Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAB12_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RAB12_HUMAN
GO:0003924 GTPase activity 57.1429 7 yes
GO:0005525 GTP binding 57.1429 5 yes
GO:0016462 pyrophosphatase activity 57.1429 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 57.1429 4 yes
GO:0017076 purine nucleotide binding 57.1429 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 57.1429 6 yes
GO:0019001 guanyl nucleotide binding 57.1429 5 yes
GO:0032555 purine ribonucleotide binding 57.1429 4 yes
GO:0032561 guanyl ribonucleotide binding 57.1429 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 57.1429 4 yes
GO:0019003 GDP binding 28.5714 4 yes
GO:0045296 cadherin binding 28.5714 4 no
GO:0017022 myosin binding 28.5714 4 no
GO:0031489 myosin V binding 28.5714 5 no
GO:0005092 GDP-dissociation inhibitor activity 28.5714 5 no
GO:0005093 Rab GDP-dissociation inhibitor activity 28.5714 6 no
GO:0005096 GTPase activator activity 28.5714 4 no
GO:0030695 GTPase regulator activity 28.5714 4 no
GO:0031267 small GTPase binding 28.5714 5 no
GO:0051020 GTPase binding 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in RAB12_HUMAN
GO:0008104 protein localization 100.0000 4 yes
GO:0015031 protein transport 85.7143 4 yes
GO:0016192 vesicle-mediated transport 85.7143 4 yes
GO:0071702 organic substance transport 85.7143 4 yes
GO:0071705 nitrogen compound transport 85.7143 4 yes
GO:0051049 regulation of transport 71.4286 4 yes
GO:0046903 secretion 57.1429 4 yes
GO:0060627 regulation of vesicle-mediated transport 57.1429 4 yes
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0051128 regulation of cellular component organization 57.1429 4 no
GO:0007264 small GTPase mediated signal transduction 42.8571 4 yes
GO:0009306 protein secretion 42.8571 4 yes
GO:0017157 regulation of exocytosis 42.8571 5 yes
GO:0035592 establishment of protein localization to extracellular region 42.8571 4 yes
GO:0048278 vesicle docking 42.8571 4 yes
GO:0051046 regulation of secretion 42.8571 5 yes
GO:0071692 protein localization to extracellular region 42.8571 5 yes
GO:0072657 protein localization to membrane 42.8571 4 yes
GO:0072659 protein localization to plasma membrane 42.8571 5 yes
GO:1903530 regulation of secretion by cell 42.8571 4 yes
GO:1990778 protein localization to cell periphery 42.8571 5 yes
GO:0006996 organelle organization 42.8571 4 no
GO:0051240 positive regulation of multicellular organismal process 42.8571 4 no
GO:0044087 regulation of cellular component biogenesis 42.8571 4 no
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0051129 negative regulation of cellular component organization 42.8571 5 no
GO:0007265 Ras protein signal transduction 28.5714 5 yes
GO:0010243 response to organonitrogen compound 28.5714 4 yes
GO:0032482 Rab protein signal transduction 28.5714 6 yes
GO:0032868 response to insulin 28.5714 5 yes
GO:0032869 cellular response to insulin stimulus 28.5714 6 yes
GO:0032870 cellular response to hormone stimulus 28.5714 4 yes
GO:0043434 response to peptide hormone 28.5714 4 yes
GO:0071310 cellular response to organic substance 28.5714 4 yes
GO:0071375 cellular response to peptide hormone stimulus 28.5714 5 yes
GO:0071417 cellular response to organonitrogen compound 28.5714 4 yes
GO:1901652 response to peptide 28.5714 4 yes
GO:1901653 cellular response to peptide 28.5714 5 yes
GO:1901699 cellular response to nitrogen compound 28.5714 4 yes
GO:1901701 cellular response to oxygen-containing compound 28.5714 4 yes
GO:0023061 signal release 28.5714 4 no
GO:0048193 Golgi vesicle transport 28.5714 5 no
GO:0051650 establishment of vesicle localization 28.5714 4 no
GO:0010646 regulation of cell communication 28.5714 4 no
GO:0034330 cell junction organization 28.5714 4 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0050808 synapse organization 28.5714 5 no
GO:0051051 negative regulation of transport 28.5714 4 no
GO:0051094 positive regulation of developmental process 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0051960 regulation of nervous system development 28.5714 5 no
GO:0051962 positive regulation of nervous system development 28.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no
GO:0006887 exocytosis 28.5714 4 no
GO:0007409 axonogenesis 28.5714 8 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0032990 cell part morphogenesis 28.5714 4 no
GO:0033043 regulation of organelle organization 28.5714 5 no
GO:0045055 regulated exocytosis 28.5714 5 no
GO:0048812 neuron projection morphogenesis 28.5714 7 no
GO:0048858 cell projection morphogenesis 28.5714 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 28.5714 6 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0031345 negative regulation of cell projection organization 28.5714 6 no
GO:0032880 regulation of protein localization 28.5714 5 no
GO:0060341 regulation of cellular localization 28.5714 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:1903828 negative regulation of protein localization 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
S36A4_HUMAN [view interactions] Low throughput no yes
OPTN_HUMAN [view interactions] Low throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
RAE1_HUMAN [view interactions] High throughput no yes
RAB10_HUMAN [view entry] [view interactions] High throughput yes yes
RIPL1_HUMAN [view interactions] High throughput no yes
RB39A_HUMAN [view interactions] High throughput no no
GDIB_HUMAN [view entry] [view interactions] High throughput yes yes
RAB6C_HUMAN [view interactions] High throughput no no
LRRT1_HUMAN [view entry] [view interactions] High throughput yes yes
RIPL2_HUMAN [view interactions] High throughput no yes
BICL1_HUMAN [view interactions] High throughput no yes
BICL2_HUMAN [view interactions] High throughput no no
CD177_HUMAN [view interactions] High throughput no no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3A_HUMAN [view entry] [view interactions] High throughput yes yes
CI072_HUMAN [view interactions] High throughput no no
HEXI1_HUMAN [view interactions] High throughput no yes
FLCN_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
CHM4C_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
EDEM1_HUMAN [view interactions] High throughput no yes
LSS_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes