GNA13_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed, PubMed, PubMed, PubMed). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed, PubMed). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) . Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed, PubMed, PubMed). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GNA13_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 42.5926 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 42.5926 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 42.5926 | 4 | yes |
| GO:0043168 | anion binding | 42.5926 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 38.8889 | 4 | yes |
| GO:0043169 | cation binding | 37.0370 | 4 | yes |
| GO:0046872 | metal ion binding | 35.1852 | 5 | yes |
| GO:0019900 | kinase binding | 33.3333 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 31.4815 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 31.4815 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 31.4815 | 6 | yes |
| GO:0019901 | protein kinase binding | 31.4815 | 5 | no |
| GO:0003924 | GTPase activity | 27.7778 | 7 | yes |
| GO:0005525 | GTP binding | 22.2222 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 22.2222 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 22.2222 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 22.2222 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.2222 | 5 | no |
| GO:0001664 | G protein-coupled receptor binding | 18.5185 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 9.2593 | 4 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 5.5556 | 5 | yes |
| GO:0050780 | dopamine receptor binding | 3.7037 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GNA13_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.5556 | 4 | no |
| GO:0010646 | regulation of cell communication | 53.7037 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 51.8519 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.2963 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 44.4444 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.5926 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.5926 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 38.8889 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 37.0370 | 4 | no |
| GO:0051049 | regulation of transport | 35.1852 | 4 | no |
| GO:0071310 | cellular response to organic substance | 35.1852 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 35.1852 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0008104 | protein localization | 31.4815 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.4815 | 5 | no |
| GO:0022607 | cellular component assembly | 29.6296 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 29.6296 | 4 | no |
| GO:0010468 | regulation of gene expression | 29.6296 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 29.6296 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.6296 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 27.7778 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.7778 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 27.7778 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 27.7778 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 27.7778 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 25.9259 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.9259 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.9259 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.9259 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 25.9259 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 25.9259 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.9259 | 5 | no |
| GO:0006996 | organelle organization | 25.9259 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.9259 | 5 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 25.9259 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 24.0741 | 5 | no |
| GO:0014070 | response to organic cyclic compound | 24.0741 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.0741 | 6 | no |
| GO:0031399 | regulation of protein modification process | 24.0741 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.0741 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.0741 | 6 | no |
| GO:0141124 | intracellular signaling cassette | 22.2222 | 4 | yes |
| GO:2000145 | regulation of cell motility | 22.2222 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 22.2222 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 22.2222 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.2222 | 7 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.2222 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.2222 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.2222 | 4 | no |
| GO:0030334 | regulation of cell migration | 22.2222 | 5 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.3704 | 6 | no |
| GO:0043412 | macromolecule modification | 20.3704 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.3704 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.3704 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.3704 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 18.5185 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 18.5185 | 4 | yes |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 16.6667 | 5 | yes |
| GO:2000146 | negative regulation of cell motility | 11.1111 | 5 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 11.1111 | 5 | yes |
| GO:0022604 | regulation of cell morphogenesis | 11.1111 | 5 | yes |
| GO:0030336 | negative regulation of cell migration | 11.1111 | 6 | yes |
| GO:0040013 | negative regulation of locomotion | 11.1111 | 4 | yes |
| GO:0002009 | morphogenesis of an epithelium | 9.2593 | 4 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 7.4074 | 6 | yes |
| GO:0007266 | Rho protein signal transduction | 5.5556 | 6 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 5.5556 | 5 | yes |
| GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 3.7037 | 6 | yes |
| GO:0001701 | in utero embryonic development | 3.7037 | 6 | yes |
| GO:0009792 | embryo development ending in birth or egg hatching | 3.7037 | 4 | yes |
| GO:0010762 | regulation of fibroblast migration | 3.7037 | 6 | yes |
| GO:0043009 | chordate embryonic development | 3.7037 | 5 | yes |
| GO:0048660 | regulation of smooth muscle cell proliferation | 3.7037 | 5 | yes |
| GO:0048754 | branching morphogenesis of an epithelial tube | 3.7037 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARHG1_HUMAN | [view interactions] | Low throughput | no | no |
| PAR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARHGB_HUMAN | [view interactions] | Low throughput | no | yes |
| AKAP3_HUMAN | [view interactions] | Low throughput | no | no |
| RADI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIC8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DRD5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARHGC_HUMAN | [view interactions] | Low throughput | no | yes |
| TA2R_HUMAN | [view interactions] | Low throughput | no | no |
| MCF2_HUMAN | [view interactions] | Low throughput | no | no |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| ARG28_HUMAN | [view interactions] | Low throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AHR_HUMAN | [view interactions] | Low throughput | no | yes |
| GPR35_HUMAN | [view interactions] | Low throughput | no | no |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TEC_HUMAN | [view interactions] | Low throughput | no | yes |
| CADH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RGS16_HUMAN | [view interactions] | Low throughput | no | no |
| PPP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| S1PR2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AGRL3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGRG1_HUMAN | [view interactions] | Low throughput | no | yes |
| AGRE5_HUMAN | [view interactions] | Low throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| UBP3_HUMAN | [view interactions] | High throughput | no | no |
| S1PR1_HUMAN | [view interactions] | High throughput | no | no |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| FANCE_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| GBG4_HUMAN | [view interactions] | High throughput | no | no |
| GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKH4B_HUMAN | [view interactions] | High throughput | no | yes |
| PHAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CXCR5_HUMAN | [view interactions] | High throughput | no | yes |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| PHF19_HUMAN | [view interactions] | High throughput | no | no |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| TA2R7_HUMAN | [view interactions] | High throughput | no | no |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| MINY2_HUMAN | [view interactions] | High throughput | no | no |
| RD3_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| GLI1_HUMAN | [view interactions] | High throughput | no | no |
| CDC73_HUMAN | [view interactions] | High throughput | no | yes |
| CP2S1_HUMAN | [view interactions] | High throughput | no | no |
| PVR_HUMAN | [view interactions] | High throughput | no | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| SPSB3_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG1_HUMAN | [view interactions] | High throughput | no | no |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG10_HUMAN | [view interactions] | High throughput | no | no |
| GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG5_HUMAN | [view interactions] | High throughput | no | no |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA12_HUMAN | [view interactions] | High throughput | no | no |
| TRMO_HUMAN | [view interactions] | High throughput | no | no |
| EBLN2_HUMAN | [view interactions] | High throughput | no | no |
| CAH14_HUMAN | [view interactions] | High throughput | no | yes |
| DPOG2_HUMAN | [view interactions] | High throughput | no | yes |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CMIP_HUMAN | [view interactions] | High throughput | no | yes |
| MUS81_HUMAN | [view interactions] | High throughput | no | no |
| UXS1_HUMAN | [view interactions] | High throughput | no | yes |
| PEX1_HUMAN | [view interactions] | High throughput | no | no |
| GIMA4_HUMAN | [view interactions] | High throughput | no | yes |
| ISOC1_HUMAN | [view interactions] | High throughput | no | no |
| SMC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLDN1_HUMAN | [view interactions] | High throughput | no | yes |
| CCG4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFNA5_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KTAP2_HUMAN | [view interactions] | High throughput | no | no |
| TEX29_HUMAN | [view interactions] | High throughput | no | no |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD3_HUMAN | [view interactions] | High throughput | no | yes |
| RT18C_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| WDR36_HUMAN | [view interactions] | High throughput | no | no |
| RAMAC_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| MOT1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |