EAA2_HUMAN
Evidence for PS localization
Functions
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed, PubMed, PubMed, PubMed). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EAA2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 46.6667 | 4 | no |
| GO:0043169 | cation binding | 20.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 20.0000 | 5 | yes |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 16.6667 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 16.6667 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 16.6667 | 5 | yes |
| GO:0015081 | sodium ion transmembrane transporter activity | 13.3333 | 6 | yes |
| GO:0015291 | secondary active transmembrane transporter activity | 13.3333 | 4 | yes |
| GO:0022853 | active monoatomic ion transmembrane transporter activity | 13.3333 | 4 | yes |
| GO:0046943 | carboxylic acid transmembrane transporter activity | 13.3333 | 4 | yes |
| GO:0005283 | amino acid:sodium symporter activity | 10.0000 | 5 | yes |
| GO:0005343 | organic acid:sodium symporter activity | 10.0000 | 4 | yes |
| GO:0005416 | amino acid:monoatomic cation symporter activity | 10.0000 | 4 | yes |
| GO:0008509 | monoatomic anion transmembrane transporter activity | 10.0000 | 4 | yes |
| GO:0015175 | neutral L-amino acid transmembrane transporter activity | 10.0000 | 4 | yes |
| GO:0015179 | L-amino acid transmembrane transporter activity | 10.0000 | 4 | yes |
| GO:0015293 | symporter activity | 10.0000 | 5 | yes |
| GO:0015294 | solute:monoatomic cation symporter activity | 10.0000 | 5 | yes |
| GO:0015370 | solute:sodium symporter activity | 10.0000 | 6 | yes |
| GO:0000099 | sulfur amino acid transmembrane transporter activity | 6.6667 | 4 | yes |
| GO:0005313 | L-glutamate transmembrane transporter activity | 6.6667 | 5 | yes |
| GO:0005314 | high-affinity L-glutamate transmembrane transporter activity | 6.6667 | 6 | yes |
| GO:0015172 | acidic amino acid transmembrane transporter activity | 6.6667 | 4 | yes |
| GO:0015501 | glutamate:sodium symporter activity | 6.6667 | 5 | yes |
| GO:0033229 | cysteine transmembrane transporter activity | 6.6667 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EAA2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.6667 | 4 | yes |
| GO:0010646 | regulation of cell communication | 43.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.3333 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.3333 | 4 | no |
| GO:0022607 | cellular component assembly | 43.3333 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0051049 | regulation of transport | 36.6667 | 4 | yes |
| GO:0043933 | protein-containing complex organization | 36.6667 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 30.0000 | 5 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 30.0000 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 30.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | no |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 26.6667 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 26.6667 | 4 | no |
| GO:0030030 | cell projection organization | 26.6667 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.3333 | 4 | yes |
| GO:0098657 | import into cell | 23.3333 | 4 | yes |
| GO:0009059 | macromolecule biosynthetic process | 23.3333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.3333 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.3333 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.3333 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.3333 | 6 | no |
| GO:0010038 | response to metal ion | 23.3333 | 4 | no |
| GO:0050890 | cognition | 23.3333 | 4 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 23.3333 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.3333 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 23.3333 | 5 | no |
| GO:0031175 | neuron projection development | 23.3333 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.3333 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 23.3333 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 23.3333 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 20.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 20.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 20.0000 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 20.0000 | 4 | yes |
| GO:0043279 | response to alkaloid | 20.0000 | 5 | yes |
| GO:0051259 | protein complex oligomerization | 16.6667 | 6 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 16.6667 | 6 | yes |
| GO:0099536 | synaptic signaling | 16.6667 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 16.6667 | 5 | yes |
| GO:0007268 | chemical synaptic transmission | 16.6667 | 7 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 16.6667 | 5 | yes |
| GO:0046942 | carboxylic acid transport | 13.3333 | 6 | yes |
| GO:0051260 | protein homooligomerization | 13.3333 | 7 | yes |
| GO:0071312 | cellular response to alkaloid | 13.3333 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 13.3333 | 5 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 13.3333 | 4 | yes |
| GO:0098810 | neurotransmitter reuptake | 13.3333 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 13.3333 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 13.3333 | 4 | yes |
| GO:0001504 | neurotransmitter uptake | 13.3333 | 5 | yes |
| GO:0006811 | monoatomic ion transport | 13.3333 | 4 | yes |
| GO:0006836 | neurotransmitter transport | 13.3333 | 4 | yes |
| GO:0006865 | amino acid transport | 13.3333 | 5 | yes |
| GO:0015711 | organic anion transport | 13.3333 | 5 | yes |
| GO:0015849 | organic acid transport | 13.3333 | 5 | yes |
| GO:0043200 | response to amino acid | 13.3333 | 4 | yes |
| GO:0089718 | amino acid import across plasma membrane | 10.0000 | 4 | yes |
| GO:0150104 | transport across blood-brain barrier | 10.0000 | 5 | yes |
| GO:1902475 | L-alpha-amino acid transmembrane transport | 10.0000 | 4 | yes |
| GO:1905039 | carboxylic acid transmembrane transport | 10.0000 | 4 | yes |
| GO:0003018 | vascular process in circulatory system | 10.0000 | 4 | yes |
| GO:0009416 | response to light stimulus | 10.0000 | 4 | yes |
| GO:0010232 | vascular transport | 10.0000 | 4 | yes |
| GO:0015800 | acidic amino acid transport | 10.0000 | 6 | yes |
| GO:0015807 | L-amino acid transport | 10.0000 | 5 | yes |
| GO:0042220 | response to cocaine | 10.0000 | 4 | yes |
| GO:0046326 | positive regulation of glucose import | 6.6667 | 7 | yes |
| GO:0051938 | L-glutamate import | 6.6667 | 6 | yes |
| GO:0070206 | protein trimerization | 6.6667 | 7 | yes |
| GO:0070207 | protein homotrimerization | 6.6667 | 8 | yes |
| GO:0070633 | transepithelial transport | 6.6667 | 4 | yes |
| GO:0070777 | D-aspartate transmembrane transport | 6.6667 | 5 | yes |
| GO:0070778 | L-aspartate transmembrane transport | 6.6667 | 5 | yes |
| GO:0070779 | D-aspartate import across plasma membrane | 6.6667 | 5 | yes |
| GO:0071314 | cellular response to cocaine | 6.6667 | 5 | yes |
| GO:0098712 | L-glutamate import across plasma membrane | 6.6667 | 5 | yes |
| GO:0140009 | L-aspartate import across plasma membrane | 6.6667 | 5 | yes |
| GO:0006750 | glutathione biosynthetic process | 6.6667 | 4 | yes |
| GO:0006835 | dicarboxylic acid transport | 6.6667 | 7 | yes |
| GO:0010827 | regulation of glucose transmembrane transport | 6.6667 | 5 | yes |
| GO:0010828 | positive regulation of glucose transmembrane transport | 6.6667 | 6 | yes |
| GO:0015740 | C4-dicarboxylate transport | 6.6667 | 8 | yes |
| GO:0015810 | aspartate transmembrane transport | 6.6667 | 4 | yes |
| GO:0015813 | L-glutamate transmembrane transport | 6.6667 | 5 | yes |
| GO:0019184 | nonribosomal peptide biosynthetic process | 6.6667 | 5 | yes |
| GO:0042398 | cellular modified amino acid biosynthetic process | 6.6667 | 4 | yes |
| GO:0042940 | D-amino acid transport | 6.6667 | 5 | yes |
| GO:0043043 | peptide biosynthetic process | 6.6667 | 4 | yes |
| GO:0044272 | sulfur compound biosynthetic process | 6.6667 | 4 | yes |
| GO:0046324 | regulation of glucose import | 6.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AJUBA_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PML_HUMAN | [view interactions] | Low throughput | no | yes |
| EAA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CASP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| HG2A_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC2C_HUMAN | [view interactions] | High throughput | no | yes |
| LBR_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| MYO16_HUMAN | [view interactions] | High throughput | no | no |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| NFASC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXL2_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1L_HUMAN | [view interactions] | High throughput | no | yes |
| RASFA_HUMAN | [view interactions] | High throughput | no | no |
| UBP38_HUMAN | [view interactions] | High throughput | no | no |
| UBP40_HUMAN | [view interactions] | High throughput | no | yes |
| THYN1_HUMAN | [view interactions] | High throughput | no | yes |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| RL17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL38_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBW1A_HUMAN | [view interactions] | High throughput | no | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |