PPP5_HUMAN
Evidence for PS localization
Functions
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1 (PubMed, PubMed, PubMed). Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress (PubMed). Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function . Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1 . Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E (PubMed). May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels (PubMed). Dephosphorylates and may play a role in the regulation of TAU/MAPT (PubMed). Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2 . Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PPP5_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 41.2844 | 4 | yes |
| GO:0000166 | nucleotide binding | 35.7798 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 35.7798 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 33.0275 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 33.0275 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.1101 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 30.2752 | 5 | yes |
| GO:0005524 | ATP binding | 29.3578 | 5 | yes |
| GO:0003723 | RNA binding | 28.4404 | 4 | yes |
| GO:0043169 | cation binding | 28.4404 | 4 | yes |
| GO:0046872 | metal ion binding | 26.6055 | 5 | yes |
| GO:0048156 | tau protein binding | 9.1743 | 4 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 6.4220 | 4 | yes |
| GO:0004722 | protein serine/threonine phosphatase activity | 5.5046 | 4 | yes |
| GO:0016791 | phosphatase activity | 5.5046 | 5 | yes |
| GO:0051879 | Hsp90 protein binding | 5.5046 | 4 | yes |
| GO:0017018 | myosin phosphatase activity | 3.6697 | 5 | yes |
| GO:0043531 | ADP binding | 2.7523 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PPP5_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.8807 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 48.6239 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.7890 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.7890 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.9541 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.2018 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 42.2018 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 41.2844 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.3670 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 39.4495 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.6972 | 4 | yes |
| GO:0010468 | regulation of gene expression | 36.6972 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 34.8624 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.9450 | 5 | no |
| GO:0006996 | organelle organization | 32.1101 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.1101 | 5 | no |
| GO:0036211 | protein modification process | 31.1927 | 4 | yes |
| GO:0043412 | macromolecule modification | 31.1927 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 31.1927 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 31.1927 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.2752 | 5 | no |
| GO:0022607 | cellular component assembly | 30.2752 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 29.3578 | 4 | yes |
| GO:0051049 | regulation of transport | 29.3578 | 4 | no |
| GO:0008104 | protein localization | 28.4404 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 27.5229 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 27.5229 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 27.5229 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.5229 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.5229 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.6055 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 25.6881 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.7706 | 6 | no |
| GO:0043933 | protein-containing complex organization | 24.7706 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.7706 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 23.8532 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 22.9358 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.9358 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 22.9358 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.9358 | 6 | no |
| GO:0009894 | regulation of catabolic process | 22.9358 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 22.0183 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.0183 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.1009 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.1009 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 21.1009 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.1835 | 5 | no |
| GO:0071702 | organic substance transport | 20.1835 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.1835 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.1835 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 18.3486 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 17.4312 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 16.5138 | 4 | yes |
| GO:0033993 | response to lipid | 13.7615 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 13.7615 | 6 | yes |
| GO:0016070 | RNA metabolic process | 11.9266 | 5 | yes |
| GO:0141124 | intracellular signaling cassette | 11.9266 | 4 | yes |
| GO:0009059 | macromolecule biosynthetic process | 11.0092 | 4 | yes |
| GO:0006974 | DNA damage response | 10.0917 | 4 | yes |
| GO:0006259 | DNA metabolic process | 8.2569 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 8.2569 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 7.3394 | 4 | yes |
| GO:0006281 | DNA repair | 6.4220 | 5 | yes |
| GO:0010038 | response to metal ion | 6.4220 | 4 | yes |
| GO:0043279 | response to alkaloid | 5.5046 | 5 | yes |
| GO:0006302 | double-strand break repair | 4.5872 | 6 | yes |
| GO:0006470 | protein dephosphorylation | 4.5872 | 5 | yes |
| GO:0016311 | dephosphorylation | 4.5872 | 5 | yes |
| GO:0141187 | nucleic acid biosynthetic process | 4.5872 | 5 | yes |
| GO:0000165 | MAPK cascade | 3.6697 | 5 | yes |
| GO:0010288 | response to lead ion | 3.6697 | 5 | yes |
| GO:0043122 | regulation of canonical NF-kappaB signal transduction | 3.6697 | 6 | yes |
| GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 3.6697 | 7 | yes |
| GO:0035970 | peptidyl-threonine dephosphorylation | 2.7523 | 6 | yes |
| GO:0070262 | peptidyl-serine dephosphorylation | 2.7523 | 6 | yes |
| GO:0006351 | DNA-templated transcription | 1.8349 | 6 | yes |
| GO:0014072 | response to isoquinoline alkaloid | 1.8349 | 5 | yes |
| GO:0032774 | RNA biosynthetic process | 1.8349 | 5 | yes |
| GO:0043278 | response to morphine | 1.8349 | 6 | yes |
| GO:0070542 | response to fatty acid | 1.8349 | 4 | yes |
| GO:1904550 | response to arachidonic acid | 1.8349 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ESR2_HUMAN | [view interactions] | Low throughput | no | no |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| PP2AA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRAF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HS90B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC37_HUMAN | [view interactions] | Low throughput | no | yes |
| CHRD1_HUMAN | [view interactions] | Low throughput | no | yes |
| CRY2_HUMAN | [view interactions] | Low throughput | no | yes |
| KC1E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRY1_HUMAN | [view interactions] | Low throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P2R3A_HUMAN | [view interactions] | Low throughput | no | yes |
| CDC27_HUMAN | [view interactions] | Low throughput | no | yes |
| CDC16_HUMAN | [view interactions] | Low throughput | no | yes |
| TP53B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNA12_HUMAN | [view interactions] | Low throughput | no | no |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | Low throughput | no | yes |
| KC1D_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTG_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ATR_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GNA13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDK20_HUMAN | [view interactions] | Low throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHD1_HUMAN | [view interactions] | High throughput | no | no |
| RXRA_HUMAN | [view interactions] | High throughput | no | yes |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| PP1R8_HUMAN | [view interactions] | High throughput | no | yes |
| FCSK_HUMAN | [view interactions] | High throughput | no | yes |
| SYFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| ACBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIG3_HUMAN | [view interactions] | High throughput | no | yes |
| ASGL1_HUMAN | [view interactions] | High throughput | no | yes |
| ATG2B_HUMAN | [view interactions] | High throughput | no | no |
| BIRC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DGKG_HUMAN | [view interactions] | High throughput | no | no |
| DLGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| FBX41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCE2_HUMAN | [view interactions] | High throughput | no | yes |
| GLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARBK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
| ERF3B_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KNDC1_HUMAN | [view interactions] | High throughput | no | no |
| MAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NP1L4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| NOS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NT5D3_HUMAN | [view interactions] | High throughput | no | no |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| PER1_HUMAN | [view interactions] | High throughput | no | no |
| SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLAP_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBGPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBG1L_HUMAN | [view interactions] | High throughput | no | yes |
| RL23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUFY3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| EAA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EAA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPKAP_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCF25_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRN1_HUMAN | [view interactions] | High throughput | no | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| TUT4_HUMAN | [view interactions] | High throughput | no | yes |
| ZNFX1_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DET1_HUMAN | [view interactions] | High throughput | no | no |
| UBP49_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW5_HUMAN | [view interactions] | High throughput | no | no |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ULK2_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD37L_HUMAN | [view interactions] | High throughput | no | yes |
| IRS4_HUMAN | [view interactions] | High throughput | no | no |
| TEBP_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| KS6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCF2_HUMAN | [view interactions] | High throughput | no | yes |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| AGO3_HUMAN | [view interactions] | High throughput | no | yes |
| NOL9_HUMAN | [view interactions] | High throughput | no | no |
| KSR2_HUMAN | [view interactions] | High throughput | no | yes |
| DPOD2_HUMAN | [view interactions] | High throughput | no | no |
| HSP76_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRRC1_HUMAN | [view interactions] | High throughput | no | yes |
| DDB1_HUMAN | [view interactions] | High throughput | no | yes |
| U520_HUMAN | [view interactions] | High throughput | no | yes |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELP1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| H90B4_HUMAN | [view interactions] | High throughput | no | no |
| ELP3_HUMAN | [view interactions] | High throughput | no | no |
| MRCKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBBP5_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS905_HUMAN | [view interactions] | High throughput | no | no |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| CNTLN_HUMAN | [view interactions] | High throughput | no | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCG_HUMAN | [view interactions] | High throughput | no | no |
| GRK6_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| LIMK2_HUMAN | [view interactions] | High throughput | no | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| CDK13_HUMAN | [view interactions] | High throughput | no | no |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MK15_HUMAN | [view interactions] | High throughput | no | no |
| TSSK2_HUMAN | [view interactions] | High throughput | no | no |
| PSKH2_HUMAN | [view interactions] | High throughput | no | no |
| DYRK4_HUMAN | [view interactions] | High throughput | no | no |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD1_HUMAN | [view interactions] | High throughput | no | yes |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SIM2_HUMAN | [view interactions] | High throughput | no | yes |
| BRWD1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CPNE1_HUMAN | [view interactions] | High throughput | no | no |
| CPNE2_HUMAN | [view interactions] | High throughput | no | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRGR_HUMAN | [view interactions] | High throughput | no | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| BPHL_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| PSN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBBP6_HUMAN | [view interactions] | High throughput | no | yes |
| UBP45_HUMAN | [view interactions] | High throughput | no | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| DUS8_HUMAN | [view interactions] | High throughput | no | no |
| TPTE_HUMAN | [view interactions] | High throughput | no | no |
| RAB41_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| YAF2_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR7_HUMAN | [view interactions] | High throughput | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| DJB13_HUMAN | [view interactions] | High throughput | no | no |
| DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJC8_HUMAN | [view interactions] | High throughput | no | yes |
| M4K1_HUMAN | [view interactions] | High throughput | no | no |
| GADL1_HUMAN | [view interactions] | High throughput | no | no |
| INTU_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN3_HUMAN | [view interactions] | High throughput | no | no |
| DEFI8_HUMAN | [view interactions] | High throughput | no | yes |
| FA83F_HUMAN | [view interactions] | High throughput | no | no |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLD2_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE4_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITBP2_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRP44_HUMAN | [view interactions] | High throughput | no | yes |
| FETUA_HUMAN | [view interactions] | High throughput | no | no |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABHEA_HUMAN | [view interactions] | High throughput | no | yes |
| 5MP1_HUMAN | [view interactions] | High throughput | no | no |
| IF6_HUMAN | [view interactions] | High throughput | no | yes |
| PSF3_HUMAN | [view interactions] | High throughput | no | yes |
| GSHB_HUMAN | [view interactions] | High throughput | no | no |
| PNCB_HUMAN | [view interactions] | High throughput | no | no |
| PA1B2_HUMAN | [view interactions] | High throughput | no | yes |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYRG1_HUMAN | [view interactions] | High throughput | no | no |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| DFFA_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUT_HUMAN | [view interactions] | High throughput | no | yes |
| MINP1_HUMAN | [view interactions] | High throughput | no | yes |
| NOL10_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| IMDH1_HUMAN | [view interactions] | High throughput | no | yes |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANM8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |