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ANO6_HUMAN

GO
G2C
SynaptomeDB

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide . Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ANO6_HUMAN
GO:0000166 nucleotide binding 45.4545 4 no
GO:0017076 purine nucleotide binding 45.4545 5 no
GO:0032555 purine ribonucleotide binding 45.4545 4 no
GO:0043168 anion binding 45.4545 4 no
GO:0016462 pyrophosphatase activity 43.1818 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 43.1818 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 43.1818 6 no
GO:0035639 purine ribonucleoside triphosphate binding 43.1818 4 no
GO:0019001 guanyl nucleotide binding 40.9091 6 no
GO:0032561 guanyl ribonucleotide binding 40.9091 5 no
GO:0003924 GTPase activity 38.6364 7 no
GO:0005525 GTP binding 38.6364 5 no
GO:0019003 GDP binding 20.4545 5 no
GO:0008324 monoatomic cation transmembrane transporter activity 15.9091 4 yes
GO:0015267 channel activity 15.9091 4 yes
GO:0043169 cation binding 15.9091 4 yes
GO:0005216 monoatomic ion channel activity 13.6364 4 yes
GO:0015276 ligand-gated monoatomic ion channel activity 13.6364 5 yes
GO:0022834 ligand-gated channel activity 13.6364 6 yes
GO:0022836 gated channel activity 13.6364 5 yes
GO:0046872 metal ion binding 13.6364 5 yes
GO:0005261 monoatomic cation channel activity 11.3636 5 yes
GO:0099094 ligand-gated monoatomic cation channel activity 11.3636 6 yes
GO:0005229 intracellularly calcium-gated chloride channel activity 6.8182 7 yes
GO:0005253 monoatomic anion channel activity 6.8182 5 yes
GO:0005254 chloride channel activity 6.8182 6 yes
GO:0008509 monoatomic anion transmembrane transporter activity 6.8182 4 yes
GO:0015103 inorganic anion transmembrane transporter activity 6.8182 4 yes
GO:0015108 chloride transmembrane transporter activity 6.8182 5 yes
GO:0099095 ligand-gated monoatomic anion channel activity 6.8182 6 yes
GO:0141147 intracellularly calcium-gated channel activity 6.8182 7 yes
GO:0005227 calcium-activated cation channel activity 4.5455 7 yes
GO:0005244 voltage-gated monoatomic ion channel activity 4.5455 5 yes
GO:0005247 voltage-gated chloride channel activity 4.5455 7 yes
GO:0008308 voltage-gated monoatomic anion channel activity 4.5455 6 yes
GO:0017128 phospholipid scramblase activity 4.5455 4 yes
GO:0022832 voltage-gated channel activity 4.5455 6 yes
GO:0022839 monoatomic ion-gated channel activity 4.5455 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ANO6_HUMAN
GO:0048522 positive regulation of cellular process 54.5455 4 yes
GO:0008104 protein localization 52.2727 4 no
GO:0071702 organic substance transport 47.7273 4 yes
GO:0051128 regulation of cellular component organization 43.1818 4 yes
GO:0006996 organelle organization 43.1818 4 no
GO:0071705 nitrogen compound transport 43.1818 4 no
GO:0015031 protein transport 40.9091 4 no
GO:0022607 cellular component assembly 38.6364 4 yes
GO:0051049 regulation of transport 38.6364 4 yes
GO:0048523 negative regulation of cellular process 34.0909 4 no
GO:0010646 regulation of cell communication 31.8182 4 no
GO:0060255 regulation of macromolecule metabolic process 31.8182 4 no
GO:0006886 intracellular protein transport 29.5455 4 no
GO:0061024 membrane organization 27.2727 4 yes
GO:0009893 positive regulation of metabolic process 27.2727 4 no
GO:0010604 positive regulation of macromolecule metabolic process 27.2727 5 no
GO:0044087 regulation of cellular component biogenesis 27.2727 4 no
GO:0080090 regulation of primary metabolic process 27.2727 4 no
GO:0030030 cell projection organization 25.0000 4 yes
GO:0030334 regulation of cell migration 25.0000 5 yes
GO:0048584 positive regulation of response to stimulus 25.0000 4 yes
GO:2000145 regulation of cell motility 25.0000 4 yes
GO:0141124 intracellular signaling cassette 25.0000 4 no
GO:0031323 regulation of cellular metabolic process 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0030335 positive regulation of cell migration 22.7273 6 yes
GO:0040017 positive regulation of locomotion 22.7273 4 yes
GO:0060627 regulation of vesicle-mediated transport 22.7273 4 yes
GO:2000147 positive regulation of cell motility 22.7273 5 yes
GO:0007264 small GTPase-mediated signal transduction 22.7273 5 no
GO:0009889 regulation of biosynthetic process 22.7273 4 no
GO:0009966 regulation of signal transduction 22.7273 4 no
GO:0010468 regulation of gene expression 22.7273 6 no
GO:0010556 regulation of macromolecule biosynthetic process 22.7273 5 no
GO:0031326 regulation of cellular biosynthetic process 22.7273 5 no
GO:0060341 regulation of cellular localization 22.7273 4 no
GO:0051050 positive regulation of transport 20.4545 4 yes
GO:0051240 positive regulation of multicellular organismal process 20.4545 4 yes
GO:0120036 plasma membrane bounded cell projection organization 20.4545 5 yes
GO:0007010 cytoskeleton organization 20.4545 5 no
GO:0031325 positive regulation of cellular metabolic process 20.4545 5 no
GO:0031344 regulation of cell projection organization 20.4545 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 20.4545 6 no
GO:0032880 regulation of protein localization 20.4545 5 no
GO:0002684 positive regulation of immune system process 18.1818 4 yes
GO:0030031 cell projection assembly 18.1818 5 yes
GO:0042981 regulation of apoptotic process 18.1818 5 yes
GO:0043067 regulation of programmed cell death 18.1818 4 yes
GO:0051130 positive regulation of cellular component organization 18.1818 5 yes
GO:0006811 monoatomic ion transport 15.9091 4 yes
GO:0043933 protein-containing complex organization 15.9091 4 yes
GO:0120031 plasma membrane bounded cell projection assembly 15.9091 6 yes
GO:0030100 regulation of endocytosis 13.6364 5 yes
GO:0032101 regulation of response to external stimulus 13.6364 4 yes
GO:0032103 positive regulation of response to external stimulus 13.6364 5 yes
GO:0032535 regulation of cellular component size 13.6364 4 yes
GO:0051094 positive regulation of developmental process 13.6364 4 yes
GO:0065003 protein-containing complex assembly 13.6364 5 yes
GO:2000026 regulation of multicellular organismal development 13.6364 4 yes
GO:0002685 regulation of leukocyte migration 11.3636 4 yes
GO:0002687 positive regulation of leukocyte migration 11.3636 5 yes
GO:0006812 monoatomic cation transport 11.3636 5 yes
GO:0030001 metal ion transport 11.3636 6 yes
GO:0050920 regulation of chemotaxis 11.3636 4 yes
GO:0050921 positive regulation of chemotaxis 11.3636 5 yes
GO:0002688 regulation of leukocyte chemotaxis 9.0909 5 yes
GO:0002690 positive regulation of leukocyte chemotaxis 9.0909 6 yes
GO:0006816 calcium ion transport 9.0909 7 yes
GO:0008361 regulation of cell size 9.0909 5 yes
GO:0043065 positive regulation of apoptotic process 9.0909 6 yes
GO:0043068 positive regulation of programmed cell death 9.0909 5 yes
GO:0006820 monoatomic anion transport 6.8182 5 yes
GO:0006821 chloride transport 6.8182 5 yes
GO:0007009 plasma membrane organization 6.8182 5 yes
GO:0010959 regulation of metal ion transport 6.8182 6 yes
GO:0015698 inorganic anion transport 6.8182 4 yes
GO:0030278 regulation of ossification 6.8182 4 yes
GO:0030500 regulation of bone mineralization 6.8182 5 yes
GO:0034762 regulation of transmembrane transport 6.8182 4 yes
GO:0034764 positive regulation of transmembrane transport 6.8182 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 6.8182 5 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 6.8182 6 yes
GO:0043269 regulation of monoatomic ion transport 6.8182 5 yes
GO:0043270 positive regulation of monoatomic ion transport 6.8182 5 yes
GO:0045807 positive regulation of endocytosis 6.8182 5 yes
GO:0070167 regulation of biomineral tissue development 6.8182 5 yes
GO:0070588 calcium ion transmembrane transport 6.8182 5 yes
GO:0071675 regulation of mononuclear cell migration 6.8182 5 yes
GO:0071677 positive regulation of mononuclear cell migration 6.8182 6 yes
GO:0080134 regulation of response to stress 6.8182 4 yes
GO:0098655 monoatomic cation transmembrane transport 6.8182 4 yes
GO:0098662 inorganic cation transmembrane transport 6.8182 4 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 6.8182 6 yes
GO:1904064 positive regulation of cation transmembrane transport 6.8182 7 yes
GO:0002543 activation of blood coagulation via clotting cascade 4.5455 6 yes
GO:0006814 sodium ion transport 4.5455 7 yes
GO:0006869 lipid transport 4.5455 5 yes
GO:0007599 hemostasis 4.5455 4 yes
GO:0015748 organophosphate ester transport 4.5455 5 yes
GO:0015914 phospholipid transport 4.5455 6 yes
GO:0017121 plasma membrane phospholipid scrambling 4.5455 6 yes
GO:0030193 regulation of blood coagulation 4.5455 4 yes
GO:0030194 positive regulation of blood coagulation 4.5455 5 yes
GO:0030501 positive regulation of bone mineralization 4.5455 6 yes
GO:0032060 bleb assembly 4.5455 7 yes
GO:0034204 lipid translocation 4.5455 4 yes
GO:0035590 purinergic nucleotide receptor signaling pathway 4.5455 4 yes
GO:0035725 sodium ion transmembrane transport 4.5455 5 yes
GO:0043266 regulation of potassium ion transport 4.5455 7 yes
GO:0043268 positive regulation of potassium ion transport 4.5455 6 yes
GO:0045332 phospholipid translocation 4.5455 5 yes
GO:0045778 positive regulation of ossification 4.5455 5 yes
GO:0045794 negative regulation of cell volume 4.5455 4 yes
GO:0046931 pore complex assembly 4.5455 6 yes
GO:0050764 regulation of phagocytosis 4.5455 6 yes
GO:0050766 positive regulation of phagocytosis 4.5455 6 yes
GO:0050818 regulation of coagulation 4.5455 4 yes
GO:0050820 positive regulation of coagulation 4.5455 5 yes
GO:0060099 regulation of phagocytosis, engulfment 4.5455 6 yes
GO:0060100 positive regulation of phagocytosis, engulfment 4.5455 7 yes
GO:0061041 regulation of wound healing 4.5455 6 yes
GO:0061588 calcium activated phospholipid scrambling 4.5455 7 yes
GO:0061589 calcium activated phosphatidylserine scrambling 4.5455 8 yes
GO:0061590 calcium activated phosphatidylcholine scrambling 4.5455 8 yes
GO:0070169 positive regulation of biomineral tissue development 4.5455 5 yes
GO:0090025 regulation of monocyte chemotaxis 4.5455 6 yes
GO:0090026 positive regulation of monocyte chemotaxis 4.5455 7 yes
GO:0090303 positive regulation of wound healing 4.5455 6 yes
GO:0097045 phosphatidylserine exposure on blood platelet 4.5455 6 yes
GO:0098656 monoatomic anion transmembrane transport 4.5455 4 yes
GO:0098661 inorganic anion transmembrane transport 4.5455 4 yes
GO:1900048 positive regulation of hemostasis 4.5455 4 yes
GO:1901379 regulation of potassium ion transmembrane transport 4.5455 7 yes
GO:1901381 positive regulation of potassium ion transmembrane transport 4.5455 7 yes
GO:1902476 chloride transmembrane transport 4.5455 5 yes
GO:1903034 regulation of response to wounding 4.5455 5 yes
GO:1903036 positive regulation of response to wounding 4.5455 5 yes
GO:1903764 regulation of potassium ion export across plasma membrane 4.5455 8 yes
GO:1903766 positive regulation of potassium ion export across plasma membrane 4.5455 8 yes
GO:1904035 regulation of epithelial cell apoptotic process 4.5455 6 yes
GO:1904037 positive regulation of epithelial cell apoptotic process 4.5455 7 yes
GO:1905153 regulation of membrane invagination 4.5455 5 yes
GO:1905155 positive regulation of membrane invagination 4.5455 6 yes
GO:2000351 regulation of endothelial cell apoptotic process 4.5455 7 yes
GO:2000353 positive regulation of endothelial cell apoptotic process 4.5455 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ANO6_HUMAN [view entry] [view interactions] Low throughput yes no
GPR21_HUMAN [view interactions] High throughput no no
LEG8_HUMAN [view entry] [view interactions] High throughput yes yes
AGRG5_HUMAN [view interactions] High throughput no no
DLK1_HUMAN [view interactions] High throughput no no
ZNRF4_HUMAN [view interactions] High throughput no no
LEG9C_HUMAN [view interactions] High throughput no no
EREP1_HUMAN [view interactions] High throughput no yes
MIA2_HUMAN [view interactions] High throughput no yes
CDC27_HUMAN [view interactions] High throughput no yes
LEMD2_HUMAN [view interactions] High throughput no yes
CDC26_HUMAN [view interactions] High throughput no yes
APC1_HUMAN [view interactions] High throughput no no
PREB_HUMAN [view interactions] High throughput no yes
CDC23_HUMAN [view interactions] High throughput no yes
APC5_HUMAN [view interactions] High throughput no yes
APC4_HUMAN [view interactions] High throughput no yes
LRC8B_HUMAN [view interactions] High throughput no yes
OSTA_HUMAN [view interactions] High throughput no no
TECT3_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TECT2_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
POPD2_HUMAN [view interactions] High throughput no no
CDC16_HUMAN [view interactions] High throughput no yes
LMA2L_HUMAN [view interactions] High throughput no yes
UPK1A_HUMAN [view interactions] High throughput no no
TGO1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
TMC4_HUMAN [view interactions] High throughput no no
ACHB4_HUMAN [view entry] [view interactions] High throughput yes no
TTMP_HUMAN [view interactions] High throughput no no
ANO4_HUMAN [view interactions] High throughput no no
KCMB3_HUMAN [view interactions] High throughput no no
LEG9B_HUMAN [view interactions] High throughput no no
KTAP2_HUMAN [view interactions] High throughput no no
O10H2_HUMAN [view interactions] High throughput no no
SIDT2_HUMAN [view interactions] High throughput no yes
CLGN_HUMAN [view interactions] High throughput no no
FBX2_HUMAN [view entry] [view interactions] High throughput yes yes
ACHB2_HUMAN [view entry] [view interactions] High throughput yes no
NKAI1_HUMAN [view interactions] High throughput no no
TS1R2_HUMAN [view interactions] High throughput no no
ACH10_HUMAN [view entry] [view interactions] High throughput yes no
MARH4_HUMAN [view interactions] High throughput no yes
TR10C_HUMAN [view interactions] High throughput no no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
RN133_HUMAN [view interactions] High throughput no no
SMIM5_HUMAN [view interactions] High throughput no yes
O10H1_HUMAN [view interactions] High throughput no no
ANK1_HUMAN [view entry] [view interactions] High throughput yes no
B2CL1_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
SNG1_HUMAN [view entry] [view interactions] High throughput yes yes
S1PR4_HUMAN [view interactions] High throughput no no
PIGH_HUMAN [view interactions] High throughput no yes
PDE2A_HUMAN [view entry] [view interactions] High throughput yes yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
ZRAN1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
CAH9_HUMAN [view interactions] High throughput no no
OTULL_HUMAN [view interactions] High throughput no no
ST7_HUMAN [view interactions] High throughput no yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
SC61B_HUMAN [view interactions] High throughput no yes
DNJC1_HUMAN [view interactions] High throughput no yes
DJC25_HUMAN [view interactions] High throughput no yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
BAP31_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
DERL1_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
ERGI1_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
DHB11_HUMAN [view interactions] High throughput no yes
3BHS7_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
TMT1A_HUMAN [view interactions] High throughput no no
PXMP2_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SEC62_HUMAN [view interactions] High throughput no yes
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
TMPS2_HUMAN [view interactions] High throughput no no
AMPN_HUMAN [view interactions] High throughput no no
TM11B_HUMAN [view interactions] High throughput no no
CLC4D_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
STING_HUMAN [view interactions] High throughput no yes
ARF4_HUMAN [view entry] [view interactions] High throughput yes no
SAR1A_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1B_HUMAN [view interactions] High throughput no yes
ARL1_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes