SNG1_HUMAN
Evidence for PS localization
Functions
May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation . Involved in the regulation of short-term and long-term synaptic plasticity . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SNG1_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 34.7826 | 4 | no |
| GO:0046872 | metal ion binding | 34.7826 | 5 | no |
| GO:0043168 | anion binding | 34.7826 | 4 | no |
| GO:0000166 | nucleotide binding | 30.4348 | 4 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 26.0870 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.0870 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 26.0870 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 26.0870 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 26.0870 | 5 | no |
| GO:0005524 | ATP binding | 21.7391 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 21.7391 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.7391 | 4 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 21.7391 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SNG1_HUMAN |
|---|---|---|---|---|
| GO:0051049 | regulation of transport | 52.1739 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 47.8261 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.8261 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.4783 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.4783 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.4783 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.4783 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 39.1304 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 39.1304 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.1304 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.1304 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 39.1304 | 5 | no |
| GO:0030030 | cell projection organization | 34.7826 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 34.7826 | 4 | no |
| GO:0080134 | regulation of response to stress | 34.7826 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 34.7826 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 34.7826 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 34.7826 | 5 | no |
| GO:0009966 | regulation of signal transduction | 34.7826 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.7826 | 4 | no |
| GO:0036211 | protein modification process | 30.4348 | 4 | no |
| GO:0043412 | macromolecule modification | 30.4348 | 4 | no |
| GO:0051050 | positive regulation of transport | 30.4348 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.4348 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 30.4348 | 4 | no |
| GO:0006873 | intracellular monoatomic ion homeostasis | 30.4348 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 30.4348 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 30.4348 | 6 | no |
| GO:0030003 | intracellular monoatomic cation homeostasis | 30.4348 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 30.4348 | 6 | no |
| GO:0055080 | monoatomic cation homeostasis | 30.4348 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.4348 | 5 | no |
| GO:0008104 | protein localization | 30.4348 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 30.4348 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 30.4348 | 4 | yes |
| GO:0006811 | monoatomic ion transport | 26.0870 | 4 | no |
| GO:0006874 | intracellular calcium ion homeostasis | 26.0870 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 26.0870 | 7 | no |
| GO:0055074 | calcium ion homeostasis | 26.0870 | 4 | no |
| GO:0006996 | organelle organization | 26.0870 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.0870 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.0870 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.0870 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.0870 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 26.0870 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.0870 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.0870 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 26.0870 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.0870 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.7391 | 4 | no |
| GO:0071702 | organic substance transport | 21.7391 | 4 | no |
| GO:0098657 | import into cell | 21.7391 | 4 | no |
| GO:0006812 | monoatomic cation transport | 21.7391 | 5 | no |
| GO:0022607 | cellular component assembly | 21.7391 | 4 | no |
| GO:0030001 | metal ion transport | 21.7391 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 21.7391 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 21.7391 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 21.7391 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 21.7391 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 21.7391 | 4 | no |
| GO:0044057 | regulation of system process | 21.7391 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.7391 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.7391 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 21.7391 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.7391 | 8 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.7391 | 6 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.7391 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.7391 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.7391 | 7 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.7391 | 4 | no |
| GO:0061024 | membrane organization | 21.7391 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 21.7391 | 4 | yes |
| GO:0032880 | regulation of protein localization | 21.7391 | 5 | no |
| GO:0006605 | protein targeting | 8.6957 | 4 | yes |
| GO:0034097 | response to cytokine | 8.6957 | 4 | yes |
| GO:0048168 | regulation of neuronal synaptic plasticity | 8.6957 | 4 | yes |
| GO:0048169 | regulation of long-term neuronal synaptic plasticity | 8.6957 | 5 | yes |
| GO:0048499 | synaptic vesicle membrane organization | 8.6957 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| SPNS3_HUMAN | [view interactions] | High throughput | no | no |
| OBRG_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| CKLF6_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| ECSIT_HUMAN | [view interactions] | High throughput | no | yes |
| RUSF1_HUMAN | [view interactions] | High throughput | no | yes |
| EFC4B_HUMAN | [view interactions] | High throughput | no | no |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| POTEI_HUMAN | [view interactions] | High throughput | no | no |
| PIGU_HUMAN | [view interactions] | High throughput | no | no |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CERS6_HUMAN | [view interactions] | High throughput | no | yes |
| CIA30_HUMAN | [view interactions] | High throughput | no | yes |
| APOB_HUMAN | [view interactions] | High throughput | no | no |
| AOFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPAA1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EMC7_HUMAN | [view interactions] | High throughput | no | yes |
| CLP1L_HUMAN | [view interactions] | High throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S43A3_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| ALG3_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2S_HUMAN | [view interactions] | High throughput | no | no |
| CTR1_HUMAN | [view interactions] | High throughput | no | no |
| ORC4_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM87A_HUMAN | [view interactions] | High throughput | no | yes |
| MSMO1_HUMAN | [view interactions] | High throughput | no | yes |
| BI1_HUMAN | [view interactions] | High throughput | no | yes |
| TMCO1_HUMAN | [view interactions] | High throughput | no | yes |
| GPC5C_HUMAN | [view interactions] | High throughput | no | no |
| SNG2_HUMAN | [view interactions] | High throughput | no | no |
| MTMR4_HUMAN | [view interactions] | High throughput | no | no |
| PIGO_HUMAN | [view interactions] | High throughput | no | no |
| RABL3_HUMAN | [view interactions] | High throughput | no | yes |
| SURF4_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT131_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYJ2B_HUMAN | [view interactions] | High throughput | no | no |
| RER1_HUMAN | [view interactions] | High throughput | no | yes |
| ANO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RGP1_HUMAN | [view interactions] | High throughput | no | yes |
| MAN1_HUMAN | [view interactions] | High throughput | no | yes |
| RIC1_HUMAN | [view interactions] | High throughput | no | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| GHITM_HUMAN | [view interactions] | High throughput | no | yes |
| JIP4_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH13_HUMAN | [view interactions] | High throughput | no | no |
| S38AA_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM3_HUMAN | [view interactions] | High throughput | no | no |
| MPU1_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
| PCX3_HUMAN | [view interactions] | High throughput | no | no |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| S20A1_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| FATE1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNKP_HUMAN | [view interactions] | High throughput | no | yes |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| SPG21_HUMAN | [view interactions] | High throughput | no | yes |
| NDRG4_HUMAN | [view interactions] | High throughput | no | no |
| HYAS3_HUMAN | [view interactions] | High throughput | no | no |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| UN93A_HUMAN | [view interactions] | High throughput | no | no |
| PKHB2_HUMAN | [view interactions] | High throughput | no | yes |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| ERGI3_HUMAN | [view interactions] | High throughput | no | yes |
| AA2AR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| MOT8_HUMAN | [view interactions] | High throughput | no | no |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| TM45B_HUMAN | [view interactions] | High throughput | no | yes |
| MTEF3_HUMAN | [view interactions] | High throughput | no | no |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM80_HUMAN | [view interactions] | High throughput | no | yes |
| TMM31_HUMAN | [view interactions] | High throughput | no | no |