AT131_HUMAN
Evidence for PS localization
Functions
Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AT131_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 35.4839 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 35.4839 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 32.2581 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.2581 | 4 | yes |
| GO:0043168 | anion binding | 32.2581 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 29.0323 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 29.0323 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 29.0323 | 6 | yes |
| GO:0043169 | cation binding | 19.3548 | 4 | yes |
| GO:0046872 | metal ion binding | 19.3548 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 16.1290 | 6 | yes |
| GO:0005524 | ATP binding | 12.9032 | 5 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 12.9032 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 12.9032 | 5 | yes |
| GO:0016887 | ATP hydrolysis activity | 9.6774 | 7 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 6.4516 | 4 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 6.4516 | 4 | yes |
| GO:0015662 | P-type ion transporter activity | 6.4516 | 4 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 6.4516 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 6.4516 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AT131_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 45.1613 | 4 | yes |
| GO:0006996 | organelle organization | 45.1613 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 45.1613 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.7097 | 4 | no |
| GO:0022607 | cellular component assembly | 32.2581 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 32.2581 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 32.2581 | 4 | no |
| GO:0071702 | organic substance transport | 29.0323 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 29.0323 | 4 | no |
| GO:0015031 | protein transport | 25.8065 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 25.8065 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 25.8065 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.8065 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.5806 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 22.5806 | 4 | no |
| GO:0009966 | regulation of signal transduction | 22.5806 | 4 | no |
| GO:0010468 | regulation of gene expression | 22.5806 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.5806 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.5806 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.5806 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.5806 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 22.5806 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.5806 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.5806 | 5 | no |
| GO:0033043 | regulation of organelle organization | 22.5806 | 5 | no |
| GO:0051049 | regulation of transport | 22.5806 | 4 | no |
| GO:0061024 | membrane organization | 22.5806 | 4 | no |
| GO:0034330 | cell junction organization | 22.5806 | 4 | no |
| GO:0006873 | intracellular monoatomic ion homeostasis | 12.9032 | 4 | yes |
| GO:0030003 | intracellular monoatomic cation homeostasis | 12.9032 | 5 | yes |
| GO:0055080 | monoatomic cation homeostasis | 12.9032 | 4 | yes |
| GO:0072657 | protein localization to membrane | 12.9032 | 4 | yes |
| GO:0006811 | monoatomic ion transport | 9.6774 | 4 | yes |
| GO:0006874 | intracellular calcium ion homeostasis | 9.6774 | 5 | yes |
| GO:0055074 | calcium ion homeostasis | 9.6774 | 4 | yes |
| GO:0090150 | establishment of protein localization to membrane | 6.4516 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARHG5_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| BUD31_HUMAN | [view interactions] | High throughput | no | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| RUNX1_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| KMT2E_HUMAN | [view interactions] | High throughput | no | no |
| APBP2_HUMAN | [view interactions] | High throughput | no | yes |
| S35C2_HUMAN | [view interactions] | High throughput | no | yes |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| CBARP_HUMAN | [view interactions] | High throughput | no | no |
| MANBL_HUMAN | [view interactions] | High throughput | no | yes |
| PAQRB_HUMAN | [view interactions] | High throughput | no | no |
| UN93A_HUMAN | [view interactions] | High throughput | no | no |
| ELOV4_HUMAN | [view interactions] | High throughput | no | no |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| FFAR2_HUMAN | [view interactions] | High throughput | no | yes |
| TM14B_HUMAN | [view interactions] | High throughput | no | no |
| BI1_HUMAN | [view interactions] | High throughput | no | yes |
| SYPL2_HUMAN | [view interactions] | High throughput | no | no |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| MF14B_HUMAN | [view interactions] | High throughput | no | no |
| TLCD4_HUMAN | [view interactions] | High throughput | no | no |
| TM237_HUMAN | [view interactions] | High throughput | no | no |
| ZNT2_HUMAN | [view interactions] | High throughput | no | no |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| ZNT8_HUMAN | [view interactions] | High throughput | no | no |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| MOT13_HUMAN | [view interactions] | High throughput | no | no |
| CXCR2_HUMAN | [view interactions] | High throughput | no | no |
| RNK_HUMAN | [view interactions] | High throughput | no | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| DLK1_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZY11B_HUMAN | [view interactions] | High throughput | no | yes |
| VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| SNIP1_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| MARH8_HUMAN | [view interactions] | High throughput | no | no |
| TRI13_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| CD226_HUMAN | [view interactions] | High throughput | no | yes |
| S7A14_HUMAN | [view interactions] | High throughput | no | no |
| TXD15_HUMAN | [view interactions] | High throughput | no | yes |
| CC107_HUMAN | [view interactions] | High throughput | no | no |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
| EVA1B_HUMAN | [view interactions] | High throughput | no | yes |
| RHEX_HUMAN | [view interactions] | High throughput | no | no |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| IL1R2_HUMAN | [view interactions] | High throughput | no | no |
| KI2L4_HUMAN | [view interactions] | High throughput | no | no |
| CADH5_HUMAN | [view interactions] | High throughput | no | yes |
| TSN10_HUMAN | [view interactions] | High throughput | no | no |
| PCDGL_HUMAN | [view interactions] | High throughput | no | no |
| TPRA1_HUMAN | [view interactions] | High throughput | no | yes |
| CD27_HUMAN | [view interactions] | High throughput | no | no |
| NIPA3_HUMAN | [view interactions] | High throughput | no | no |
| SCF_HUMAN | [view interactions] | High throughput | no | no |
| GBRG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM130_HUMAN | [view interactions] | High throughput | no | no |
| CXL16_HUMAN | [view interactions] | High throughput | no | no |
| CLM7_HUMAN | [view interactions] | High throughput | no | no |
| HECA2_HUMAN | [view interactions] | High throughput | no | no |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| CD244_HUMAN | [view interactions] | High throughput | no | no |
| SHSL1_HUMAN | [view interactions] | High throughput | no | yes |
| TYOBP_HUMAN | [view interactions] | High throughput | no | no |
| CCR6_HUMAN | [view interactions] | High throughput | no | no |
| PTAFR_HUMAN | [view interactions] | High throughput | no | yes |
| TNR9_HUMAN | [view interactions] | High throughput | no | no |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| HLAF_HUMAN | [view interactions] | High throughput | no | no |
| KCNE4_HUMAN | [view interactions] | High throughput | no | no |
| LRAD1_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| IOD3_HUMAN | [view interactions] | High throughput | no | no |
| ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
| SNG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| PIGH_HUMAN | [view interactions] | High throughput | no | yes |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| GPBAR_HUMAN | [view interactions] | High throughput | no | no |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| CD83_HUMAN | [view interactions] | High throughput | no | yes |
| TGFA_HUMAN | [view interactions] | High throughput | no | yes |
| AGRE5_HUMAN | [view interactions] | High throughput | no | no |
| LRC25_HUMAN | [view interactions] | High throughput | no | yes |
| TPST2_HUMAN | [view interactions] | High throughput | no | yes |
| VSTM1_HUMAN | [view interactions] | High throughput | no | no |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F241A_HUMAN | [view interactions] | High throughput | no | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| RN149_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| AT2C1_HUMAN | [view interactions] | High throughput | no | yes |
| SCN9A_HUMAN | [view interactions] | High throughput | no | yes |
| SE1L1_HUMAN | [view interactions] | High throughput | no | yes |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| SEC63_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| COIL_HUMAN | [view interactions] | High throughput | no | yes |
| CP2C9_HUMAN | [view interactions] | High throughput | no | no |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMT1A_HUMAN | [view interactions] | High throughput | no | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUP35_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| DHCR7_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |