RAB12_HUMAN
Evidence for PS localization
Functions
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAB12_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 50.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 50.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 50.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | yes |
| GO:0043168 | anion binding | 50.0000 | 4 | yes |
| GO:0003924 | GTPase activity | 40.0000 | 7 | yes |
| GO:0005525 | GTP binding | 40.0000 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 40.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 40.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 40.0000 | 6 | yes |
| GO:0019001 | guanyl nucleotide binding | 40.0000 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 40.0000 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 30.0000 | 4 | no |
| GO:0031267 | small GTPase binding | 30.0000 | 5 | no |
| GO:0051020 | GTPase binding | 30.0000 | 4 | no |
| GO:0019003 | GDP binding | 20.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAB12_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 70.0000 | 4 | yes |
| GO:0015031 | protein transport | 60.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 60.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 60.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0046903 | secretion | 40.0000 | 4 | yes |
| GO:0051049 | regulation of transport | 40.0000 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 40.0000 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 40.0000 | 5 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 30.0000 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 30.0000 | 5 | yes |
| GO:0051046 | regulation of secretion | 30.0000 | 5 | yes |
| GO:0072657 | protein localization to membrane | 30.0000 | 4 | yes |
| GO:0072659 | protein localization to plasma membrane | 30.0000 | 5 | yes |
| GO:0141124 | intracellular signaling cassette | 30.0000 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 30.0000 | 4 | yes |
| GO:1990778 | protein localization to cell periphery | 30.0000 | 5 | yes |
| GO:0030030 | cell projection organization | 30.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 30.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 30.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0098657 | import into cell | 30.0000 | 4 | no |
| GO:0032880 | regulation of protein localization | 30.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 30.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 30.0000 | 4 | no |
| GO:1902115 | regulation of organelle assembly | 30.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
| GO:0007034 | vacuolar transport | 20.0000 | 4 | yes |
| GO:0007041 | lysosomal transport | 20.0000 | 5 | yes |
| GO:0009057 | macromolecule catabolic process | 20.0000 | 4 | yes |
| GO:0009306 | protein secretion | 20.0000 | 4 | yes |
| GO:0016050 | vesicle organization | 20.0000 | 5 | yes |
| GO:0030163 | protein catabolic process | 20.0000 | 4 | yes |
| GO:0032482 | Rab protein signal transduction | 20.0000 | 6 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 20.0000 | 4 | yes |
| GO:0048278 | vesicle docking | 20.0000 | 4 | yes |
| GO:0061024 | membrane organization | 20.0000 | 4 | yes |
| GO:0071692 | protein localization to extracellular region | 20.0000 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 20.0000 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| S36A4_HUMAN | [view interactions] | Low throughput | no | yes |
| OPTN_HUMAN | [view interactions] | Low throughput | no | yes |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| CASP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMVK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAL1_HUMAN | [view interactions] | High throughput | no | no |
| NDK7_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| GDIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6C_HUMAN | [view interactions] | High throughput | no | no |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB39A_HUMAN | [view interactions] | High throughput | no | no |
| RIPL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAE1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIPL2_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| BICL1_HUMAN | [view interactions] | High throughput | no | yes |
| BICL2_HUMAN | [view interactions] | High throughput | no | no |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CI072_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| LSS_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |