.5789 4 no
GO:0009890 negative regulation of biosynthetic process 31.5789 5 no
GO:0010556 regulation of macromolecule biosynthetic process 31.5789 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 31.5789 6 no
GO:0031326 regulation of cellular biosynthetic process 31.5789 5 no
GO:0031327 negative regulation of cellular biosynthetic process 31.5789 6 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 31.5789 6 no
GO:0051050 positive regulation of transport 31.5789 4 no
GO:0051253 negative regulation of RNA metabolic process 31.5789 6 no
GO:0031325 positive regulation of cellular metabolic process 31.5789 5 no
GO:0006508 proteolysis 26.3158 4 no
GO:0008104 protein localization 26.3158 4 no
GO:0030162 regulation of proteolysis 26.3158 6 no
GO:0031329 regulation of cellular catabolic process 26.3158 5 no
GO:0043066 negative regulation of apoptotic process 26.3158 7 no
GO:0043069 negative regulation of programmed cell death 26.3158 6 no
GO:0045732 positive regulation of protein catabolic process 26.3158 6 no
GO:0045862 positive regulation of proteolysis 26.3158 7 no
GO:0048584 positive regulation of response to stimulus 26.3158 4 no
GO:0071702 organic substance transport 26.3158 4 no
GO:0080134 regulation of response to stress 26.3158 4 no
GO:1902531 regulation of intracellular signal transduction 26.3158 5 no
GO:0000122 negative regulation of transcription by RNA polymerase II 26.3158 8 no
GO:0006355 regulation of DNA-templated transcription 26.3158 6 no
GO:0006357 regulation of transcription by RNA polymerase II 26.3158 7 no
GO:0030030 cell projection organization 26.3158 4 no
GO:0031344 regulation of cell projection organization 26.3158 5 no
GO:0045892 negative regulation of DNA-templated transcription 26.3158 7 no
GO:0051094 positive regulation of developmental process 26.3158 4 no
GO:0071310 cellular response to organic substance 26.3158 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.3158 6 no
GO:0120036 plasma membrane bounded cell projection organization 26.3158 5 no
GO:1901699 cellular response to nitrogen compound 26.3158 4 no
GO:1901701 cellular response to oxygen-containing compound 26.3158 4 no
GO:1902679 negative regulation of RNA biosynthetic process 26.3158 7 no
GO:1903506 regulation of nucleic acid-templated transcription 26.3158 7 no
GO:1903507 negative regulation of nucleic acid-templated transcription 26.3158 8 no
GO:2001141 regulation of RNA biosynthetic process 26.3158 6 no
GO:0009891 positive regulation of biosynthetic process 26.3158 5 no
GO:0031328 positive regulation of cellular biosynthetic process 26.3158 6 no
GO:0031399 regulation of protein modification process 26.3158 6 no
GO:0034762 regulation of transmembrane transport 26.3158 4 no
GO:0034765 regulation of ion transmembrane transport 26.3158 5 no
GO:0043269 regulation of ion transport 26.3158 5 no
GO:0051130 positive regulation of cellular component organization 26.3158 5 no
GO:0034330 cell junction organization 26.3158 4 no
GO:0016192 vesicle-mediated transport 21.0526 4 yes
GO:0009895 negative regulation of catabolic process 21.0526 5 no
GO:0031330 negative regulation of cellular catabolic process 21.0526 6 no
GO:0036211 protein modification process 21.0526 4 no
GO:0043412 macromolecule modification 21.0526 4 no
GO:0050776 regulation of immune response 21.0526 4 no
GO:0051248 negative regulation of protein metabolic process 21.0526 6 no
GO:0071705 nitrogen compound transport 21.0526 4 no
GO:0080135 regulation of cellular response to stress 21.0526 4 no
GO:0006811 ion transport 21.0526 4 no
GO:0051129 negative regulation of cellular component organization 21.0526 5 no
GO:0010628 positive regulation of gene expression 21.0526 6 no
GO:0010629 negative regulation of gene expression 21.0526 6 no
GO:0014070 response to organic cyclic compound 21.0526 4 no
GO:0032880 regulation of protein localization 21.0526 5 no
GO:0051241 negative regulation of multicellular organismal process 21.0526 4 no
GO:0060341 regulation of cellular localization 21.0526 4 no
GO:0060627 regulation of vesicle-mediated transport 21.0526 4 no
GO:0071407 cellular response to organic cyclic compound 21.0526 5 no
GO:0071417 cellular response to organonitrogen compound 21.0526 4 no
GO:0097435 supramolecular fiber organization 21.0526 4 no
GO:0001932 regulation of protein phosphorylation 21.0526 7 no
GO:0001934 positive regulation of protein phosphorylation 21.0526 8 no
GO:0010557 positive regulation of macromolecule biosynthetic process 21.0526 6 no
GO:0010562 positive regulation of phosphorus metabolic process 21.0526 6 no
GO:0010647 positive regulation of cell communication 21.0526 5 no
GO:0019220 regulation of phosphate metabolic process 21.0526 6 no
GO:0023056 positive regulation of signaling 21.0526 4 no
GO:0031401 positive regulation of protein modification process 21.0526 7 no
GO:0042325 regulation of phosphorylation 21.0526 7 no
GO:0042327 positive regulation of phosphorylation 21.0526 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.0526 7 no
GO:0050804 modulation of chemical synaptic transmission 21.0526 5 no
GO:0051174 regulation of phosphorus metabolic process 21.0526 5 no
GO:0099177 regulation of trans-synaptic signaling 21.0526 4 no
GO:1904062 regulation of cation transmembrane transport 21.0526 6 no
GO:0050808 synapse organization 21.0526 5 no
GO:0043085 positive regulation of catalytic activity 21.0526 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ITAL_HUMAN [view interactions] Low throughput no no
PSN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
PSN2_HUMAN [view entry] [view interactions] Low throughput yes no
SHOC2_HUMAN [view interactions] High throughput no yes
PAR6B_HUMAN [view interactions] High throughput no no
SGO2_HUMAN [view interactions] High throughput no no
RMD3_HUMAN [view interactions] High throughput no yes
SART3_HUMAN [view interactions] High throughput no yes
STA5A_HUMAN [view interactions] High throughput no no
T132A_HUMAN [view interactions] High throughput no yes
KI18A_HUMAN [view interactions] High throughput no yes
TZAP_HUMAN [view interactions] High throughput no no
RNH2A_HUMAN [view interactions] High throughput no no
NAF1_HUMAN [view interactions] High throughput no yes
CD14_HUMAN [view interactions] High throughput no no
ILK_HUMAN [view interactions] High throughput no no
CBR1_HUMAN [view entry] [view interactions] High throughput yes yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
SORT_HUMAN [view interactions] High throughput no yes
CSF1_HUMAN [view interactions] High throughput no no
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PTN4_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
HEM1_HUMAN [view interactions] High throughput no yes
H3C_HUMAN [view interactions] High throughput no yes
F117B_HUMAN [view interactions] High throughput no no
KT222_HUMAN [view interactions] High throughput no no
KLH32_HUMAN [view interactions] High throughput no yes
LZTS2_HUMAN [view interactions] High throughput no no
DSN1_HUMAN [view interactions] High throughput no yes
LRC61_HUMAN [view interactions] High throughput no yes
PSF3_HUMAN [view interactions] High throughput no yes
CD248_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
RNF31_HUMAN [view interactions] High throughput no yes
REX1B_HUMAN [view interactions] High throughput no no
CRLF3_HUMAN [view interactions] High throughput no yes
MYLIP_HUMAN [view interactions] High throughput no no
TADA3_HUMAN [view interactions] High throughput no yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
MT2_HUMAN [view interactions] High throughput no no
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
KLF5_HUMAN [view interactions] High throughput no yes
AMBN_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX6_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
LEG1_HUMAN [view interactions] High throughput no yes
ARMC6_HUMAN [view interactions] High throughput no yes
SCOT2_HUMAN [view interactions] High throughput no no
DNSL1_HUMAN [view interactions] High throughput no yes
PRG2_HUMAN [view interactions] High throughput no no
IL5RA_HUMAN [view interactions] High throughput no no
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
TM2D3_HUMAN [view interactions] High throughput no yes
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
LY86_HUMAN [view interactions] High throughput no no
LEG3_HUMAN [view interactions] High throughput no yes
SLUR1_HUMAN [view interactions] High throughput no no
PTC1_HUMAN [view entry] [view interactions] High throughput yes yes
HYAL1_HUMAN [view interactions] High throughput no no
NNRD_HUMAN [view interactions] High throughput no yes
AQP3_HUMAN [view interactions] High throughput no no
GGH_HUMAN [view interactions] High throughput no yes
GML_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
TECT1_HUMAN [view interactions] High throughput no yes
PLPL5_HUMAN [view interactions] High throughput no no
EGFR_HUMAN [view interactions] High throughput no no
DHX9_HUMAN [view interactions] High throughput no yes
ITB2_HUMAN [view interactions] Computational no no