AIP_HUMAN
Evidence for PS localization
Functions
Cellular negative regulator of the hepatitis B virus (HBV) X protein. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 64%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Interacting regions
Canonical [AIP_HUMAN]
Isoform [A0A804HJ38] alignment
Isoform [A0A804HJ46] alignment
Isoform [A0A804HIX8] alignment
Isoform [V9GYQ3] alignment
Isoform [A0A804HKP8] alignment
Isoform [A0A804HKL7] alignment
Isoform [A0A804HKH9] alignment
Isoform [A0A804HKK3] alignment
Isoform [E9PMH2] alignment
LOADING 29%
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 304 | Arg | Gln | Pituitaryadenoma1,multipletypes(PITA1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AIP_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 47.6190 | 4 | no |
| GO:0017076 | purine nucleotide binding | 47.6190 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 47.6190 | 4 | no |
| GO:0043168 | anion binding | 47.6190 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 45.2381 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 40.4762 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 40.4762 | 5 | no |
| GO:0005524 | ATP binding | 38.0952 | 5 | no |
| GO:0016301 | kinase activity | 28.5714 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 28.5714 | 4 | no |
| GO:0043169 | cation binding | 23.8095 | 4 | no |
| GO:0046872 | metal ion binding | 23.8095 | 5 | no |
| GO:0019900 | kinase binding | 23.8095 | 4 | no |
| GO:0019901 | protein kinase binding | 23.8095 | 5 | no |
| GO:0003723 | RNA binding | 21.4286 | 4 | no |
| GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding | 11.9048 | 5 | yes |
| GO:0140297 | DNA-binding transcription factor binding | 11.9048 | 4 | yes |
| GO:0017162 | aryl hydrocarbon receptor binding | 4.7619 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AIP_HUMAN |
|---|---|---|---|---|
| GO:0080090 | regulation of primary metabolic process | 59.5238 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 57.1429 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 57.1429 | 4 | no |
| GO:0010646 | regulation of cell communication | 54.7619 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 54.7619 | 4 | no |
| GO:0009966 | regulation of signal transduction | 52.3810 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 47.6190 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 47.6190 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.2381 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 42.8571 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 42.8571 | 5 | no |
| GO:0031399 | regulation of protein modification process | 42.8571 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.4762 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.4762 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 40.4762 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 40.4762 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 40.4762 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.4762 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 40.4762 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 40.4762 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 40.4762 | 5 | no |
| GO:0008104 | protein localization | 38.0952 | 4 | yes |
| GO:0010468 | regulation of gene expression | 38.0952 | 6 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 5HT6R_HUMAN | [view interactions] | High throughput | no | yes |
| AGO1_HUMAN | [view interactions] | High throughput | no | no |
| AHR_HUMAN | [view interactions] | Low throughput | no | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| ARNT_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCL10_HUMAN | [view interactions] | High throughput | no | yes |
| BCL6_HUMAN | [view interactions] | Low throughput | no | no |
| BIRC5_HUMAN | [view interactions] | Low throughput | no | no |
| BLK_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| BTG3_HUMAN | [view interactions] | High throughput | no | yes |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| CDK13_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CHRD1_HUMAN | [view interactions] | High throughput | no | yes |