ACH10_HUMAN
Evidence for PS localization
Functions
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACH10_HUMAN |
|---|---|---|---|---|
| GO:0005216 | monoatomic ion channel activity | 100.0000 | 4 | yes |
| GO:0005261 | monoatomic cation channel activity | 100.0000 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 100.0000 | 4 | yes |
| GO:0015267 | channel activity | 100.0000 | 4 | yes |
| GO:0015276 | ligand-gated monoatomic ion channel activity | 100.0000 | 5 | yes |
| GO:0022834 | ligand-gated channel activity | 100.0000 | 6 | yes |
| GO:0022836 | gated channel activity | 100.0000 | 5 | yes |
| GO:0099094 | ligand-gated monoatomic cation channel activity | 100.0000 | 6 | yes |
Biological process
No data found.
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SIDT2_HUMAN | [view interactions] | High throughput | no | yes |
| D19L4_HUMAN | [view interactions] | High throughput | no | no |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| DJC18_HUMAN | [view interactions] | High throughput | no | yes |
| ANO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| PIGU_HUMAN | [view interactions] | High throughput | no | no |
| I2BP2_HUMAN | [view interactions] | High throughput | no | yes |