Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GNA13_HUMAN

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed, PubMed, PubMed, PubMed). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed, PubMed). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) . Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed, PubMed, PubMed). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GNA13_HUMAN
GO:0017076 purine nucleotide binding 39.0625 4 yes
GO:0032555 purine ribonucleotide binding 39.0625 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 37.5000 4 yes
GO:0019900 kinase binding 31.2500 4 no
GO:0019901 protein kinase binding 29.6875 5 no
GO:0016462 pyrophosphatase activity 28.1250 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 28.1250 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 28.1250 6 yes
GO:0046872 metal ion binding 28.1250 4 yes
GO:0003924 GTPase activity 25.0000 7 yes
GO:0030554 adenyl nucleotide binding 21.8750 5 no
GO:0032559 adenyl ribonucleotide binding 21.8750 5 no
GO:0005524 ATP binding 20.3125 5 no
GO:0005525 GTP binding 18.7500 5 yes
GO:0019001 guanyl nucleotide binding 18.7500 5 yes
GO:0032561 guanyl ribonucleotide binding 18.7500 5 yes
GO:0030695 GTPase regulator activity 17.1875 4 yes
GO:0001664 G protein-coupled receptor binding 12.5000 4 yes
GO:0005085 guanyl-nucleotide exchange factor activity 9.3750 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GNA13_HUMAN
GO:0010646 regulation of cell communication 62.5000 4 yes
GO:0048522 positive regulation of cellular process 60.9375 4 no
GO:0009966 regulation of signal transduction 59.3750 4 yes
GO:0048523 negative regulation of cellular process 59.3750 4 yes
GO:1902531 regulation of intracellular signal transduction 46.8750 5 yes
GO:0060255 regulation of macromolecule metabolic process 45.3125 4 no
GO:0031323 regulation of cellular metabolic process 43.7500 4 no
GO:0051171 regulation of nitrogen compound metabolic process 43.7500 4 no
GO:0080090 regulation of primary metabolic process 43.7500 4 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0009893 positive regulation of metabolic process 35.9375 4 no
GO:0010647 positive regulation of cell communication 35.9375 5 no
GO:0023056 positive regulation of signaling 35.9375 4 no
GO:0071310 cellular response to organic substance 35.9375 4 no
GO:0009967 positive regulation of signal transduction 34.3750 5 no
GO:0048584 positive regulation of response to stimulus 34.3750 4 no
GO:0051128 regulation of cellular component organization 34.3750 4 no
GO:0010604 positive regulation of macromolecule metabolic process 31.2500 5 no
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 no
GO:0051049 regulation of transport 31.2500 4 no
GO:0043085 positive regulation of catalytic activity 29.6875 4 yes
GO:0009892 negative regulation of metabolic process 29.6875 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.6875 5 no
GO:1902533 positive regulation of intracellular signal transduction 29.6875 6 no
GO:0006996 organelle organization 29.6875 4 no
GO:0010468 regulation of gene expression 29.6875 5 no
GO:0010243 response to organonitrogen compound 28.1250 4 no
GO:0010648 negative regulation of cell communication 28.1250 5 no
GO:0023057 negative regulation of signaling 28.1250 4 no
GO:1901701 cellular response to oxygen-containing compound 28.1250 4 no
GO:0008104 protein localization 28.1250 4 no
GO:0006796 phosphate-containing compound metabolic process 26.5625 4 no
GO:0010605 negative regulation of macromolecule metabolic process 26.5625 5 no
GO:0031399 regulation of protein modification process 26.5625 6 no
GO:0043408 regulation of MAPK cascade 26.5625 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 26.5625 5 no
GO:0051247 positive regulation of protein metabolic process 26.5625 6 no
GO:0014070 response to organic cyclic compound 26.5625 4 no
GO:0051336 regulation of hydrolase activity 25.0000 4 yes
GO:2000145 regulation of cell motility 25.0000 4 yes
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0048585 negative regulation of response to stimulus 25.0000 4 no
GO:0033043 regulation of organelle organization 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0031324 negative regulation of cellular metabolic process 25.0000 5 no
GO:0030334 regulation of cell migration 23.4375 5 yes
GO:0019220 regulation of phosphate metabolic process 23.4375 6 no
GO:0050804 modulation of chemical synaptic transmission 23.4375 5 no
GO:0051174 regulation of phosphorus metabolic process 23.4375 5 no
GO:0051240 positive regulation of multicellular organismal process 23.4375 4 no
GO:0099177 regulation of trans-synaptic signaling 23.4375 4 no
GO:0010941 regulation of cell death 23.4375 4 no
GO:0042981 regulation of apoptotic process 23.4375 6 no
GO:0043067 regulation of programmed cell death 23.4375 5 no
GO:0009889 regulation of biosynthetic process 23.4375 4 no
GO:0010556 regulation of macromolecule biosynthetic process 23.4375 5 no
GO:0031326 regulation of cellular biosynthetic process 23.4375 5 no
GO:0042127 regulation of cell population proliferation 21.8750 4 yes
GO:0001932 regulation of protein phosphorylation 21.8750 7 no
GO:0042325 regulation of phosphorylation 21.8750 7 no
GO:0043410 positive regulation of MAPK cascade 21.8750 7 no
GO:0043412 macromolecule modification 21.8750 4 no
GO:0043066 negative regulation of apoptotic process 21.8750 7 no
GO:0043069 negative regulation of programmed cell death 21.8750 6 no
GO:0060548 negative regulation of cell death 21.8750 5 no
GO:0032880 regulation of protein localization 21.8750 5 no
GO:0060341 regulation of cellular localization 21.8750 4 no
GO:0051252 regulation of RNA metabolic process 21.8750 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 20.3125 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 20.3125 4 yes
GO:0030155 regulation of cell adhesion 20.3125 4 no
GO:0036211 protein modification process 20.3125 4 no
GO:0045595 regulation of cell differentiation 20.3125 4 no
GO:0051248 negative regulation of protein metabolic process 20.3125 6 no
GO:0033993 response to lipid 20.3125 4 no
GO:0010628 positive regulation of gene expression 20.3125 6 no
GO:0007010 cytoskeleton organization 20.3125 5 no
GO:0009894 regulation of catabolic process 20.3125 4 no
GO:0044087 regulation of cellular component biogenesis 20.3125 4 no
GO:0051056 regulation of small GTPase mediated signal transduction 18.7500 6 yes
GO:0051345 positive regulation of hydrolase activity 18.7500 5 yes
GO:0022604 regulation of cell morphogenesis 14.0625 5 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 12.5000 5 yes
GO:0040013 negative regulation of locomotion 12.5000 4 yes
GO:2000146 negative regulation of cell motility 12.5000 5 yes
GO:0002009 morphogenesis of an epithelium 10.9375 4 yes
GO:0007264 small GTPase mediated signal transduction 10.9375 4 yes
GO:0008285 negative regulation of cell population proliferation 10.9375 5 yes
GO:0008360 regulation of cell shape 10.9375 6 yes
GO:0030336 negative regulation of cell migration 10.9375 6 yes
GO:0007265 Ras protein signal transduction 9.3750 5 yes
GO:0048660 regulation of smooth muscle cell proliferation 7.8125 5 yes
GO:0060191 regulation of lipase activity 7.8125 5 yes
GO:0060193 positive regulation of lipase activity 7.8125 6 yes
GO:0007266 Rho protein signal transduction 6.2500 6 yes
GO:0010517 regulation of phospholipase activity 6.2500 6 yes
GO:0010518 positive regulation of phospholipase activity 6.2500 7 yes
GO:0048754 branching morphogenesis of an epithelial tube 6.2500 4 yes
GO:1904705 regulation of vascular associated smooth muscle cell proliferation 6.2500 6 yes
GO:0001701 in utero embryonic development 4.6875 6 yes
GO:0009792 embryo development ending in birth or egg hatching 4.6875 4 yes
GO:0014910 regulation of smooth muscle cell migration 4.6875 6 yes
GO:0043009 chordate embryonic development 4.6875 5 yes
GO:0001569 branching involved in blood vessel morphogenesis 3.1250 5 yes
GO:0014912 negative regulation of smooth muscle cell migration 3.1250 7 yes
GO:0048662 negative regulation of smooth muscle cell proliferation 3.1250 6 yes
GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation 3.1250 7 yes
GO:1904752 regulation of vascular associated smooth muscle cell migration 3.1250 7 yes
GO:1904753 negative regulation of vascular associated smooth muscle cell migration 3.1250 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
S1PR2_HUMAN [view interactions] Low throughput no no
AIP_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHG1_HUMAN [view interactions] Low throughput no no
PAR1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHGB_HUMAN [view interactions] Low throughput no yes
AKAP3_HUMAN [view interactions] Low throughput no no
RADI_HUMAN [view entry] [view interactions] Low throughput yes yes
RIC8A_HUMAN [view entry] [view interactions] Low throughput yes no
DRD5_HUMAN [view entry] [view interactions] Low throughput yes no
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
KAP2_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHGC_HUMAN [view interactions] Low throughput no yes
TA2R_HUMAN [view interactions] Low throughput no no
MCF2_HUMAN [view interactions] Low throughput no no
M3K5_HUMAN [view interactions] Low throughput no yes
ARG28_HUMAN [view interactions] Low throughput no yes
CADH1_HUMAN [view entry] [view interactions] Low throughput yes no
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
AHR_HUMAN [view interactions] Low throughput no yes
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
TEC_HUMAN [view interactions] Low throughput no yes
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
RGS16_HUMAN [view interactions] Low throughput no no
PPP5_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCB_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCE_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
GLUT4_HUMAN [view interactions] High throughput no no
UBP3_HUMAN [view interactions] High throughput no no
S1PR1_HUMAN [view interactions] High throughput no no
S2541_HUMAN [view interactions] High throughput no no
PACC1_HUMAN [view interactions] High throughput no no
FANCE_HUMAN [view interactions] High throughput no yes
T185A_HUMAN [view interactions] High throughput no no
GBG3_HUMAN [view entry] [view interactions] High throughput yes no
GBG4_HUMAN [view interactions] High throughput no no
PKH4B_HUMAN [view interactions] High throughput no yes
PHAG1_HUMAN [view interactions] High throughput no yes
CXCR5_HUMAN [view interactions] High throughput no yes
CXCR4_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
CD177_HUMAN [view interactions] High throughput no no
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
TGFR1_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
PHF19_HUMAN [view interactions] High throughput no no
HXB5_HUMAN [view interactions] High throughput no no
TA2R7_HUMAN [view interactions] High throughput no no
UIF_HUMAN [view interactions] High throughput no yes
GNAI1_HUMAN [view entry] [view interactions] High throughput yes yes
CCR1_HUMAN [view interactions] High throughput no no
MINY2_HUMAN [view interactions] High throughput no no
RD3_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
HERC2_HUMAN [view interactions] High throughput no yes
GLI1_HUMAN [view interactions] High throughput no no
CDC73_HUMAN [view interactions] High throughput no yes
CP2S1_HUMAN [view interactions] High throughput no no
PVR_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
R144A_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
SPSB3_HUMAN [view interactions] High throughput no yes
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
GBG1_HUMAN [view interactions] High throughput no no
AASD1_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
GDS1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
SGT1_HUMAN [view interactions] High throughput no no
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
GBG10_HUMAN [view interactions] High throughput no no
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
GBG5_HUMAN [view interactions] High throughput no no
GBG8_HUMAN [view interactions] High throughput no no
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
GBB4_HUMAN [view entry] [view interactions] High throughput yes yes
GNA12_HUMAN [view interactions] High throughput no no
TRMO_HUMAN [view interactions] High throughput no no
EBLN2_HUMAN [view interactions] High throughput no no
GPR35_HUMAN [view interactions] High throughput no no
CAH14_HUMAN [view interactions] High throughput no yes
DPOG2_HUMAN [view interactions] High throughput no yes
DUS3_HUMAN [view entry] [view interactions] High throughput yes no
CMIP_HUMAN [view interactions] High throughput no yes
MUS81_HUMAN [view interactions] High throughput no no
UXS1_HUMAN [view interactions] High throughput no yes
PEX1_HUMAN [view interactions] High throughput no no
GIMA4_HUMAN [view interactions] High throughput no yes
ISOC1_HUMAN [view interactions] High throughput no no
SMC3_HUMAN [view entry] [view interactions] High throughput yes yes
CLDN1_HUMAN [view interactions] High throughput no yes
CCG4_HUMAN [view entry] [view interactions] High throughput yes no
JIP1_HUMAN [view entry] [view interactions] High throughput yes yes
EFNA5_HUMAN [view interactions] High throughput no yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
KTAP2_HUMAN [view interactions] High throughput no no
TEX29_HUMAN [view interactions] High throughput no no
STX8_HUMAN [view interactions] High throughput no yes
OTUD3_HUMAN [view interactions] High throughput no yes
RT18C_HUMAN [view interactions] High throughput no yes
ATG9A_HUMAN [view interactions] High throughput no yes
WDR36_HUMAN [view interactions] High throughput no yes
RAMAC_HUMAN [view interactions] High throughput no yes
FBX32_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
MOT1_HUMAN [view interactions] High throughput no no
FAS_HUMAN [view entry] [view interactions] High throughput yes no
EGFR_HUMAN [view interactions] High throughput no no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
GNA11_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] High throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
CTND1_HUMAN [view entry] [view interactions] Computational yes no
CTNA1_HUMAN [view entry] [view interactions] Computational yes yes
S1PR5_HUMAN [view interactions] Computational no no
ITA2B_HUMAN [view interactions] Computational no no
PTH1R_HUMAN [view interactions] Computational no no
ITB3_HUMAN [view entry] [view interactions] Computational yes no
CYH1_HUMAN [view interactions] Computational no no
PAR4_HUMAN [view entry] [view interactions] Computational yes no
V1AR_HUMAN [view interactions] Computational no no
ARHG5_HUMAN [view interactions] Computational no yes
GRM1_HUMAN [view entry] [view interactions] Computational yes yes
LPAR1_HUMAN [view entry] [view interactions] Computational yes no
ADA1B_HUMAN [view interactions] Computational no no
CAC1A_HUMAN [view interactions] Computational no no
PI3R6_HUMAN [view interactions] Computational no yes
CYH3_HUMAN [view entry] [view interactions] Computational yes yes
ADA1D_HUMAN [view interactions] Computational no no
PI3R5_HUMAN [view interactions] Computational no no
GNB5_HUMAN [view entry] [view interactions] Computational yes yes
ADA1A_HUMAN [view entry] [view interactions] Computational yes no
BIG2_HUMAN [view entry] [view interactions] Computational yes yes
PAR3_HUMAN [view interactions] Computational no no
SDF1_HUMAN [view interactions] Computational no no
BIG1_HUMAN [view interactions] Computational no yes
ESR1_HUMAN [view interactions] Computational no no
CYH2_HUMAN [view entry] [view interactions] Computational yes yes
LPAR2_HUMAN [view interactions] Computational no yes
VAV_HUMAN [view interactions] Computational no no
GBB3_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
LPAR4_HUMAN [view interactions] Computational no no
CYH4_HUMAN [view interactions] Computational no yes
PLCB1_HUMAN [view entry] [view interactions] Computational yes yes
AGTR1_HUMAN [view interactions] Computational no no
EDNRA_HUMAN [view interactions] Computational no yes
ROCK2_HUMAN [view entry] [view interactions] Computational yes yes
V1BR_HUMAN [view interactions] Computational no no
CRFR1_HUMAN [view interactions] Computational no yes
AKP13_HUMAN [view interactions] Computational no yes
PK3CG_HUMAN [view interactions] Computational no yes
TRIO_HUMAN [view entry] [view interactions] Computational yes yes
S1PR4_HUMAN [view interactions] Computational no no
CTNB1_HUMAN [view entry] [view interactions] Computational yes yes
S1PR3_HUMAN [view interactions] Computational no no
LPAR5_HUMAN [view interactions] Computational no yes