FBX2_HUMAN
Evidence for PS localization
Functions
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in FBX2_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 29.3103 | 4 | no |
| GO:0001540 | amyloid-beta binding | 6.8966 | 4 | yes |
| GO:0004842 | ubiquitin-protein transferase activity | 6.8966 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in FBX2_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 53.4483 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 53.4483 | 4 | no |
| GO:0009966 | regulation of signal transduction | 51.7241 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.2759 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 44.8276 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 44.8276 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 44.8276 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.3793 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 39.6552 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 34.4828 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.4828 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.4828 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 32.7586 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.7586 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 32.7586 | 4 | no |
| GO:0031399 | regulation of protein modification process | 31.0345 | 6 | yes |
| GO:0030030 | cell projection organization | 29.3103 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.5862 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 27.5862 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.5862 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.5862 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.5862 | 4 | no |
| GO:0051049 | regulation of transport | 27.5862 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.5862 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 27.5862 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 27.5862 | 5 | no |
| GO:0023057 | negative regulation of signaling | 27.5862 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 27.5862 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 25.8621 | 4 | yes |
| GO:0036211 | protein modification process | 25.8621 | 4 | yes |
| GO:0043412 | macromolecule modification | 25.8621 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 25.8621 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 25.8621 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.1379 | 5 | no |
| GO:2000145 | regulation of cell motility | 24.1379 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 24.1379 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.1379 | 5 | no |
| GO:0022607 | cellular component assembly | 24.1379 | 4 | no |
| GO:0023056 | positive regulation of signaling | 24.1379 | 4 | no |
| GO:0008104 | protein localization | 24.1379 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.1379 | 4 | no |
| GO:0030334 | regulation of cell migration | 24.1379 | 5 | no |
| GO:0071310 | cellular response to organic substance | 22.4138 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 22.4138 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.4138 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.4138 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.4138 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 22.4138 | 7 | no |
| GO:0080134 | regulation of response to stress | 22.4138 | 4 | no |
| GO:0006996 | organelle organization | 22.4138 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.6897 | 5 | no |
| GO:0051960 | regulation of nervous system development | 20.6897 | 5 | no |
| GO:0060284 | regulation of cell development | 20.6897 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 20.6897 | 5 | no |
| GO:0030162 | regulation of proteolysis | 20.6897 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.6897 | 4 | no |
| GO:0043269 | regulation of ion transport | 20.6897 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 20.6897 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 20.6897 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.6897 | 5 | no |
| GO:0010941 | regulation of cell death | 20.6897 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.6897 | 6 | no |
| GO:0030155 | regulation of cell adhesion | 20.6897 | 4 | no |
| GO:0006508 | proteolysis | 18.9655 | 4 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 13.7931 | 7 | yes |
| GO:0009057 | macromolecule catabolic process | 12.0690 | 4 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 12.0690 | 6 | yes |
| GO:0032446 | protein modification by small protein conjugation | 12.0690 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 12.0690 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 12.0690 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 12.0690 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 12.0690 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 12.0690 | 4 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 10.3448 | 7 | yes |
| GO:0010498 | proteasomal protein catabolic process | 10.3448 | 5 | yes |
| GO:0016567 | protein ubiquitination | 10.3448 | 7 | yes |
| GO:0030163 | protein catabolic process | 10.3448 | 4 | yes |
| GO:0031396 | regulation of protein ubiquitination | 10.3448 | 8 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 10.3448 | 6 | yes |
| GO:0030433 | ubiquitin-dependent ERAD pathway | 8.6207 | 6 | yes |
| GO:0034976 | response to endoplasmic reticulum stress | 8.6207 | 4 | yes |
| GO:0036503 | ERAD pathway | 8.6207 | 5 | yes |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 5.1724 | 7 | yes |
| GO:1901136 | carbohydrate derivative catabolic process | 5.1724 | 4 | yes |
| GO:0006516 | glycoprotein catabolic process | 3.4483 | 5 | yes |
| GO:0009100 | glycoprotein metabolic process | 3.4483 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in FBX2_HUMAN |
|---|---|---|---|---|
| DOID:0080001 | bone disease | 3.4483 | 4 | no |
| DOID:0080006 | bone development disease | 3.4483 | 5 | no |
| DOID:65 | connective tissue disease | 3.4483 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PDE4D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PAQRB_HUMAN | [view interactions] | Low throughput | no | no |
| FETUA_HUMAN | [view interactions] | Low throughput | no | no |
| UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2D3_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2E1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2L3_HUMAN | [view interactions] | Low throughput | no | yes |
| FBX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SKP1_HUMAN | [view interactions] | Low throughput | no | yes |
| ITB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BACE1_HUMAN | [view interactions] | Low throughput | no | yes |
| CUL1_HUMAN | [view interactions] | Low throughput | no | yes |
| CXB2_HUMAN | [view interactions] | Low throughput | no | yes |
| CUL7_HUMAN | [view interactions] | Low throughput | no | yes |
| ANC2_HUMAN | [view interactions] | Low throughput | no | no |
| RBX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TOR1A_HUMAN | [view interactions] | Low throughput | no | yes |
| A1AT_HUMAN | [view interactions] | Low throughput | no | no |
| SIRPG_HUMAN | [view interactions] | Low throughput | no | no |
| SHPS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IL6RA_HUMAN | [view interactions] | Low throughput | no | no |
| IL6RB_HUMAN | [view interactions] | Low throughput | no | no |
| FBN1_HUMAN | [view interactions] | Low throughput | no | no |
| LAMP2_HUMAN | [view interactions] | Low throughput | no | yes |
| BTD_HUMAN | [view interactions] | High throughput | no | no |
| C4BPB_HUMAN | [view interactions] | High throughput | no | no |
| PLOD3_HUMAN | [view interactions] | High throughput | no | yes |
| AGRG6_HUMAN | [view interactions] | High throughput | no | no |
| SEM6A_HUMAN | [view interactions] | High throughput | no | yes |
| OSMR_HUMAN | [view interactions] | High throughput | no | yes |
| ADA17_HUMAN | [view interactions] | High throughput | no | yes |
| IGSF2_HUMAN | [view interactions] | High throughput | no | yes |
| CSTL1_HUMAN | [view interactions] | High throughput | no | no |
| GXLT1_HUMAN | [view interactions] | High throughput | no | no |
| NPTXR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| GPAA1_HUMAN | [view interactions] | High throughput | no | yes |
| CTHR1_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| BMP4_HUMAN | [view interactions] | High throughput | no | no |
| SPA9_HUMAN | [view interactions] | High throughput | no | no |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| ARSB_HUMAN | [view interactions] | High throughput | no | yes |
| I12R1_HUMAN | [view interactions] | High throughput | no | no |
| H6ST1_HUMAN | [view interactions] | High throughput | no | no |
| OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
| LIFR_HUMAN | [view interactions] | High throughput | no | no |
| CADM4_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| TINAL_HUMAN | [view interactions] | High throughput | no | no |
| SUCO_HUMAN | [view interactions] | High throughput | no | yes |
| LAMB3_HUMAN | [view interactions] | High throughput | no | yes |
| SCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| LRP10_HUMAN | [view interactions] | High throughput | no | no |
| PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ICAM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM3C_HUMAN | [view interactions] | High throughput | no | no |
| CD47_HUMAN | [view interactions] | High throughput | no | no |
| NCLN_HUMAN | [view interactions] | High throughput | no | yes |
| GPI8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRG_HUMAN | [view interactions] | High throughput | no | no |
| TMM25_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
| KLK5_HUMAN | [view interactions] | High throughput | no | no |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| GOLM2_HUMAN | [view interactions] | High throughput | no | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| L1CAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRFN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGRN1_HUMAN | [view interactions] | High throughput | no | yes |
| COCA1_HUMAN | [view interactions] | High throughput | no | yes |
| LRP1B_HUMAN | [view interactions] | High throughput | no | yes |
| PVR_HUMAN | [view interactions] | High throughput | no | yes |
| PIGS_HUMAN | [view interactions] | High throughput | no | yes |
| COIA1_HUMAN | [view interactions] | High throughput | no | no |
| ITA6_HUMAN | [view interactions] | High throughput | no | yes |
| TIMP1_HUMAN | [view interactions] | High throughput | no | no |
| CRLF1_HUMAN | [view interactions] | High throughput | no | no |
| HXK2_HUMAN | [view interactions] | High throughput | no | yes |
| SIAE_HUMAN | [view interactions] | High throughput | no | yes |
| SEM6B_HUMAN | [view interactions] | High throughput | no | yes |
| GNPTA_HUMAN | [view interactions] | High throughput | no | yes |
| QSOX1_HUMAN | [view interactions] | High throughput | no | no |
| PCYOX_HUMAN | [view interactions] | High throughput | no | yes |
| NICA_HUMAN | [view interactions] | High throughput | no | yes |
| LRIG2_HUMAN | [view interactions] | High throughput | no | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| SE6L2_HUMAN | [view interactions] | High throughput | no | yes |
| TM231_HUMAN | [view interactions] | High throughput | no | yes |
| LAMC3_HUMAN | [view interactions] | High throughput | no | no |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| GNS_HUMAN | [view interactions] | High throughput | no | yes |
| CA2D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNED1_HUMAN | [view interactions] | High throughput | no | yes |
| LAMA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMA4_HUMAN | [view interactions] | High throughput | no | no |
| DUOX1_HUMAN | [view interactions] | High throughput | no | no |
| LAMB2_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN3_HUMAN | [view interactions] | High throughput | no | no |
| LAMC1_HUMAN | [view interactions] | High throughput | no | yes |
| MEST_HUMAN | [view interactions] | High throughput | no | no |
| LGMN_HUMAN | [view interactions] | High throughput | no | yes |
| JAG1_HUMAN | [view interactions] | High throughput | no | no |
| CD276_HUMAN | [view interactions] | High throughput | no | yes |
| AGRF1_HUMAN | [view interactions] | High throughput | no | no |
| ANR46_HUMAN | [view interactions] | High throughput | no | yes |
| S4A7_HUMAN | [view interactions] | High throughput | no | no |
| T131L_HUMAN | [view interactions] | High throughput | no | yes |
| LICH_HUMAN | [view interactions] | High throughput | no | yes |
| PKD2_HUMAN | [view interactions] | High throughput | no | yes |
| MINP1_HUMAN | [view interactions] | High throughput | no | yes |
| PGLT1_HUMAN | [view interactions] | High throughput | no | no |
| SC11A_HUMAN | [view interactions] | High throughput | no | no |
| HPSE_HUMAN | [view interactions] | High throughput | no | no |
| GDN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPBG_HUMAN | [view interactions] | High throughput | no | yes |
| CHST8_HUMAN | [view interactions] | High throughput | no | no |
| CTU1_HUMAN | [view interactions] | High throughput | no | no |
| SEM4C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FPRP_HUMAN | [view interactions] | High throughput | no | yes |
| SCAP_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| TUTLA_HUMAN | [view interactions] | High throughput | no | no |
| LRIG3_HUMAN | [view interactions] | High throughput | no | yes |
| GRAH_HUMAN | [view interactions] | High throughput | no | no |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| POMT2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMC2_HUMAN | [view interactions] | High throughput | no | no |
| BGLR_HUMAN | [view interactions] | High throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIA8D_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view interactions] | High throughput | no | yes |
| H6ST2_HUMAN | [view interactions] | High throughput | no | no |
| NOTC2_HUMAN | [view interactions] | High throughput | no | yes |
| SORL_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC3_HUMAN | [view interactions] | High throughput | no | yes |
| ATF6B_HUMAN | [view interactions] | High throughput | no | yes |
| AGRG1_HUMAN | [view interactions] | High throughput | no | yes |
| ASIC5_HUMAN | [view interactions] | High throughput | no | yes |
| CD48_HUMAN | [view interactions] | High throughput | no | no |
| CEIP2_HUMAN | [view interactions] | High throughput | no | yes |
| AGRA3_HUMAN | [view interactions] | High throughput | no | yes |
| SPHM_HUMAN | [view interactions] | High throughput | no | yes |
| CD14_HUMAN | [view interactions] | High throughput | no | no |
| EMC7_HUMAN | [view interactions] | High throughput | no | yes |
| GAS6_HUMAN | [view interactions] | High throughput | no | no |
| TMTC3_HUMAN | [view interactions] | High throughput | no | yes |
| GALT5_HUMAN | [view interactions] | High throughput | no | no |
| ANAG_HUMAN | [view interactions] | High throughput | no | no |
| SPIT1_HUMAN | [view interactions] | High throughput | no | yes |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
| LCAP_HUMAN | [view interactions] | High throughput | no | yes |
| PCSK5_HUMAN | [view interactions] | High throughput | no | yes |
| AGRV1_HUMAN | [view interactions] | High throughput | no | no |
| PRAM2_HUMAN | [view interactions] | High throughput | no | no |
| SEM4D_HUMAN | [view interactions] | High throughput | no | yes |
| PAG15_HUMAN | [view interactions] | High throughput | no | yes |
| PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
| TGO1_HUMAN | [view interactions] | High throughput | no | yes |
| TM131_HUMAN | [view interactions] | High throughput | no | yes |
| TXD15_HUMAN | [view interactions] | High throughput | no | yes |
| PLGT3_HUMAN | [view interactions] | High throughput | no | no |
| MYORG_HUMAN | [view interactions] | High throughput | no | yes |
| CA2D2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPSN_HUMAN | [view interactions] | High throughput | no | yes |
| ANO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRFN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| TGFB1_HUMAN | [view interactions] | High throughput | no | no |
| LAMA3_HUMAN | [view interactions] | High throughput | no | no |
| COEA1_HUMAN | [view interactions] | High throughput | no | no |
| LMF2_HUMAN | [view interactions] | High throughput | no | yes |
| SIA7D_HUMAN | [view interactions] | High throughput | no | no |
| BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
| CD320_HUMAN | [view interactions] | High throughput | no | yes |
| EMIL2_HUMAN | [view interactions] | High throughput | no | yes |
| EMC3_HUMAN | [view interactions] | High throughput | no | yes |
| EMC8_HUMAN | [view interactions] | High throughput | no | no |
| LAMB1_HUMAN | [view interactions] | High throughput | no | yes |
| VKGC_HUMAN | [view interactions] | High throughput | no | yes |
| GSLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAAA_HUMAN | [view interactions] | High throughput | no | yes |
| LAG3_HUMAN | [view interactions] | High throughput | no | no |
| PGBM_HUMAN | [view interactions] | High throughput | no | no |
| CSPG4_HUMAN | [view interactions] | High throughput | no | yes |
| NPTX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATF_HUMAN | [view interactions] | High throughput | no | yes |
| LEPR_HUMAN | [view interactions] | High throughput | no | no |
| GLYC_HUMAN | [view interactions] | High throughput | no | no |
| AMOL1_HUMAN | [view interactions] | High throughput | no | no |
| PIGU_HUMAN | [view interactions] | High throughput | no | no |
| CO8A_HUMAN | [view interactions] | High throughput | no | no |
| PLBL2_HUMAN | [view interactions] | High throughput | no | yes |
| COL12_HUMAN | [view interactions] | High throughput | no | no |
| SULF2_HUMAN | [view interactions] | High throughput | no | yes |
| UNC5B_HUMAN | [view interactions] | High throughput | no | yes |
| CATL2_HUMAN | [view interactions] | High throughput | no | yes |
| TM39A_HUMAN | [view interactions] | High throughput | no | yes |
| SELN_HUMAN | [view interactions] | High throughput | no | yes |
| CHSTA_HUMAN | [view interactions] | High throughput | no | yes |
| CELR3_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MEGF8_HUMAN | [view interactions] | High throughput | no | yes |
| TXD11_HUMAN | [view interactions] | High throughput | no | yes |
| ABCA2_HUMAN | [view interactions] | High throughput | no | yes |
| MRC2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMF1_HUMAN | [view interactions] | High throughput | no | yes |
| OSTM1_HUMAN | [view interactions] | High throughput | no | yes |
| PCYXL_HUMAN | [view interactions] | High throughput | no | yes |
| KAT7_HUMAN | [view interactions] | High throughput | no | yes |
| EMC4_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC13_HUMAN | [view interactions] | High throughput | no | no |
| TGBR3_HUMAN | [view interactions] | High throughput | no | yes |
| K319L_HUMAN | [view interactions] | High throughput | no | yes |
| FBN2_HUMAN | [view interactions] | High throughput | no | no |
| NOMO3_HUMAN | [view interactions] | High throughput | no | yes |
| TEN3_HUMAN | [view interactions] | High throughput | no | yes |
| DIAC_HUMAN | [view interactions] | High throughput | no | yes |
| CTF1_HUMAN | [view interactions] | High throughput | no | no |
| ENPP1_HUMAN | [view interactions] | High throughput | no | yes |
| EDIL3_HUMAN | [view interactions] | High throughput | no | yes |
| JAG2_HUMAN | [view interactions] | High throughput | no | yes |
| ECE1_HUMAN | [view interactions] | High throughput | no | yes |
| ADA23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| CGT_HUMAN | [view interactions] | High throughput | no | no |
| G6PE_HUMAN | [view interactions] | High throughput | no | yes |
| SDK2_HUMAN | [view interactions] | High throughput | no | no |
| KPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| I17RA_HUMAN | [view interactions] | High throughput | no | yes |
| CDHR2_HUMAN | [view interactions] | High throughput | no | yes |
| B3GL2_HUMAN | [view interactions] | High throughput | no | yes |
| CO6A1_HUMAN | [view interactions] | High throughput | no | no |
| CO6A2_HUMAN | [view interactions] | High throughput | no | no |
| VPS25_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM2_HUMAN | [view interactions] | High throughput | no | yes |
| IGSF3_HUMAN | [view interactions] | High throughput | no | yes |
| RN157_HUMAN | [view interactions] | High throughput | no | no |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRU_HUMAN | [view interactions] | High throughput | no | yes |
| SULF1_HUMAN | [view interactions] | High throughput | no | no |
| NID1_HUMAN | [view interactions] | High throughput | no | no |
| CBPD_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ENPP4_HUMAN | [view interactions] | High throughput | no | yes |
| ASPG_HUMAN | [view interactions] | High throughput | no | yes |
| FRAS1_HUMAN | [view interactions] | High throughput | no | yes |
| PIGT_HUMAN | [view interactions] | High throughput | no | no |
| IDUA_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
| CAHD1_HUMAN | [view interactions] | High throughput | no | no |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| VPS36_HUMAN | [view interactions] | High throughput | no | yes |
| ITAV_HUMAN | [view interactions] | High throughput | no | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADAM9_HUMAN | [view interactions] | High throughput | no | no |
| TM2D3_HUMAN | [view interactions] | High throughput | no | yes |
| ROBO1_HUMAN | [view interactions] | High throughput | no | yes |
| NELL2_HUMAN | [view interactions] | High throughput | no | no |
| ITA8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POMT1_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| CHLE_HUMAN | [view interactions] | High throughput | no | no |
| ITA1_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| ITA2_HUMAN | [view interactions] | High throughput | no | yes |
| VASN_HUMAN | [view interactions] | High throughput | no | yes |
| NOMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPSP_HUMAN | [view interactions] | High throughput | no | no |
| EMB_HUMAN | [view interactions] | High throughput | no | no |
| CBLN4_HUMAN | [view interactions] | High throughput | no | no |
| SLIT2_HUMAN | [view interactions] | High throughput | no | no |
| ADA33_HUMAN | [view interactions] | High throughput | no | yes |
| BMP1_HUMAN | [view interactions] | High throughput | no | yes |
| SIA7E_HUMAN | [view interactions] | High throughput | no | no |
| B4GT3_HUMAN | [view interactions] | High throughput | no | yes |
| OPCM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOLR3_HUMAN | [view interactions] | High throughput | no | no |
| ERO1B_HUMAN | [view interactions] | High throughput | no | yes |
| ERAP2_HUMAN | [view interactions] | High throughput | no | yes |
| AMGO3_HUMAN | [view interactions] | High throughput | no | no |
| ARSK_HUMAN | [view interactions] | High throughput | no | no |
| GDF9_HUMAN | [view interactions] | High throughput | no | no |
| PCP_HUMAN | [view interactions] | High throughput | no | yes |
| CAP7_HUMAN | [view interactions] | High throughput | no | no |
| PIEZ1_HUMAN | [view interactions] | High throughput | no | no |
| CHSTC_HUMAN | [view interactions] | High throughput | no | yes |
| CD109_HUMAN | [view interactions] | High throughput | no | no |
| RNT2_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE2_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PO210_HUMAN | [view interactions] | High throughput | no | yes |
| CAV2_HUMAN | [view interactions] | High throughput | no | no |
| TMED9_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMIL3_HUMAN | [view interactions] | High throughput | no | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED4_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADA10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYRM4_HUMAN | [view interactions] | High throughput | no | yes |
| PFD6_HUMAN | [view interactions] | High throughput | no | yes |
| SUN1_HUMAN | [view interactions] | High throughput | no | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| LIGO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRAP_HUMAN | [view interactions] | High throughput | no | yes |
| LRIG1_HUMAN | [view interactions] | High throughput | no | yes |
| PAX4_HUMAN | [view interactions] | High throughput | no | no |
| SUSD1_HUMAN | [view interactions] | High throughput | no | no |
| VSTM1_HUMAN | [view interactions] | High throughput | no | no |
| ENPP5_HUMAN | [view interactions] | High throughput | no | yes |
| PLXC1_HUMAN | [view interactions] | High throughput | no | no |
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| PPT2_HUMAN | [view interactions] | High throughput | no | no |
| MGMT_HUMAN | [view interactions] | High throughput | no | no |
| PLTP_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
| S12A7_HUMAN | [view interactions] | High throughput | no | yes |
| NID2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMA1_HUMAN | [view interactions] | High throughput | no | no |
| EPHB4_HUMAN | [view interactions] | High throughput | no | yes |
| SLAF7_HUMAN | [view interactions] | High throughput | no | no |
| LRP2_HUMAN | [view interactions] | High throughput | no | no |
| NECT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCDH9_HUMAN | [view interactions] | High throughput | no | no |
| NTRI_HUMAN | [view interactions] | High throughput | no | yes |
| PLXD1_HUMAN | [view interactions] | High throughput | no | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| BOC_HUMAN | [view interactions] | High throughput | no | yes |
| ITB5_HUMAN | [view interactions] | High throughput | no | yes |
| IF_HUMAN | [view interactions] | High throughput | no | yes |
| PPAL_HUMAN | [view interactions] | High throughput | no | no |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| CLPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD166_HUMAN | [view interactions] | High throughput | no | no |
| CLN5_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| CATZ_HUMAN | [view interactions] | High throughput | no | yes |
| DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MA2B2_HUMAN | [view interactions] | High throughput | no | no |
| CDHR4_HUMAN | [view interactions] | High throughput | no | no |
| CEMIP_HUMAN | [view interactions] | High throughput | no | no |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| SCRB1_HUMAN | [view interactions] | High throughput | no | no |
| HEXB_HUMAN | [view interactions] | High throughput | no | no |
| PXDN_HUMAN | [view interactions] | High throughput | no | no |
| LYAG_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| IL25_HUMAN | [view interactions] | High throughput | no | no |
| CREG1_HUMAN | [view interactions] | High throughput | no | no |
| WNT7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PMGT2_HUMAN | [view interactions] | High throughput | no | yes |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| TTC17_HUMAN | [view interactions] | High throughput | no | yes |
| INSL3_HUMAN | [view interactions] | High throughput | no | no |
| ATRN_HUMAN | [view interactions] | High throughput | no | yes |
| THSD4_HUMAN | [view interactions] | High throughput | no | no |
| MA2B1_HUMAN | [view interactions] | High throughput | no | yes |
| C1RL_HUMAN | [view interactions] | High throughput | no | yes |
| MANBA_HUMAN | [view interactions] | High throughput | no | yes |
| PRELP_HUMAN | [view interactions] | High throughput | no | no |
| COCH_HUMAN | [view interactions] | High throughput | no | no |
| DJC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSC2_HUMAN | [view interactions] | High throughput | no | no |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| ATF6A_HUMAN | [view interactions] | High throughput | no | yes |
| SEM4G_HUMAN | [view interactions] | High throughput | no | yes |
| OFUT1_HUMAN | [view interactions] | High throughput | no | yes |
| WN10B_HUMAN | [view interactions] | High throughput | no | yes |
| CC28A_HUMAN | [view interactions] | High throughput | no | no |
| ST14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SE1L3_HUMAN | [view interactions] | High throughput | no | yes |
| LTBP4_HUMAN | [view interactions] | High throughput | no | yes |
| INGR1_HUMAN | [view interactions] | High throughput | no | no |
| CILP2_HUMAN | [view interactions] | High throughput | no | no |
| TPA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MER34_HUMAN | [view interactions] | High throughput | no | no |
| FBW1B_HUMAN | [view interactions] | Computational | no | yes |
| UBC9_HUMAN | [view interactions] | Computational | no | yes |
| DISP3_HUMAN | [view interactions] | Computational | no | no |
| FBW1A_HUMAN | [view interactions] | Computational | no | yes |
| FBX6_HUMAN | [view interactions] | Computational | no | yes |
| UBIA1_HUMAN | [view interactions] | Computational | no | no |
| SKP2_HUMAN | [view interactions] | Computational | no | yes |
| FBXW7_HUMAN | [view interactions] | Computational | no | yes |
| FBX4_HUMAN | [view interactions] | Computational | no | no |
| SAE1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |