Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EAA2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed, PubMed, PubMed, PubMed). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EAA2_HUMAN
GO:0003723 RNA binding 39.1304 4 no
GO:0046872 metal ion binding 30.4348 4 yes
GO:0019900 kinase binding 26.0870 4 no
GO:0008324 cation transmembrane transporter activity 21.7391 4 yes
GO:0008509 anion transmembrane transporter activity 21.7391 4 yes
GO:0008514 organic anion transmembrane transporter activity 21.7391 5 yes
GO:0015081 sodium ion transmembrane transporter activity 21.7391 6 yes
GO:0015171 amino acid transmembrane transporter activity 21.7391 5 yes
GO:0015291 secondary active transmembrane transporter activity 21.7391 4 yes
GO:0015293 symporter activity 21.7391 5 yes
GO:0015294 solute:cation symporter activity 21.7391 5 yes
GO:0015370 solute:sodium symporter activity 21.7391 6 yes
GO:0022853 active ion transmembrane transporter activity 21.7391 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 21.7391 4 yes
GO:0046873 metal ion transmembrane transporter activity 21.7391 5 yes
GO:0046943 carboxylic acid transmembrane transporter activity 21.7391 4 yes
GO:0005283 amino acid:sodium symporter activity 17.3913 5 yes
GO:0005313 L-glutamate transmembrane transporter activity 17.3913 6 yes
GO:0005343 organic acid:sodium symporter activity 17.3913 4 yes
GO:0005416 amino acid:cation symporter activity 17.3913 6 yes
GO:0015172 acidic amino acid transmembrane transporter activity 17.3913 6 yes
GO:0015179 L-amino acid transmembrane transporter activity 17.3913 6 yes
GO:0005314 high-affinity L-glutamate transmembrane transporter activity 13.0435 7 yes
GO:0015175 neutral amino acid transmembrane transporter activity 13.0435 6 yes
GO:0015501 glutamate:sodium symporter activity 13.0435 6 yes
GO:0000099 sulfur amino acid transmembrane transporter activity 8.6957 4 yes
GO:0033229 cysteine transmembrane transporter activity 8.6957 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EAA2_HUMAN
GO:0010646 regulation of cell communication 52.1739 4 no
GO:0022607 cellular component assembly 52.1739 4 yes
GO:0048522 positive regulation of cellular process 52.1739 4 yes
GO:0043933 protein-containing complex organization 47.8261 4 yes
GO:1901566 organonitrogen compound biosynthetic process 47.8261 4 yes
GO:0051049 regulation of transport 43.4783 4 yes
GO:0065003 protein-containing complex assembly 43.4783 5 yes
GO:0009966 regulation of signal transduction 39.1304 4 no
GO:0048523 negative regulation of cellular process 39.1304 4 no
GO:0050804 modulation of chemical synaptic transmission 39.1304 5 no
GO:0099177 regulation of trans-synaptic signaling 39.1304 4 no
GO:0044271 cellular nitrogen compound biosynthetic process 39.1304 4 yes
GO:0071310 cellular response to organic substance 39.1304 4 yes
GO:0031323 regulation of cellular metabolic process 34.7826 4 no
GO:0051128 regulation of cellular component organization 34.7826 4 no
GO:0060255 regulation of macromolecule metabolic process 34.7826 4 no
GO:0006518 peptide metabolic process 34.7826 4 yes
GO:0043043 peptide biosynthetic process 34.7826 5 yes
GO:0043603 cellular amide metabolic process 34.7826 4 yes
GO:0043604 amide biosynthetic process 34.7826 5 yes
GO:0006996 organelle organization 30.4348 4 no
GO:0051171 regulation of nitrogen compound metabolic process 30.4348 4 no
GO:0051246 regulation of protein metabolic process 30.4348 5 no
GO:0080090 regulation of primary metabolic process 30.4348 4 no
GO:0007268 chemical synaptic transmission 30.4348 6 yes
GO:0014070 response to organic cyclic compound 30.4348 4 yes
GO:0051050 positive regulation of transport 30.4348 4 yes
GO:0098916 anterograde trans-synaptic signaling 30.4348 5 yes
GO:0099537 trans-synaptic signaling 30.4348 4 yes
GO:1901701 cellular response to oxygen-containing compound 30.4348 4 yes
GO:0009893 positive regulation of metabolic process 26.0870 4 no
GO:0031325 positive regulation of cellular metabolic process 26.0870 5 no
GO:0031399 regulation of protein modification process 26.0870 6 no
GO:0050890 cognition 26.0870 4 no
GO:0051130 positive regulation of cellular component organization 26.0870 5 no
GO:0002181 cytoplasmic translation 26.0870 5 no
GO:0006412 translation 26.0870 4 no
GO:0009059 macromolecule biosynthetic process 26.0870 4 no
GO:0034645 cellular macromolecule biosynthetic process 26.0870 4 no
GO:0010647 positive regulation of cell communication 26.0870 5 no
GO:0023056 positive regulation of signaling 26.0870 4 no
GO:0006811 ion transport 26.0870 4 yes
GO:0006836 neurotransmitter transport 26.0870 4 yes
GO:0010243 response to organonitrogen compound 26.0870 4 yes
GO:0034762 regulation of transmembrane transport 26.0870 4 yes
GO:0071407 cellular response to organic cyclic compound 26.0870 5 yes
GO:0071702 organic substance transport 26.0870 4 yes
GO:0009892 negative regulation of metabolic process 21.7391 4 no
GO:0010468 regulation of gene expression 21.7391 5 no
GO:0010605 negative regulation of macromolecule metabolic process 21.7391 5 no
GO:0019220 regulation of phosphate metabolic process 21.7391 6 no
GO:0033043 regulation of organelle organization 21.7391 5 no
GO:0042325 regulation of phosphorylation 21.7391 7 no
GO:0044087 regulation of cellular component biogenesis 21.7391 4 no
GO:0051174 regulation of phosphorus metabolic process 21.7391 5 no
GO:0051338 regulation of transferase activity 21.7391 4 no
GO:0007612 learning 21.7391 4 no
GO:0043269 regulation of ion transport 21.7391 5 no
GO:0050806 positive regulation of synaptic transmission 21.7391 5 no
GO:0001504 neurotransmitter uptake 21.7391 4 yes
GO:0006820 anion transport 21.7391 5 yes
GO:0034764 positive regulation of transmembrane transport 21.7391 5 yes
GO:0043279 response to alkaloid 21.7391 5 yes
GO:0051259 protein complex oligomerization 21.7391 6 yes
GO:0071417 cellular response to organonitrogen compound 21.7391 4 yes
GO:0071705 nitrogen compound transport 21.7391 4 yes
GO:0098657 import into cell 21.7391 4 yes
GO:1901699 cellular response to nitrogen compound 21.7391 4 yes
GO:0003018 vascular process in circulatory system 17.3913 4 yes
GO:0006865 amino acid transport 17.3913 5 yes
GO:0010232 vascular transport 17.3913 4 yes
GO:0015711 organic anion transport 17.3913 5 yes
GO:0015800 acidic amino acid transport 17.3913 6 yes
GO:0015849 organic acid transport 17.3913 5 yes
GO:0042220 response to cocaine 17.3913 4 yes
GO:0046942 carboxylic acid transport 17.3913 6 yes
GO:0051260 protein homooligomerization 17.3913 7 yes
GO:0071312 cellular response to alkaloid 17.3913 5 yes
GO:0098656 anion transmembrane transport 17.3913 4 yes
GO:0098810 neurotransmitter reuptake 17.3913 4 yes
GO:0150104 transport across blood-brain barrier 17.3913 5 yes
GO:0003333 amino acid transmembrane transport 13.0435 5 yes
GO:0006835 dicarboxylic acid transport 13.0435 7 yes
GO:0009416 response to light stimulus 13.0435 4 yes
GO:0015740 C4-dicarboxylate transport 13.0435 8 yes
GO:0015807 L-amino acid transport 13.0435 5 yes
GO:0015813 L-glutamate transmembrane transport 13.0435 5 yes
GO:0042940 D-amino acid transport 13.0435 6 yes
GO:0051938 L-glutamate import 13.0435 6 yes
GO:0070633 transepithelial transport 13.0435 4 yes
GO:0070777 D-aspartate transport 13.0435 7 yes
GO:0070778 L-aspartate transmembrane transport 13.0435 5 yes
GO:0070779 D-aspartate import across plasma membrane 13.0435 5 yes
GO:0071314 cellular response to cocaine 13.0435 5 yes
GO:0089718 amino acid import across plasma membrane 13.0435 4 yes
GO:0098712 L-glutamate import across plasma membrane 13.0435 5 yes
GO:1902475 L-alpha-amino acid transmembrane transport 13.0435 6 yes
GO:1905039 carboxylic acid transmembrane transport 13.0435 4 yes
GO:0006749 glutathione metabolic process 8.6957 4 yes
GO:0006750 glutathione biosynthetic process 8.6957 5 yes
GO:0010827 regulation of glucose transmembrane transport 8.6957 5 yes
GO:0010828 positive regulation of glucose transmembrane transport 8.6957 6 yes
GO:0019184 nonribosomal peptide biosynthetic process 8.6957 6 yes
GO:0042398 cellular modified amino acid biosynthetic process 8.6957 4 yes
GO:0043200 response to amino acid 8.6957 4 yes
GO:0044272 sulfur compound biosynthetic process 8.6957 4 yes
GO:0046324 regulation of glucose import 8.6957 6 yes
GO:0046326 positive regulation of glucose import 8.6957 7 yes
GO:0070206 protein trimerization 8.6957 7 yes
GO:0070207 protein homotrimerization 8.6957 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
AJUBA_HUMAN [view interactions] Low throughput no yes
SUMO1_HUMAN [view interactions] Low throughput no yes
UBC9_HUMAN [view interactions] Low throughput no yes
PML_HUMAN [view interactions] Low throughput no yes
EAA2_HUMAN [view entry] [view interactions] Low throughput yes no
CASP3_HUMAN [view interactions] Low throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
RD23B_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
APBB1_HUMAN [view interactions] High throughput no yes
SYPH_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
OXDA_HUMAN [view interactions] High throughput no no
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
TIA1_HUMAN [view interactions] High throughput no no
RL17_HUMAN [view entry] [view interactions] High throughput yes yes
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
RL32_HUMAN [view entry] [view interactions] High throughput yes yes
RL38_HUMAN [view entry] [view interactions] High throughput yes yes
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
RL3_HUMAN [view entry] [view interactions] High throughput yes yes
NBEA_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] Computational yes no
EAA1_HUMAN [view entry] [view interactions] Computational yes no
AQP4_HUMAN [view entry] [view interactions] Computational yes no
XCT_HUMAN [view interactions] Computational no no
F171B_HUMAN [view interactions] Computational no yes
GLNA_HUMAN [view entry] [view interactions] Computational yes yes
VGLU1_HUMAN [view entry] [view interactions] Computational yes no