Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SEM4D_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed). Regulates GABAergic synapse development . Promotes the development of inhibitory synapses in a PLXNB1-dependent manner . Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed). Promotes the migration of cerebellar granule cells (PubMed). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SEM4D_HUMAN
GO:0030215 semaphorin receptor binding 33.3333 4 yes
GO:0019900 kinase binding 33.3333 4 no
GO:0019901 protein kinase binding 33.3333 5 no
GO:0045499 chemorepellent activity 22.2222 5 yes
GO:0048018 receptor ligand activity 22.2222 4 yes
GO:0005096 GTPase activator activity 22.2222 4 no
GO:0017154 semaphorin receptor activity 22.2222 4 no
GO:0030695 GTPase regulator activity 22.2222 4 no
GO:0000166 nucleotide binding 22.2222 4 no
GO:0003924 GTPase activity 22.2222 7 no
GO:0005525 GTP binding 22.2222 5 no
GO:0016462 pyrophosphatase activity 22.2222 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 22.2222 4 no
GO:0017076 purine nucleotide binding 22.2222 5 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 22.2222 6 no
GO:0019001 guanyl nucleotide binding 22.2222 6 no
GO:0019003 GDP binding 22.2222 5 no
GO:0032555 purine ribonucleotide binding 22.2222 4 no
GO:0032561 guanyl ribonucleotide binding 22.2222 5 no
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 no
GO:0043168 anion binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SEM4D_HUMAN
GO:0048522 positive regulation of cellular process 88.8889 4 yes
GO:0048523 negative regulation of cellular process 88.8889 4 yes
GO:0060255 regulation of macromolecule metabolic process 77.7778 4 yes
GO:0080090 regulation of primary metabolic process 77.7778 4 yes
GO:0010646 regulation of cell communication 77.7778 4 yes
GO:0048584 positive regulation of response to stimulus 66.6667 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 66.6667 6 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:1902531 regulation of intracellular signal transduction 66.6667 5 yes
GO:1902533 positive regulation of intracellular signal transduction 66.6667 6 yes
GO:0009966 regulation of signal transduction 66.6667 4 yes
GO:0009967 positive regulation of signal transduction 66.6667 5 yes
GO:0010647 positive regulation of cell communication 66.6667 5 yes
GO:0023056 positive regulation of signaling 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0045595 regulation of cell differentiation 55.5556 4 yes
GO:0045597 positive regulation of cell differentiation 55.5556 5 yes
GO:0050767 regulation of neurogenesis 55.5556 6 yes
GO:0050769 positive regulation of neurogenesis 55.5556 6 yes
GO:0051057 positive regulation of small GTPase mediated signal transduction 55.5556 7 yes
GO:0051094 positive regulation of developmental process 55.5556 4 yes
GO:0051128 regulation of cellular component organization 55.5556 4 yes
GO:0051240 positive regulation of multicellular organismal process 55.5556 4 yes
GO:0051247 positive regulation of protein metabolic process 55.5556 6 yes
GO:0051960 regulation of nervous system development 55.5556 5 yes
GO:0051962 positive regulation of nervous system development 55.5556 5 yes
GO:0060284 regulation of cell development 55.5556 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 55.5556 6 yes
GO:2000026 regulation of multicellular organismal development 55.5556 4 yes
GO:2000145 regulation of cell motility 55.5556 4 yes
GO:0042127 regulation of cell population proliferation 55.5556 4 no
GO:0009889 regulation of biosynthetic process 55.5556 4 yes
GO:0009893 positive regulation of metabolic process 55.5556 4 yes
GO:0010468 regulation of gene expression 55.5556 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 55.5556 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 55.5556 5 yes
GO:0010720 positive regulation of cell development 55.5556 6 yes
GO:0010975 regulation of neuron projection development 55.5556 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 55.5556 4 yes
GO:0030030 cell projection organization 55.5556 4 yes
GO:0030155 regulation of cell adhesion 55.5556 4 yes
GO:0030334 regulation of cell migration 55.5556 5 yes
GO:0031325 positive regulation of cellular metabolic process 55.5556 5 yes
GO:0031326 regulation of cellular biosynthetic process 55.5556 5 yes
GO:0031344 regulation of cell projection organization 55.5556 5 yes
GO:0031399 regulation of protein modification process 55.5556 6 yes
GO:0045596 negative regulation of cell differentiation 44.4444 5 yes
GO:0045927 positive regulation of growth 44.4444 4 yes
GO:0045937 positive regulation of phosphate metabolic process 44.4444 7 yes
GO:0048585 negative regulation of response to stimulus 44.4444 4 yes
GO:0050770 regulation of axonogenesis 44.4444 5 yes
GO:0050772 positive regulation of axonogenesis 44.4444 6 yes
GO:0051093 negative regulation of developmental process 44.4444 4 yes
GO:0051130 positive regulation of cellular component organization 44.4444 5 yes
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 yes
GO:0051252 regulation of RNA metabolic process 44.4444 5 yes
GO:0051336 regulation of hydrolase activity 44.4444 4 yes
GO:0071526 semaphorin-plexin signaling pathway 44.4444 4 yes
GO:0120036 plasma membrane bounded cell projection organization 44.4444 5 yes
GO:2000147 positive regulation of cell motility 44.4444 5 yes
GO:0022607 cellular component assembly 44.4444 4 no
GO:0001558 regulation of cell growth 44.4444 4 yes
GO:0001932 regulation of protein phosphorylation 44.4444 7 yes
GO:0001934 positive regulation of protein phosphorylation 44.4444 8 yes
GO:0010562 positive regulation of phosphorus metabolic process 44.4444 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.4444 5 yes
GO:0019220 regulation of phosphate metabolic process 44.4444 6 yes
GO:0022604 regulation of cell morphogenesis 44.4444 5 yes
GO:0030307 positive regulation of cell growth 44.4444 5 yes
GO:0030335 positive regulation of cell migration 44.4444 6 yes
GO:0031175 neuron projection development 44.4444 6 yes
GO:0031346 positive regulation of cell projection organization 44.4444 6 yes
GO:0031401 positive regulation of protein modification process 44.4444 7 yes
GO:0032101 regulation of response to external stimulus 44.4444 4 yes
GO:0032102 negative regulation of response to external stimulus 44.4444 5 yes
GO:0035023 regulation of Rho protein signal transduction 44.4444 7 yes
GO:0040013 negative regulation of locomotion 44.4444 4 yes
GO:0040017 positive regulation of locomotion 44.4444 4 yes
GO:0042325 regulation of phosphorylation 44.4444 7 yes
GO:0042327 positive regulation of phosphorylation 44.4444 8 yes
GO:0042981 regulation of apoptotic process 44.4444 5 yes
GO:0043066 negative regulation of apoptotic process 44.4444 6 yes
GO:0043067 regulation of programmed cell death 44.4444 4 yes
GO:0043069 negative regulation of programmed cell death 44.4444 5 yes
GO:0043087 regulation of GTPase activity 44.4444 5 yes
GO:0044087 regulation of cellular component biogenesis 33.3333 4 yes
GO:0044089 positive regulation of cellular component biogenesis 33.3333 5 yes
GO:0045926 negative regulation of growth 33.3333 4 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 33.3333 5 yes
GO:0048638 regulation of developmental growth 33.3333 4 yes
GO:0048639 positive regulation of developmental growth 33.3333 5 yes
GO:0048640 negative regulation of developmental growth 33.3333 5 yes
GO:0048841 regulation of axon extension involved in axon guidance 33.3333 6 yes
GO:0048843 negative regulation of axon extension involved in axon guidance 33.3333 6 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 33.3333 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 33.3333 9 yes
GO:0050768 negative regulation of neurogenesis 33.3333 6 yes
GO:0050771 negative regulation of axonogenesis 33.3333 6 yes
GO:0050773 regulation of dendrite development 33.3333 4 yes
GO:0050920 regulation of chemotaxis 33.3333 4 yes
GO:0050922 negative regulation of chemotaxis 33.3333 5 yes
GO:0051129 negative regulation of cellular component organization 33.3333 5 yes
GO:0051241 negative regulation of multicellular organismal process 33.3333 4 yes
GO:0051253 negative regulation of RNA metabolic process 33.3333 6 yes
GO:0051345 positive regulation of hydrolase activity 33.3333 5 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 33.3333 6 yes
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 33.3333 7 yes
GO:0051961 negative regulation of nervous system development 33.3333 5 yes
GO:0061387 regulation of extent of cell growth 33.3333 5 yes
GO:0090497 mesenchymal cell migration 33.3333 5 yes
GO:0097485 neuron projection guidance 33.3333 7 yes
GO:1901888 regulation of cell junction assembly 33.3333 5 yes
GO:1901890 positive regulation of cell junction assembly 33.3333 6 yes
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 yes
GO:0008104 protein localization 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0051493 regulation of cytoskeleton organization 33.3333 6 no
GO:0008284 positive regulation of cell population proliferation 33.3333 5 no
GO:0001667 ameboidal-type cell migration 33.3333 4 yes
GO:0001755 neural crest cell migration 33.3333 6 yes
GO:0006355 regulation of DNA-templated transcription 33.3333 7 yes
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 8 yes
GO:0007162 negative regulation of cell adhesion 33.3333 5 yes
GO:0007411 axon guidance 33.3333 8 yes
GO:0009890 negative regulation of biosynthetic process 33.3333 5 yes
GO:0009892 negative regulation of metabolic process 33.3333 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 33.3333 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 yes
GO:0010721 negative regulation of cell development 33.3333 6 yes
GO:0010977 negative regulation of neuron projection development 33.3333 7 yes
GO:0030308 negative regulation of cell growth 33.3333 5 yes
GO:0030516 regulation of axon extension 33.3333 5 yes
GO:0030517 negative regulation of axon extension 33.3333 6 yes
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 yes
GO:0031345 negative regulation of cell projection organization 33.3333 6 yes
GO:0035025 positive regulation of Rho protein signal transduction 33.3333 8 yes
GO:0043085 positive regulation of catalytic activity 33.3333 4 yes
GO:0043547 positive regulation of GTPase activity 33.3333 6 yes
GO:0045667 regulation of osteoblast differentiation 22.2222 5 yes
GO:0045668 negative regulation of osteoblast differentiation 22.2222 6 yes
GO:0045892 negative regulation of DNA-templated transcription 22.2222 8 yes
GO:0045936 negative regulation of phosphate metabolic process 22.2222 7 yes
GO:0048670 regulation of collateral sprouting 22.2222 5 yes
GO:0048672 positive regulation of collateral sprouting 22.2222 6 yes
GO:0048814 regulation of dendrite morphogenesis 22.2222 5 yes
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 22.2222 9 yes
GO:0050807 regulation of synapse organization 22.2222 5 yes
GO:0050919 negative chemotaxis 22.2222 4 yes
GO:0051248 negative regulation of protein metabolic process 22.2222 6 yes
GO:0051963 regulation of synapse assembly 22.2222 6 yes
GO:0051965 positive regulation of synapse assembly 22.2222 6 yes
GO:0061430 bone trabecula morphogenesis 22.2222 4 yes
GO:0070486 leukocyte aggregation 22.2222 5 yes
GO:1902679 negative regulation of RNA biosynthetic process 22.2222 7 yes
GO:1905702 regulation of inhibitory synapse assembly 22.2222 7 yes
GO:1905704 positive regulation of inhibitory synapse assembly 22.2222 7 yes
GO:0001764 neuron migration 22.2222 4 no
GO:0006996 organelle organization 22.2222 4 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 22.2222 4 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 22.2222 5 no
GO:0010810 regulation of cell-substrate adhesion 22.2222 5 no
GO:0010811 positive regulation of cell-substrate adhesion 22.2222 6 no
GO:0014910 regulation of smooth muscle cell migration 22.2222 6 no
GO:0014911 positive regulation of smooth muscle cell migration 22.2222 7 no
GO:0032956 regulation of actin cytoskeleton organization 22.2222 5 no
GO:0032970 regulation of actin filament-based process 22.2222 4 no
GO:0035020 regulation of Rac protein signal transduction 22.2222 7 no
GO:0035022 positive regulation of Rac protein signal transduction 22.2222 8 no
GO:0035728 response to hepatocyte growth factor 22.2222 4 no
GO:0043393 regulation of protein binding 22.2222 4 no
GO:0043408 regulation of MAPK cascade 22.2222 6 no
GO:0043410 positive regulation of MAPK cascade 22.2222 7 no
GO:0045785 positive regulation of cell adhesion 22.2222 5 no
GO:0060326 cell chemotaxis 22.2222 4 no
GO:0071363 cellular response to growth factor stimulus 22.2222 4 no
GO:1900024 regulation of substrate adhesion-dependent cell spreading 22.2222 6 no
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 22.2222 7 no
GO:0008285 negative regulation of cell population proliferation 22.2222 5 no
GO:0048812 neuron projection morphogenesis 22.2222 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.2222 4 no
GO:0000165 MAPK cascade 22.2222 5 no
GO:0001936 regulation of endothelial cell proliferation 22.2222 6 no
GO:0001938 positive regulation of endothelial cell proliferation 22.2222 7 no
GO:0007264 small GTPase-mediated signal transduction 22.2222 5 no
GO:0007265 Ras protein signal transduction 22.2222 6 no
GO:0050678 regulation of epithelial cell proliferation 22.2222 5 no
GO:0050679 positive regulation of epithelial cell proliferation 22.2222 6 no
GO:0141124 intracellular signaling cassette 22.2222 4 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010628 positive regulation of gene expression 22.2222 7 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0033365 protein localization to organelle 22.2222 5 no
GO:0002009 morphogenesis of an epithelium 22.2222 4 no
GO:0043523 regulation of neuron apoptotic process 22.2222 6 no
GO:0043524 negative regulation of neuron apoptotic process 22.2222 7 no
GO:0048754 branching morphogenesis of an epithelial tube 22.2222 4 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:0000122 negative regulation of transcription by RNA polymerase II 22.2222 9 yes
GO:0001933 negative regulation of protein phosphorylation 22.2222 8 yes
GO:0007159 leukocyte cell-cell adhesion 22.2222 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 22.2222 6 yes
GO:0031400 negative regulation of protein modification process 22.2222 7 yes
GO:0042326 negative regulation of phosphorylation 22.2222 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PLXB1_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRC_HUMAN [view interactions] Low throughput no no
SEM4D_HUMAN [view entry] [view interactions] Low throughput yes yes
CD72_HUMAN [view interactions] Low throughput no no
SG1D1_HUMAN [view interactions] High throughput no no
SIA8D_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
CRK_HUMAN [view entry] [view interactions] High throughput yes no
DSCAM_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SG2A2_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
FBXW8_HUMAN [view interactions] High throughput no yes
CUL9_HUMAN [view interactions] High throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
NKG2A_HUMAN [view interactions] High throughput no no
CST9L_HUMAN [view interactions] High throughput no no
LCN6_HUMAN [view interactions] High throughput no no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
CL12B_HUMAN [view interactions] High throughput no no
DJC25_HUMAN [view interactions] High throughput no yes
CA054_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
SDF2L_HUMAN [view interactions] High throughput no yes
BTNL2_HUMAN [view interactions] High throughput no no
T106A_HUMAN [view interactions] High throughput no no
SEM4G_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
PLXB2_HUMAN [view interactions] High throughput no yes
PLXB3_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes