LRRT1_HUMAN
Evidence for PS localization
Functions
Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LRRT1_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 38.4615 | 4 | no |
| GO:0097109 | neuroligin family protein binding | 30.7692 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LRRT1_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 53.8462 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 46.1538 | 4 | yes |
| GO:0072657 | protein localization to membrane | 46.1538 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.4615 | 4 | yes |
| GO:0035418 | protein localization to synapse | 38.4615 | 6 | yes |
| GO:0048522 | positive regulation of cellular process | 38.4615 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 38.4615 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 38.4615 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 38.4615 | 4 | yes |
| GO:1902414 | protein localization to cell junction | 38.4615 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 30.7692 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 30.7692 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 30.7692 | 4 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 30.7692 | 5 | yes |
| GO:0051049 | regulation of transport | 30.7692 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 30.7692 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 30.7692 | 5 | yes |
| GO:0051963 | regulation of synapse assembly | 30.7692 | 6 | yes |
| GO:1901888 | regulation of cell junction assembly | 30.7692 | 5 | yes |
| GO:0046903 | secretion | 30.7692 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 30.7692 | 6 | no |
| GO:0007612 | learning | 30.7692 | 4 | no |
| GO:0050890 | cognition | 30.7692 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 30.7692 | 5 | no |
| GO:0099537 | trans-synaptic signaling | 30.7692 | 4 | no |
| GO:0034330 | cell junction organization | 23.0769 | 4 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 23.0769 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 23.0769 | 4 | yes |
| GO:0050808 | synapse organization | 23.0769 | 5 | yes |
| GO:0051051 | negative regulation of transport | 23.0769 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 23.0769 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 23.0769 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 23.0769 | 5 | yes |
| GO:0051965 | positive regulation of synapse assembly | 23.0769 | 6 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 23.0769 | 4 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 23.0769 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 23.0769 | 4 | yes |
| GO:0015031 | protein transport | 23.0769 | 4 | no |
| GO:0071702 | organic substance transport | 23.0769 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.0769 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 23.0769 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.0769 | 4 | no |
| GO:0022607 | cellular component assembly | 23.0769 | 4 | no |
| GO:0030030 | cell projection organization | 23.0769 | 4 | no |
| GO:0031175 | neuron projection development | 23.0769 | 6 | no |
| GO:0031644 | regulation of nervous system process | 23.0769 | 5 | no |
| GO:0043113 | receptor clustering | 23.0769 | 5 | no |
| GO:0044057 | regulation of system process | 23.0769 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.0769 | 5 | no |
| GO:1990778 | protein localization to cell periphery | 23.0769 | 5 | no |
| GO:0007158 | neuron cell-cell adhesion | 23.0769 | 4 | no |
| GO:0002090 | regulation of receptor internalization | 15.3846 | 7 | yes |
| GO:0002091 | negative regulation of receptor internalization | 15.3846 | 7 | yes |
| GO:0030100 | regulation of endocytosis | 15.3846 | 5 | yes |
| GO:0045806 | negative regulation of endocytosis | 15.3846 | 5 | yes |
| GO:0048259 | regulation of receptor-mediated endocytosis | 15.3846 | 6 | yes |
| GO:0048261 | negative regulation of receptor-mediated endocytosis | 15.3846 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 15.3846 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRP11_HUMAN | [view interactions] | High throughput | no | no |
| NGBR_HUMAN | [view interactions] | High throughput | no | no |
| FRAS1_HUMAN | [view interactions] | High throughput | no | yes |
| NOCT_HUMAN | [view interactions] | High throughput | no | no |
| TYW1_HUMAN | [view interactions] | High throughput | no | yes |
| TM39A_HUMAN | [view interactions] | High throughput | no | yes |
| NSUN3_HUMAN | [view interactions] | High throughput | no | no |
| LRFN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNPY3_HUMAN | [view interactions] | High throughput | no | yes |
| TTC17_HUMAN | [view interactions] | High throughput | no | yes |
| TM131_HUMAN | [view interactions] | High throughput | no | yes |
| PDZD8_HUMAN | [view interactions] | High throughput | no | yes |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| AMGO1_HUMAN | [view interactions] | High throughput | no | yes |
| RETST_HUMAN | [view interactions] | High throughput | no | yes |
| RAB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| PDE3B_HUMAN | [view interactions] | High throughput | no | no |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SUN1_HUMAN | [view interactions] | High throughput | no | yes |
| NSMA_HUMAN | [view interactions] | High throughput | no | yes |
| TSN6_HUMAN | [view interactions] | High throughput | no | yes |
| SPTC2_HUMAN | [view interactions] | High throughput | no | no |
| UPK3L_HUMAN | [view interactions] | High throughput | no | yes |
| TM223_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AREL1_HUMAN | [view interactions] | High throughput | no | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| MARC1_HUMAN | [view interactions] | High throughput | no | yes |
| CA043_HUMAN | [view interactions] | High throughput | no | yes |
| PIGA_HUMAN | [view interactions] | High throughput | no | yes |
| NDC1_HUMAN | [view interactions] | High throughput | no | yes |
| K319L_HUMAN | [view interactions] | High throughput | no | yes |
| AT131_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCX3_HUMAN | [view interactions] | High throughput | no | no |
| CSTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDKAL_HUMAN | [view interactions] | High throughput | no | no |
| F263_HUMAN | [view interactions] | High throughput | no | yes |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| UBP33_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TPC10_HUMAN | [view interactions] | Computational | no | no |
| NRX2A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NRX3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |