Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CASP3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Thiol protease that acts as a major effector caspase involved in the execution phase of apoptosis (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of many proteins (PubMed, PubMed, PubMed, PubMed). At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a 216-Asp-|-Gly-217 bond (PubMed, PubMed, PubMed, PubMed). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain . Cleaves and activates caspase-6, -7 and -9 (PubMed). Involved in the cleavage of huntingtin (PubMed). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed). Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (PubMed). Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (PubMed, PubMed). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed, PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CASP3_HUMAN
GO:0043169 cation binding 32.6923 4 no
GO:0046872 metal ion binding 32.6923 5 no
GO:0019900 kinase binding 32.6923 4 no
GO:0003723 RNA binding 28.8462 4 no
GO:0000166 nucleotide binding 28.8462 4 no
GO:0017076 purine nucleotide binding 28.8462 5 no
GO:0019901 protein kinase binding 28.8462 5 no
GO:0043168 anion binding 26.9231 4 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0045296 cadherin binding 25.0000 4 no
GO:0030554 adenyl nucleotide binding 23.0769 6 no
GO:0019887 protein kinase regulator activity 13.4615 4 yes
GO:0004860 protein kinase inhibitor activity 9.6154 5 yes
GO:0019210 kinase inhibitor activity 9.6154 4 yes
GO:0030291 protein serine/threonine kinase inhibitor activity 9.6154 6 yes
GO:0005126 cytokine receptor binding 7.6923 4 yes
GO:0032813 tumor necrosis factor receptor superfamily binding 7.6923 5 yes
GO:0002020 protease binding 5.7692 4 yes
GO:0016004 phospholipase activator activity 5.7692 5 yes
GO:0060229 lipase activator activity 5.7692 4 yes
GO:0004175 endopeptidase activity 3.8462 4 yes
GO:0004190 aspartic-type endopeptidase activity 3.8462 5 yes
GO:0004197 cysteine-type endopeptidase activity 3.8462 5 yes
GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3.8462 6 yes
GO:0005123 death receptor binding 3.8462 6 yes
GO:0008234 cysteine-type peptidase activity 3.8462 4 yes
GO:0016005 phospholipase A2 activator activity 3.8462 6 yes
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 3.8462 5 yes
GO:0070001 aspartic-type peptidase activity 3.8462 4 yes
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process 3.8462 6 yes
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3.8462 7 yes
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis 3.8462 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CASP3_HUMAN
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0031323 regulation of cellular metabolic process 71.1538 4 yes
GO:0048522 positive regulation of cellular process 71.1538 4 yes
GO:0060255 regulation of macromolecule metabolic process 67.3077 4 yes
GO:0080090 regulation of primary metabolic process 67.3077 4 yes
GO:0009893 positive regulation of metabolic process 61.5385 4 yes
GO:0051246 regulation of protein metabolic process 61.5385 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 55.7692 5 yes
GO:0010646 regulation of cell communication 55.7692 4 no
GO:0009889 regulation of biosynthetic process 53.8462 4 yes
GO:0010468 regulation of gene expression 53.8462 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 53.8462 5 yes
GO:0031326 regulation of cellular biosynthetic process 53.8462 5 yes
GO:0031325 positive regulation of cellular metabolic process 53.8462 5 no
GO:0009892 negative regulation of metabolic process 48.0769 4 yes
GO:0031324 negative regulation of cellular metabolic process 48.0769 5 yes
GO:0042981 regulation of apoptotic process 48.0769 5 yes
GO:0043067 regulation of programmed cell death 48.0769 4 yes
GO:0009966 regulation of signal transduction 48.0769 4 no
GO:0010605 negative regulation of macromolecule metabolic process 46.1538 5 yes
GO:0071310 cellular response to organic substance 46.1538 4 yes
GO:0051128 regulation of cellular component organization 42.3077 4 no
GO:0006996 organelle organization 42.3077 4 no
GO:0051247 positive regulation of protein metabolic process 40.3846 6 yes
GO:0008104 protein localization 40.3846 4 no
GO:0009891 positive regulation of biosynthetic process 40.3846 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 40.3846 6 no
GO:0031328 positive regulation of cellular biosynthetic process 40.3846 6 no
GO:0009894 regulation of catabolic process 38.4615 4 yes
GO:0022607 cellular component assembly 38.4615 4 no
GO:1902531 regulation of intracellular signal transduction 38.4615 5 no
GO:0051049 regulation of transport 36.5385 4 no
GO:0048584 positive regulation of response to stimulus 36.5385 4 no
GO:0006915 apoptotic process 34.6154 4 yes
GO:0010628 positive regulation of gene expression 34.6154 7 no
GO:0036211 protein modification process 34.6154 4 no
GO:0043412 macromolecule modification 34.6154 4 no
GO:0031399 regulation of protein modification process 34.6154 6 no
GO:0051174 regulation of phosphorus metabolic process 32.6923 5 no
GO:0010243 response to organonitrogen compound 32.6923 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.6923 5 no
GO:0043066 negative regulation of apoptotic process 32.6923 6 no
GO:0043069 negative regulation of programmed cell death 32.6923 5 no
GO:0051248 negative regulation of protein metabolic process 32.6923 6 no
GO:0019220 regulation of phosphate metabolic process 32.6923 6 no
GO:0071417 cellular response to organonitrogen compound 30.7692 4 yes
GO:1901699 cellular response to nitrogen compound 30.7692 4 yes
GO:0051252 regulation of RNA metabolic process 30.7692 5 no
GO:0060341 regulation of cellular localization 30.7692 4 no
GO:1901701 cellular response to oxygen-containing compound 30.7692 4 no
GO:0051240 positive regulation of multicellular organismal process 28.8462 4 no
GO:0031329 regulation of cellular catabolic process 28.8462 5 yes
GO:0042127 regulation of cell population proliferation 28.8462 4 yes
GO:0032880 regulation of protein localization 28.8462 5 no
GO:0045595 regulation of cell differentiation 28.8462 4 no
GO:0048585 negative regulation of response to stimulus 28.8462 4 no
GO:0071702 organic substance transport 26.9231 4 no
GO:0141124 intracellular signaling cassette 26.9231 4 no
GO:0009890 negative regulation of biosynthetic process 26.9231 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 26.9231 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 26.9231 6 yes
GO:0051726 regulation of cell cycle 26.9231 4 yes
GO:0009968 negative regulation of signal transduction 26.9231 5 no
GO:0010648 negative regulation of cell communication 26.9231 5 no
GO:0023057 negative regulation of signaling 26.9231 4 no
GO:0051129 negative regulation of cellular component organization 26.9231 5 no
GO:0080134 regulation of response to stress 26.9231 4 no
GO:0009967 positive regulation of signal transduction 26.9231 5 no
GO:0010563 negative regulation of phosphorus metabolic process 26.9231 6 no
GO:0010647 positive regulation of cell communication 26.9231 5 no
GO:0023056 positive regulation of signaling 26.9231 4 no
GO:0031400 negative regulation of protein modification process 26.9231 7 no
GO:0042325 regulation of phosphorylation 26.9231 7 no
GO:0044087 regulation of cellular component biogenesis 26.9231 4 no
GO:0045936 negative regulation of phosphate metabolic process 26.9231 7 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0006796 phosphate-containing compound metabolic process 25.0000 4 no
GO:0032101 regulation of response to external stimulus 25.0000 4 no
GO:2000026 regulation of multicellular organismal development 23.0769 4 no
GO:0010506 regulation of autophagy 23.0769 6 yes
GO:0010629 negative regulation of gene expression 23.0769 7 yes
GO:0014070 response to organic cyclic compound 23.0769 4 yes
GO:0030030 cell projection organization 23.0769 4 yes
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0051094 positive regulation of developmental process 23.0769 4 no
GO:2000145 regulation of cell motility 23.0769 4 no
GO:0001932 regulation of protein phosphorylation 23.0769 7 no
GO:0033043 regulation of organelle organization 23.0769 5 no
GO:0042326 negative regulation of phosphorylation 23.0769 8 no
GO:0051338 regulation of transferase activity 21.1538 4 no
GO:0051130 positive regulation of cellular component organization 21.1538 5 no
GO:0120036 plasma membrane bounded cell projection organization 21.1538 5 yes
GO:0009896 positive regulation of catabolic process 21.1538 5 no
GO:0030334 regulation of cell migration 21.1538 5 no
GO:0031344 regulation of cell projection organization 21.1538 5 no
GO:0043933 protein-containing complex organization 21.1538 4 no
GO:0065003 protein-containing complex assembly 21.1538 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.1538 6 no
GO:1903829 positive regulation of protein localization 21.1538 5 no
GO:0010608 post-transcriptional regulation of gene expression 21.1538 7 no
GO:0016310 phosphorylation 21.1538 5 no
GO:0031347 regulation of defense response 21.1538 5 no
GO:0043549 regulation of kinase activity 21.1538 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 21.1538 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 19.2308 4 yes
GO:0034097 response to cytokine 19.2308 4 yes
GO:0043068 positive regulation of programmed cell death 19.2308 5 yes
GO:0051241 negative regulation of multicellular organismal process 19.2308 4 yes
GO:0071407 cellular response to organic cyclic compound 19.2308 5 yes
GO:0001817 regulation of cytokine production 17.3077 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 17.3077 5 yes
GO:0009057 macromolecule catabolic process 17.3077 4 yes
GO:0009416 response to light stimulus 17.3077 4 yes
GO:0010038 response to metal ion 17.3077 4 yes
GO:0030155 regulation of cell adhesion 17.3077 4 yes
GO:0030163 protein catabolic process 17.3077 4 yes
GO:0031175 neuron projection development 17.3077 6 yes
GO:0033993 response to lipid 17.3077 4 yes
GO:0043065 positive regulation of apoptotic process 17.3077 6 yes
GO:1901565 organonitrogen compound catabolic process 17.3077 4 yes
GO:0002683 negative regulation of immune system process 15.3846 4 yes
GO:0002694 regulation of leukocyte activation 15.3846 4 yes
GO:0006508 proteolysis 15.3846 4 yes
GO:0050865 regulation of cell activation 15.3846 4 yes
GO:0051249 regulation of lymphocyte activation 15.3846 5 yes
GO:0062197 cellular response to chemical stress 15.3846 4 yes
GO:0000302 response to reactive oxygen species 13.4615 4 yes
GO:0006974 DNA damage response 13.4615 4 yes
GO:0043523 regulation of neuron apoptotic process 13.4615 6 yes
GO:0050890 cognition 13.4615 4 yes
GO:0008285 negative regulation of cell population proliferation 11.5385 5 yes
GO:0009411 response to UV 11.5385 5 yes
GO:0010212 response to ionizing radiation 11.5385 4 yes
GO:0022407 regulation of cell-cell adhesion 11.5385 5 yes
GO:0030855 epithelial cell differentiation 11.5385 4 yes
GO:0036293 response to decreased oxygen levels 11.5385 4 yes
GO:0050863 regulation of T cell activation 11.5385 6 yes
GO:0007507 heart development 9.6154 4 yes
GO:0016241 regulation of macroautophagy 9.6154 7 yes
GO:0030099 myeloid cell differentiation 9.6154 4 yes
GO:0042542 response to hydrogen peroxide 9.6154 4 yes
GO:0045786 negative regulation of cell cycle 9.6154 5 yes
GO:0048545 response to steroid hormone 9.6154 4 yes
GO:0051402 neuron apoptotic process 9.6154 5 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 9.6154 6 yes
GO:0007162 negative regulation of cell adhesion 7.6923 5 yes
GO:0022408 negative regulation of cell-cell adhesion 7.6923 6 yes
GO:0030182 neuron differentiation 7.6923 4 yes
GO:0031960 response to corticosteroid 7.6923 5 yes
GO:0032355 response to estradiol 7.6923 4 yes
GO:0032944 regulation of mononuclear cell proliferation 7.6923 6 yes
GO:0042692 muscle cell differentiation 7.6923 4 yes
GO:0043200 response to amino acid 7.6923 4 yes
GO:0043279 response to alkaloid 7.6923 5 yes
GO:0043525 positive regulation of neuron apoptotic process 7.6923 7 yes
GO:0050670 regulation of lymphocyte proliferation 7.6923 6 yes
GO:0051604 protein maturation 7.6923 4 yes
GO:0070663 regulation of leukocyte proliferation 7.6923 5 yes
GO:0071312 cellular response to alkaloid 7.6923 5 yes
GO:0071887 leukocyte apoptotic process 7.6923 5 yes
GO:0001782 B cell homeostasis 5.7692 4 yes
GO:0001818 negative regulation of cytokine production 5.7692 5 yes
GO:0002237 response to molecule of bacterial origin 5.7692 4 yes
GO:0002695 negative regulation of leukocyte activation 5.7692 5 yes
GO:0009913 epidermal cell differentiation 5.7692 5 yes
GO:0016485 protein processing 5.7692 5 yes
GO:0030888 regulation of B cell proliferation 5.7692 7 yes
GO:0030889 negative regulation of B cell proliferation 5.7692 8 yes
GO:0032496 response to lipopolysaccharide 5.7692 4 yes
GO:0032945 negative regulation of mononuclear cell proliferation 5.7692 7 yes
GO:0034248 regulation of amide metabolic process 5.7692 4 yes
GO:0034612 response to tumor necrosis factor 5.7692 5 yes
GO:0042129 regulation of T cell proliferation 5.7692 7 yes
GO:0050672 negative regulation of lymphocyte proliferation 5.7692 7 yes
GO:0050864 regulation of B cell activation 5.7692 6 yes
GO:0050866 negative regulation of cell activation 5.7692 5 yes
GO:0050869 negative regulation of B cell activation 5.7692 7 yes
GO:0051146 striated muscle cell differentiation 5.7692 5 yes
GO:0051250 negative regulation of lymphocyte activation 5.7692 6 yes
GO:0051384 response to glucocorticoid 5.7692 6 yes
GO:0070664 negative regulation of leukocyte proliferation 5.7692 6 yes
GO:0097193 intrinsic apoptotic signaling pathway 5.7692 4 yes
GO:1902003 regulation of amyloid-beta formation 5.7692 5 yes
GO:1902991 regulation of amyloid precursor protein catabolic process 5.7692 6 yes
GO:1903038 negative regulation of leukocyte cell-cell adhesion 5.7692 7 yes
GO:1904019 epithelial cell apoptotic process 5.7692 5 yes
GO:0007413 axonal fasciculation 3.8462 4 yes
GO:0007600 sensory perception 3.8462 4 yes
GO:0007605 sensory perception of sound 3.8462 6 yes
GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress 3.8462 5 yes
GO:0009743 response to carbohydrate 3.8462 4 yes
GO:0009746 response to hexose 3.8462 6 yes
GO:0009749 response to glucose 3.8462 7 yes
GO:0010165 response to X-ray 3.8462 5 yes
GO:0030216 keratinocyte differentiation 3.8462 6 yes
GO:0030218 erythrocyte differentiation 3.8462 5 yes
GO:0032025 response to cobalt ion 3.8462 5 yes
GO:0034250 positive regulation of amide metabolic process 3.8462 5 yes
GO:0034284 response to monosaccharide 3.8462 5 yes
GO:0034349 glial cell apoptotic process 3.8462 5 yes
GO:0038179 neurotrophin signaling pathway 3.8462 4 yes
GO:0042130 negative regulation of T cell proliferation 3.8462 8 yes
GO:0043029 T cell homeostasis 3.8462 4 yes
GO:0044346 fibroblast apoptotic process 3.8462 5 yes
GO:0046006 regulation of activated T cell proliferation 3.8462 8 yes
GO:0046007 negative regulation of activated T cell proliferation 3.8462 9 yes
GO:0048011 neurotrophin TRK receptor signaling pathway 3.8462 5 yes
GO:0050868 negative regulation of T cell activation 3.8462 7 yes
GO:0050954 sensory perception of mechanical stimulus 3.8462 5 yes
GO:0060606 tube closure 3.8462 4 yes
GO:0061713 anterior neural tube closure 3.8462 5 yes
GO:0070269 pyroptosis 3.8462 4 yes
GO:0071470 cellular response to osmotic stress 3.8462 4 yes
GO:0072733 response to staurosporine 3.8462 5 yes
GO:0072734 cellular response to staurosporine 3.8462 6 yes
GO:0106030 neuron projection fasciculation 3.8462 7 yes
GO:0140639 positive regulation of pyroptosis 3.8462 6 yes
GO:1902004 positive regulation of amyloid-beta formation 3.8462 6 yes
GO:1902993 positive regulation of amyloid precursor protein catabolic process 3.8462 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
1433E_HUMAN [view entry] [view interactions] Low throughput yes yes
THA11_HUMAN [view interactions] Low throughput no yes
AKAP8_HUMAN [view interactions] Low throughput no yes
XIAP_HUMAN [view interactions] Low throughput no yes
THIO_HUMAN [view interactions] Low throughput no yes
CRYAB_HUMAN [view entry] [view interactions] Low throughput yes no
NMT2_HUMAN [view interactions] Low throughput no yes
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
WNK3_HUMAN [view interactions] Low throughput no no
CASP9_HUMAN [view interactions] Low throughput no yes
APAF_HUMAN [view interactions] Low throughput no no
CASP3_HUMAN [view entry] [view interactions] Low throughput yes yes
NUCB2_HUMAN [view interactions] Low throughput no yes
GATA1_HUMAN [view interactions] Low throughput no no
PARP1_HUMAN [view entry] [view interactions] Low throughput yes yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
A16L1_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] Low throughput yes yes
CASP8_HUMAN [view interactions] Low throughput no yes
CASP6_HUMAN [view interactions] Low throughput no no
BID_HUMAN [view interactions] Low throughput no no
TEBP_HUMAN [view interactions] Low throughput no yes
OSTP_HUMAN [view interactions] Low throughput no yes
PANX1_HUMAN [view interactions] Low throughput no no
CDON_HUMAN [view interactions] Low throughput no no
BIRC2_HUMAN [view interactions] Low throughput no yes
BIRC7_HUMAN [view interactions] Low throughput no no
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT2_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT3_HUMAN [view interactions] Low throughput no yes
CALB1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMT1_HUMAN [view interactions] Low throughput no yes
DFFA_HUMAN [view interactions] Low throughput no yes
CDN1A_HUMAN [view interactions] Low throughput no no
SRC8_HUMAN [view entry] [view interactions] Low throughput yes yes
HCLS1_HUMAN [view interactions] Low throughput no no
DCC_HUMAN [view entry] [view interactions] Low throughput yes yes
CFLAR_HUMAN [view interactions] Low throughput no yes
CH60_HUMAN [view entry] [view interactions] Low throughput yes yes
CH10_HUMAN [view interactions] Low throughput no yes
HEY2_HUMAN [view interactions] Low throughput no no
RBX1_HUMAN [view entry] [view interactions] Low throughput yes no
FBW1B_HUMAN [view interactions] Low throughput no yes
FBW1A_HUMAN [view interactions] Low throughput no yes
HSPB1_HUMAN [view entry] [view interactions] Low throughput yes no
BIRC6_HUMAN [view entry] [view interactions] Low throughput yes yes
BIRC3_HUMAN [view interactions] Low throughput no no
MK14_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
SKP2_HUMAN [view interactions] Low throughput no yes
FETA_HUMAN [view interactions] Low throughput no no
OTUL_HUMAN [view interactions] Low throughput no yes
BIRC5_HUMAN [view interactions] Low throughput no no
ARNT_HUMAN [view entry] [view interactions] Low throughput yes yes
BCL2_HUMAN [view interactions] Low throughput no no
BLM_HUMAN [view interactions] Low throughput no yes
MCL1_HUMAN [view interactions] Low throughput no yes
TRAF3_HUMAN [view entry] [view interactions] Low throughput yes yes
CASP2_HUMAN [view interactions] Low throughput no yes
PARG_HUMAN [view interactions] Low throughput no yes
GORS1_HUMAN [view interactions] Low throughput no yes
SRBP2_HUMAN [view interactions] Low throughput no yes
DBNL_HUMAN [view entry] [view interactions] Low throughput yes yes
BMX_HUMAN [view interactions] Low throughput no no
USO1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRAP1_HUMAN [view entry] [view interactions] Low throughput yes yes
NDUS1_HUMAN [view entry] [view interactions] Low throughput yes no
RING2_HUMAN [view interactions] Low throughput no yes
GEMI_HUMAN [view interactions] Low throughput no no
MDC1_HUMAN [view interactions] Low throughput no yes
CSN6_HUMAN [view interactions] Low throughput no yes
EAA2_HUMAN [view entry] [view interactions] Low throughput yes no
ZBT16_HUMAN [view interactions] Low throughput no yes
PSME3_HUMAN [view interactions] Low throughput no yes
FEM1B_HUMAN [view interactions] Low throughput no yes
PKN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SP1_HUMAN [view interactions] Low throughput no yes
DFFB_HUMAN [view interactions] Low throughput no yes
MK08_HUMAN [view interactions] Low throughput no yes
MK09_HUMAN [view interactions] Low throughput no yes
RB_HUMAN [view interactions] Low throughput no yes
PRKDC_HUMAN [view entry] [view interactions] Low throughput yes yes
PA24B_HUMAN [view interactions] Low throughput no no
GRAB_HUMAN [view interactions] Low throughput no no
TNF10_HUMAN [view interactions] Low throughput no no
BECN1_HUMAN [view interactions] Low throughput no yes
IL16_HUMAN [view interactions] Low throughput no no
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
RU17_HUMAN [view interactions] Low throughput no yes
TRAF2_HUMAN [view interactions] Low throughput no yes
BAX_HUMAN [view interactions] Low throughput no yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCA10_HUMAN [view interactions] High throughput no no
LS14B_HUMAN [view interactions] High throughput no yes
S35A1_HUMAN [view interactions] High throughput no no
ERP44_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
GLRX1_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
SOCS5_HUMAN [view interactions] High throughput no yes
SOLH1_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ATX3_HUMAN [view interactions] High throughput no yes
ACTA_HUMAN [view interactions] High throughput no no
KPYM_HUMAN [view interactions] High throughput no yes
RS18_HUMAN [view entry] [view interactions] High throughput yes yes
HDGF_HUMAN [view interactions] High throughput no yes
NUCKS_HUMAN [view interactions] High throughput no yes
WAC2C_HUMAN [view interactions] High throughput no yes
WAC2A_HUMAN [view interactions] High throughput no yes
GDIR2_HUMAN [view interactions] High throughput no no
STK3_HUMAN [view interactions] High throughput no yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
M3K14_HUMAN [view interactions] High throughput no yes
TRAF1_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
RAD51_HUMAN [view interactions] High throughput no yes
MLH1_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
STK4_HUMAN [view interactions] High throughput no yes
RON_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
MKRN2_HUMAN [view interactions] High throughput no yes
MED20_HUMAN [view interactions] High throughput no no
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
PTTG1_HUMAN [view interactions] High throughput no no
CASPA_HUMAN [view interactions] High throughput no yes
GELS_HUMAN [view entry] [view interactions] High throughput yes no
GDIR1_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
ROCK1_HUMAN [view entry] [view interactions] High throughput yes yes
CASP7_HUMAN [view interactions] High throughput no no
ATG4D_HUMAN [view interactions] High throughput no yes
ARMT1_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
IDH3B_HUMAN [view entry] [view interactions] High throughput yes yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
LCMT1_HUMAN [view interactions] High throughput no yes
SPB8_HUMAN [view interactions] High throughput no no
SLK_HUMAN [view entry] [view interactions] High throughput yes yes
IF4G2_HUMAN [view entry] [view interactions] High throughput yes yes
SYSM_HUMAN [view interactions] High throughput no yes
UBE4B_HUMAN [view interactions] High throughput no yes
GMDS_HUMAN [view interactions] High throughput no yes
PYGL_HUMAN [view interactions] High throughput no yes
RAB12_HUMAN [view entry] [view interactions] High throughput yes no
TRUB1_HUMAN [view interactions] High throughput no no
SAMH1_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes