AIP_HUMAN
Evidence for PS localization
Functions
Cellular negative regulator of the hepatitis B virus (HBV) X protein. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 304 | Arg | Gln | Pituitaryadenoma1,multipletypes(PITA1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AIP_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 54.0541 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 51.3514 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 48.6486 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 45.9459 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 43.2432 | 5 | no |
| GO:0005524 | ATP binding | 40.5405 | 5 | no |
| GO:0016301 | kinase activity | 29.7297 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 29.7297 | 4 | no |
| GO:0004712 | protein serine/threonine/tyrosine kinase activity | 27.0270 | 4 | no |
| GO:0003723 | RNA binding | 21.6216 | 4 | no |
| GO:0019900 | kinase binding | 21.6216 | 4 | no |
| GO:0019901 | protein kinase binding | 21.6216 | 5 | no |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 13.5135 | 5 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 13.5135 | 4 | yes |
| GO:0017162 | aryl hydrocarbon receptor binding | 5.4054 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AIP_HUMAN |
|---|---|---|---|---|
| GO:0051171 | regulation of nitrogen compound metabolic process | 62.1622 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 62.1622 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 59.4595 | 4 | no |
| GO:0010646 | regulation of cell communication | 59.4595 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 59.4595 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 59.4595 | 4 | no |
| GO:0009966 | regulation of signal transduction | 56.7568 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 54.0541 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 54.0541 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 48.6486 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 48.6486 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 45.9459 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 45.9459 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 45.9459 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 43.2432 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 43.2432 | 5 | no |
| GO:0031399 | regulation of protein modification process | 43.2432 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 43.2432 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 43.2432 | 6 | no |
| GO:0010468 | regulation of gene expression | 43.2432 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 40.5405 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.5405 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.5405 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 40.5405 | 7 | no |
| GO:0051128 | regulation of cellular component organization | 40.5405 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 40.5405 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 40.5405 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 37.8378 | 5 | no |
| GO:0071702 | organic substance transport | 37.8378 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 37.8378 | 4 | yes |
| GO:0010941 | regulation of cell death | 37.8378 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 37.8378 | 7 | no |
| GO:0031401 | positive regulation of protein modification process | 35.1351 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 35.1351 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 35.1351 | 7 | no |
| GO:0008104 | protein localization | 35.1351 | 4 | yes |
| GO:0015031 | protein transport | 35.1351 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 35.1351 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 35.1351 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 35.1351 | 5 | no |
| GO:0036211 | protein modification process | 35.1351 | 4 | no |
| GO:0043412 | macromolecule modification | 35.1351 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.1351 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 35.1351 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 32.4324 | 8 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 32.4324 | 6 | no |
| GO:0071310 | cellular response to organic substance | 32.4324 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 32.4324 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 32.4324 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.4324 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.7297 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 29.7297 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 29.7297 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.7297 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 29.7297 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 29.7297 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.7297 | 5 | no |
| GO:0006886 | intracellular protein transport | 29.7297 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 29.7297 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 29.7297 | 8 | no |
| GO:0009891 | positive regulation of biosynthetic process | 29.7297 | 5 | no |
| GO:0043549 | regulation of kinase activity | 27.0270 | 5 | no |
| GO:0051338 | regulation of transferase activity | 27.0270 | 4 | no |
| GO:0080134 | regulation of response to stress | 27.0270 | 4 | no |
| GO:0006996 | organelle organization | 27.0270 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.0270 | 6 | no |
| GO:0022607 | cellular component assembly | 24.3243 | 4 | no |
| GO:0032880 | regulation of protein localization | 24.3243 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 24.3243 | 6 | no |
| GO:0060341 | regulation of cellular localization | 24.3243 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.3243 | 6 | no |
| GO:0060548 | negative regulation of cell death | 24.3243 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 24.3243 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.3243 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.3243 | 4 | no |
| GO:0006468 | protein phosphorylation | 24.3243 | 5 | no |
| GO:0016310 | phosphorylation | 24.3243 | 5 | no |
| GO:0009894 | regulation of catabolic process | 24.3243 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.6216 | 4 | no |
| GO:0050776 | regulation of immune response | 21.6216 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 21.6216 | 4 | no |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 21.6216 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 21.6216 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 21.6216 | 4 | no |
| GO:0051049 | regulation of transport | 21.6216 | 4 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 21.6216 | 7 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 21.6216 | 6 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 21.6216 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 21.6216 | 8 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.6216 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.6216 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 21.6216 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 21.6216 | 6 | no |
| GO:0043086 | negative regulation of catalytic activity | 18.9189 | 4 | yes |
| GO:0006605 | protein targeting | 13.5135 | 5 | yes |
| GO:0006839 | mitochondrial transport | 13.5135 | 4 | yes |
| GO:0033365 | protein localization to organelle | 13.5135 | 5 | yes |
| GO:0070585 | protein localization to mitochondrion | 13.5135 | 6 | yes |
| GO:0072594 | establishment of protein localization to organelle | 13.5135 | 4 | yes |
| GO:0072655 | establishment of protein localization to mitochondrion | 13.5135 | 5 | yes |
| GO:0006626 | protein targeting to mitochondrion | 10.8108 | 5 | yes |
| GO:0051346 | negative regulation of hydrolase activity | 10.8108 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in AIP_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 5.4054 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 5.4054 | 5 | no |
| DOID:114 | heart disease | 5.4054 | 3 | no |
| DOID:12930 | dilated cardiomyopathy | 5.4054 | 6 | no |
| DOID:331 | central nervous system disease | 5.4054 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RET_HUMAN | [view interactions] | Low throughput | no | yes |
| PPARA_HUMAN | [view interactions] | Low throughput | no | yes |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIRC5_HUMAN | [view interactions] | Low throughput | no | no |
| FBX11_HUMAN | [view interactions] | Low throughput | no | no |
| BCL6_HUMAN | [view interactions] | Low throughput | no | no |
| UCHL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARNT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TOM20_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNI3K_HUMAN | [view interactions] | Low throughput | no | no |
| THB_HUMAN | [view interactions] | Low throughput | no | no |
| PDE2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNA13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDE4A_HUMAN | [view interactions] | Low throughput | no | no |
| AHR_HUMAN | [view interactions] | Low throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TEBP_HUMAN | [view interactions] | Low throughput | no | yes |
| SGK3_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| KPSH2_HUMAN | [view interactions] | High throughput | no | no |
| TSSK6_HUMAN | [view interactions] | High throughput | no | no |
| TSSK1_HUMAN | [view interactions] | High throughput | no | no |
| PLK3_HUMAN | [view interactions] | High throughput | no | no |
| SGK2_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK4_HUMAN | [view interactions] | High throughput | no | no |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NBEL2_HUMAN | [view interactions] | High throughput | no | no |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMP_HUMAN | [view interactions] | High throughput | no | yes |
| SIM2_HUMAN | [view interactions] | High throughput | no | yes |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R2_HUMAN | [view interactions] | High throughput | no | no |
| NPHP4_HUMAN | [view interactions] | High throughput | no | yes |
| OFD1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK8_HUMAN | [view interactions] | High throughput | no | yes |
| MKS1_HUMAN | [view interactions] | High throughput | no | no |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| EPHB6_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| INSRR_HUMAN | [view interactions] | High throughput | no | no |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| PTN18_HUMAN | [view interactions] | High throughput | no | yes |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| NEUR4_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| STYL1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| SYCN_HUMAN | [view interactions] | High throughput | no | no |
| KHDC1_HUMAN | [view interactions] | High throughput | no | no |
| REL2_HUMAN | [view interactions] | High throughput | no | no |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| RIPR3_HUMAN | [view interactions] | High throughput | no | yes |
| PDE3A_HUMAN | [view interactions] | High throughput | no | no |
| SAMH1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB24_HUMAN | [view interactions] | High throughput | no | no |
| PDE7A_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB3_HUMAN | [view interactions] | High throughput | no | no |
| SHFL_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2G_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| PPCE_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
| TOM34_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHD1_HUMAN | [view interactions] | High throughput | no | no |
| FKBPL_HUMAN | [view interactions] | High throughput | no | yes |
| HACE1_HUMAN | [view interactions] | High throughput | no | no |
| LRC40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHLB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPCD_HUMAN | [view interactions] | High throughput | no | yes |
| DAA10_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F120C_HUMAN | [view interactions] | High throughput | no | yes |
| SYMPK_HUMAN | [view interactions] | High throughput | no | yes |
| GLE1_HUMAN | [view interactions] | High throughput | no | yes |
| MFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB5_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| HROB_HUMAN | [view interactions] | High throughput | no | yes |
| CLC7A_HUMAN | [view interactions] | High throughput | no | no |
| WIPI2_HUMAN | [view interactions] | High throughput | no | yes |
| IRF7_HUMAN | [view interactions] | High throughput | no | yes |
| NADE_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| UBP19_HUMAN | [view interactions] | High throughput | no | no |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| PRA17_HUMAN | [view interactions] | High throughput | no | no |
| TDGF1_HUMAN | [view interactions] | High throughput | no | no |
| PRA10_HUMAN | [view interactions] | High throughput | no | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGR_HUMAN | [view interactions] | High throughput | no | no |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| KPSH1_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FER_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCG_HUMAN | [view interactions] | High throughput | no | no |
| GRK6_HUMAN | [view interactions] | High throughput | no | yes |
| CLK3_HUMAN | [view interactions] | High throughput | no | yes |
| BLK_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKX_HUMAN | [view interactions] | High throughput | no | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| CDK13_HUMAN | [view interactions] | High throughput | no | no |
| PDK4_HUMAN | [view interactions] | High throughput | no | yes |
| ULK3_HUMAN | [view interactions] | High throughput | no | yes |
| PKN3_HUMAN | [view interactions] | High throughput | no | yes |
| STAT4_HUMAN | [view interactions] | Computational | no | yes |
| AIPL1_HUMAN | [view interactions] | Computational | no | no |