MCR_HUMAN
Evidence for PS localization
Functions
Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MCR_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 30.7692 | 4 | no |
| GO:0005524 | ATP binding | 30.7692 | 5 | no |
| GO:0017076 | purine nucleotide binding | 30.7692 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 30.7692 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 30.7692 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 30.7692 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.7692 | 4 | no |
| GO:0046872 | metal ion binding | 19.2308 | 4 | yes |
| GO:0000976 | transcription cis-regulatory region binding | 11.5385 | 5 | yes |
| GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | 11.5385 | 6 | yes |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | 11.5385 | 7 | yes |
| GO:0000987 | cis-regulatory region sequence-specific DNA binding | 11.5385 | 6 | yes |
| GO:0001067 | transcription regulatory region nucleic acid binding | 11.5385 | 4 | yes |
| GO:0003677 | DNA binding | 11.5385 | 4 | yes |
| GO:0003690 | double-stranded DNA binding | 11.5385 | 5 | yes |
| GO:0008270 | zinc ion binding | 11.5385 | 6 | yes |
| GO:0043565 | sequence-specific DNA binding | 11.5385 | 5 | yes |
| GO:0046914 | transition metal ion binding | 11.5385 | 5 | yes |
| GO:1990837 | sequence-specific double-stranded DNA binding | 11.5385 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MCR_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 46.1538 | 4 | yes |
| GO:0006996 | organelle organization | 42.3077 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.4615 | 4 | yes |
| GO:0022607 | cellular component assembly | 38.4615 | 4 | no |
| GO:0009966 | regulation of signal transduction | 34.6154 | 4 | yes |
| GO:0010646 | regulation of cell communication | 34.6154 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 34.6154 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 34.6154 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 34.6154 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 30.7692 | 4 | yes |
| GO:0010468 | regulation of gene expression | 30.7692 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.7692 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 30.7692 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 30.7692 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 30.7692 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 30.7692 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 26.9231 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 26.9231 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.9231 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 26.9231 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 26.9231 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 26.9231 | 5 | yes |
| GO:0036211 | protein modification process | 26.9231 | 4 | no |
| GO:0043412 | macromolecule modification | 26.9231 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.9231 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 26.9231 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.0769 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 23.0769 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 23.0769 | 5 | no |
| GO:0007010 | cytoskeleton organization | 23.0769 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 19.2308 | 6 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 19.2308 | 7 | yes |
| GO:0051252 | regulation of RNA metabolic process | 19.2308 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 19.2308 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 19.2308 | 6 | yes |
| GO:0030518 | intracellular steroid hormone receptor signaling pathway | 15.3846 | 4 | yes |
| GO:0043401 | steroid hormone mediated signaling pathway | 15.3846 | 4 | yes |
| GO:1901222 | regulation of NIK/NF-kappaB signaling | 7.6923 | 6 | yes |
| GO:1901224 | positive regulation of NIK/NF-kappaB signaling | 7.6923 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NCOA1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC9_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO1_HUMAN | [view interactions] | Low throughput | no | yes |
| FAF1_HUMAN | [view interactions] | Low throughput | no | yes |
| DAXX_HUMAN | [view interactions] | Low throughput | no | yes |
| C8AP2_HUMAN | [view interactions] | Low throughput | no | no |
| TEBP_HUMAN | [view interactions] | Low throughput | no | yes |
| NRIP1_HUMAN | [view interactions] | Low throughput | no | yes |
| TIF1A_HUMAN | [view interactions] | Low throughput | no | yes |
| CBP_HUMAN | [view interactions] | Low throughput | no | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| KAT2B_HUMAN | [view interactions] | Low throughput | no | yes |
| CAV1_HUMAN | [view interactions] | Low throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROX1_HUMAN | [view interactions] | High throughput | no | no |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP5_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| PPID_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CARME_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| RXRA_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| DCTN4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DC1L1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DHI2_HUMAN | [view interactions] | Computational | no | no |
| DCTN3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN5_HUMAN | [view interactions] | Computational | no | yes |
| PIAS1_HUMAN | [view interactions] | Computational | no | yes |
| ACE_HUMAN | [view interactions] | Computational | no | no |
| RENI_HUMAN | [view interactions] | Computational | no | no |
| ACTZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAZA3_HUMAN | [view interactions] | Computational | no | no |
| DC1L2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN6_HUMAN | [view interactions] | Computational | no | no |
| CAZA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ARP10_HUMAN | [view interactions] | Computational | no | no |
| DYL2_HUMAN | [view entry] [view interactions] | Computational | yes | no |