Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

MCR_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in MCR_HUMAN
GO:0003723 RNA binding 47.0588 4 no
GO:0043169 cation binding 35.2941 4 yes
GO:0046872 metal ion binding 35.2941 5 yes
GO:0000166 nucleotide binding 29.4118 4 no
GO:0005524 ATP binding 29.4118 5 no
GO:0017076 purine nucleotide binding 29.4118 5 no
GO:0030554 adenyl nucleotide binding 29.4118 6 no
GO:0032555 purine ribonucleotide binding 29.4118 4 no
GO:0032559 adenyl ribonucleotide binding 29.4118 5 no
GO:0035639 purine ribonucleoside triphosphate binding 29.4118 4 no
GO:0043168 anion binding 29.4118 4 no
GO:0048156 tau protein binding 29.4118 4 no
GO:0031625 ubiquitin protein ligase binding 29.4118 5 no
GO:0044389 ubiquitin-like protein ligase binding 29.4118 4 no
GO:0017025 TBP-class protein binding 23.5294 5 yes
GO:0140296 general transcription initiation factor binding 23.5294 4 yes
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 23.5294 5 no
GO:0140297 DNA-binding transcription factor binding 23.5294 4 no
GO:0019900 kinase binding 23.5294 4 no
GO:0051879 Hsp90 protein binding 23.5294 4 no
GO:0000976 transcription cis-regulatory region binding 17.6471 5 yes
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 17.6471 6 yes
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 17.6471 7 yes
GO:0000987 cis-regulatory region sequence-specific DNA binding 17.6471 6 yes
GO:0001067 transcription regulatory region nucleic acid binding 17.6471 4 yes
GO:0003677 DNA binding 17.6471 4 yes
GO:0003690 double-stranded DNA binding 17.6471 5 yes
GO:0008270 zinc ion binding 17.6471 7 yes
GO:0034056 estrogen response element binding 17.6471 8 yes
GO:0043565 sequence-specific DNA binding 17.6471 5 yes
GO:0046914 transition metal ion binding 17.6471 6 yes
GO:1990837 sequence-specific double-stranded DNA binding 17.6471 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in MCR_HUMAN
GO:0048522 positive regulation of cellular process 82.3529 4 yes
GO:0031323 regulation of cellular metabolic process 76.4706 4 yes
GO:0060255 regulation of macromolecule metabolic process 76.4706 4 yes
GO:0080090 regulation of primary metabolic process 76.4706 4 yes
GO:0009889 regulation of biosynthetic process 70.5882 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 70.5882 5 yes
GO:0031326 regulation of cellular biosynthetic process 70.5882 5 yes
GO:0010468 regulation of gene expression 64.7059 6 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 64.7059 5 yes
GO:0006355 regulation of DNA-templated transcription 52.9412 7 yes
GO:0010646 regulation of cell communication 52.9412 4 yes
GO:0051252 regulation of RNA metabolic process 52.9412 5 yes
GO:2001141 regulation of RNA biosynthetic process 52.9412 6 yes
GO:0048523 negative regulation of cellular process 52.9412 4 no
GO:0036211 protein modification process 52.9412 4 no
GO:0043412 macromolecule modification 52.9412 4 no
GO:0009966 regulation of signal transduction 47.0588 4 yes
GO:0048584 positive regulation of response to stimulus 47.0588 4 yes
GO:0009893 positive regulation of metabolic process 47.0588 4 no
GO:0010604 positive regulation of macromolecule metabolic process 47.0588 5 no
GO:0006357 regulation of transcription by RNA polymerase II 41.1765 8 yes
GO:0043933 protein-containing complex organization 41.1765 4 no
GO:0051128 regulation of cellular component organization 41.1765 4 no
GO:0051246 regulation of protein metabolic process 41.1765 5 no
GO:0009967 positive regulation of signal transduction 35.2941 5 yes
GO:0010647 positive regulation of cell communication 35.2941 5 yes
GO:0023056 positive regulation of signaling 35.2941 4 yes
GO:0030518 intracellular steroid hormone receptor signaling pathway 35.2941 5 yes
GO:0043401 steroid hormone mediated signaling pathway 35.2941 4 yes
GO:0141193 nuclear receptor signaling pathway 35.2941 4 yes
GO:0022607 cellular component assembly 35.2941 4 no
GO:0009891 positive regulation of biosynthetic process 35.2941 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 35.2941 6 no
GO:0031325 positive regulation of cellular metabolic process 35.2941 5 no
GO:0031328 positive regulation of cellular biosynthetic process 35.2941 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 35.2941 5 no
GO:0009894 regulation of catabolic process 35.2941 4 no
GO:0032446 protein modification by small protein conjugation 35.2941 7 no
GO:0043687 post-translational protein modification 35.2941 5 no
GO:0070647 protein modification by small protein conjugation or removal 35.2941 6 no
GO:1902531 regulation of intracellular signal transduction 29.4118 5 yes
GO:0043254 regulation of protein-containing complex assembly 29.4118 5 no
GO:0044087 regulation of cellular component biogenesis 29.4118 4 no
GO:0065003 protein-containing complex assembly 29.4118 5 no
GO:0008104 protein localization 29.4118 4 no
GO:0042981 regulation of apoptotic process 29.4118 5 no
GO:0043067 regulation of programmed cell death 29.4118 4 no
GO:0009057 macromolecule catabolic process 29.4118 4 no
GO:0009892 negative regulation of metabolic process 29.4118 4 no
GO:0010605 negative regulation of macromolecule metabolic process 29.4118 5 no
GO:0006259 DNA metabolic process 29.4118 5 no
GO:0051247 positive regulation of protein metabolic process 29.4118 6 no
GO:0090304 nucleic acid metabolic process 29.4118 4 no
GO:0031399 regulation of protein modification process 29.4118 6 no
GO:1901873 regulation of post-translational protein modification 29.4118 7 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 29.4118 8 no
GO:1902533 positive regulation of intracellular signal transduction 23.5294 6 yes
GO:0031344 regulation of cell projection organization 23.5294 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.5294 6 no
GO:0045893 positive regulation of DNA-templated transcription 23.5294 8 no
GO:0051049 regulation of transport 23.5294 4 no
GO:0051254 positive regulation of RNA metabolic process 23.5294 6 no
GO:1902680 positive regulation of RNA biosynthetic process 23.5294 7 no
GO:0006508 proteolysis 23.5294 4 no
GO:0016567 protein ubiquitination 23.5294 8 no
GO:0019941 modification-dependent protein catabolic process 23.5294 6 no
GO:0043632 modification-dependent macromolecule catabolic process 23.5294 5 no
GO:0051603 proteolysis involved in protein catabolic process 23.5294 5 no
GO:0031334 positive regulation of protein-containing complex assembly 23.5294 6 no
GO:0044089 positive regulation of cellular component biogenesis 23.5294 5 no
GO:0051130 positive regulation of cellular component organization 23.5294 5 no
GO:0009059 macromolecule biosynthetic process 23.5294 4 no
GO:0009890 negative regulation of biosynthetic process 23.5294 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0014070 response to organic cyclic compound 23.5294 4 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0031327 negative regulation of cellular biosynthetic process 23.5294 6 no
GO:0045892 negative regulation of DNA-templated transcription 23.5294 8 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 23.5294 5 no
GO:0051253 negative regulation of RNA metabolic process 23.5294 6 no
GO:1902679 negative regulation of RNA biosynthetic process 23.5294 7 no
GO:0030162 regulation of proteolysis 23.5294 6 no
GO:0032880 regulation of protein localization 23.5294 5 no
GO:0034605 cellular response to heat 23.5294 4 no
GO:0042176 regulation of protein catabolic process 23.5294 5 no
GO:0050821 protein stabilization 23.5294 4 no
GO:0060341 regulation of cellular localization 23.5294 4 no
GO:1903050 regulation of proteolysis involved in protein catabolic process 23.5294 7 no
GO:2000058 regulation of ubiquitin-dependent protein catabolic process 23.5294 5 no
GO:0031396 regulation of protein ubiquitination 23.5294 9 no
GO:0031401 positive regulation of protein modification process 23.5294 7 no
GO:1901222 regulation of non-canonical NF-kappaB signal transduction 11.7647 6 yes
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction 11.7647 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GCR_HUMAN [view entry] [view interactions] Low throughput yes yes
NCOA1_HUMAN [view interactions] Low throughput no yes
UBC9_HUMAN [view entry] [view interactions] Low throughput yes yes
SUMO1_HUMAN [view entry] [view interactions] Low throughput yes yes
FAF1_HUMAN [view interactions] Low throughput no yes
DAXX_HUMAN [view interactions] Low throughput no yes
C8AP2_HUMAN [view interactions] Low throughput no no
TEBP_HUMAN [view interactions] Low throughput no yes
NRIP1_HUMAN [view interactions] Low throughput no yes
TIF1A_HUMAN [view interactions] Low throughput no yes
CBP_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
KAT2B_HUMAN [view interactions] Low throughput no yes
CAV1_HUMAN [view interactions] Low throughput no no
PP1A_HUMAN [view entry] [view interactions] Low throughput yes yes
UBE3A_HUMAN [view entry] [view interactions] Low throughput yes yes
MCR_HUMAN [view entry] [view interactions] Low throughput yes yes
ACSL1_HUMAN [view interactions] High throughput no no
RXRA_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
PRAF1_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
PROX1_HUMAN [view interactions] High throughput no no
PRS8_HUMAN [view interactions] High throughput no yes
CHIP_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP5_HUMAN [view interactions] High throughput no yes
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes
PPID_HUMAN [view entry] [view interactions] High throughput yes yes
AIP_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
CARME_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no